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| 1 | 亚洲地区肺炎支原体和肺炎衣原体在成人社区获得性肺炎中的流行病学研究显示文摘目的由Malaya大学医学中心牵头进行的非典型病原在亚洲社区获得性肺炎(CAP)患者中的流行病学研究。结果显示,肺炎支原体和肺炎衣原体分别占成人病原的11.4%和5.8%。本研究将对这2种病原所致感染的临床和实验室资料进一步总结分析。方法亚洲7个国家12个研究中心采用统一的检测方法(DNA检测及血清学方法)和判断标准,对16岁以上的CAP患者进行肺炎支原体和肺炎衣原体的检测。结果在急性肺部感染者中,肺炎支原体和肺炎衣原体肺炎的临床表现与其他病原所致者非常相似,并无特征性。肺炎支原体和肺炎衣原体在男性和女性中检出率相仿,但肺炎支原体感染在16至44岁患者中更为多见(22.2%),而肺炎衣原体感染者重症患者相对较多。88例在病程中血清抗体显著增高的肺炎支原体感染者中,48例(54.5%)患者急性期抗体阴性,如果未检测恢复期血清抗体,上述患者则会漏诊;51例肺炎衣原体感染者中急性期血清抗体阴性则较为少见(21.6%)。肺炎支原体和肺炎衣原体既往感染和(或)病原携带率分别为5.7%和7.9%。结论肺炎支原体肺炎和肺炎衣原体肺炎发病率高,诊断困难,因此在亚洲成人CAP抗感染经验治疗时宜选用对这2种病原亦有效的药物。 | 黄海辉 张婴元 汪复 Mediadora SANIEL Marissa ALEJANDRIA Seung-Chul PARK 刘又宁 Po-Ren HSUEH Ahmad M. AZIAH Wing-Hong SETO Cecilia C. L. NGAN Mangunnegoro HADIARTO Subharee SUWANJUTHA Yun-Fong NGEOW Alsagaff HOOD | 2008 | 中国感染与化疗杂志2008，8，2： | 67 |
| 2 | “加拿大血友病儿童生活质量评估工具”中文版测试研究显示文摘[目的]描述加拿大血友病儿童生活质量评估工具CHO-KLAT在中国的使用情况,并对其进行信效度分析。[方法]对35例5岁~18岁中度、重度血友病儿童进行测验,用Cronbach’sα系数测量内在一致性信度,用内容效度指数表示专家内容效度。[结果]中文版问卷总的Cron-bach’sα系数为0.755,问卷总的内容效度指数(CVI)及各条目的CVI均为1.0。[结论]CHO-KLAT的信效度较好,能用于中国血友病儿童生活质量的测量。 | 刘云 陈京立 郭爱敏 李魁星 Marissa Hang | 2008 | 护理研究(中旬版)2008，22，4： | 5 |
| 3 | First report on Guanshan Biota(Cambrian Stage 4) at the stratotype area of Wulongqing Formation in Malong County, Eastern Yunnan, China显示文摘Exceptionally preserved fossils,such as those from Cambrian Burgess Shale-type fossil-Lagerstatten are critical because of their unique contributions to knowledge of the phylogenetic radiation and palaeoecological expansion of metazoans during the Cambrian explosion.Critically,these deposits provide information that is usually unobtainable from shelly and skeletonized fossils alone.The Guanshan Biota(Cambrian Series 2,Stage 4)in the Yunnan Province of South China,has produced abundant and diverse,exquisitely preserved fossils that often retain soft tissues and organs.To date,most fossils from the Guanshan Biota have been collected from localities such as Gaoloufang and Gangtoucun,which have become inaccessible due to new urban expansions and constructions of residential buildings.Here we present the first report of soft bodied fossils from a new section at Kanfuqing,close to the Wulongqing village in Malong County,approximately 3 km east of the Wulongqing Formation stratotype section.Fossils retain soft morphology,and include brachiopods with delicate marginal setae,priapulids with well-preserved sclerites and vetulicolians with entire sections of body.In addition,this fauna includes rare occurrences of trilobites preserved with soft tissues replicated as pyrite pseudomorphs after weathering.This discovery represents an important palaeogeographical extension of soft-bodied fossils of the Guanshan fauna to the east of the Xiaojiang Fault(related to Tsinning tectonic movements ca.700 Ma).The fauna from the new Kanfuqing section is similar to that reported from the Wulongqing Formation west of the Xiaojiang Fault,and thus has significant implications for early Cambrian palaeogeography,faunal successions and palaeoenvironments of eastern Yunnan. | Feiyang Chen Zhifei Zhang Marissa J. Betts Zhiliang Zhang Fan Liu | 2019 | Geoscience Frontiers2019，10，4： | 4 |
| 4 | NLRP3 inflammasome activation determines the fibrogenic potential of PM_(2.5) air pollution particles in the lung显示文摘Airborne fine particulate matter(PM_(2.5))is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung fibrosis.NLRP3 inflammasome activation has been implicated in these diseases;however,due to the complexity in PM_(2.5)compositions,it is difficult to differentiate the roles of the components in triggering this pathway.We collected eight real-life PM_(2.5)samples for a comparative analysis of their effects on NLRP3 inflammasome activation and lung fibrosis.In vitro assays showed that although the PM_(2.5)particles did not induce significant cytotoxicity at the dose range of 12.5to 100μg/m L,they induced potent TNF-αand IL-1βproduction in PMA differentiated THP-1 human macrophages and TGF-β1 production in BEAS-2B human bronchial epithelial cells.At the dose of 100μg/m L,PM_(2.5)induced NLRP3 inflammasome activation by inducing lysosomal damage and cathepsin B release,leading to IL-1βproduction.This was confirmed by using NLRP3-and ASC-deficient cells as well as a cathepsin B inhibitor,ca-074 ME.Administration of PM_(2.5)via oropharyngeal aspiration at 2 mg/kg induced significant TGF-β1 production in the bronchoalveolar