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| 1 | Management of acute nonvariceal upper gastrointestinal bleeding:Current policies and future perspectives显示文摘Acute upper gastrointestinal bleeding(UGIB) is a gastroenterological emergency with a mortality of 6%-13%.The vast majority of these bleeds are due to peptic ulcers.Nonsteroidal anti-inflammatory drugs and Helicobacter pylori are the main risk factors for peptic ulcer disease.Endoscopy has become the mainstay for diagnosis and treatment of acute UGIB,and is recommended within 24 h of presentation.Proton pump inhibitor(PPI) administration before endoscopy can downstage the bleeding lesion and reduce the need for endoscopic therapy,but has no effect on rebleeding,mortality and need for surgery.Endoscopic therapy should be undertaken for ulcers with high-risk stigmata,to reduce the risk of rebleeding.This can be done with a variety of modalities.High-dose PPI administration after endoscopy can prevent rebleeding and reduce the need for further intervention and mortality,particularly in patients with high-risk stigmata. | Ingrid Lisanne Holster Ernst Johan Kuipers | 2012 | World Journal of Gastroenterology2012，18，11： | 53 |
| 2 | China’s New Rural Income Support Policy:Impacts on Grain Production and Rural Income Inequality显示文摘This paper analyses the impact of agricultural tax abolition and direct income payments to grain farmers on grain production and rural inequality in China. To separate the impact of the income support measures from recent price trends for grains and inputs, and to account for differences in household responses, we use a village-level general equilibrium model that we calibrate for two villages with different degrees of market access in Jiangxi province. The results show that the income support policy does not reach its goal of promoting grain production. The increased incomes allow farm households to buy more inputs for livestock production and involve other activities that are more profitable than grain farming. Selling of rice outside the villages declines more than rice production, because households in the villages consume more rice when incomes rise. We further find that the income support measures tend to reduce income within a village, but that tax abolition tends to widen income inequality between villages. | Nico Heerink Marijke Kuiper | 2006 | China & World Economy2006，14，6： | 26 |
| 3 | Biomechanical analysis of tension band wiring (TBW) of transverse fractures of patella显示文摘目的紧张乐队配线通常为简单横向的破裂的固定被使用。流行配置是平行 Kirschner 电线(K 电线) 和在垂直地面向的 figure-of-8 放的一个不锈钢电线环。我们与中途的横向的破裂使用了髌的一个木模型并且比较了固定的四种不同类型的方法。第一构造与电线的一扭曲有垂直 figure-of-8。第二与电线的二扭曲包含了垂直 figure-of-8。第三是有当最后一个与在邻近的角落放的电线的二扭曲有水平 figure-of-8 时,在邻近的角落放的电线的二扭曲的垂直 figure-of-8。在电线破裂的点的 Interfragmentary 压缩在周期的装载上为每构造以及永久排水量被测量。在有在角落的二电线扭曲的水平取向的 figure-of-eight 的结果放置在 63% 改进了 interfragmentary 压缩(p p = 0.01;Fishers 准确测试) 。在周期的装载以后的永久破裂排水量是 67% 与水平 figure-of-eight 构造(p t 测试) 更低。把电线扭曲放在角落和 figure-of-8 的水平放置的结论改进构造的稳定性。 | Mohammed Ali Jan Kuiper Joby John | 2016 | Chinese Journal of Traumatology2016，19，5： | 16 |
| 4 | Two-fluid modeling of Geldart A particles in gas-fluidized beds显示文摘We have investigated the effect of cohesion and drag models on the bed hydrodynamics of Geldart A particles based on the two-fluid (TF) model. For a high gas velocity U0 = 0.03 m/s, we found a transition from the homogeneous fluidization to bubbling fluidization with an increase of the coefficient C1, which is used to account for the contribution of cohesion to the excess compressibility. Thus cohesion can play a role in the bed expansion of Geldart A particles. Apart from cohesion, we have also investigated the influence of the drag models. When using the Wen and Yu drag correlation with an exponent n = 4.65, we find an under-prediction of the bed expansion at low gas velocities (U0 = 0.009 m/s). When using a larger exponent (n = 9.6), as reported in experimental studies of gas-fluidization, a much better agreement with the experimental bed expansion is obtained. These findings suggest that at low gas velocity, a scale-down of the commonly used drag model is required. On the other hand, a scale-up of the commonly used drag model is necessary at high gas velocity (U0 = 0.2 and 0.06 m/s). We therefore conclude that scaling the drag force represent only an ad hoc way of repairing the deficiencies of the TF model, and that a far more detailed study is required into the origin of the failure of the TF model for simulating fluidized beds of fine powders. | M.A. van der Hoef J.A.M. Kuipers | 2008 | Particuology2008，6，6： | 16 |
