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| 1 | In-situ stress measurements and stress change monitoring to monitor overburden caving behaviour and hydraulic fracture pre-conditioning显示文摘A coal mine in New South Wales is longwall mining 300 m wide panels at a depth of 160–180 m directly below a 16–20 m thick conglomerate strata. As part of a strategy to use hydraulic fracturing to manage potential windblast and periodic caving hazards associated with these conglomerate strata,the in-situ stresses in the conglomerate were measured using ANZI strain cells and the overcoring method of stress relief. Changes in stress associated with abutment loading and placement of hydraulic fractures were also measured using ANZI strain cells installed from the surface and from underground. Overcore stress measurements have indicated that the vertical stress is the lowest principal stress so that hydraulic fractures placed ahead of mining form horizontally and so provide effective pre-conditioning to promote caving of the conglomerate strata. Monitoring of stress changes in the overburden strata during longwall retreat was undertaken at two different locations at the mine. The monitoring indicated stress changes were evident 150 m ahead of the longwall face and abutment loading reached a maximum increase of about7.5 MPa. The stresses ahead of mining change gradually with distance to the approaching longwall and in a direction consistent with the horizontal in-situ stresses. There was no evidence in the stress change monitoring results to indicate significant cyclical forward abutment loading ahead of the face. The forward abutment load determined from the stress change monitoring is consistent with the weight of overburden strata overhanging the goaf indicated by subsidence monitoring. | Puller Jesse W. Mills Ken W. Jeffrey Rob G. Walker Rick J. | 2016 | International Journal of Mining Science and Technology2016，26，1： | 5 |
| 2 | Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy显示文摘 | Omry Koren Julia K. Goodrich Tyler C. Cullender Aymé Spor Kirsi Laitinen Helene Kling B?ckhed Antonio Gonzalez Jeffrey J. Werner Largus T. Angenent Rob Knight Fredrik B?ckhed Erika Isolauri Seppo Salminen Ruth E. Ley | 2012 | Cell2012，，3： | 2 |
| 3 | ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 Expert Consensus Document on Coronary Computed Tomographic Angiography: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents显示文摘 | Daniel B. Mark Daniel S. Berman Matthew J. Budoff J. Jeffrey Carr Thomas C. Gerber Harvey S. Hecht Mark A. Hlatky John McB. Hodgson Michael S. Lauer Julie M. Miller Richard L. Morin Debabrata Mukherjee Michael Poon Geoffrey D. Rubin Robert S. Schwartz Rob | 2010 | Circulation2010，，22： | 1 |
| 4 | Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota显示文摘 | Purna C. Kashyap Angela Marcobal Luke K. Ursell Samuel A. Smits Erica D. Sonnenburg Elizabeth K. Costello Steven K. Higginbottom Steven E. Domino Susan P. Holmes David A. Relman Rob Knight Jeffrey I. Gordon Justin L. Sonnenburg | 2013 | Proceedings of the National Academy of Sciences2013，，42： | 1 |
| 5 | A Typology for Analyzing Digital Curricula in Mathematics Education显示文摘 | Choppin Jeffrey Carson Cynthia Bows Zenon Cerosaletti Cathleen GiUis Rob | 2014 | International Journal of Education in Mathematics Science and Technology2014，，1： | 1 |
| 6 | High glucose variability increases cerebral infarction in patients with spontaneous subarachnoid hemorrhage显示文摘 | Jeffrey F.B Bryan E.F Rob D | | 0，，05： | 1 |