lavage fluid and collagen deposition in the lung at 21days post-exposure,suggesting PM_(2.5)has the potential to induce pulmonary fibrosis.The ranking of in vitro IL-1βproduction correlates well with the in vivo total cell count,TGF-β1 production,and collagen deposition.In summary,we demonstrate that the PM_(2.5)is capable of inducing NLRP3 inflammasome activation,which triggers a series of cellular responses in the lung to induce fibrosis. | Wei Cao Xiang Wang Jiulong Li Ming Yan Chong Hyun Chang Joshua Kim Jinhong Jiang Yu-Pei Liao Shannon Tseng Sydney Kusumoputro Candice Lau Marissa Huang Pengli Han Pengju Lu Tian Xia | 2022 | Journal of Environmental Sciences2022，34，1： | 3 |
| 5 | Endoscopic ultrasound and paracentesis in the evaluation of small volume ascites in patients with intra-abdominal malignancies显示文摘The evaluation of ascites in patients with known or suspected malignancy is a critical aspect of preoperative staging.Endoscopic evaluation by ultrasound of low volume ascites and sampling of the ascitic fluid by endoscopic ultrasound guided paracentesis(EUS-P)is both a sensitive and specific modality for the determination of peritoneal implants,which is not only an important prognostic indicator but a crucial factor in determining treatment strategy.It is common practice to utilize EUS for gastrointestinal malignancies such as pancreatic or gastric masses,with the performance of paracentesis during the same procedure for the purpose of imaging the abnormality and possibly performing fine needle aspiration for biopsy of the neoplasm itself.However,given the ability of EUS-P to adequately sample even minimal ascites,detecting much smaller volumes than traditional computed tomography or magnetic resonance imaging,EUS-P may be a useful modality for the standard metastatic workup of any newly diagnosed or suspected malignancy.In this'Field of Vision'commentary,we discuss the role of EUS-P,including the article by Suzuki et al reporting their experience with EUS-P using an automated spring-loaded needle device.We also review the utility of EUS-P for non-gastrointestinal malignancies,such as ovarian cancer,which has a high incidence of malignant ascites. | Marissa M Montgomery I Michael Leitman | 2014 | World Journal of Gastroenterology2014，20，30： | 3 |
| 6 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 7 | Neoadjuvant chemotherapy for colorectal liver metastases:A contemporary review of the literature显示文摘Colorectal carcinoma(CRC)is one of the leading causes of cancer-related deaths worldwide,and up to 50%of patients with CRC develop colorectal liver metastases(CRLM).For these patients,surgical resection remains the only opportunity for cure and long-term survival.Over the past few decades,outcomes of patients with metastatic CRC have improved significantly due to advances in systemic therapy,as well as improvements in operative technique and perioperative care.Chemotherapy in the modern era of oxaliplatin-and irinotecancontaining regimens has been augmented by the introduction of targeted biologics and immunotherapeutic agents.The increasing efficacy of contemporary systemic therapies has led to an expansion in the proportion of patients eligible for curative-intent surgery.Consequently,the use of neoadjuvant strategies is becoming progressively more established.For patients with CRLM,the primary advantage of neoadjuvant chemotherapy(NCT)is the potential to down-stage metastatic disease in order to facilitate hepatic resection.On the other hand,the routine use of NCT for patients with resectable metastases remains controversial,especially given the potential risk of inducing chemotherapy-associated liver injury prior to hepatectomy.Current guidelines recommend upfront surgery in patients with initially resectable disease and low operative risk,reserving NCT for patients with borderline resectable or unresectable disease and high operative risk.Patients undergoing NCT require close monitoring for tumor response and conversion of CRLM to resectability.In light of the growing number of treatment options available to patients with metastatic CRC,it is generally agreed that these patients are best served at tertiary centers with an expert multidisciplinary team. | Marissa Guo Ning Jin Timothy Pawlik Jordan M Cloyd | 2021 | World Journal of Gastrointestinal Oncology2021，13，9： | 2 |
