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| 1 | Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-Hybrid Rice显示文摘杂种优势比也是从二父母表演的后代改善了的生物现象和优异性能生来的父母线。混合米饭是在利用杂种优势的庄稼的最成功的 apotheoses 之一。由基因表示(半自动地面防空系统)的连续分析 F1 超级混血儿的米饭 Liangyou-2186 和它的父母介绍的 Transcriptional 表明 1183 差别表示了基因( DG ),在哪个之中 DG 被发现显著地在象光合作用和碳固定那样的小径充实,并且大多数涉及碳固定小径的关键基因在 F1 混合米饭展出了起来调整的表示。而且,相应的酶的增加的分解代谢的活动和光合的效率也被检测,它联合了显示那碳固定可能在 F1 混血儿,和力量被提高在超级混血儿的米饭与收益活力和杂种优势被联系。由有收益相关的量的特点 loci (QTL ) 的相关 DG,在微分基因表示和 phenotypic 变化之间的一种潜在的关系也被发现。另外,当以前在 Arabidopsis 报导了,包含生理节奏节奏、轻的发信号的小径的一个规章的网络也被发现,它建议如此的一个网络可能也与在混合米饭的杂种优势是相关的。总的来说,现在的学习为理解在米饭位于杂种优势下面的分子的机制提供另一个看法。 | Gui-Sheng Song Hong-Li Zhai Yong-Gang Peng Lei Zhang Gang Wei Xiao- Ying Chen Yu-Guo Xiao Lili Wang Yue-Jun Chen Bin Wu Bin Chen Yu Zhang Hua Chen Xiu-Jing Feng Wan-Kui Gong Yao Liu Zhi-Jie Yin Feng Wang Guo-Zhen Liu Hong-Lin Xu Xiao-Li Wei Xiao-Ling Zhao Pieter B.F. Ouwerkerk Thomas Hankemeier Theo Reijmers Rob van der Heijden Cong-Ming Lu Mei Wang Jan van der Greef Zhen Zhu | 2010 | Molecular Plant2010，3，6： | 12 |
| 2 | Incidence and risk factors for nevirapine-associated rash显示文摘 | Monique M. R. Maat Rob Heine Jan W. Mulder Pieter L. Meenhorst Albert T. A. Mairuhu Eric C. M. Gorp Alwin D. R. Huitema Jos H. Beijnen | 2003 | European Journal of Clinical Pharmacology (-)2003，，5： | 1 |
| 3 | Determinants of Red Cell Distribution Width (RDW) in Cardiorenal Patients: RDW is Not Related to Erythropoietin Resistance显示文摘 | Mireille E. Emans Karien van der Putten Karlijn L. van Rooijen Rob J. Kraaijenhagen Dorine Swinkels Wouter W. van Solinge Maarten J. Cramer Pieter A.F.M. Doevendans Branko Braam Carlo A.J.M. Gaillard | 2011 | Journal of Cardiac Failure2011，，： | 1 |
| 4 | A Multi-resolution Image Segmentation Technique Based on Pyramidal Segmentation and Fuzzy Clustering显示文摘 | Pieter M J Van Der Zwet Boudewijn P F Lelieveldt Rob J Van Der Geest | 2000 | IEEE Trans on Image Processing2000，9，7： | 1 |
| 5 | Current and future applications of dried blood spots in viral disease management显示文摘 | Ingrid J.M. Snijdewind Jeroen J.A. van Kampen Pieter L.A. Fraaij Marchina E. van der Ende Albert D.M.E. Osterhaus Rob A. Gruters | 2012 | Antiviral Research2012，，3： | 1 |
| 6 | Tropical forest canopies and their relationships with climate and disturbance: results from a global dataset of consistent field-based measurements显示文摘Background: Canopy structure, defined by leaf area index(LAI), fractional vegetation cover(FCover) and fraction of absorbed photosynthetically active radiation(f APAR), regulates a wide range of forest functions and ecosystem services. Spatially consistent field-measurements of canopy structure are however lacking, particularly for the tropics.Methods: Here, we introduce the Global LAI database: a global dataset of field-based canopy structure measurements spanning tropical forests in four continents(Africa, Asia, Australia and the Americas). We use these measurements to test for climate dependencies within and across continents, and to test for the potential of anthropogenic disturbance and forest protection to modulate those dependences.Results: Using data collected from 887 tropical forest plots, we show that maximum water deficit, defined across the most arid months of the year, is an important predictor of canopy structure, with all three canopy attributes declining