| 5 | 幽门螺杆菌感染处理的当前观念——MaastrichtⅢ共识报告显示文摘名词缩写欧洲幽门螺杆菌研究小组:European Helicobacter Study Group,EHSG胃食管反流病:gastro-esophageal reflux disease。 | P Malfertheiner F Megraud C O'Morain F Bazzoli E El-Omar D Graham R Hunt T Rokkas N Vakil EJ Kuipers 朱琦 | 2007 | 胃肠病学2007，12，3： | 15 |
| 6 | Treatment of acute periprosthetic infections with prosthesis retention: Review of current concepts显示文摘Periprosthetic joint infection(PJI) is a devastating complication after total joint arthroplasty, occurring in approximately 1%-2% of all cases. With growing populations and increasing age, PJI will have a growing effect on health care costs. Many risk factors have been identified that increase the risk of developing PJI, including obesity, immune system deficiencies, malignancy, previous surgery of the same joint and longer operating time. Acute PJI occurs either postoperatively(4 wk to 3 mo after initial arthroplasty, depending on the classification system), or via hematogenous spreading after a period in which the prosthesis had functioned properly. Diagnosis and the choice of treatment are the cornerstones to success. Although different definitions for PJI have been used in the past, most are more or less similar and include the presence of a sinus tract, blood infection values, synovial white blood cell count, signs of infection on histopathological analysis and one ormore positive culture results. Debridement, antibiotics and implant retention(DAIR) is the primary treatment for acute PJI, and should be performed as soon as possible after the development of symptoms. Success rates differ, but most studies report success rates of around 60%-80%. Whether single or multiple debridement procedures are more successful remains unclear. The use of local antibiotics in addition to the administration of systemic antibiotic agents is also subject to debate, and its pro's and con's should be carefully considered. Systemic treatment, based on culture results, is of importance for all PJI treatments. Additionally, rifampin should be given in Staphylococcal PJIs, unless all foreign material is removed. The most important factors contributing to treatment failure are longer duration of symptoms, a longer time after initial arthroplasty, the need for more debridement procedures, the retention of exchangeable components, and PJI caused by Staphylococcus(aureus or coagulase negative). If DAIR treatment is unsuccessful, the following treatment option should be based on the patient health status and his or her expectations. For the best functional outcome, one- or two-stage revision should be performed after DAIR failure. In conclusion, DAIR is the obvious choice for treatment of acute PJI, with good success rates in selected patients. | Jesse WP Kuiper Robin Tjeenk Willink Dirk Jan F Moojen Michel PJ van den Bekerom Sascha Colen | 2014 | World Journal of Orthopedics2014，5，5： | 12 |
| 7 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 8 | 农村市场发育与村庄经济研究显示文摘近年来随着农村改革的不断深入以及农户非农就业的增加 ,农村要素市场和产品市场已逐渐出现。当农户之间的市场交换活动发生在村庄内或一个小区域之内时 ,农户之间的市场交换就会使农户之间产生很强的市场联系 ,一部分农户的生产、消费决策行为的变化就和另一部分农户行为的变化紧密联系起来 ,政策变化对农户的影响就要考虑农户之间的这种联系 ,这时就适用村庄经济的研究方法如村庄社会核算矩阵乘数模型、一般均衡模型等方法。本文通过对三个村的要素市场和产品市场的分析发现 ,农村土地租赁、农业劳动力、借贷市场已经相当发育 ,农户之间由于这些市场的存在而产生了紧密的联系 ,其他要素和产品市场也在一定程度上得到发育 ,但由于主要是外向性以及农户较少参与其中而对农户之间的联系影响较弱 ,但三个市场农户的参与以及市场紧密的联系已经为应用村庄经济研究方法提供了充分的证据。 | 石晓平 曲福田 Nico Heerink Marijke Kuiper | 2004 | 中国农村观察2004，，1： | 9 |
