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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病痴呆诊断标准的推荐显示文摘由美国国立老化研究所(NIA)和阿尔茨海默病(AD)协会组织了一个工作组,负责修订1984年版AD痴呆的诊断标准。旨在确保修订后的标准具有足够的灵活性,既可供缺乏神经心理学测验、先进的影像技术和脑脊液检查措施的普通医务人员使用,也可供具备上述措施的科研、临床试验的专业研究者使用。新的标准广泛适用于各种原因的痴呆以及专门针对AD痴呆的标准,保留了1984年版标准中的“很可能的AD痴呆”的总体框架。在过去27年的经验基础上,工作组对临床诊断标准做了一些修改,保留了“可能的AD痴呆”的术语,但对其进行了更有针对性的重新定义。在科研用的“很可能的和可能的AD痴呆”的诊断标准中纳入了生物标志物证据。AD痴呆的核心临床标准仍将是临床实践中诊断的基础,但用生物标志物证据来提高AD痴呆诊断的病理生理学特异性也被人们寄予厚望。要实现AD痴呆的生物标志物诊断,还有许多工作摆在面前。 | McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly J J Mayeux R Mohs RC Morris JC Rossor MN Scheltens P Carrillo MC Thies B Weintraub S Phelps CH 贾建平(译) 陆璐(译) 张逸驰(译) 黄丽(译) 韩阅(译) | 2012 | 中华神经科杂志2012，45，5： | 52 |
| 2 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 3 | 血管性认知障碍的诊断标准:国际血管性行为与认知障碍学会的申明显示文摘长期以来,脑血管病(CVD)就被认为是认知损害的一个重要原因,但是有关脑血管病后认知障碍的概念化却有着一段多变的历史。'动脉变硬'或脑的动脉粥样硬化是'老化'的原因,是存在已久的观点,在20世纪60年代受到了来自英格兰纽卡斯尔的神经病理学研究的质疑。这些研究表明,血管性痴呆(vascular dementia,Va D)与超过一定程度的多发性脑梗死有关。 | 徐岩 郭起浩 Sachdev P Kalaria R O'Brien J Skoog I Alladi S Black SE Blacker D Blazer DG Chen C Chui H Ganguli M Jellinger K Jeste DV Pasquier F Paulsen J Prins N Rockwood K Roman G Scheltens P | 2014 | 神经病学与神经康复学杂志2014，11，3： | 19 |
| 4 | Mineral Chemistry and Crystallization Conditions of the Late Cretaceous Mamba Pluton from the Eastern Gangdese, Southern Tibetan Plateau显示文摘The Late Cretaceous Mamba granodiorite belongs to a part of the Mesozoic Gangdese continental magmatic belt. No quantitative mineralogical study has been made hitherto, and hence the depth at which it formed is poorly constrained. Here we present mineralogical data for the Mamba pluton, including host rocks and their mafic microgranular enclaves(MMEs), to provide insights into their overall crystallization conditions and information about magma mixing. All amphiboles in the Mamba pluton are calcic, with ~B(Ca+Na)>1.5, and Si=6.81–7.42 apfu for the host rocks and Si=6.77–7.35 apfu for the MMEs. The paramount cation substitutions in amphibole include edenite type and tschermakite type. Biotites both in the host rocks and the MMEs collectively have high Mg O(13.19 wt.%–13.03 wt.%) contents, but define a narrow range of Al apfu(atoms per formula unit) variations(2.44–2.57). The oxygen fugacity estimates are based on the biotite compositions cluster around the NNO buffer. The calculated pressure ranges from 1.2 to 2.1 kbar according to the aluminum-in-hornblende barometer. The computed pressure varies from 0.9 to 1.3 kbar based on the aluminum-in-biotite barometer which corresponds to an average depth of ca. 3.9 km. Besides, the estimates of crystallization pressures vary from 0.8 to 1.4 kbar based on the amphibole barometer proposed by Ridolfi et al.(2010), which can be equivalent to the depths ranging from 3.1 to 5.2 km. The MMEs have plagioclase oscillatory zonings and quartz aggregates, probably indicating the presence of magma mixing. Besides, core-to-rim element variations(Rb, Sr, Ba, and P) for the K-feldspar megacrysts serve as robust evidence to support magma mixing and crystal fractionation. This indicates the significance of the magma mixing that contributes to the formation of K-feldspar megacryst zonings in the Mamba pluton. | Xiaowei Li Xuanxue Mo Mark Scheltens Qi Guan | 2016 | Journal of Earth Science2016，27，4： | 11 |
| 5 | 记忆门诊的微出血患病率和严重程度研究显示文摘Objective: To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic. Methods: The authors consecutively included patients attending their memory clinic between January 2002 and April 2005. They analyzed prevalence and number of MBs according to demographic, diagnostic, and MRI data. Results: The authors included 772 patients (53%men, age 66 ±11). One hundred twenty-seven patients (17%) exhibited at least one MB. The prevalence differed according to diagnostic groups (p < 0.0001): Sixty-five percent of patients with vascular dementia exhibited MBs vs 18%of Alzheimer disease patients, 20%of mild cognitive impairment patients, and 10%of patients with subjective complaints. The presence of MBs was associated with age, white matter hyperintensities, lacunar infarcts, and infarcts. Conclusion: The prevalence of microbleeds (MBs) in a large cohort of patients attending a memory clinic is higher than previously described in community samples and lower than reported in stroke patients. This finding of a relatively high proportion of MBs in Alzheimer disease and mild cognitive impairment provides further evidence for the involvement of vascular factors in neurodegenerative diseases such as Alzheimer disease. | Cordonnier C. Van Der Flier W.M. Sluimer J.D. P. Scheltens 王鹏 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 8 |