| 8 | Selective removal of arsenic and monovalent ions from brackish water reverse osmosis concentrate显示文摘 | Pei Xu Marissa Capito Tzahi Cath | 2013 | Journal of Hazardous Materials2013，，： | 2 |
| 9 | 肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。 | Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，4： | 2 |
| 10 | Tumor microRNA-29a expression and the risk of recurrence in stage IIcolon cancer显示文摘 | Alina Weissmann-Brenner Michal Kushnir Gila Lithwick Yanai Ranit Aharonov Hadas Gibori Ofer Purim Yulia Kundel Sara Morgenstern Marissa Halperin Yaron Niv Baruch Brenner | 2012 | International Journal of Oncology2012，，： | 2 |
| 11 | Applied information retrieval and multidisciplinary research: new mechanistic hypotheses in Complex Regional Pain Syndrome显示文摘 | Kristina M Hettne Marissa de Mos Anke GJ de Bruijn | 2007 | Journal of Biomedical Discovery and Collaboration2007，2，2： | 1 |
| 12 | QUADRATURE METHODS FOR HIGHLY OSCILLATORY SINGULAR INTEGRALS显示文摘We address the evaluation of highly oscillatory integrals,with power-law and logarithmic singularities.Such problems arise in numerical methods in engineering.Notably,the evaluation of oscillatory integrals dominates the run-time for wave-enriched boundary integral formulations for wave scattering,and many of these exhibit singularities.We show that the asymptotic behaviour of the integral depends on the integrand and its derivatives at the singular point of the integrand,the stationary points and the endpoints of the integral.A truncated asymptotic expansion achieves an error that decays faster for increasing frequency.Based on the asymptotic analysis,a Filon-type method is constructed to approximate the integral.Unlike an asymptotic expansion,the Filon method achieves high accuracy for both small and large frequency.Complex-valued quadrature involves interpolation at the zeros of polynomials orthogonal to a complex weight function.Numerical results indicate that the complex-valued Gaussian quadrature achieves the highest accuracy when the three methods are compared.However,while it achieves higher accuracy for the same number of function evaluations,it requires signi cant additional cost of computation of orthogonal polynomials and their zeros. | Jing Gao Marissa Condon Arieh Iserles Benjamin Gilvey Jon Trevelyan | 2021 | Journal of Computational Mathematics2021，39，2： | 1 |
| 13 | Estradiol activates group I and II metabotropic glutamatereceptor signaling,leading to opposing influences on cAMPresponse element-binding protein显示文摘 | Marissa I Boulware Jason P Weick Bryan R Becklund ^al | 2005 | J Neuroscience2005，25，20： | 1 |
| 14 | A combination of eurcumin and ginger extract improves abrasion wound healing in corticosteroid- impaired hairless rat skin 显示文摘 | Bhagavathula Narasimharao Warner Roscoe L Dasilva Marissa | 2009 | Wound Repair and Regeneration2009，17，3： | 1 |
| 15 | Integrating The Diverse Definitions of Happiness: A Time-Sequential Framework of Subjective Well-Being显示文摘 | Chu Kim-Prieto Ed Diener Maya Tamir Christie Scollon Marissa Diener | 2005 | Journal of Happiness Studies2005，，3： | 1 |
| 16 | The combination ofepigallocatechin gallate and curcumin suppresses ERa - breastcancer cell growth in vitro and in vivo 显示文摘 | Tiffany J Somers - Edgar Marissa J | 2008 | Int J Cancer2008，122，9： | 1 |
| 17 | Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions显示文摘 | Rik Ossenkoppele Wiesje M. van der Flier Sander C.J. Verfaillie Hugo Vrenken Adriaan Versteeg Ronald A. van Schijndel Sietske A. Sikkes Jos Twisk Sofie M. Adriaanse Marissa D. Zwan Ronald Boellaard Albert D. Windhorst Frederik Barkhof Philip Scheltens Adr | 2014 | Neurology2014，，20： | 1 |
| 18 | Human colon tissue in organ culture: preservation of normal and neoplastic characteristics显示文摘 | Michael K. Dame Narasimharao Bhagavathula Cohra Mankey Marissa DaSilva Tejaswi Paruchuri Muhammad Nadeem Aslam James Varani | 2010 | In Vitro Cellular & Developmental Biology - Animal2010，，2： | 1 |
| 19 | Basilar artery strokes in children: good outcomes with conservative medical treatment显示文摘 | Ana Marissa Lagman‐Bartolome Ann‐Marie Pontigon Mahendranath Moharir Daune L. Macgregor Rand Askalan Ivanna Yau Gabrielle Deveber | 2013 | Dev Med Child Neurol2013，，： | 1 |
| 20 | Association between medical injections and HIV infection in a community-based study in India显示文摘 | Marissa L Becker Sushena Reza-Paul BM Ramesh Reynold Washington Stephen Moses James F Blanchard | 2005 | AIDS2005，，12： | 1 |
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