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| 1 | Balb/C小鼠免疫系统结构与功能的增龄性变化显示文摘目的 观察不同月龄 Balb/ C小鼠免疫系统结构与功能的改变 ,以增进对衰老免疫学机制的了解。 方法 采用 3H-胸腺嘧啶核苷 (3H- Td R)掺入法、噻唑蓝 (MTT)法、白细胞介素 - 2 (IL- 2 )依赖细胞株 (CTL L- 2 )测定等实验 ,检测 1、5、10和 19月龄小鼠脾细胞表面抗原表达及免疫功能 ,并用苏木精伊红 (HE)染色检测胸腺和脾脏的组织学变化。 结果 随着增龄 ,小鼠胸腺皮、髓质比例减小 ,界限消失 ,有分泌液泡形成 ;脾脏白髓结构不规则。与 1月龄小鼠相比 ,19月龄小鼠 T细胞增殖能力、自然杀伤 (NK)和淋巴因子激活的杀伤 (L A K)细胞活性及脾细胞诱生 IL- 2的能力分别下降95 %、45 %、49%和 6 1% ,碘化丙啶 (PI)染色检测显示 ,脾脏和胸腺的 S期细胞随增龄而减少。免疫荧光染色显示 ,1、5、10月龄小鼠脾细胞表面抗原阳性细胞百分率差异无显著性。 结论 增龄过程中小鼠免疫系统的结构退化 ,功能降低。 | 冯仁田 潘宏志 何维 Hirotomo Ochi | 2000 | 中华老年医学杂志2000，19，3： | 18 |
| 2 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 3 | 采用共轭梯度法的管内壁温度导热反问题求解显示文摘建立了采用共轭梯度法的非稳态二维导热反问题数学模型,并利用FORTRAN语言编写了程序进行计算求解,由同心圆管外壁温度随时间的变化得到管内壁温度随时间的变化。计算结果表明,计算值与准实验值吻合,共轭梯度法能够准确地计算得到管内壁不同位置温度随时间的变化。 | 张有为 李辉 姜培学 KIMINOBU Hojo MAYUMI Ochi KOICHI Tanimoto | 2009 | 工程热物理学报2009，30，7： | 12 |
| 4 | Genome-wide scan revealed that polymorphisms in the PNPLA3 , SAMM50 , and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan显示文摘 | Takuya Kitamoto Aya Kitamoto Masato Yoneda Hideyuki Hyogo Hidenori Ochi Takahiro Nakamura Hajime Teranishi Seiho Mizusawa Takato Ueno Kazuaki Chayama Atsushi Nakajima Kazuwa Nakao Akihiro Sekine Kikuko Hotta | 2013 | Human Genetics2013，，7： | 5 |
| 5 | Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury显示文摘Old astrocyte specifically induced substance(OASIS) is an endoplasmic reticulum(ER) stress transducer specifically expressed in astrocytes and osteoblasts. OASIS regulates the differentiation of neural precursor cells into astrocytes in the central nervous system. This study aimed to elucidate the involvement of ER stress responses stimulated via OASIS in astrogliosis following spinal cord injury. In a mouse model of spinal cord contusion injury, OASIS m RNA and protein expression were evaluated at days 7 and 14. A significant increase in OASIS m RNA on day 7 and an increase in protein on days 7 and 14 was observed in injured spinal cords. Immunostaining on day 7 revealed co-localization of OASIS and astrocytes in the periphery of the injury site. Furthermore, anti-OASIS small interfering RNA(si RNA) was injected at the injury sites on day 5 to elucidate the function of OASIS. Treatment with anti-OASIS si RNA caused a significant decrease in OASIS m RNA on day 7 and protein on days 7 and 14, and was associated with the inhibition of astrogliosis and hindlimb motor function recovery. Results of our study show that OASIS expression synchronizes with astrogliosis and is functionally associated with astrogliosis after spinal cord injury. | Atsushi Takazawa Naosuke Kamei Nobuo Adachi Mitsuo Ochi | 2018 | Neural Regeneration Research2018，13，3： | 4 |
| 6 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis显示文摘 | Nirav Thosani Harvinder Singh Asha Kapadia Nobuo Ochi Jeffrey H. Lee Jaffer Ajani Stephen G. Swisher Wayne L. Hofstetter Sushovan Guha Manoop S. Bhutani | 2012 | Gastrointestinal Endoscopy2012，，2： | 3 |
| 7 | Involvement of micro RNA ‐224 in cell proliferation, migration, invasion, and anti‐apoptosis in hepatocellular carcinoma显示文摘 | Yizhou Zhang Shoichi Takahashi Akiko Tasaka Tadahiko Yoshima Hidenori Ochi Kazuaki Chayama | 2013 | J Gastroenterol Hepatol2013，，3： | 2 |
