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| 1 | Antioxidant enriched enteral nutrition and oxidative stress after major gastrointestinal tract surgery显示文摘AIM: To investigate the effects of an enteral supple-ment containing antioxidants on circulating levels of antioxidants and indicators of oxidative stress after major gastrointestinal surgery.METHODS: Twenty-one patients undergoing major upper gastrointestinal tract surgery were randomised in a single centre, open label study on the effect of postoperative enteral nutrition supplementedwith antioxidants. The effect on circulating levels of antioxidants and indicators of oxidative stress, such as F2-isoprostane, was studied. RESULTS: The antioxidant enteral supplement showed no adverse effects and was well tolerated. After surgery a decrease in the circulating levels of antioxidant parameters was observed. Only selenium and glutamine levels were restored to pre-operative values one week after surgery. F2-isoprostane increased in the first three postoperative days only in the antioxidant supplemented group. Lipopolysaccharide binding protein (LBP) levels decreased faster in the antioxidant group after surgery.CONCLUSION: Despite lower antioxidant levels there was no increase in the circulating markers of oxidative stress on the first day after major abdominal surgery. The rise in F2-isoprostane in patients receiving the antioxidant supplement may be related to the conversion of antioxidants to oxidants which raises questions on antioxidant supplementation. Module AOX restored the postoperative decrease in selenium levels. The rapid decrease in LBP levels in the antioxidant group suggests a possible protective effect on gut wall integrity. Further studies are needed on the role of oxidative stress on outcome and the use of antioxidants in patients undergoing major abdominal surgery. | Mireille FM van Stijn Gerdien C Ligthart-Melis Petra G Boelens Peter G Scheffer Tom Teerlink Jos WR Twisk Alexander PJ Houdijk Paul AM van Leeuwen | 2008 | World Journal of Gastroenterology2008，14，45： | 4 |
| 2 | Altered Myocardial Substrate Metabolism and Decreased Diastolic Function in Nonischemic Human Diabetic Cardiomyopathy显示文摘 | Luuk J. Rijzewijk Rutger W. van der Meer Hildo J. Lamb Hugo W.A.M. de Jong Mark Lubberink Johannes A. Romijn Jeroen J. Bax Albert de Roos Jos W. Twisk Robert J. Heine Adriaan A. Lammertsma Johannes W.A. Smit Michaela Diamant | 2009 | Journal of the American College of Cardiology2009，，16： | 2 |
| 3 | Intensity of leg and arm training after primary middle-cerebral-artery stroke:a randomised trial 显示文摘 | Kwakkel G Wagenaar RC Twisk JW | 1999 | Lancet1999，17，： | 2 |
| 4 | Physical activity guidelines for children andadolescents : a critical review 显示文摘 | Twisk J W | 2001 | Sports Med2001，31，8： | 1 |
| 5 | Central fat mass versus peripheral fat and lean mass:opposite(adverse versus favorable) associations with arterial stiffness?The Amsterdam Growth and Health Longitudinal Study显示文摘 | Ferreira I Snijder MB Twisk JW | 2004 | J Clin Endocrinol Metab2004，89，6： | 1 |
| 6 | Heliox re- duces respiratory system resistance in respiratory syncyti- al virus induced respiratory failure显示文摘 | Kneyber MC van Heerde M Twisk JW | 2009 | Critical care Med2009，13，3： | 1 |
| 7 | Increased urinary albu- min excretion,endothelial dysfunction, and chronic low-grade in- flammation in type 2 diabetes: progressive, interrelated, and inde- pendently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 8 | Tracking of risk factors for coronary heart disease over a 14-year period:A comparison between lifestyle and biologic risk factors with data from the Amsterdam Growth and Health Study显示文摘 | TWISK JW KEMPER HC VAN MECHELEN W | 1997 | Am J Epidemic1997，14，5： | 1 |
| 9 | intensity of leg and afterprimary middle-cerebral-artery stroke:a randomized tral显示文摘 | Kwakkel G Wagenaar RC’Twisk JW | 1999 | lancet1999，354，9174： | 1 |
| 10 | Increased urinary albumin excretion,endothelial dysfunction,and chronic low-grade inflammation in type 2 diabetes:progressive,interrelated,and independently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 11 | Functional Recovery After Acute Myocardial Infarction显示文摘 | Robin Nijveldt Aernout M. Beek Alexander Hirsch Martin G. Stoel Mark B.M. Hofman Victor A.W.M. Umans Paul R. Algra Jos W.R. Twisk Albert C. van Rossum | 2008 | Journal of the American College of Cardiology2008，，3： | 1 |
| 12 | How success- ful is fetal echocardiographic examination in the first tri- mester of pregnancy 显示文摘 | Haak M C Twisk I W R Van Vugt J M G | 2002 | Ultrasound Obstet Gynecol2002，20，1： | 1 |
| 13 | P-selectin as a candidate target in atherosclerosis 显示文摘 | Molenaar TJ Twisk J Haas SA | 2003 | Biochemical Pharmacology2003，66，5： | 1 |
| 14 | Fluobodies green fluorescent single-chain Fv fusion proteins显示文摘 | Griep RA Twisk C Wolf JM | 1999 | Journal of Immunological Methods1999，230，12： | 1 |
| 15 | Comparison of the haemodynamic effects of right ventricular outflow2tract pacingwith right ventricular apex pacing 显示文摘 | Cock CC Giudici MC Twisk JW | 2003 | Europace2003，5，3： | 1 |
| 16 | Preimplantation genetic screening: a systematic review and meta-analysis of RCTs 显示文摘 | Mastenbroek S Twisk M van der Veen F | | Hum Reprod Update0，17，4： | 1 |
| 17 | Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients显示文摘 | Erik S. Stroes Melchior C. Nierman Janneke J. Meulenberg Remco Franssen Jaap Twisk C Pieter Henny Mario M. Maas Aeilko H. Zwinderman Colin Ross Eleonora Aronica Katherine A. High Marcel M. Levi Michael R. Hayden John J. Kastelein Jan Albert Kuivenhoven | 2008 | Arteriosclerosis Thrombosis and Vascular Biology2008，，12： | 1 |
| 18 | Type 2 diabetes mel- litus as a risk factor for the onset of depression:a systematic review and meta-analysis 显示文摘 | Nouwen A Winkley K Twisk J | 2010 | Diabetologia2010，53，12： | 1 |
| 19 | Increased urinary albumin excretion,endothelial dvsfunction and chronic low-grade inflammation in type-2 diabetes:progressive,interre-lated,and independently associated with risk of death显示文摘 | Stehouwer CD Gall MA Twisk JW | 2002 | Diabetes2002，51，4： | 1 |
| 20 | Improving Homogeneity by Dynamic Speed Limit Systems 显示文摘 | VAN NES N BRANDENBURG S TWISK D | 2010 | Accident Analysis & Prevention2010，42，： | 1 |
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