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| 1 | Association between Diabetes Mellitus and Oral Health Status in Japanese Adults显示文摘Aim The objective of this study was to analyze the oral health among Japanese adults, with and without diabetes mellitus. Methodology The subjects were 518 community residents aged 20 to 91 years in Japan, who participated in the 'Akita health and nutrition survey' and the 'Akita dental disease survey', conducted in 2006. The surveys comprised a self-administered questionnaire, along with medical and dental examinations. Results Using the community periodontal index (CPI), the mean numbers of sextants presenting codes 0, 1 and 2 were significantly lower in diabetics than non-diabetics among the 59 years or younger age group. Although the mean numbers of sextants with codes 0, 1 and 2 among the 60 to 69 years age group were lower, and sextants with a code X among the 59 years or younger age group were higher in diabetics than non-diabetics, no statistically significant differences were detected. The tendency of lower mean numbers of natural teeth and functional tooth units in diabetics than non-diabetics was observed, however no differences were statistically significant. Conclusion The outcome of periodontal disease seemed to be influenced by the diabetic state to some degree, but a clear association between diabetes and oral health status was not found. | Masayuki Ueno Susumu Takeuchi Akiko Oshiro Kayoko Shinada Satoko Ohara Yoko Kawaguchi | 2010 | International Journal of Oral Science2010，2，2： | 6 |
| 2 | Clinical outcomes of Clutch Cutter endoscopic submucosal dissection for older patients with early gastric cancer显示文摘AIM To evaluate the clinical outcome of endoscopic submucosal dissection using the Clutch Cutter(ESDCC) in older patients. METHODS We reviewed 232 consecutive patients with early gastric cancer who underwent ESDCC between June 2010 and February 2014 at Aso Iizuka Hospital. We divided patients into two groups according to age: Older patients(> 80 years, n = 64) and non-older patients(≤ 80 years, n = 168). We retrospectively compared the prevalence rates of pre-existing comorbidities, anticoagulant therapy, en bloc resection, mean duration of hospitalization, incidence of ESDCC-related complications, change in performance status(PS) before and after ESDCC, and financial cost of admission. RESULTS The older group comprised 64 patients with a mean age of 84.1 years, and the non-older group comprised 168 patients with a mean age of 69.5 years. Older patients had significantly more pre-existing comorbidities than did non-older patients, specifically heart disease(P < 0.05). The en bloc resection rate in non-older patients was significantly higher than that in older patients(100% vs 95.3%, P = 0.02). There were no significant differences between the older and non-older groups in the incidence of ESDCC-related complications(i.e., postoperative bleeding and perforation) and the post-ESDCC change in PS. There were also no significant differences between the older and non-older groups in the mean duration of hospitalization(11.4 and 10.7 d, respectively) and financial cost of admission(657040 JPY and 574890 JPY, respectively).CONCLUSION ESDCC has a good clinical outcome in older patients. | Yoshihiro Otsuka Kazuya Akahoshi Kayoko Yasunaga Masaru Kubokawa Junya Gibo Shigeki Osada Kayo Tokumaru Kazuaki Miyamoto Takao Sato Yuki Shiratsuchi Masafumi Oya Hidenobu Koga Eikichi Ihara Kazuhiko Nakamura | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 3 | Endoscopic characteristics of small intestinal malignant tumors observed by balloon-assisted enteroscopy显示文摘BACKGROUND Capsule endoscopy and balloon-assisted enteroscopy(BAE) enable visualization of rare small bowel conditions such as small intestinal malignant tumors.However,details of the endoscopic characteristics of small intestinal malignant tumors are still unknown.AIM To elucidate the endoscopic characteristics of small intestinal malignant tumors.METHODS From March 2005 to February 2017,1329 BAE procedures were performed at Keio University Hospital. Of these procedures,malignant