|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 食物过敏的定义、流行性、诊断及治疗显示文摘食物过敏是异质性群体相关疾病,会通过一种或多种方式对多个器官造成影响。其反应的严重程度可从轻度的局部反应到全身性的过敏反应。从机制上来看,食物过敏是Th2细胞驱动的免疫紊乱疾病,食物特异性IgE是这种速发型不良反应的基础。过敏的部位和症状并不一定相同。食物过敏常会与自身免疫性(如乳糜泻)和非免疫性(如乳糖不耐受)的其他食物不良反应相混淆。为了正确诊断食物过敏,需要详细了解患者病史,检测特异性IgE,并进行经口激发试验来确诊。一些辅助因素(如运动、药物和酒精)有助于诱发食物过敏,会进一步增加诊断的复杂性。以食物提取物为基础的诊断试验并不能反映症状的严重程度,而检测单个食物致敏原IgE的新一代分子诊断技术,则能够为临床医生和患者提供可靠的症状严重程度依据。分子诊断还有助于确定食物过敏是直接源于对食物的暴露还是间接源于花粉过敏(交叉反应)。流行病学调查表明,桃过敏在欧洲主要是源于对桃的食用,而在中国则是源于对艾蒿花粉的初级致敏。但这两种情况都是由来自同一家族的致敏原分子介导的。流行病学调查深入揭示了食物过敏的病因、流行性及其所包含的风险因素,为预防食物过敏提供了循证策略。过去的十年中,食物过敏在发达国家盛行。经济发展和城市化进程都被认为会导致食物过敏流行性的增加,而且饮食习惯不同,过敏的食物也不同。目前,分子变态反应学和生物技术正在开发安全的免疫治疗方法,有望能够减轻日益加重的食物过敏负担。一种使用低致敏性突变重组分子的免疫疗法已经开始进行第一阶段临床试验的评估。食物致敏原名单的不断完善为转基因食品致敏性的评估提供了坚实基础。 | Ronald van Ree Lars K. Poulsen Gary WK Wong Barbara K. Ballmer-Weber 高中山 贾旭东 | 2015 | 中华预防医学杂志2015，49，1： | 28 |
| 2 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 3 | Climatic and tectonic controls on the fluvial morphology of the Northeastern Tibetan Plateau (China)显示文摘The geomorphological evolution of the Northeastern Tibetan Plateau(NETP)could provide valuable information for reconstructing the tectonic movements of the region.And the considerable uplift and climatic changes at here,provide an opportunity for studying the impact of tectonic and monsoon climate on fluvial morphological development and sedimentary architecture of fluvial deposits.The development of peneplain-like surface and related landscape transition from basin filling to incision indicate an intense uplift event with morphological significance at around 10–17 Ma in the NETP.After that,incision into the peneplain was not continuous but a staircase of terraces,developed as a result of climatic influences.In spite of the generally persisting uplift of the whole region,the neighbouring tectonic blocks had different uplift rates,leading to a complicated fluvial response with accumulation terraces alternating with erosion terraces at a small spatial and temporal scale.The change in fluvial activity as a response to climatic impact is reflected in the general sedimentary sequence on the terraces from high-energy(braided)channel deposits(at full glacial)to lower-energy deposits of small channels(towards the end of the glacial),mostly separated by a rather sharp boundary from overlying flood-loams(at the glacial-interglacial transition)and overall soil formation(interglacial).Pronounced incision took place at the subsequent warm-cold transitions.In addition,it is hypothesized that in some strongly uplifted blocks energy thresholds could be crossed to allow terrace formation as a response to small climatic fluctuations(10~3–10~4 year timescale).Although studies of morpho-tectonic and geomorphological evolution of the NETP,improve understanding on the impacts of tectonic motions and monsoonal climate on fluvial processes,a number of aspects,such as the distribution and correlation of peneplain and the related morphological features,the extent and intensity of tectonic movements influencing the crossing of climatic thresholds,leading to terrace development,need to be studied further. | WANG Xianyan Jef VANDENBERGHE LU Huayu Ronald VAN BALEN | 2017 | Journal of Geographical Sciences2017，27，11： | 6 |
| 4 | The No Apical Meristem Gene of Petunia Is Required for Pattern Formation in Embryos and Flowers and Is Expressed at Meristem and Primordia Boundaries显示文摘 | Erik Souer Adèle van Houwelingen Daisy Kloos Jos Mol Ronald Koes | 1996 | Cell1996，，2： | 5 |