significantly with increasing water deficit. Canopy attributes also increase with minimum temperature, and with the protection of forests according to both active(within protected areas) and passive measures(through topography). Once protection and continent effects are accounted for, other anthropogenic measures(e.g. human population) do not improve the model.Conclusions: We conclude that canopy structure in the tropics is primarily a consequence of forest adaptation to the maximum water deficits historically experienced within a given region. Climate change, and in particular changes in drought regimes may thus affect forest structure and function, but forest protection may offer some resilience against this effect. | marion pfeifer alemu gonsamo william woodgate luis cayuela andrew r.marshall alicia ledo timothy c.e.paine rob marchant andrew burt kim calders colin courtney-mustaphi aida cuni-sanchez nicolas j.deere dereje denu jose gonzalez de tanago robin hayward alvaro lau manuel j.macía pieter i.olivier petri pellikka hamidu seki deo shirima rebecca trevithick beatrice wedeux charlotte wheeler pantaleo k.t.munishi thomas martin abdul mustari philip j.platts | 2018 | Forest Ecosystems2018，5，1： | 1 |
| 7 | Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia显示文摘 | Jasmijn D.E. de Rooij Eva Beuling Marry M. van den Heuvel-Eibrink Askar Obulkasim André Baruchel Jan Trka Dirk Reinhardt Edwin Sonneveld Brenda E.S. Gibson Rob Pieters Martin Zimmermann C. Michel Zwaan Maarten Fornerod | 2015 | Haematologica2015，，9： | 1 |
| 8 | Three conceptions of quantified societal risk显示文摘 | Geerts Rob and Vrijling Han K | 1996 | Risk Analysis1996，，： | 1 |
| 9 | A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial显示文摘 | Rob Pieters Martin Schrappe Paola De Lorenzo Ian Hann Giulio De Rossi Maria Felice Liisa Hovi Thierry LeBlanc Tomasz Szczepanski Alice Ferster Gritta Janka Jeffrey Rubnitz Lewis Silverman Jan Stary Myriam Campbell Chi-Kong Li Georg Mann Ram Suppiah Andrea | 2007 | The Lancet2007，，9583： | 1 |
| 10 | 婴儿急性淋巴细胞白血病治疗方案(Interfant-99):一项多中心随机临床试验及观察研究显示文摘背景急性淋巴细胞白血病(ALL)极少见于1岁以内的婴儿,一旦患病其预后将比年长幼儿更差。本项国际研究旨在观察一种新的兼具ALL与急性髓系白血病(AML)治疗要素的混合治疗方案的应用效果,并确定可能影响婴儿预后的因素。本研究同时还进行了一项随机临床试验,以确定晚期强化治疗的,临床价值。
方法本研究包括来自22个国家的17个研究组,分别于1999-2005年选取年龄为0~12个月的ALL婴儿。根据前期泼尼松治疗7d后外周血的反应,对患儿进行风险分层,然后给予以ALL标准疗法为基础的混合治疗,该疗法亦包含某些AML治疗要素。在维持期之前,将完全缓解的一组患儿随机分为标准治疗组和应用高剂量阿糖胞苷及甲氨蝶呤的高强度化疗组。主要结局指标为初选治疗组的无事件生存率(EFS)与随机治疗组的无病存活率(DFS)。数据处理以意向治疗分析为基础。该试验在ClinicalTrials.gov网站上的注册号为NCT 00015873,在controlled—trials.com网站上注册号为ISRCTN24251487。
结果共计482例患婴接受混合治疗,其中260例(58%)完全缓解,中位随访期为38个月(极差1~78),4年EFS达47.0%(si=2.6,95%CI41.9%~52.1%)。诱导治疗5周后445例获完全缓解,入选随机分组191例,其中晚期强化治疗组95例,对照组96例。在中位数为42个月(极差1~73)的随访期后,治疗组无病存活60例,对照组57例。2组间4年DFS无显著差异[治疗组为60.9%(sx^-=5.2)VS对照组为57.0%;P=0.81]。在强化治疗期,71例随机治疗组患婴反馈有毒性统计数据,其中感染35例(49%)、黏膜炎21例(30%)、肝脏毒性反应22例(33%)、神经毒性2例(3%)。反映预后不佳的独立因素包括:各种M比(混合系白血病)基因重排、极高的白细胞计数、年龄〈6个月、前期泼尼松治疗反应差。
结论与多数报道相比,ALL婴儿(特别是那些对泼尼松反应差的患儿)接受混合治疗后可获得较好的EFS。但晚期强化化疗的效果并不明显。 | Rob Pieters Martin Schrappe Paola De Lorenzo lan Hann Giulio De Rossi Maria Felice Liisa Houi Thierry LeBlanc Tomasz Szczepanski Alice Ferster Gritta Janka Jeffrey Rubnitz Lewis Silverman Jan Story Myriam Campbell Chi-Kong Li Georg Mann Ram Suppiah Andrea Biondi Ajay Vora Maria Grazia Valsecchi 王顺涛(译) | 2008 | 世界临床医学2008，2，1： | 0 |
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