tumors were classified into three groups,Group 1: epithelial tumors including primary small intestinal cancer,metastatic small intestinal cancer,and direct small intestinal invasion by an adjacent organ cancer; Group 2: small intestinal malignant lymphoma; and Group 3,small intestinal gastrointestinal stromal tumors. We systematically collected clinical and endoscopic data from patients' medical records to determine the endoscopic characteristics for each group.RESULTS The number of patients in each group was 16(Group 1),23(Group 2),and 6(Group 3),and the percentage of solitary tumors was 100%,43.5%,and 100%,respectively(P < 0.001). Patients' clinical background parameters including age,symptoms,and laboratory data were not significantly different between the groups. Seventy-five percent of epithelial tumors(Group 1) were located in the upper small intestine(duodenum and ileum),and approximately 70% of gastrointestinal stromal tumors(Group 3) were located in the jejunum. Solitary protruding or mass-type tumors were not seen in malignant lymphoma(Group2)(P < 0.001). Stenosis was seen more often in Group 1,(68.8%,27.3%,and 0%;Group 1,2,and 3,respectively; P = 0.004). Enlarged white villi inside and/or surrounding the tumor were seen in 12.5%,54.5%,and 0% in Group 1,2,and 3,respectively(P = 0.001).CONCLUSION The differential diagnosis of small intestinal malignant tumors could be tentatively made based on BAE findings. | Tomofumi Horie Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Kenji JL Limpias Kamiya Ryoichi Miyanaga Shinta Mizuno Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Masayuki Shimoda Haruhiko Ogata Takanori Kanai | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，5： | 4 |
| 4 | Endoscopic removal of foreign bodies:A retrospective study in Japan显示文摘BACKGROUND The ingestion of foreign bodies(FBs)and food bolus impaction(FBI)in the digestive tract are commonly encountered clinical problems.Methods to handle such problems continue to evolve offering advantages,such as the avoidance of surgery,reduced cost,improved visualization,reduced morbidity,and high removal success rate.However,to date,no studies have evaluated the endoscopic management of FBs in Japan.AIM To elucidate level of safety and efficacy in the endoscopic management of FBs and FBI.METHODS A total of 215 procedures were performed at Keio University Hospital between November 2007 and August 2018.Data were collected from medical charts,and endoscopic details were collected from an endoscopic reporting system.Procedures performed with a flexible gastrointestinal endoscope were only taken into account.Patients who underwent a technique involving FB or FBI from the digestive tract were only included.Data on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed retrospectively.RESULTS Among the 215 procedures,136(63.3%)were performed in old adults(≥60 years),180(83.7%)procedures were performed in outpatients.The most common type of FBs were press-through-pack(PTP)medications[72(33.5%)cases],FBI[47(21.9%)],Anisakis parasite(AP)[41(19.1%)cases].Most FBs were located in the esophagus[130(60.5%)cases]followed by the stomach[68(31.6%)cases].AP was commonly found in the stomach[39(57.4%)cases],and it was removed using biopsy forceps in 97.5%of the cases.The most common FBs according to anatomical location were PTP medications(40%)and dental prostheses(DP)(40%)in the laryngopharynx,PTP(48.5%)in the esophagus,AP(57.4%)in the stomach,DP(37.5%)in the small intestine and video capsule endoscopy device(75%)in the colon.A transparent cap with grasping forceps was the most commonly used device[82(38.1%)cases].The success rate of the procedure was 100%,and complication were observed in only one case(0.5%).CONCLUSION Endoscopic management of FBs and FBI in our Hospital is extremely safe and effective. | Kenji JL Limpias Kamiya Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Xi Sun Ryoichi Miyanaga Kayoko Fukuhara Seiichiro Fukuhara Makoto Naganuma Atsushi Nakayama Motohiko Kato Tadateru Maehata Rieko Nakamura Koichi Ueno Junichi Sasaki Yuko Kitagawa Naohisa Yahagi Haruhiko Ogata Takanori Kanai | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，1： | 3 |
