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| 1 | 中国的健康人力资本与收入增长显示文摘文首次将人口健康作为人力资本的一种形式,探讨其在中国经济奇迹中的作用。基于中国健康与营养调查(CHNS)数据,我们估计了以家庭为基础的个人收入生产函数,发现以下主要结论。首先,个人健康是决定中国家庭人均收入的重要因素。第二.,相对而言,农村人口比城市人口的健康经济回报更大。第三,女性比男性的健康经济回报更大。 | 刘国恩 William H.Dow 傅正泓 John Akin | 2004 | 经济学(季刊)2004，4，1： | 213 |
| 2 | Dynamic contrast-enhanced magnetic resonance imaging of prostate cancer: A review of current methods and applications显示文摘In many areas of oncology, dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) has proven to be a clinically useful, non-invasive functional imaging technique to quantify tumor vasculature and tumor perfusion characteristics. Tumor angiogenesis is an essential process for tumor growth, proliferation, and metastasis. Malignant lesions demonstrate rapid extravasation of contrast from the intravascular space to the capillary bed due to leaky capillaries associated with tumor neovascularity. DCE-MRI has the potential to provide information regarding blood flow, areas of hypoperfusion, and variations in endothelial permeability and microvessel density to aid treatment selection, enable frequent monitoring during treatment and assess response to targeted therapy following treatment. This review will discuss the current status of DCE-MRI in cancer imaging, with a focus on its use in imaging prostate malignancies as well as weaknesses that limit its widespread clinical use. The latest techniques for quantification of DCE-MRI parameters will be reviewed and compared. | Yousef Mazaheri Oguz Akin Hedvig Hricak | 2017 | World Journal of Radiology2017，9，12： | 8 |
| 3 | Comparison of one and three initial monthly intravitreal ranibizumab injection in patients with macular edema secondary to branch retinal vein occlusion显示文摘AIM: To compare three initial monthly intravitreal ranibizumab(IVR) injections followed by pro re nata(PRN) dosing with one initial monthly IVR injections followed by PRN dosing for macular edema(ME) secondary to branch retinal vein occlusion(BRVO).METHODS: Forty-two eyes of 42 patients who had IVR injections for BRVO were retrospectively studied. Eighteen eyes received 1 initial IVR injection(1+PRN group) and 24 eyes received 3 monthly IVR injections(3+PRN). At 1, 3, 6 and 12mo; spectral-domain optical coherence tomography(SD-OCT) was performed. Central macular thickness(CMT), the integrity of the external limiting membrane(ELM), the presence of subretinal fluid, cyst size, the presence of inner segment/outer segment(IS/OS) defect were determined.RESULTS: At baseline the mean CMT was 521.3±153.2 μm in the 3+PRN group while it was 438.1±162.4 μm in 1+PRN group. At the final visit, mean CMT was 278.3±87.8 μm in the 3+PRN group and 285.2±74.2 μm in the 1+PRN group(P=0.079). The changes in CMT over the entire study period were also comparable in both groups(243±160 μm in the 3+PRN group, and 152.9±175.3 μm in the 1+PRN group; P=0.090). At baseline, best-corrected visual acuity(BCVA) was 0.92±0.60 logarithm of the minimal angle of resolution(logMAR) in the 3+PRN group, while it was 0.72±0.46 logMAR in the 1+PRN group. Final BCVA was 0.42±0.55 logMAR in the 3+PRN group and 0.38±0.50 logMAR in the 1+PRN group(P=0.979). Additionally, the BCVA changes from baseline to final visit were not significantly different(-0.50±0.45 logMAR in the 3+PRN group, and-0.33±0.39 logMAR in the 1+PRN group; P=0.255).CONCLUSION: No significant differences in the anatomical or functional results are found between 3+PRN and 1+PRN regimens in the patients receiving ranibizumab for ME secondary to BRVO. Intact IS/OS and baseline BCVA are good predictor of the visual gain, while baseline CMT is a good predictor of the anatomical gain. | Alper Halil Bayat Akin Cakir Seyma Gülcenur Ozturan Selim Bolükbasi Burak Erden Mustafa Nuri Elcioglu | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 6 |
