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| 1 | Non-invasive determination of hepatic steatosis by acoustic structure quantification from ultrasound echo amplitude显示文摘AIM:To use leptin-deficient(ob/ob) mice with demonstrated differences in steatosis levels to test a new diagnostic method using the acoustical structure quantification(ASQ) mode and the associated analytical parameter,'focal disturbance ratio'(FD-ratio).METHODS:Nine ob/ob mice,at 5,8,and 12 wk of age(n = 3 in each age group),were used as models for hepatic steatosis.Echo signals obtained from ultrasonography in the mice were analyzed by ASQ,which uses a statistical analysis of echo amplitude to estimate inhomogeneity in the diagnostic region.FD-ratio,as calculated from this analysis,was the focus of the present study.FD-ratio and fat droplet areas and sizes were compared between age groups.RESULTS:No fibrosis or inflammation was observed in any of the groups.The fat droplet area significantly(P < 0.01) increased with age from 1.25% ± 0.28% at 5 wk to 31.07% ± 0.48% at 8 wk to 51.69% ± 3.19% at 12 wk.The median fat droplet size also significantly(P < 0.01) increased with age,from 1.33(0.55-10.52) m at 5 wk,2.82(0.61-44.13) m at 8 wk and 6.34(0.66-81.83) m at 12 wk.The mean FD-ratio was 0.42 ± 0.11 at 5 wk,0.11 ± 0.05 at 8 wk,and 0.03 ± 0.02 at 12 wk.The FD-ratio was significantly lower at 12 wk than at 5 wk and 8 wk(P < 0.01).A significant negative correlation was observed between the FD-ratio and either the fat droplet area(r =-0.7211,P = 0.0017) or fat droplet size(r =-0.9811,P = 0.0052).CONCLUSION:This tool for statistical analysis of signals from ultrasonography using the FD-ratio can be used to accurately quantify fat in vivo in an animal model of hepatic steatosis,and may serve as a quantitative biomarker of hepatic steatosis. | Hidekatsu Kuroda Keisuke Kakisaka Naohisa Kamiyama Takayoshi Oikawa Mio Onodera Kei Sawara Kanta Oikawa Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki | 2012 | World Journal of Gastroenterology2012，18，29： | 15 |
| 2 | Scale-up method of planetary ball mill显示文摘 | Hiroshi Mio Junya Kano Fumio Saito | 2004 | Chemical Engineering Science2004，，24： | 2 |
| 3 | Optimum revolution and rotational directions and their speeds in planetary ball milling显示文摘 | Hiroshi Mio Junya Kano Fumio Saito Kantaro Kaneko | 2004 | International Journal of Mineral Processing2004，，： | 2 |
| 4 | Clinical Features, Management, and Outcome of Children With Fetal and Postnatal Diagnoses of Isomerism Syndromes显示文摘 | Joyce S.L. Lim Brian W. McCrindle Jeffrey F. Smallhorn Fraser Golding Christopher A. Caldarone Mio Taketazu Edgar T. Jaeggi | 2005 | Circulation2005，，16： | 2 |
| 5 | Presidential leadership and charisma: The effects of metaphor显示文摘 | Jeffery Scott Mio Ronald E. Riggio Shana Levin Renford Reese | 2005 | The Leadership Quarterly2005，，2： | 2 |
| 6 | Spectrum of Cardiovascular Disease, Accuracy of Diagnosis, and Outcome in Fetal Heterotaxy Syndrome显示文摘 | Mio Taketazu Jane Lougheed Shi-Joon Yoo Joyce S.L. Lim Lisa K. Hornberger | 2006 | The American Journal of Cardiology2006，，5： | 2 |