| 5 | Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury显示文摘Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable condition.It is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic cavitation.Previously,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue integration.Here,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal cord.Immunohistochemistry demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host interface.Few reactive astroglial or regenerating axonal profiles could be seen traversing this layer.Such encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the implant.Characterization of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine. | Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach Ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook | 2019 | Regenerative Biomaterials2019，6，2： | 4 |
| 6 | Illumina Sequencing Technology as a Method of Identifying T-DNA Insertion Loci in Activation- Tagged Arabidopsis thaliana Plants显示文摘 | Joanna K. Polko Mohamed-Ramzi Temanni Martijn van Zanten Wilbert van Workum Sven Iburg Ronald Pierik Laurentius A.C.J. Voesenek Anton J.M. Peeters | 2012 | Molecular Plant2012，5，4： | 3 |
| 7 | Prevalence and prognosis of synchronous colorectal cancer: A Dutch population-based study显示文摘 | Sanna A. Mulder Ries Kranse Ronald A. Damhuis Johannes H.W. de Wilt Rob J.Th. Ouwendijk Ernst J. Kuipers Monique E. van Leerdam | 2011 | Cancer Epidemiology2011，，5： | 3 |
| 8 | Positron emission tomography to assess hypoxia and perfusion in lung cancer显示文摘In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with decreased perfusion, perfusion measurements provide more insight into the relation between hypoxia and perfusion in malignant tumors. Positron emission tomography(PET) is a highly sensitive nuclear imaging technique that is suited for non-invasive in vivo monitoring of dynamic processes including hypoxia and its associated parameter perfusion. The PET technique enables quantitative assessment of hypoxia and perfusion in tumors. To this end, consecutive PET scans can be performed in one scan session. Using different hypoxia tracers, PET imaging may provide insight into the prognostic significance of hypoxia and perfusion in lung cancer. In addition, PET studies may play an important role in various stages of personalized medicine, as these may help to select patients for specifictreatments including radiation therapy, hypoxia modifying therapies, and antiangiogenic strategies. In addition, specific PET tracers can be applied for monitoring therapy. The present review provides an overview of the clinical applications of PET to measure hypoxia and perfusion in lung cancer. Available PET tracers and their characteristics as well as the applications of combined hypoxia and perfusion PET imaging are discussed. | Eline E Verwer Ronald Boellaard Astrid AM van der Veldt | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 9 | Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit显示文摘Chinese bayberry Myrica rubra is a very popular fruit in southeastern China.In spite of its wide consumption,no allergies to this fruit have been reported previously.Here we report on a 40-year-old woman suffering from anaphylaxis to Chinese bayberry fruit.Prick-prick skin tests revealed strong reactions to fresh Chinese bayberry fruits as well as to peach,and weaker reactions to some other fruits including apple,melon,and banana.ImmunoCAP analysis revealed identical titers of specific IgE(4.3 kU A /L) to peach extract and its lipid transfer protein(LTP,rPru p 3),which was confirmed by detection of a 9 kD band following immunoblotting.Immunoblot analysis with Chinese bayberry extract gave bands of 22,45,and 90 kD,but no 9 kD band was recognized.There was also no evidence of LTP recognition for loquat(36 kD) or melon(24 kD).This first report of a severe allergic reaction to Chinese bayberry fruit in a patient with LTP-mediated peach allergy indicates that other as yet unidentified non-pollen related fruit allergens are involved in this new severe fruit allergy. | Hui-ying WANG Zhong-shan GAO Zhao-wei YANG Jing-xin SHAO Xiu-zhen ZHAO Yu DAI Ronald VAN REE | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，10： | 3 |