| 4 | Dexmedetomidine and meperidine prevent postanaesthetic shivering显示文摘 | C. Bicer A. Esmaoglu A. Akin A. Boyaci | 2006 | European Journal of Anaesthesiology2006，，2： | 4 |
| 5 | 伴有或不伴有肝实质侵犯的卵巢癌周围性转移CT检出的敏感性与特异性研究显示文摘目的回顾性确定由不同经验水平的放射医生读片时,伴有或不伴肝实质侵犯(LPI)的卵巢癌病人肝周围性转移CT鉴别的敏感性与特异性。研究以剖腹探查分期及病理检查为参考标准。方法学院医学伦理委员会批准此项研究不必签署知情同意书,研究符合HIPAA要求。121例卵巢癌病人(年龄29~94岁,平均57.8岁)纳入本研究。2位放射医生(放射医生1:6个月专业经验;放射医生2:2年6个月专业经验)在不知道病人临床资料情况下,相互独立地回顾性记录CT显示是否有周围性转移, | O. Akin E. Sala C.S. Moskowitz N. Ishill R.A. Soslow D.S. Chi 唐光健(译) | 2008 | 国际医学放射学杂志2008，31，5： | 4 |
| 6 | 2012年北美放射学年会前列腺影像学最新研究进展显示文摘第98届北美放射学年会(RSNA 2012)在美国芝加哥召开,该届大会共收录与前列腺相关的论文共58篇,以MRI为主,超声、PET等技术在前列腺中的的论文相对较少。这些论文主要关注于不同成像技术间的组合和优化在前列腺癌诊断与鉴别诊断中的应用价值。作者对以上方面的研究进展进行综述,旨在为我国前列腺影像学研究提供新的思路。 | 李亮 冯朝燕 Jinxiang Yu Oguz Akin 王良 | 2013 | 磁共振成像2013，4，3： | 4 |
| 7 | Adipokines and ghrelin in gastric cancer cachexia显示文摘AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor. | Mustafa Kerem Zafer Ferahkose Utku Tonguc Yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin | 2008 | World Journal of Gastroenterology2008，14，23： | 4 |
| 8 | Extensive hepatic-portal and mesenteric venous gas due to sigmoid diverticulitis显示文摘Hepatic portal venous gas is most often associated with extensive bowel necrosis due to mesenteric infarction.Mortality exceeds 75% with this condition.The most common precipitating factors include ischemia,intra-abdominal abscesses and inflammatory bowel disease.In this report,we present a 75-year-old woman with extensive hepatic portal and mesenteric venous gas due to colonic diverticulitis.She had a 10-year history of type diabetes mellitus and hypertension.She was treated by sigmoid resection and Hartmann's procedure and discharged from the hospital without any complications. | Meral Sen Ayhan Akpinar Aydin Snan Mete Sisman Cenap Dener Kayihan Akin | 2009 | World Journal of Gastroenterology2009，15，7： | 4 |
| 9 | Assessment of rock slope stability by probabilistic-based Slope Stability Probability Classification method along highway cut slopes in Adilcevaz-Bitlis(Turkey)显示文摘Rock slope stability is of great concern along highway routes as stability problems on cut slopes may cause fatal events as well as loss of property.In rock slope engineering,stability evaluations are commonly performed by means of analytical or numerical analyses,principally considering the factor of safety concept.As a matter of fact,the probabilistic assessment of slope stability is progressively getting popularity due to difficulties in assigning the most appropriate values to design parameters in analytical or numerical methods.Additionally,the effect of heterogeneities in rock masses and discontinuities on the analysis results is minimized through the probabilistic concept.In this study,slope stability of high and steep sedimentary rock cut slopes along a state highway in AdilcevazBitlis(Turkey) was evaluated on the basis of probabilistic approach using the Slope Stability Probability Classification(SSPC) system.The probabilistic assessment indicates major slope stability problems because of discontinuity controlled and discontinuity orientation independent mass movements.Almost all studied cut slopes suffer from orientation-independent stability problems with very low stability probabilities.Additionally,the probability of planar and toppling failures issignificantly high with respect to the SSPC system.The stability problems along the investigated rock slopes were also verified by field reconnaissance.Remedial measures such as slope re-design and reinforcement at the studied locations should be taken to prevent hazardous events along the highway.On the other hand,the probabilistic approach may be a useful tool during rock slope engineering to overcome numerous uncertainties when probabilistic and analytic results are compared. | Akgun CANAL Mutluhan AKIN | 2016 | Journal of Mountain Science2016，13，11： | 4 |