| 7 | A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial显示文摘 | Rob Pieters Martin Schrappe Paola De Lorenzo Ian Hann Giulio De Rossi Maria Felice Liisa Hovi Thierry LeBlanc Tomasz Szczepanski Alice Ferster Gritta Janka Jeffrey Rubnitz Lewis Silverman Jan Stary Myriam Campbell Chi-Kong Li Georg Mann Ram Suppiah Andrea | 2007 | The Lancet2007，，9583： | 1 |
| 8 | 婴儿急性淋巴细胞白血病治疗方案(Interfant-99):一项多中心随机临床试验及观察研究显示文摘背景急性淋巴细胞白血病(ALL)极少见于1岁以内的婴儿,一旦患病其预后将比年长幼儿更差。本项国际研究旨在观察一种新的兼具ALL与急性髓系白血病(AML)治疗要素的混合治疗方案的应用效果,并确定可能影响婴儿预后的因素。本研究同时还进行了一项随机临床试验,以确定晚期强化治疗的,临床价值。
方法本研究包括来自22个国家的17个研究组,分别于1999-2005年选取年龄为0~12个月的ALL婴儿。根据前期泼尼松治疗7d后外周血的反应,对患儿进行风险分层,然后给予以ALL标准疗法为基础的混合治疗,该疗法亦包含某些AML治疗要素。在维持期之前,将完全缓解的一组患儿随机分为标准治疗组和应用高剂量阿糖胞苷及甲氨蝶呤的高强度化疗组。主要结局指标为初选治疗组的无事件生存率(EFS)与随机治疗组的无病存活率(DFS)。数据处理以意向治疗分析为基础。该试验在ClinicalTrials.gov网站上的注册号为NCT 00015873,在controlled—trials.com网站上注册号为ISRCTN24251487。
结果共计482例患婴接受混合治疗,其中260例(58%)完全缓解,中位随访期为38个月(极差1~78),4年EFS达47.0%(si=2.6,95%CI41.9%~52.1%)。诱导治疗5周后445例获完全缓解,入选随机分组191例,其中晚期强化治疗组95例,对照组96例。在中位数为42个月(极差1~73)的随访期后,治疗组无病存活60例,对照组57例。2组间4年DFS无显著差异[治疗组为60.9%(sx^-=5.2)VS对照组为57.0%;P=0.81]。在强化治疗期,71例随机治疗组患婴反馈有毒性统计数据,其中感染35例(49%)、黏膜炎21例(30%)、肝脏毒性反应22例(33%)、神经毒性2例(3%)。反映预后不佳的独立因素包括:各种M比(混合系白血病)基因重排、极高的白细胞计数、年龄〈6个月、前期泼尼松治疗反应差。
结论与多数报道相比,ALL婴儿(特别是那些对泼尼松反应差的患儿)接受混合治疗后可获得较好的EFS。但晚期强化化疗的效果并不明显。 | Rob Pieters Martin Schrappe Paola De Lorenzo lan Hann Giulio De Rossi Maria Felice Liisa Houi Thierry LeBlanc Tomasz Szczepanski Alice Ferster Gritta Janka Jeffrey Rubnitz Lewis Silverman Jan Story Myriam Campbell Chi-Kong Li Georg Mann Ram Suppiah Andrea Biondi Ajay Vora Maria Grazia Valsecchi 王顺涛(译) | 2008 | 世界临床医学2008，2，1： | 0 |
| 9 | Deep Geothermal: The ‘Moon Landing' Mission in the Unconventional Energy and Minerals Space显示文摘Deep geothermal from the hot crystalline basement has remained an unsolved frontier for the geothermal industry for the past 30 years. This poses the challenge for developing a new unconventional geomechanics approach to stimulate such reservoirs. While a number of new unconventional brittle techniques are still available to improve stimulation on short time scales,the astonishing richness of failure modes of longer time scales in hot rocks has so far been overlooked. These failure modes represent a series of microscopic processes: brittle microfracturing prevails at low temperatures and fairly high deviatoric stresses,while upon increasing temperature and decreasing applied stress or longer time scales,the failure modes switch to transgranular and intergranular creep fractures. Accordingly,fluids play an active role and create their own pathways through facilitating shear localization by a process of time-dependent dissolution and precipitation creep,rather than being a passive constituent by simply following brittle fractures that are generated inside a shear zone caused by other localization mechanisms. We lay out a new theoretical approach for the design of new strategies to utilize,enhance and maintain the natural permeability in the deeper and hotter domain of geothermal reservoirs. The advantage of the approach is that,rather than engineering an entirely new EGS reservoir,we acknowledge a suite of creep-assisted geological processes that are driven by the current tectonic stress field. Such processes are particularly supported by higher temperatures potentially allowing in the future to target commercially viable combinations of temperatures and flow rates. | Klaus Regenauer-Lieb Andrew Bunger Hui Tong Chua Arcady Dyskin Florian Fusseis Oliver Gaede Rob Jeffrey Ali Karrech Thomas Kohl Jie Liu Vladimir Lyakhovsky Elena Pasternak Robert Podgorney Thomas Poulet Sheik Rahman Christoph Schrank Mike Trefry Manolis Veveakis Bisheng Wu David A.Yuen Florian Wellmann Xi Zhang | 2015 | Journal of Earth Science2015，26，1： | 0 |
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