| 9 | Pharmacomicrobiomics: a novel route towards personalized medicine?显示文摘在药反应的内部个人的异质是影响病人幸福并且在社会水平上提出庞大的临床、金融的负担的一个严重问题。Pharmacogenomics 在关于药反应可变性或药毒性的对单个基因背景的影响的研究的最前线,并且最近,内脏 microbiome,也被称为第二个染色体,在这个方面作为一个重要播放器被认出了。而且, microbiome 是为由于机会改进药功效和安全操作它的作文的一个很吸引人的目标。Pharmacomicrobiomics 是调查 microbiome 变化和药反应和布置(吸收,分发,新陈代谢和排泄) 的相互影响的一个新兴的领域。在这评论,我们提供历史的概述并且在在内脏 microbiome,主人和药之间的复杂相互作用上检验当前的最先进的知识。我们主张那联合 pharmacogenomics 和 pharmacomicrobiomics 将为在个性化的药做主要进展提供一个重要基础。 | Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga Jingyuan Fu | 2018 | Protein & Cell2018，9，5： | 7 |
| 10 | Bowel preparation for colonoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | C. Hassan M. Bretthauer M. Kaminski M. Polkowski B. Rembacken B. Saunders R. Benamouzig O. Holme S. Green T. Kuiper R. Marmo M. Omar L. Petruzziello C. Spada A. Zullo J. Dumonceau | 2013 | Endoscopy2013，，02： | 7 |
| 11 | BLADE SECTION DESIGN OF MARINE PROPELLERS WITH MAXIMUM CAVITATION INCEPTION SPEED显示文摘Kuiper and Jessup(1993)developed a design method for propellers in a wake based on the Eppler foil design method.The optimized section is transformed into the three-dimensional propeller flow using the approach of the effective blade sections.Effective blade sections are two-dimensional sections in two-dimensional flow which have the same chordwise loading distribution as the three-dimensional blade sections of a propeller.However,the design procedure is laborious in two aspects:finding an optimum blade section using the Eppler program requires much skill of the designer,and transforming the two-dimensional blade section into a propeller blade section in three-dimensional flow is complex.In this work,these two problems were coped with.A blade section design procedure was presented using an optimization technique and an alternative procedure for the effective blade section is developed using a lifting surface design method.To validate the method a benchmark model of a naval ship was used.This benchmark model was extended by new appendices and a reference propeller,and designed using conventional design methods.This reference propeller was optimized using the new design procedure and model tests were carried out.Special attention was given to the data of the model and the reference propeller,to make the configuration suitable for the Reynolds-Averaged Navier-Stokes(RANS)calculations. | ZENG Zhi-bo KUIPER Gert | 2012 | Journal of Hydrodynamics2012，24，1： | 6 |
| 12 | Influence of liquid layers on energy absorption during particle impact显示文摘The influence of the thickness of a covering liquid layer and its viscosity as well as the impact velocity on energy loss during the normal impact on a flat steel wall of spherical granules with a liquid layer was studied. Free-fall experiments were performed to obtain the restitution coefficient of elastic–plastic Al2O3 granules by impact on the liquid layer, using aqueous solutions of hydroxypropyl methylcellulose with different concentrations for variation of viscosity (1–300 mPa s). In the presence of a liquid layer, increase of liquid viscosity decreases the restitution coefficient and the minimum thickness of the liquid layer at which the granule sticks to the wall. The measured restitution coefficients were compared with experiments performed without liquid layer. In contrast to the dry restitution coefficient, due to viscous losses at lower impact velocity, higher energy dissipation was obtained. A rational explanation for the effects obtained was given by results of numerically solved force and energy balances for a granule impact on a liquid layer on the wall. The model takes into account forces acting on the granule including viscous, surface tension, capillary, contact, drag, buoyancy and gravitational forces. Good agreement between simulations and experiments has been achieved. | Sergiy Antonyuk Stefan Heinrich Niels Deen Hans Kuipers | 2009 | Particuology2009，7，4： | 5 |
| 13 | 成年精神病与精神分裂症患者的管理:MCE最新指南概要显示文摘这是新指南系列BMJ概述中的一个,这些指南都是基于现有的最佳证据制定的;他们突出了临床实践中的重要建议,尤其是那些不确定或具争议性的方面。 | Elizabeth Kuipers Amina Yesufu- Udechuku Clare Taylor Tim Kendall 王琰 何燕玲 | 2014 | 英国医学杂志中文版2014，，4： | 5 |
