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| 1 | Specific probiotics alleviate allergic rhinitis during the birch pollen season显示文摘AIM:To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these.METHODS:Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus (L.acidophilus) NCFMTM (ATCC 700396) and Bifidobacterium lactis (B.lactis) Bl-04 (ATCC SD5219) or placebo in a double-blind manner for 4 mo,starting prior to onset of the birch pollen season.Symptoms were recorded in a diary.Blood samples were taken for analysis of cytokines and eosinophils.Fecal samples were analysed for microbiota components,calprotectin and IgA.Nasal swabs were taken for analysis of eosinophils.RESULTS:The pollen season induced a reduction in Bifidobacterium,Clostridium and Bacteroides which could not be prevented by the probiotic intervention.During the intervention,significantly higher numbers of B.lactis 11.2×107 ± 4.2×107 vs 0.1×107 ± 0.1×107 bacteria/g feces (P<0.0001) and L.acidophilus NCFMTM 3.5×106 ± 1.3×106 vs 0.2×106 ± 0.1×106 bacteria/g feces (P<0.0001) were observed in the probiotic group compared to the placebo group.During May,there was a tendency for fewer subjects,(76.2% vs 95.2%,P=0.078) to report runny nose,while during June,fewer subjects,11.1% vs 33.3%,reported nasal blocking in the probiotics group (P =0.101).Concomitantly,fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group,57.1% vs 95% (P=0.013).Eye symptoms tended to be slightly more frequent in the probiotic group,12.5 d [interquartile range (IQR) 6-18] vs 7.5 d (IQR 0-11.5) (P=0.066) during May.Fecal IgA was increased in the placebo group during the pollen season;this increase was prevented by the probiotics (P=0.028).CONCLUSION:Birch pollen allergy was shown to be associated with changes in fecal microbiota composition.The specific combination of probiotics used was shown to prevent the pollen-induced infiltration of eosinophils into the nasal mucosa,and indicated a trend for reduced nasal symptoms. | Arthur C Ouwehand Merja Nermes Maria Carmen Collado Nina Rautonen Seppo Salminen Erika Isolauri | 2009 | World Journal of Gastroenterology2009，15，26： | 19 |
| 2 | Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy显示文摘 | Omry Koren Julia K. Goodrich Tyler C. Cullender Aymé Spor Kirsi Laitinen Helene Kling B?ckhed Antonio Gonzalez Jeffrey J. Werner Largus T. Angenent Rob Knight Fredrik B?ckhed Erika Isolauri Seppo Salminen Ruth E. Ley | 2012 | Cell2012，，3： | 2 |
| 3 | The role of the intestinal microflora for the development of the immune system in early childhood显示文摘 | Isolauri E Salminen S | 2002 | Eur J Nutr2002，411，： | 1 |
| 4 | Clinical Applica-tions of Probiotic Bacteria显示文摘 | SALMINAN S OUWEHAND A C ISOLAURI E | 1998 | International Dairy Journal1998，8，56： | 1 |
| 5 | Probiotics in the management of atopic eczema显示文摘 | ISOLAURI E ARVOLA T | 2000 | Clinical and Experimental Allergy2000，，30： | 1 |
| 6 | Probiotics modulate host-microbe interaction in the placenta and fetal gut: a randomized, double-blind, placebo-controlled trial 显示文摘 | Rautava S Collado MC Salminen S Isolauri E | 2011 | Neonatology2011，102，3： | 1 |
| 7 | Probiotics in human disease 显示文摘 | | 2001 | Am J ClinNutr2001，，： | 1 |
| 8 | Probiotics:effects on immunity显示文摘 | Yelda Sutas Pasi Kankaanp (aa) Heikki Arvilommi and Seppo Salminen | 2001 | Am J Clin Nutr2001，73，： | 1 |
| 9 | Lactobacillus reuteri as a therapeutic agent in acute diarrhea in young children显示文摘 | Shornikova AV Casas IA Isolauri E | 1997 | J Pediatr Gastroenterol Nutr1997，24，4： | 1 |
| 10 | Probiotics: an overview of beneficial effects 显示文摘 | OUWEHAND A C SALMINEN S ISOLAURI E | 2002 | Antonie Van Leeuwenhoek2002，82，14： | 1 |
| 11 | Impact of maternal atopy and probiotic supplementation during pregnancy on infant sensitization: a double-blind placebo-cbntrolled study显示文摘 | Huurre A Laitinen K Rautava S Korkeamaki M Isolauri E | 2008 | Clin Exp Allergy2008，38，8： | 1 |
| 12 | Probiotics:effects on immunity显示文摘 | Isolauri E Sutas Y Kankaanpaa P | 2001 | Am J Clin Nutr2001，73，： | 1 |
| 13 | Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain显示文摘 | KAILA M ISOLAURI E SOPPI E | 1992 | Pediatric Research1992，32，： | 1 |
| 14 | Probiotics : effects on immunity 显示文摘 | Isolauri E Sutas Y Kankaanpaa P | 2001 | The American Journal of Clinical Nutrition2001，73，2： | 1 |
| 15 | Treatment of acute diarrhea in practice显示文摘 | Kaila M Onnela T Isolauri E | 1997 | Acta Paediatr1997，86，12： | 1 |
| 16 | Specific probioties in enhancing maturation of IgA responses in formula-fed infants显示文摘 | Rautava S Arvilommi H Isolauri E | 2006 | Pediatr Res2006，60，2： | 1 |
| 17 | Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis显示文摘 | MAJAMAA H ISOLAURI E SAXELIN M | 1995 | J Pediatr Gastroenterol Nutr1995，20，： | 1 |
| 18 | Probiotics: an overview of beneficial effects显示文摘 | OUWEHAND A C SALMINEN S ISOLAURI E | 2002 | Antonie Van Leeuwenhoek2002，82，14： | 1 |
| 19 | Distinctcomposition of gut microbiota during pregnancy in overweight andnormal-weight women显示文摘 | COLLADO M C ISOLAURI E LAITINEN K | 2008 | American Journal of Clinical Nutrition2008，88，4： | 1 |
| 20 | Probiotics: a role in the teratment of infection and inflammation 显示文摘 | Isolauri E Kirjavainen PV Salminen S | 2002 | Gut2002，50，： | 1 |
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