| 8 | Prolonged survival in patients with hand-foot skin reaction secondary to cooperative sorafenib treatment显示文摘BACKGROUND Sorafenib is an oral drug that prolongs overall survival(OS)in patients with hepatocellular carcinoma.Adverse events,including hand-foot skin reaction(HFSR),lead to permanent sorafenib discontinuation.AIM To clarify the association between interventions for adverse events and patient prognosis.METHODS We performed a retrospective,multicenter study of patients treated with sorafenib monotherapy between May 2009 and March 2018.We developed a mutual cooperation system that was initiated at the start of sorafenib treatment to effectively manage adverse events.The mutual cooperation system entailed patients receiving consultations during which pharmacists provided accurate information about sorafenib to alleviate the fear and anxiety related to adverse events.We stratified the patients into three groups:Group A,patients without HFSR but with pharmacist intervention;Group B,patients with HFSR and pharmacist interventions unreported to oncologists(nonmutual cooperation system);and Group C,patients with HFSR and pharmacist interventions known to oncologists(mutual cooperation system).OS and time to treatment failure(TTF)were evaluated using the Kaplan-Meier method.RESULTS We enrolled 134 patients(Group A,n=41;Group B,n=30;Group C,n=63).The median OS was significantly different between Groups A and C(6.2 vs 13.9 mo,p<0.01)but not between Groups A and B(6.2 vs 7.7 mo,P=0.62).Group A vs Group C was an independent OS predictor(HR,0.41;95%CI:0.25-0.66;P<0.01).In Group B alone,TTF was significantly lower and the nonadherence rate was higher(P<0.01).In addition,the Spearman’s rank correlation coefficients between OS and TTF in each group were 0.41(Group A;P<0.01),0.13(Group B;P=0.51),and 0.58(Group C;P<0.01).There was a highly significant correlation between OS and TTF in Group C.However,there was no correlation between OS and TTF in Group B.CONCLUSION The mutual cooperation system increased treatment duration and improved prognosis in patients with HFSR.Future prospective studies(e.g.,randomized controlled trials)and improved adherence could help prevent OS underestimation. | Masanori Ochi Toshiro Kamoshida Masahiro Araki Tadashi Ikegami | 2021 | World Journal of Gastroenterology2021，27，32： | 2 |
| 9 | Efficacy of preoperative endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘 | Norikazu Arakura Mari Takayama Yayoi Ozaki Masafumi Maruyama Yoshimi Chou Ryou Kodama Yasuhide Ochi Hideaki Hamano Takenari Nakata Shouji Kajikawa Eiji Tanaka Shigeyuki Kawa | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，4： | 2 |
| 10 | High total Joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection显示文摘BACKGROUND We hypothesized that thermal damage accumulation during endoscopic submucosal dissection(ESD)causes the pathogenesis of post-ESD electrocoagulation syndrome(PECS).AIM To determine the association between Joule heat and the onset of PECS.METHODS We performed a retrospective cohort study in patients who underwent colorectal ESD from May 2013 to March 2021 in Japan.We developed a novel device that measures swift coagulation time with a sensor adjacent to the electrosurgical coagulation unit foot switch,which enabled us to calculate total Joule heat.PECS was defined as localized abdominal pain(visual analogue scale≥30 mm during hospitalization