| 5 | Applicability of second‐generation colon capsule endoscope to ulcerative colitis: A clinical feasibility study显示文摘 | Naoki Hosoe Katsuyoshi Matsuoka Makoto Naganuma Yosuke Ida Yuka Ishibashi Kayoko Kimura Kazuaki Yoneno Shingo Usui Kazuhiro Kashiwagi Tadakazu Hisamatsu Nagamu Inoue Takanori Kanai Hiroyuki Imaeda Haruhiko Ogata Toshifumi Hibi | 2013 | J Gastroenterol Hepatol2013，，7： | 3 |
| 6 | Periostin as a Novel Factor Responsible for Ventricular Dilation显示文摘 | Naruto Katsuragi Ryuichi Morishita Noriko Nakamura Tayehito Ochiai Yoshiaki Taniyama Yasuhiro Hasegawa Kayoko Kawashima Yasufumi Kaneda Toshio Ogihara Keijiro Sugimura | 2004 | Circulation2004，，13： | 2 |
| 7 | Percutaneous endoscopic gastrostomy under steadypressure automatically controlled endoscopy:First clinicalseries显示文摘AIM: To elucidate the safety of percutaneous endoscopic gastrostomy(PEG) under steady pressure automatically controlled endoscopy(SPACE) using carbon dioxide(CO_2).METHODS: Nine patients underwent PEG with a modified introducer method under conscious sedation. A T-tube was attached to the channel of an endoscope connected to an automatic surgical insufflator. The stomach was inflated under the SPACE system. The intragastric pressure was kept between 4-8 mmH g with a flow of CO_2 at 35 L/min. Median procedure time, intragastric pressure, median systolic blood pressure, partial pressure of CO_2, abdominal girth before and immediately after PEG, and free gas and small intestinal gas on abdominal X-ray before and after PEG were recorded. RESULTS: PEG was completed under stable pneumostomach in all patients, with a median procedural time of 22 min. Median intragastric pressure was 6.9 mmH g and median arterial CO_2 pressure before and after PEG was 42.1 and 45.5 Torr(NS). The median abdominal girth before and after PEG was 68.1 and 69.6 cm(NS). A mild free gas image after PEG was observed in two patients, and faint abdominal gas in the downstream bowel was documented in two patients.CONCLUSION: SPACE might enable standardized pneumostomach and modified introducer procedure of PEG. | Hiroyuki Imaeda Kiyokazu Nakajima Naoki Hosoe Masanori Nakahara Shinichiro Zushi Motohiko Kato Kazuhiro Kashiwagi Yasushi Matsumoto Kayoko Kimura Rieko Nakamura Norihito Wada Masahiko Tsujii Naohisa Yahagi Toshifumi Hibi Takanori Kanai Tetsuo Takehara Haruhiko Ogata | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，3： | 2 |
| 8 | Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness显示文摘 | Takayuki Kondo Masashi Asai Kayoko Tsukita Yumiko Kutoku Yutaka Ohsawa Yoshihide Sunada Keiko Imamura Naohiro Egawa Naoki Yahata Keisuke Okita Kazutoshi Takahashi Isao Asaka Takashi Aoi Akira Watanabe Kaori Watanabe Chie Kadoya Rie Nakano Dai Watanabe Kei | 2013 | Cell Stem Cell2013，，4： | 2 |
| 9 | Loss of gastric gland mucin‐specific O ‐glycan is associated with progression of differentiated‐type adenocarcinoma of the stomach显示文摘 | Kazuo Shiratsu Kayoko Higuchi Jun Nakayama | 2014 | Cancer Sci2014，，： | 2 |
| 10 | Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia–reperfusion injury显示文摘 | Kentaro Hayashida Motoaki Sano Ikuroh Ohsawa Ken Shinmura Kayoko Tamaki Kensuke Kimura Jin Endo Takaharu Katayama Akio Kawamura Shun Kohsaka Shinji Makino Shigeo Ohta Satoshi Ogawa Keiichi Fukuda | 2008 | Biochemical and Biophysical Research Communications2008，，1： | 2 |
| 11 | Mechanisms and anatomical risk factors of pneumothorax after Bevacizumab use:A case report显示文摘BACKGROUND Bevacizumab is an antiangiogenic agent,and that synergizes with chemotherapeutic drugs.When used in combination therapies,Bevacizumab is associated with adverse events such as hemorrhage,gastrointestinal perforation,delayed wound healing,and pneumothorax.However,the molecular mechanisms underlying these adverse events are not fully understood.CASE SUMMARY A 45-year-old female with multiple lung metastases that were derived from primary breast cancer,was placed on Bevacizumab+paclitaxel therapy,since this combination has a potent antitumor effect.She reported dyspnea before cycle 3,day 1 and we therefore ran a chest