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| 1 | Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity显示文摘AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty patients(12 men and 8 women; median age, 66.8 years; range, 46-81 years) with decompensated cirrhosis(Child-pugh score > 7) underwent cognitive neuropsychological testing, endotoxin analysis, and fecal microbiome assessment at baseline and after 4 wk of treatment with rifaximin 400 mg thrice a day. HE was determined by serum ammonia level and number connection test(NCT)-A. Changes in whole blood endotoxin activity(EA) was analyzed by endotoxinactivity assay. Fecal microbiome was assessed by 16 S ribosome RNA(rR NA) gene sequencing.RESULTS Treatment with rifaximin for 4 wk improved hyperammonemia(from 90.6 ± 23.9 μg/d L to 73.1 ± 33.1 μg/dL; P < 0.05) and time required for NCT(from 68.2 ± 17.4 s to 54.9 ± 20.3 s; P < 0.05) in patients who had higher levels at baseline. Endotoxin activity was reduced(from 0.43 ± 0.03 to 0.32 ± 0.09; P < 0.05) in direct correlation with decrease in serum ammonia levels(r = 0.5886, P < 0.05). No statistically significant differences were observed in the diversity estimator(Shannon diversity index) and major components of the gut microbiome between the baseline and after treatment groups(3.948 ± 0.548 at baseline vs 3.980 ± 0.968 after treatment; P = 0.544), but the relative abundances of genus Veillonella and Streptococcus were lowered.CONCLUSION Rifaximin significantly improved cognition and reduced endotoxin activity without significantly affecting the composition of the gut microbiome in patients with decompensated cirrhosis. | Kosuke Kaji Hiroaki Takaya Soichiro Saikawa Masanori Furukawa Shinya Sato Hideto Kawaratani Mitsuteru Kitade Kei Moriya Tadashi Namisaki Takemi Akahane Akira Mitoro Hitoshi Yoshiji | 2017 | World Journal of Gastroenterology2017，23，47： | 14 |
| 2 | Minimally invasive surgery for gastric cancer — toward a confluence of two major streams: a review显示文摘 | Yuko Kitagawa Seigo Kitano Tetsuro Kubota Koichiro Kumai Yoshihide Otani Yoshiro Saikawa Masashi Yoshida Masaki Kitajima | 2005 | Gastric Cancer2005，，2： | 2 |
| 3 | Characterization of Organic Aerosol at a Rural Site in the North China Plain Region:Sources,Volatility and Organonitrates显示文摘The North China Plain(NCP)is a region that experiences serious aerosol pollution.A number of studies have focused on aerosol pollution in urban areas in the NCP region;however,research on characterizing aerosols in rural NCP areas is comparatively limited.In this study,we deployed a TD-HR-AMS(thermodenuder high-resolution aerosol mass spectrometer)system at a rural site in the NCP region in summer 2013 to characterize the chemical compositions and volatility of submicron aerosols(PM_(1)).The average PM_(1)mass concentration was 51.2±48.0μg m^(−3) and organic aerosol(OA)contributed most(35.4%)to PM_(1).Positive matrix factorization(PMF)analysis of OA measurements identified four OA factors,including hydrocarbon-like OA(HOA,accounting for 18.4%),biomass burning OA(BBOA,29.4%),lessoxidized oxygenated OA(LO-OOA,30.8%)and more-oxidized oxygenated OA(MO-OOA,21.4%).The volatility sequence of the OA factors was HOA>BBOA>LO-OOA>MO-OOA,consistent with their oxygen-to-carbon(O:C)ratios.Additionally,the mean concentration of organonitrates(ON)was 1.48−3.39μg m−3,contributing 8.1%-19%of OA based on cross validation of two estimation methods with the high-resolution time-of-flight aerosol mass spectrometer(HRToF-AMS)measurement.Correlation analysis shows that ON were more correlated with BBOA and black carbon emitted from biomass burning but poorly correlated with LO-OOA.Also,volatility analysis for ON further confirmed that particulate ON formation might be closely associated with primary emissions in rural NCP areas. | Qiao ZHU Li-Ming CAO Meng-Xue TANG Xiao-Feng HUANG Eri SAIKAWA Ling-Yan HE | 2021 | Advances in Atmospheric Sciences2021，38，7： | 2 |