| 10 | Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats显示文摘AIM: To investigate the preventive effect of kefir on colitis induced with dextran sulfate sodium(DSS) in rats.METHODS: Twenty-four male Wistar-albino rats were randomized into four groups: normal control,kefircontrol,colitis,and kefir-colitis groups. Rats in the normal and kefir-control groups were administered tap water as drinking water for 14 d. Rats in the colitis and kefir-colitis groups were administered a 3% DSS solution as drinking water for 8-14 d to induce colitis. Rats in the kefir-control and kefir-colitis groups were administered 5 m L kefir once a day for 14 d while rats in the normal control and colitis group were administered an identical volume of the placebo(skim milk) using an orogastric feeding tube. Clinical colitis was evaluated with reference to the disease activity index(DAI),based on daily weight loss,stool consistency,and presence of bleeding in feces. Rats were sacrificed on the 15 th day,blood specimens were collected,and colon tissues were rapidly removed. Levels of myeloperoxidase(MPO),tumor necrosisfactor(TNF)-α,interleukin(IL)-10,malondialdehyde,and inducible nitric oxide synthase(i NOS) were measured in colon tissue.RESULTS: The DAI was lower in the kefir-colitis group than in the colitis group(on the 3rd and 5th days of colitis induction; P < 0.01). The DAI was also significantly higher in the colitis group between days 2 and 6 of colitis induction when compared to the normal control and kefir-control groups. The DAI was statistically higher only on the 6th day in the kefircolitis group when compared to that in the normal control groups. Increased colon weight and decreased colon length were observed in colitis-induced rats. Mean colon length in the colitis group was significantly shorter than that of the kefir-control group. Kefir treatment significantly decreased histologic colitis scores(P < 0.05). MPO activity in the colitis group was significantly higher than in the kefir-control group(P < 0.05). Kefir treatment significantly reduced the DSS colitis-induced TNF-α increase(P < 0.01). No statistically significant differences were observed among groups for IL-10 and MDA levels. Colon tissue i NOS levels in the colitis group were significantly higher than those in the control and kefir-colitis groups(P < 0.05).CONCLUSION: Kefir reduces the clinical DAI and histologic colitis scores in a DSS-induced colitis model,possibly via reduction of MPO,TNF-α,and i NOS levels. | Altug Senol Mehmet Isler Recep Sutcu Mete Akin Ebru Cakir Betul M Ceyhan M Cem Kockar | 2015 | World Journal of Gastroenterology2015，21，46： | 3 |
| 11 | Dexmedetomidine Added to Levobupivacaine Prolongs Axillary Brachial Plexus Block显示文摘 | Aliye Esmaoglu Fusun Yegenoglu Aynur Akin Cemil Yildirim Turk | 2010 | Anesthesia & Analgesia2010，，6： | 3 |
