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| 1 | 记忆门诊的微出血患病率和严重程度研究显示文摘Objective: To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic. Methods: The authors consecutively included patients attending their memory clinic between January 2002 and April 2005. They analyzed prevalence and number of MBs according to demographic, diagnostic, and MRI data. Results: The authors included 772 patients (53%men, age 66 ±11). One hundred twenty-seven patients (17%) exhibited at least one MB. The prevalence differed according to diagnostic groups (p < 0.0001): Sixty-five percent of patients with vascular dementia exhibited MBs vs 18%of Alzheimer disease patients, 20%of mild cognitive impairment patients, and 10%of patients with subjective complaints. The presence of MBs was associated with age, white matter hyperintensities, lacunar infarcts, and infarcts. Conclusion: The prevalence of microbleeds (MBs) in a large cohort of patients attending a memory clinic is higher than previously described in community samples and lower than reported in stroke patients. This finding of a relatively high proportion of MBs in Alzheimer disease and mild cognitive impairment provides further evidence for the involvement of vascular factors in neurodegenerative diseases such as Alzheimer disease. | Cordonnier C. Van Der Flier W.M. Sluimer J.D. P. Scheltens 王鹏 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 8 |
| 2 | Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium显示文摘 | Laurens G. van der Flier Hans Clevers | 2009 | Annual Review of Physiology2009，，： | 4 |
| 3 | Adipose tissue as an endocrine organ 显示文摘 | Ahima RS Flier JS | 2000 | TEM2000，11，： | 4 |
| 4 | Leptin显示文摘 | Rexford S. Ahima Jeffrey S. Flier | 2000 | Annual Review of Physiology2000，，： | 2 |
| 5 | 记忆临床病人全脑萎缩率和认知功能损害的纵向MR研究显示文摘目的前瞻胜地研究轻度认知功能障碍(MCI)和阿尔茨海默病(AD)的全脑萎缩率及其与认知功能损害的关系,研究已有基础脑容量与全脑萎缩率,但尚未痴呆的病人发展为痴呆的概率。方法本研究经学术审查委员会批准并取得所有病人书面的知情同意。65例AD病人(女38例,男27例;年龄52~81岁),45例MCI病人(女22例,男23例;年龄56~80岁),27例有主观症状的病人(女12例。男15例;年龄50~87岁),以及10名健康人(女6例,男4例;年龄53-80岁)作为对照纳入研究。2次MR检查时间间隔为(1.8±0.7)a。采用3DT1WI(1.0T,单块采集,168层, | J.D. Sluimer W.M. van der Flier G.B. Karas N.C. Fox P. Scheltens F.Barkhof 郭雪梅(译) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 2 |
| 6 | Insulin receptors and insulin resistance显示文摘 | Flier JS | 1983 | AnnuRev Med1983，34，： | 1 |
| 7 | A thyrotropin-sereting pituitary adenoma as a cause of thyrotoxic periodic paralysis显示文摘 | Alings AM Fliers E de Herder WW | 1998 | J Endocrinol Invest1998，21，10： | 1 |
| 8 | Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes 显示文摘 | Flier JS Mueckler MM Usher P | 1987 | Science1987，235，： | 1 |
| 9 | Small Vessel Disease and General Cognitive Function in Non disabled Elderly the LADIS Study显示文摘 | vander Flier WM van Straaten EC Barkhof F | 2005 | Stroke2005，3，10： | 1 |
| 10 | Insulin resistance-mechanisms,syndromes,and implications显示文摘 | Moller DE Flier JS | 1991 | N Engl J Med1991，325，13： | 1 |
| 11 | Melanin-Concentrating hormone activates signaling pathways in 3T3-L1 adipocytes显示文摘 | Bradley R L Mansfield J P R Maratos Flier E | 2002 | Am J Physiol Endocrinol Metab2002，284，： | 1 |
| 12 | 显示文摘 | Kershaw EE Flier JS | 2004 | J Clin Endoerinol Metab2004，89，6： | 1 |
| 13 | Leptin,nutrition,and the thyroid:the why? the wherefore,and the wiring显示文摘 | Flier JS Harris M Hollenberg AN | 2000 | J Clin Invest2000，105，： | 1 |
| 14 | Transcellular transport of leptin by the short leptin receptor isoform ObRa in madindarby canine kidney cells显示文摘 | Hileman SM Tornoe J Flier JS | | 0，，： | 1 |
| 15 | Progression of white matter hyperintensities and incedence of new lacunes over a 3-year period : the leukeariosisi and disabilty study 显示文摘 | Gouw AA van der Flier WM Fazekas F | 2008 | Stroke2008，39，： | 1 |
| 16 | Obesity wars:molecular progress confronts an expanding epidemic显示文摘 | | 2004 | Cell2004，116，2： | 1 |
| 17 | Plasma vascular endothelial growth factor in severe sepsis显示文摘 | Vander Flier M Van Leeuwen HJ Van Kessel KP | 2005 | Shock2005，23，1： | 1 |
| 18 | Neurogenesis in the hypothalamus of adult mice: potential role in energy balance显示文摘 | Kokoeva MV Yin H Flier JS | 2005 | Science2005，310，5748： | 1 |
| 19 | Obesity and insulin resistance显示文摘 | KAHN BB FLIER JS | 2000 | J Clin Invest2000，106，4： | 1 |
| 20 | Adipose tissue as an endocrine organ显示文摘 | Kershaw EE Flier JS | 2004 | J Clin Endocrinol Metab2004，89，6： | 1 |
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