| 4 | A Novel Approach to the Prevention of Postoperative Delirium in the Elderly After Gastrointestinal Surgery显示文摘 | Ken-ichiro Aizawa Toshio Kanai Yoshiro Saikawa Tsukasa Takabayashi Yukio Kawano Naoto Miyazawa Tetsuya Yamamoto | 2002 | Surgery Today2002，，4： | 2 |
| 5 | Diagnosis and Treatment of a Gastric Hamartomatous Inverted Polyp: Report of a Case显示文摘 | Masahiko Aoki Masashi Yoshida Yoshiro Saikawa Yoshihide Otani Tetsuro Kubota Koichiro Kumai Go Wakabayashi Tai Omori Makio Mukai Masaki Kitajima | 2004 | Surgery Today2004，，6： | 2 |
| 6 | A novel approach to the prevention of postoperative delirium in the elderly aftergastrointestinal surgery显示文摘 | Aizawa K Kanai T Saikawa Y | 2002 | Surg Today2002，32，4： | 1 |
| 7 | Gastric carcinogenesis and the cancer stem cell hypothesis显示文摘 | Yoshiro Saikawa Kazumasa Fukuda Tsunehiro Takahashi Rieko Nakamura Hiroya Takeuchi Yuko Kitagawa | 2010 | Gastric Cancer2010，，1： | 1 |
| 8 | Cyclooxygenase -2 gene induction causes CDDP resistance in colon cancer cell line, HCT - 15显示文摘 | Saikawa Y Sugiura T Toriumi F | 2004 | Anticancer Res2004，24，5： | 1 |
| 9 | Ultrastructural features of the monconstricting ringtrapin Dactylelle leptospora 显示文摘 | | 1985 | Trans Mycol Soc JPN1985，26，： | 1 |
| 10 | Anti-tumour effects of nobiletin,a citrus flavonoid,on gastric cancer include:antiproliferative effects,induction of apoptosis and cell cycle deregulation显示文摘 | Yoshimizu N Otani Y Saikawa Y | 2004 | Aliment Pharmacol Ther2004，20，1： | 1 |
| 11 | Inhibition of DNA methyltransferase by antisense oligodeoxynucleotide modifies cell characteristics in gastric cancer cell lines显示文摘 | SAIKAWA Y KUBOTA T MAEDA S | 2004 | Oncol Rep2004，12，3： | 1 |
| 12 | Role of the MTT ehemosensitivity test in the prognosis of gastric cancer patients after postoperative adjuvant chemotherapy显示文摘 | Nakamura R Saikawa Y Kubota T | 2006 | Anticancer Res2006，26，2： | 1 |
| 13 | Preoperative combination chemotherapy with S-1 and low dose eisplatin against highly advanced gastric carcinoma 显示文摘 | Saikawa Y Akasaka Y Kanai T | 2003 | Oncol Rep2003，10，2： | 1 |
| 14 | Expression of a candidate marker for progenitor cells, Musashi-1,in the proliferative regions of human antrum and its decreased expression in intestinal metaplasia显示文摘 | Akasaka Y Saikawa Y Fujita K | 2005 | Histopathology2005，47，： | 1 |
| 15 | Diminished expression of sarcoplasmic reticulum Ca (2 + ) - ATPase and ryanodine sensitive Ca(2 + ) channel mRNA in streptozotocin- induced diabetic rat heart显示文摘 | Teshima Y Takahashi N Saikawa T | 2000 | J Mol Cell Cardiol2000，32，4： | 1 |
| 16 | Sentinel node naviga- tion in early stage gastric cancer-updated data and cmTent status 显示文摘 | Kitagawa Y Saikawa Y Takeuchi H | 2006 | Seand J Surg2006，95，4： | 1 |
| 17 | Lipoprotein (a) as a risk factor for silent cerebral infarction in hemodialysis patients显示文摘 | Naoya Fukunaga Futoshi Anan Koji Kaneda Tomoko Nawata Tetsunori Saikawa Hironobu Yoshimatsu | 2008 | Metabolism2008，，： | 1 |
| 18 | Predictive value of GADD153, p21 and c-Jun for chemotherapy response in gastric cancer 显示文摘 | Akatsu Y Saikawa Y Kubota T | 2007 | Cancer Sci2007，98，5： | 1 |
| 19 | In vitro and in vivo antim icrobial act ivities of T-3262, a new fluoroquinolone显示文摘 | Fujimaki K Noumi T Saikawa I | | Antimicrob Agents Chemother0，32，6： | 1 |
| 20 | Gastric cancer: Current status of diagnosis and treatment显示文摘 | Takahashi T Saikawa Y Kitagawa Y | 2013 | Cancers2013，5，： | 1 |
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