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| 1 | Evaluating alternative stem cell hypotheses for adult corneal epithelial maintenance显示文摘In this review we evaluate evidence for three different hypotheses that explain how the corneal epithelium is maintained. The limbal epithelial stem cell(LESC)hypothesis is most widely accepted. This proposes that stem cells in the basal layer of the limbal epithelium, at the periphery of the cornea, maintain themselves and also produce transient(or transit) amplifying cells(TACs). TACs then move centripetally to the centre of the cornea in the basal layer of the corneal epithelium and also replenish cells in the overlying suprabasal layers. The LESCs maintain the corneal epithelium during normal homeostasis and become more active to repair significant wounds. Second, the corneal epithelial stem cell(CESC) hypothesis postulates that, during normal homeostasis, stem cells distributed throughout the basal corneal epithelium, maintain the tissue. According to this hypothesis, LESCs are present in the limbus but are only active during wound healing. We also consider a third possibility, that the corneal epithelium is maintained during normal homeostasis by proliferation of basal corneal epithelial cells without any input from stem cells. After reviewing the published evidence, we conclude that the LESC and CESC hypotheses are consistent with more of the evidence than the third hypothesis, so we do not consider this further. The LESC and CESC hypotheses each have difficulty accounting for one main type of evidence so we evaluate the two key lines of evidence that discriminate between them. Finally, we discuss how lineage-tracing experiments have begun to resolve the debate in favour of the LESC hypothesis. Nevertheless, it also seems likely that some basal corneal epithelial cells can act as long-term progenitors if limbal stem cell function is compromised. Thus, this aspect of the CESC hypothesis may have a lasting impact on our understanding of corneal epithelial maintenance, even if it is eventually shown that stem cells are restricted to the limbus as proposed by the LESC hypothesis. | John D West Natalie J Dorà J Martin Collinson | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Long‐term follow‐up of the Medical Research Council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer显示文摘 | B. L. Green H. C. Marshall F. Collinson P. Quirke P. Guillou D. G. Jayne J. M. Brown | 2012 | Br J Surg2012，，1： | 5 |
| 3 | An international, multicentre, prospective, randomised, controlled, unblinded, parallel-group trial of robotic-assisted versus standard laparoscopic surgery for the curative treatment of rectal cancer显示文摘 | Fiona J. Collinson David G. Jayne Alessio Pigazzi Charles Tsang Jennifer M. Barrie Richard Edlin Christopher Garbett Pierre Guillou Ivana Holloway Helen Howard Helen Marshall Christopher McCabe Sue Pavitt Phil Quirke Carly S. Rivers Julia M. B. Brown | 2012 | International Journal of Colorectal Disease2012，，2： | 2 |
| 4 | Homocysteine and Its Relationship to Stroke Subtypes in a UK Black Population: The South London Ethnicity and Stroke Study显示文摘 | Usman Khan Carollyn Crossley Lalit Kalra Anthony Rudd Charles D.A. Wolfe Paul Collinson Hugh S. Markus | 2008 | Stroke2008，，11： | 2 |
| 5 | Sol-gel strategies for the preparation of selective materials for chemical analysis显示文摘 | | 1999 | Crit Rev Anal Chem1999，29，： | 1 |
| 6 | Trust Relations in High-Reliability Organizations显示文摘 | Cox S Jones B Collinson D | 2006 | (5):1123-11382006，，5： | 1 |
| 7 | F0 membrane domain of ATP synthase from bovine heart mitochondria:purification subunit composition and reconstitution with F1-ATPase 显示文摘 | COLLINSON L R RUNSWICK M J BUCHANAN S K | 1994 | Biochem1994，33，25： | 1 |
| 8 | DNA-based diagnostic tests for Salmonella species targeting agfA,the structural gene for thin,aggregative fimbriae显示文摘 | DORAN J L COLLINSON S K BURIAN J | 1993 | J Clin Microbiol1993，31，： | 1 |
| 9 | Biomarkers of cardiovasculardamage显示文摘 | COLLINSON P 0 GAZE D C | 2007 | Med Princ Pract2007，16，4： | 1 |
| 10 | Long-term follOw-upof the Medical Research Council CLASICC trial of conventional versus laparoscopically assisted resection in colorectal cancer 显示文摘 | Green BL Marshall HC Collinson F | 2013 | Br J Surg2013，100，1： | 1 |
| 11 | Clinical evaluation of the first medical whole blood, point-of-care testing device for detection of myocardial infarction 显示文摘 | Apple F S Anderson F P Collinson P | 2000 | Clin Chem2000，46，： | 1 |
| 12 | Cardiac troponin I measurement using the ACS:180 to predict four-year cardiac event rate显示文摘 | Collinson P Gaynor GH Gaze DC | 2008 | Ann Clin Biochem2008，45，2： | 1 |
| 13 | Elevated homocysteine levels are associated with increased ischemic myocardial injury in acute coronary syndromes 显示文摘 | Al-Obaidi MK Stubbs PJ Collinson P | 2000 | J Am Coll Cardiol2000，36，4： | 1 |
| 14 | Analytical characteristics of high- sensitivity cardiac troponin assays 显示文摘 | Apple FS Collinson PO | 2012 | Clin Chem2012，58，： | 1 |
| 15 | A ditopic ferrocene receptor for anions and cations that functions as a chromogenic molecular switch显示文摘 | M(YAJI H coLLINSON S R TUCKER J H R | 2003 | Chem Commun2003，6465，： | 1 |
| 16 | Amino termina 1 pro-B-type natriuretic peptide: analytic considerations 显示文摘 | Ordonez-Llanos J Collinson PO Christenson RH | 2008 | Am J Cardiol2008，101，3： | 1 |
| 17 | Biomarkers of cardiovascular dam- age and dysfunction-an overview显示文摘 | Collinson PO Gaze DC | 2007 | Heart Lung Circ2007，16，3： | 1 |
| 18 | Elevated homocysteine levels are associated with increased ischemic myocardial injury in acute coronary syndromes显示文摘 | Stubbs PJ Collinson P | 2000 | JACC2000，36，4： | 1 |
| 19 | Multicentre evaluation of the diagnostic value of cardiac troponin-T,CK-MB mass,and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice显示文摘 | COLLINSON P O STUBBS P J KESSLER AC | 2003 | Heart2003，89，3： | 1 |
| 20 | Magnetism of the Moon-a lunar core dynamo or impact magnetization显示文摘 | Collinson D W | 1993 | Surveys in Geophysics1993，14，1： | 1 |
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