| 12 | Left atrial appendage occlusion: A better alternative to anticoagulation?显示文摘Non-valvular atrial fibrillation is associated with a significantly increased risk of embolic stroke due to blood clot forming predominantly in the left atrial appendage(LAA). Preventive measures to avoid embolic events are permanent administration of anticoagulants or surgical closure of the LAA. Various clinical trials provide evidence about safety, effectiveness and therapeutic success of LAA occlusion using various cardiac occluder devices. The use of such implants for interventional closure of the LAA is likely to become a valuable alternative for stroke prevention, especially in patients with contraindication for oral anticoagulation as safety, clinical benefit and cost-effectiveness of LAA occlusion has recently been demonstrated. | Ibrahim Akin Christoph A Nienaber | 2017 | World Journal of Cardiology2017，9，2： | 3 |
| 13 | 机械循环支持流感病毒相关心肌炎所致难治性心源性休克显示文摘机械循环辅助在流感病毒相关心肌炎合并难治性心源性休克(rCS)的应用仍缺乏证据。本研究为基于近两个流感流行季的单中心、前瞻性、观察性研究。目的为观察应用静脉‐动脉体外膜肺氧合(V‐A ECMO)和心室辅助系统进行联合机械循环辅助对流感相关心肌炎合并rCS患者的影响。 | Sieweke JT Akin M Stetskamp S 孙兵 唐晓 | 2021 | 中华医学杂志2021，101，8： | 3 |
| 14 | Neuronal apoptosis: Current understanding of molecular mechanisms and potential role in ischemic brain injury显示文摘 | Johnson EM Jr Greenlund LJ Akins PT | 1995 | J Neurotrauma1995，12，84： | 2 |
| 15 | Comparison between Capsule Endoscopy and Magnetic Resonance Enterography for the Detection of Polyps of the Small Intestine in Patients with Familial Adenomatous Polyposis显示文摘 | E. Akin A. Demirezer Bolat S. Buyukasik O. Algin E. Selvi O. Ersoy Martin Keuchel | 2012 | Gastroenterology Research and Practice2012，，： | 2 |
| 16 | Postoperative fluid management显示文摘Postoperative care units are run by an anesthesiologist or a surgeon, or a team formed of both. Management of postoperative fluid therapy should be done considering both patients' status and intraoperative events. Types of the fluids, amount of the fluid given and timing of the administration are the main topics that determine the fluid management strategy. The main goal of fluid resuscitation is to provide adequate tissue perfusion without harming the patient. The endothelial glycocalyx dysfunction and fluid shift to extracellular compartment should be considered wisely. Fluid management must be done based on patient's body fluid status. Patients who are responsive to fluids can benefit from fluid resuscitation, whereas patients who are not fluid responsive are more likely to suffer complications of overhydration. Therefore, common use of central venous pressure measurement, which is proved to be inefficient to predict fluid responsiveness, should be avoided. Goal directed strategy is the most rational approach to assess the patient and maintain optimum fluid balance. However, accessible and applicable monitoring tools for determining patient's actual fluid need should be further studied and universalized. The debate around colloids and crystalloids should also be considered with goal directed therapies. Advantages and disadvantages of each solution must be evaluated with the patient's specific condition. | Selami Ilgaz Kayilioglu Tolga Dinc Isa Sozen Akin Bostanoglu Mukerrem Cete Faruk Coskun | 2015 | World Journal of Critical Care Medicine2015，4，3： | 2 |
| 17 | The relation between oxidant and antioxidant parameters and severity of acute coronary syndromes 显示文摘 | Serdar Z Serdar A Akin A etal | 2007 | Acta cardiologiea2007，62，4： | 1 |
| 18 | Glutamate AMPA receptor antagonist treat- merit forischemic stroke 显示文摘 | Akins PT Atkinson RP | 2002 | Curr Med Res Opin2002，18，2： | 1 |
| 19 | Prevalence of urinary incontinence in the 12-month postpartum period and related risk factors in Turkey 显示文摘 | Ege E Akin B Altuntug K | 2008 | Urel Int2008，80，4： | 1 |
| 20 | Comparison of the effects of fentanyl and remifentanil on splanchnic tissue perfusion during cardiac surgery 显示文摘 | Bedirli N Boyaci A Akin A | 2007 | J Anesth2007，21，： | 1 |
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