| 14 | Precancerous lesions in the stomach: From biology to clinical patient management显示文摘 | Massimo Rugge Lisette G. Capelle Rocco Cappellesso Donato Nitti Ernst J. Kuipers | 2013 | Best Practice & Research Clinical Gastroenterology2013，，2： | 4 |
| 15 | Discrete particle modeling of granular temperature distribution in a bubbling fluidized bed显示文摘The discrete hard sphere particle model (DPM) is applied in this work to study numerically the distributions of particle and bubble granular temperatures in a bubbling fluidized bed. The dimensions of the bed and other parameters are set to correspond to those of Müller et al. (2008). Various drag models and operational parameters are investigated to find their influence on particle and bubble granular temperatures. Various inlet superficial gas velocities are used in this work to obtain their effect on flow characteristics. It is found that the superficial gas velocity has the most important effect on granular temperatures including bubble granular temperature, particle translational granular temperature and particle rotational granular temperature. The drag force model affects more seriously the large scale variables such as the bubble granular temperature. Restitution coefficient influences all granular temperatures to some degree. Simulation results are compared with experimental results by Müller et al. (2008) showing reasonable agreement. | Yurong He Tianyu Wang Niels Deen Martin van Sint Annaland Hans Kuipers Dongsheng Wen | 2012 | Particuology2012，10，4： | 4 |
| 16 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 17 | Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. | Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 18 | Coefficient of restitution for particles impacting on wet surfaces: An improved experimental approach显示文摘 | B. Cunger V. Salikov S. Heinrich S. Antonyuk V.S. Sutkar N.G. Deen J.A.M. Kuipers | 2016 | Particuology2016，14，2： | 4 |
| 19 | A numerical model of gas-fluidized beds显示文摘 | Kuipers J A M Van Duin K J Van Beckum F P H | 1992 | Chem Eng Sci1992，47，5： | 4 |
| 20 | COMPUTATIONAL FLUID DYNAMICS FOR DENSE GAS-SOLID FLUIDIZED BEDS: A MULTI-SCALE MODELING STRATEGY显示文摘Dense gas-particle flows are encountered in a variety of industrially important processes for large scale production of fuels, fertilizers and base chemicals. The scale-up of these processes is often problematic and is related to the intrinsic complexities of these flows which are unfortunately not yet fully understood despite significant efforts made in both academic and industrial research laboratories. In dense gas-particle flows both (effective) fluid-particle and (dissipative) particle-particle interactions need to be accounted for because these phenomena to a large extent govern the prevailing flow phenomena, i.e. the formation and evolution of heterogeneous structures. These structures have significant impact on the quality of the gas-solid contact and as a direct consequence thereof strongly affect the performance of the process. Due to the inherent complexity of dense gas-particles flows, we have adopted a multi-scale modeling approach in which both fluid-particle and particle-particle interactions can be properly accounted for. The idea is essentially that fundamental models, taking into account the relevant details of fluid-particle (lattice Boltzmann model) and particle-particle (discrete particle model) interactions, are used to develop closure laws to feed continuum models which can be used to compute the flow structures on a much larger (industrial) scale. Our multi-scale approach (see Fig. 1 ) involves the lattice Boltzmann model, the discrete particle model, the continuum model based on the kinetic theory of granular flow and the discrete bubble model. In this paper we give an overview of the multi-scale modeling strategy, accompanied by illustrative computational results for bubble formation. In addition, areas which need substantial further attention will be highlighted. | M. A. van der Hoef M. van Sint Annaland J. A. M. Kuipers | 2005 | China Particuology2005，3，1： | 4 |
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