| 6 | Northward subduction-related orogenesis of the southern Altaids:Constraints from structural and metamorphic analysis of the HP/UHP accretionary complex in Chinese southwestern Tianshan,NW China显示文摘The Chinese Tianshan belt of the southern Altaids has undergone a complicated geological evolution.Different theories have been proposed to explain its evolution and these are still hotly debated.The major subduction polarity and the way of accretion are the main problems.Southward,northward subduction and multiple subduction models have been proposed.This study focuses on the structural geology of two of the main faults in the region,the South Tianshan Fault and the Nikolaev Line.The dip direction in the Muzhaerte valley is southward and lineations all point towards the NW.Two shear sense motions have been observed within both of these fault zones,a sinistral one,and a dextral one,the latter with an age of 236-251 Ma.Structural analyses on the fault zones show that subduction has been northward rather than southward.The two shear sense directions indicate that the Yili block was first dragged along towards the east due to the clockwise rotation of the Tarim block.After the Tarim block stopped rotating,the Yili block still kept going eastward,inducing the dextral shear senses within the fault zones. | Mark Scheltens Lifei Zhang Wenjiao Xiao Jinjiang Zhang | 2015 | Geoscience Frontiers2015，6，2： | 5 |
| 7 | The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease显示文摘 | Guy M. McKhann David S. Knopman Howard Chertkow Bradley T. Hyman Clifford R. Jack Claudia H. Kawas William E. Klunk Walter J. Koroshetz Jennifer J. Manly Richard Mayeux Richard C. Mohs John C. Morris Martin N. Rossor Philip Scheltens Maria C. Carrillo Bil | 2011 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011，，3： | 2 |
| 8 | Risk of dementia in diabetes mellitus: a systematic review显示文摘 | Geert Jan Biessels Salka Staekenborg Eric Brunner Carol Brayne Philip Scheltens | 2006 | Lancet Neurology2006，，1： | 2 |
| 9 | Behavioral symptoms in mild cognitive impairment显示文摘 | H. Feldman P. Scheltens E. Scarpini N. Hermann P. Mesenbrink L. Mancione S. Tekin R. Lane S. Ferris | 2004 | Neurology2004，，7： | 2 |
| 10 | 记忆临床病人全脑萎缩率和认知功能损害的纵向MR研究显示文摘目的前瞻胜地研究轻度认知功能障碍(MCI)和阿尔茨海默病(AD)的全脑萎缩率及其与认知功能损害的关系,研究已有基础脑容量与全脑萎缩率,但尚未痴呆的病人发展为痴呆的概率。方法本研究经学术审查委员会批准并取得所有病人书面的知情同意。65例AD病人(女38例,男27例;年龄52~81岁),45例MCI病人(女22例,男23例;年龄56~80岁),27例有主观症状的病人(女12例。男15例;年龄50~87岁),以及10名健康人(女6例,男4例;年龄53-80岁)作为对照纳入研究。2次MR检查时间间隔为(1.8±0.7)a。采用3DT1WI(1.0T,单块采集,168层, | J.D. Sluimer W.M. van der Flier G.B. Karas N.C. Fox P. Scheltens F.Barkhof 郭雪梅(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
| 11 | Cholinergic challengein Alzheimer patients and mild cognitive impairment differen-tially affects hippocampal activation-a pharmacological fMRI study显示文摘 | Goekoop R Scheltens P Barkhof F | 2006 | Brain2006，129，1： | 1 |
| 12 | 显示文摘 | Boeve H Girgis E Schelten J | 2000 | Appl Phys Lett2000，76，8： | 1 |
| 13 | Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment显示文摘 | Visser PJ Scheltens P Verhey FRJ | 1999 | J Neurol1999，246，6： | 1 |
| 14 | Treatment of Alzheimer's disease: current status and new perspectives显示文摘 | SCARPINI E SCHELTENS P FELDMAN H | 2003 | Lancet Neurol2003，2，9： | 1 |
| 15 | Epidemiology and risk factors of dementia 显示文摘 | VANDER FLIER W M SCHELTENS P | 2005 | J Neurosurg Psychiatry2005，76，1： | 1 |
| 16 | Using Magnetic Resonance Imaging in Diagnosing Dementia: A Dutch Outpatient Memory Clinics Survey显示文摘 | Boelaarts L Scheltens P de Jonghe J | 2014 | Dement Geriatr Cogn Disord2014，38，56： | 1 |
| 17 | Behavioral symptoms in mild cognitive impairment显示文摘 | Scheltens P Scarpini E | 2004 | Neurology2004，62，： | 1 |
| 18 | Structural magnetic resonance imaging in the practical assessment of dementia:beyond exclusion显示文摘 | Scheltens P Fox N Barkhof F | | 0，，01： | 1 |
| 19 | Hippocampal atrophy in subcortical vascular dementia显示文摘 | van de Pol L Gertz HJ Scheltens P | 2011 | Neurodegener Dis2011，8，： | 1 |
| 20 | Epidemiology and risk factors of dementia 显示文摘 | van der Flier WM Scheltens P | 2005 | J Neurosurg Psychiatry2005，76，5： | 1 |
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