| 7 | Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence:A case report显示文摘BACKGROUND Adenomyoepithelioma(AME)of the breast is a rare type of benign breast tumor.Many AMEs show benign behavior,but reports of the malignant type are rare.We present the case of a patient with AME with repeated local recurrences and further malignant transformation.CASE SUMMARY A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast.A core needle biopsy was performed.The pathological diagnosis was AME.Lumpectomy with a safety margin was performed without axillary lymph node dissection(ALND).Two years later,local recurrence developed,and the patient again underwent lumpectomy with a safety margin.The pathology showed malignant AME,and the margin was negative.Eight months later,local recurrence developed again in the same location,and a total mastectomy was performed without ALND.The pathological diagnosis was malignant AME.The patient was disease-free for three years posttreatment.CONCLUSION The treatment of AME requires caution,as it may exhibit repeated recurrences after local excision as well as malignant transformation. | Goshi Oda Tsuyoshi Nakagawa Mio Mori Tomoyuki Fujioka Iichiro Onishi | 2021 | World Journal of Clinical Cases2021，9，29： | 2 |
| 8 | Estimation of mechanochemical dechlorination rate of poly(vinyl chloride) 显示文摘 | MIO H SAEKI S KANO J | 2002 | Environmental Science and Technology2002，36，6： | 1 |
| 9 | Cigarette smoke induces interleukirr8 release from human bronchial epithelial cells显示文摘 | Mio T Romberger DJ Thompson AB | 1997 | Am J Respir Crit Care Med1997，15，5： | 1 |
| 10 | Gamma radiation inhibits fibroblast-mediated collagen gel retraction 显示文摘 | Carnevali S Mio T Adachi Y | 2003 | Tissue Cell2003，35，6： | 1 |
| 11 | The Effect of Edible Purple Chrysanthemum Extract on Ad- vanced Glycation End Products Generation in Skin~ a Randomized Controlled Clinical Trial and in vitroStudy 显示文摘 | Masayuki Yagi Keitaro Nomoto Mio Hori | 2012 | Anti-Aging Medicine2012，9，2： | 1 |
| 12 | A functional polymorphism in COLllA1, which encodes the alpha 1 chain of type XI collagen,is associated with susceptibili-ty to lumbar disc herniation显示文摘 | Mio F Chiba K Hirose Y Kawaguchi Y Mikami Y Oya T | 2007 | Am J Hum Genet2007，81，： | 1 |
| 13 | Cigarette smoke induces interleukirr-8 release from human bronchial epithelial cells显示文摘 | Mio T Romberger DJ Thompson AB | 1997 | Am J Respir Crit Care Med1997，155，： | 1 |
| 14 | Hypotensive effect ofanthocyanin-rich extract from purple-fleshed sweet potato cultivarAyamurasaki in spontaneously hypertensive rats显示文摘 | MIO K TOMOYUKI O MAMI M | 2005 | Nippon ShokuhinKagaku Kogaku Kaishi2005，52，1： | 1 |
| 15 | Enrichment of carotenoids in flaxseed ( Linum usitatissimum ) by metabolic engineering with introduction of bacterial phytoene synthase gene crtB显示文摘 | Masaki Fujisawa Mio Watanabe Song-Kang Choi Maki Teramoto Kanji Ohyama Norihiko Misawa | 2008 | Journal of Bioscience and Bioengineering2008，，6： | 1 |
| 16 | Human sense of direction and wayfinding显示文摘 | Cornell E H Sorenson A Mio T | 2003 | Annals of Association of American Geographers2003，93，2： | 1 |
| 17 | Effects of rotational direction and rotation-to-revolution speed ratio in planetary ball milling显示文摘 | MIO Hiroshi KANO Junya SAITO Fumio | 2002 | Materials Science and Engineering:A2002，332，12： | 1 |
| 18 | Optimum revolution and rotational directions and their speeds in planetary ball milling显示文摘 | MIO Hiroshi KANO Junya SAITO Fumio | 2004 | International Journal of Mineral Processing2004，74，1： | 1 |
| 19 | Protein expression, gene amplification,and mutational analysis of EGFR in triple - negative breast cancer显示文摘 | Nakajima H Ishikawa Y Furuya Mio | 2014 | Breast Cancer2014，21，1： | 1 |
| 20 | Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells显示文摘 | Mio T Romberger DJ Thompson AB | 1997 | Am J Respir Crit Care Med1997，155，5： | 1 |
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