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| 1 | Pathological and therapeutic interactions between bacteriophages,microbes and the host in inflammatory bowel disease显示文摘The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions,a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease(IBD). Whether an altered microbiome is the consequence or the cause of IBD is currently not fully understood. The pathogenesis of IBD is believed to be a complex interaction between genetic predisposition,the immune system and environmental factors. In the recent years,metagenomic studies of the human microbiome have provided useful data that are helping to assemble the IBD puzzle. In this review,we summarize and discuss current knowledge on the composition of the intestinal microbiota in IBD,hostmicrobe interactions and therapeutic possibilities using bacteria in IBD. Moreover,an outlook on the possible contribution of bacteriophages in the pathogenesis and therapy of IBD is provided. | Janka Babickova Roman Gardlik | 2015 | World Journal of Gastroenterology2015，21，40： | 5 |
| 2 | Familial and acquired hemophagocytic lymphohistiocytosis显示文摘 | Gritta E. Janka | 2007 | European Journal of Pediatrics2007，，2： | 3 |
| 3 | Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway显示文摘Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats(GDX) supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed. | Barbora Filova Maria Malinova Janka Babickova Lubomira Tothova Daniela Ostatnikova Peter Celec Julius Hodosy | 2015 | Neuroscience Bulletin2015，31，3： | 3 |
| 4 | Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases显示文摘 | Andreas M. Stark Kerrin Tongers Nicolai Maass H. Maximilian Mehdorn Janka Held-Feindt | 2005 | Journal of Cancer Research and Clinical Oncology2005，，3： | 2 |
| 5 | Familia hemophagocytic lymphohistiocytosis显示文摘 | Janka G E | 1983 | Eur J Pediatr1983，140，3： | 1 |
| 6 | Comparison of basal insu- lin added to oral agents versus twice -daily permixed insulin as initialinsulin therapy for type 2 diabetes 显示文摘 | Janka I-I U Raddle M C Plewe G | 2005 | Diabetes Care2005，，28： | 1 |
| 7 | Familial hemophagocytic lymphohistiocytosis 显示文摘 | Janka GE | 1983 | Eur J Pediatr1983，140，3： | 1 |
| 8 | Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes 显示文摘 | Janka HU Plewe G Riddle MC | 2005 | Diabetes Care2005，28，2： | 1 |
| 9 | Codon 311 (Cys > Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias显示文摘 | Janka Z Juhasz A Rimanoczy A | 2002 | Mol Psychiatry2002，7，1： | 1 |
| 10 | Familial and Acquired Hemophagocytic Lymphohistiocytosis显示文摘 | Janka G E | 2012 | Annu Rev Med2012，63，： | 1 |
| 11 | Familial and acquired hemophagocytic lymphohistiocytosis显示文摘 | Janka GE | | 0，，： | 1 |
| 12 | Familial and acquired hemophagocytic lymphohistiocytosis显示文摘 | Janka GE | | 0，，： | 1 |
| 13 | Familial hemophagocytic lymphohistiocytosis 显示文摘 | Janka GE | 1983 | Eur J Pe- diatr1983，140，3： | 1 |
| 14 | Insulin glargine added to them- py with oral antidiabetic agents improves glycemic control and reduces long - term complications in patients with type 2 diabetes - a simulation with the Diabetes Mellitus Model (DMM) 显示文摘 | Janka HU Hessel F Walzer S | 2007 | Int J Clin Phannacol Ther2007，45，12： | 1 |
| 15 | In vitro drug resis- tance as independent prognostic factor in the study COALL - 05 - 99 treatment of childhood acute lymphoblastic leukemia; two -tiered classification of treatments based on accepted risk criteria and drug sensitivity profiles in study COALL -06 -97显示文摘 | Janka - Schaub GE Harms DO den Boer ML | 1999 | Klin Paediatr1999，211，4： | 1 |
| 16 | Comparison of basal insulin added to oral agents versus twice-daily premixed insulin as initial insulin therapy for type 2 diabetes显示文摘 | Janka Hid Plewe G Riddle MC | 2005 | Diabetes Care2005，28，2： | 1 |
| 17 | Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils显示文摘 | Kankaanranta H Janka -Junttila M Ilmarinen - Salo P | 2010 | J Inflamm (Lond)2010，7，： | 1 |
| 18 | Familia hemophagocytic lymphohistiocytosis显示文摘 | Janka G Zur Stadt U | 2003 | Hematology Am Soc Hematol Educ Program2003，，： | 1 |
| 19 | INFECTION- AND MALIGNANCY-ASSOCIATED HEMOPHAGOCYTIC SYNDROMES显示文摘 | Gritta Janka Shinsaku Imashuku G?ran Elinder Marion Schneider Jan-Inge Henter | 1998 | Hematology/Oncology Clinics of North America1998，，2： | 1 |
| 20 | Hemophagoeytie syndromes 显示文摘 | Janka G E | 2007 | Blood Reviews2007，21，5： | 1 |
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