X-ray,which detected a right pneumothorax.The coronal plane computed tomography revealed that one solid mass rapidly necrosed and was replaced by a cavity that passed through the bronchus in the right lower lobe.The cavity eventually ruptured the pleura and made the bronchopleural fistula that led to this pneumothorax.Thoracic cavity drainage using an intercostal catheter was performed.On the 7th day of drainage,the patient was discharged from our hospital on recovery.Recurrence of pneumothorax was not reported,and continuation of chemotherapy was made possible by changing the regimen.CONCLUSION Patients with lung metastases surrounding the bronchi and on the pleura should be monitored for pneumothorax by Bevacizumab-containing chemotherapies. | Yuri Ozaki Akiyo Yoshimura Masataka Sawaki Masaya Hattori Naomi Gondo Haruru Kotani Yayoi Adachi Ayumi Kataoka Kayoko Sugino Nanae Horisawa Yuka Endo Kazuki Nozawa Shoko Sakamoto Hiroji Iwata | 2020 | World Journal of Clinical Oncology2020，11，7： | 2 |
| 12 | 新疆地区许兰毛癣菌的PCR-RAPD分子分型研究显示文摘为了研究新疆地区许兰毛癣菌的分子分型,采用随机引物UBC701,R—ATGS和OPAOR-15结合PCR—RAPD法对分离于新疆儿童头癣的7株许兰毛癣菌进行分子分型,并与日本的3株许兰毛癣菌做比较。初步探讨新疆许兰毛癣菌的分子分型。 | 帕丽达.阿布利孜 Kazutaka Fukushima 邓淑文 Kayoko Takizawa | 2007 | 中华皮肤科杂志2007，40，8： | 2 |
| 13 | The Energy Consumption of Heatingin the Northeast Rural Area of China from the Perspective of the Kang and Agricultural Waste显示文摘In China,the heating energy consumption patterns of rural housing are changing due to economic development.This study investigated domestic heating in rural areas of Dalian,a city in northeast China.In rural areas of the country,heating devices such as coal boiler,radiator,and/or air-conditioner are typically used.The Kang,as the main heating system,has been used together with other heating methods for a long time in detached houses,one-story buildings,and quadrangles.Use of the Kang in collective housing is no longer observed.In addition to coal,agricultural wastes have been used to fuel the Kang;the associated CO2 emissions with agricultural fuels are lower than from other heating equipment.Even when a combination of the Kang and other equipment is used,with agricultural waste as fuel,CO2 emissions remain relatively low. | Han Ben Kondo Kayoko | 2015 | Meteorological and Environmental Research2015，6，1： | 2 |
| 14 | Method for Evaluating the Location of Tourist-Related Public Facilities Using Genetic Algorithms and GIS显示文摘 | Mika Inoue Kayoko Yamamoto | 2013 | 通讯和计算机(中英文版)2013，10，4： | 2 |
| 15 | Contribution of Dermal Macrophage Trafficking in the Sensitization Phase of Contact Hypersensitivity显示文摘 | Kayoko S Yasuyuki I Tatsuro I | 1998 | J Immunol1998，161，： | 1 |
| 16 | Fractionation and identification of organic nitrogen species from bio-oil produced by fast pyrolysis of sewage sludge显示文摘 | Jing-Pei Cao Xiao-Yan Zhao Kayoko Morishita Xian-Yong Wei Takayuki Takarada | 2010 | Bioresource Technology2010，，19： | 1 |
| 17 | Detection of Verotoxigenic Escherichia coli O157 and O26 in food by plating methods and LAMP method: A collaborative study显示文摘 | Yukiko Hara-Kudo Noriko Konishi Kayoko Ohtsuka Reiji Hiramatsu Hiroyuki Tanaka Hirotaka Konuma Kosuke Takatori | 2007 | International Journal of Food Microbiology2007，，1： | 1 |
| 18 | SJWD14092200000366显示文摘 | Hirotaka Akita Ryosuke Sasaki Yusuke Yokoyama Kei Negishi Kayoko Matsunaga | 2014 | Exp Dermatol2014，，： | 1 |
| 19 | Detection of Salmonella enterica in Naturally Contaminated Liquid Eggs by Loop-Mediated Isothermal Amplification,and Characterization of Salmonella Isolates显示文摘 | Kayoko Ohtsuka | 2005 | Applied and environmental microbiology2005，11，71： | 1 |
| 20 | Retrospective evaluation of colistin versus tigecycline for the treatment of Acinetobacter baumannii and/or carbapenem-resistant Enterobacteriaceae infections显示文摘 | Kimberly Ku Jason M. Pogue Judy Moshos Suchitha Bheemreddy Yujing Wang Ashish Bhargava Michelle Campbell Namir Khandker Paul R. Lephart Teena Chopra Kayoko Hayakawa Emily T. Martin Odaliz Abreu-Lanfranco Sorabh Dhar Keith S. Kaye Dror Marchaim | 2012 | AJIC: American Journal of Infection Control2012，，10： | 1 |
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