| 10 | Early Laparoscopic Cholecystectomy Improves Outcomes After Endoscopic Sphincterotomy for Choledochocystolithiasis显示文摘 | Jan Siert K. Reinders Annemarie Goud Robin Timmer Philip M. Kruyt Ben J.M. Witteman Niels Smakman Ronald Breumelhof Sandra C. Donkervoort Jeroen M. Jansen Joos Heisterkamp Marina Grubben Bert van Ramshorst Djamila Boerma | 2010 | Gastroenterology2010，，7： | 2 |
| 11 | Linking a Game Engine Environment to Architectural Information on the Semantic Web显示文摘 | Pieter Pauwels Ronald De Meyer Jan Van Campenhout | 2011 | Journal of Civil Engineering and Architecture2011，5，9： | 2 |
| 12 | Magnetic resonance imaging of miliary tuberculosis of the central nervous system in children with tuberculous meningitis显示文摘 | Pieter Janse van Rensburg Savvas Andronikou Ronald Toorn Manana Pienaar | 2008 | Pediatric Radiology2008，，12： | 1 |
| 13 | Acute Pancreatitis Due to Sulfamethoxazole-Trimethoprim显示文摘 | RONALD H.M.A. BARTELS JOHANNES A.N. van der SPEK HESSEL R. OOSTEN | 1992 | Southern Medical Journal1992，，10： | 1 |
| 14 | Thermoluminescence excitation spectroscopy: A versatile technique to study persistent luminescence phosphors 显示文摘 | Adrie J J Bos Ronald M van Duijvenvoorde Erik van der Kolk | 2011 | Journal of Luminescence2011，131，7： | 1 |
| 15 | Amygdala activity in obsessive-compulsive disorder with contamination fear: a study with oxygen-15 water positron emission tomography显示文摘 | Odile A. van den Heuvel Dick J. Veltman Henk J. Groenewegen Raymond J. Dolan Danielle C. Cath Ronald Boellaard Catalina T. Mesina Anton J.L.M. van Balkom Patricia van Oppen Menno P. Witter Adriaan A. Lammertsma Richard van Dyck | 2004 | Psychiatry Research: Neuroimaging2004，，3： | 1 |
| 16 | Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions显示文摘 | Rik Ossenkoppele Wiesje M. van der Flier Sander C.J. Verfaillie Hugo Vrenken Adriaan Versteeg Ronald A. van Schijndel Sietske A. Sikkes Jos Twisk Sofie M. Adriaanse Marissa D. Zwan Ronald Boellaard Albert D. Windhorst Frederik Barkhof Philip Scheltens Adr | 2014 | Neurology2014，，20： | 1 |
| 17 | Regulations relating to mycotoxins in food:perspectives in a global and European context显示文摘 | Van Egmond Hans P Schothorst Ronald C Jonker Marco A | 2007 | Analytical andbioanalytical chemistry2007，389，1： | 1 |
| 18 | Phylogenetic Shadowing and Computational Identification of Human microRNA Genes显示文摘 | Eugene Berezikov Victor Guryev José van de Belt Erno Wienholds Ronald H.A. Plasterk Edwin Cuppen | 2005 | Cell2005，，1： | 1 |
| 19 | Long-term safety of rituximab in rheumatoid arthritis: 9.5-year follow-up of the global clinical trial programme with a focus on adverse events of interest in RA patients显示文摘 | Ronald F van Vollenhoven Paul Emery Clifton O Bingham Edward C Keystone Roy M Fleischmann Daniel E Furst Nicola Tyson Neil Collinson Patricia B Lehane | 2013 | Annals of the Rheumatic Diseases2013，，9： | 1 |
| 20 | Aggregate planning models for field service delivery显示文摘 | RONALD K K FREDERICK C VAN BENNEKOM | 1997 | Location Science1997，5，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员