or increased by≥20 mm from the baseline)and fever(temperature≥37.5 degrees or white blood cell count≥10000μ/L).Patients exposed to more or less than the median Joule heat value were assigned to the high and low Joule heat groups,respectively.Statistical analyses included Mann-Whitney U and chisquare tests and logistic regression and receiver operating characteristic curve(ROC)analyses.RESULTS We evaluated 151 patients.The PECS incidence was 10.6%(16/151 cases),and all patients were followed conservatively and discharged without severe complications.In multivariate analysis,high Joule heat was an independent PECS risk factor.The area under the ROC curve showing the correlation between PECS and total Joule heat was high[0.788(95%confidence interval:0.666-0.909)].CONCLUSION Joule heat accumulation in the gastrointestinal wall is involved in the onset of PECS.ESD-related thermal damage to the peeled mucosal surface is probably a major component of the mechanism underlying PECS. | Masanori Ochi Ryosuke Kawagoe Toshiro Kamoshida Yukako Hamano Haruka Ohkawara Atsushi Ohkawara Nobushige Kakinoki Yuji Yamaguchi Shinji Hirai Akinori Yanaka Kiichiro Tsuchiya | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 11 | Extracorporeal shock wave lithotripsy of pancreatic duct stones and patient factors related to stone disintegration显示文摘 | Yasuyuki Karasawa Shigeyuki Kawa Yuji Aoki Yasuhide Ochi Hiroshi Unno Kendo Kiyosawa Tomofumi Watanabe | 2002 | Journal of Gastroenterology2002，，5： | 2 |
| 12 | MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells显示文摘 | Atsuo Ochi Andrew H. Nguyen Andrea S. Bedrosian Harry M. Mushlin Saman Zarbakhsh Rocky Barilla Constantinos P. Zambirinis Nina C. Fallon Adeel Rehman Yuliya Pylayeva-Gupta Sana Badar Cristina H. Hajdu Alan B. Frey Dafna Bar-Sagi George Miller | 2012 | Journal of Experimental Medicine2012，，9： | 2 |
| 13 | Juvenile muscular atrophy of the distal upper limb ( Hirayama disease) associated atropy 显示文摘 | Kira J Ochi H | 2001 | J Neurol Neurosurg Psy- chiatry2001，70，： | 1 |
| 14 | Early outcome of a randomized comparison of off - pump and on - pump multiple arterial coronary revascularization 显示文摘 | Tashiro T Ochi M | 2005 | Circulation2005，，9： | 1 |
| 15 | Epileptic spasms in older pediatric patients:MEG and ictal high-frequency oscillations suggest focal-onset seizares in a subset of epileptic spasms显示文摘 | RamachandranNair R Ochi A Imai K | 2008 | Epilepsy Re- search2008，78，2： | 1 |
| 16 | 显示文摘 | Ochi K | 1987 | bacteriol1987，169，： | 1 |
| 17 | A group buy protocol based on coalition formation for agent- mediated e- commerce 显示文摘 | ITO T OCHI H | 2002 | International Journal of Computer & Information Science2002，3，1： | 1 |
| 18 | Inactivation of pathogenic bacteria under mesophilic and therophilic conditions显示文摘 | Haruki Watanabe Tomokazu Kitamura Shuichi Ochi | 1997 | Wat Sci Tech1997，36，67： | 1 |
| 19 | Juvenile muscular atrophy of the distal upper limb (Hirayama disease) associated with atopy 显示文摘 | Kira J Ochi H | 2001 | Neurol Neurosurg Psychiatry2001，70，： | 1 |
| 20 | Accuracy of pre- and postcontrast 3D time-of-flight MR angiography in pa- tients with acute ischemic stroke~ correlation with catheter angiography显示文摘 | Ishimaru H Ochi M Morikawa M | 2007 | AJNR2007，28，： | 1 |
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