|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma显示文摘Lycium barbarum, a traditional Chinese anti-aging herb, has been shown to protect retinal ganglion cells (RGCs) in a rat chronic ocular hypertension (COH) model. Here, we investigated the expression of endothelin-1 (ET-1), a strong vasoconstrictor, and its receptors, ETA and ETB, in the COH model and assessed the effects of Lycium barbarum on the ET-1 axis. Elevated intraocular pressure (IOP) was induced in the right eye of SD rats using argon laser photocoagulation. (1) The expression of ET-1, ETA and ETB in normal and COH retinas was studied. (2) Some COH rats were fed daily with Lycium barbarum Polysaccharides (LBP) using 1 mg/kg or phosphate-buffered saline (PBS) for 3 weeks (started 1 week before photocoagulation). The effects of LBP on the expression of ET-1 and its receptors, ETA and ETB, in COH retina were evaluated. A semi-quantitative analysis of staining intensity was used to evaluate the expression levels of ET-1, ETA and ETB in retinal vasculature. We found that (1) Under COH condition, the immunoreactivity of ET-1 was increased in retina associated with an increase of ETB receptor immunoreactivity and a decrease of ETA receptor immunoreactivity. (2) After feeding COH rats with LBP, the expression of ET-1 was decreased with an increase of ETA expression and a decrease of ETB expression in the retina, especially in RGCs. (3) By comparing the staining intensity in the vasculature of COH retina in LBP-fed group with PBS-fed group, there was a decrease in the expression of ET-1 and ETA and an increase in ETB. In summary, ET-1 expression was up-regulated in the retina in COH model. LBP could decrease the expression of ET-1 and modulate the expression of its receptors, ETA and ETB, under the condition of COH. The neuroprotective effect of LBP on RGCs might be related to its ability to regulate the ET-1-mediated biological effects on RGCs and retinal vasculature. | Xue-Song Mi Kin Chiu Geoffrey Van Justin Wai Chung Leung Amy Cheuk Yin Lo SookjaKim Chung Raymond Chuen-Chung Chang Kwok-Fai So | 2012 | Neural Regeneration Research2012，7，9： | 14 |
| 2 | Lycium barbarum polysaccharides related RAGE and Aβ levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier显示文摘Our previous study verified the protective effects of Lycium barbarum polysaccharides(LBP)on retinal neurons and blood vessels in acute ocular hypertension(AOH)mice.To investigate the effect of LBP on the reactivity of retinal glial cells,an AOH mouse model was established in one eye by maintaining ocular hypertension of 90 mm Hg for 60 minutes.Either LBP solution(1 mg/kg)or phosphate-buffered saline was administrated to the mice by gavage daily,starting 7 days before the AOH insult and continuing until the mice were sacrificed for specimen collection on day 4 post-insult.After AOH insult,increased numbers of astrocytes and microglia were observed,together with decreased expression of the following glial cell biomarkers in the retinal ganglion cells of AOH mice:glial fibrillary acidic protein,glutamine synthetase,aquaporin-4,S-100 proteins,ionized calcium-binding adaptor molecule 1,amyloid precursor protein and receptor of advanced glycosylation end-products.After intervention with LBP,the above changes were significantly reduced.Remarkably,morphological remodeling of blood vessel-associated retinal astrocytes,marked by glial fibrillary acidic protein,was also observed.These results,taken together,suggest that LBP regulated the production of amyloid-βand expression of receptor of advanced glycosylation end-products,as well as mediating the activity of retinal glial cells,which may lead to the promotion of better maintenance of the blood-retinal barrier and improved neuronal survival in AOH insult.This study was approved by the Committee for the Use of Live Animals in Teaching and Research(approval No.CULTRA-#1664-08). | Xue-Song Mi Qian Feng Amy Cheuk Yin Lo Raymond Chuen-Chung Chang Sookja Kim Chung Kwok-Fai So | 2020 | Neural Regeneration Research2020，15，12： | 8 |
| 3 | Identification of aryl hydrocarbon receptor binding targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin显示文摘 | Raymond Lo Trine Celius Agnes L Forgacs | 2011 | Toxicol Appl Pharm2011，257，： | 1 |
| 4 | Arabidopsis LEAFY COTYLEDON1 Is Sufficient to Induce Embryo Development in Vegetative Cells显示文摘 | Tamar Lotan Masa-aki Ohto Kelly Matsudaira Yee Marilyn A.L West Russell Lo Raymond W Kwong Kazutoshi Yamagishi Robert L Fischer Robert B Goldberg John J Harada | 1998 | Cell1998，，7： | 1 |
| 5 | The incidence, management, and evolution of rapamycin‐related side effects in kidney transplant recipients显示文摘 | Jacobien Verhave Anne Boucher Raymond Dandavino Suzon Collette Lynne Senécal Marie‐Josée Hebert Catherine Girardin Hélo?se Cardinal | 2014 | Clin Transplant2014，，5： | 1 |
| 6 | Modified Clays for Waste Containment and Pollutant Attenuation显示文摘 | Irene M C Lo Raymond K M Mak Samuel C H Lee | 1997 | Journal of Environmental Engineering1997，123，1： | 1 |
| 7 | Applicability of the market appealrobusticity roatrix: a case study of heritage tourism 显示文摘 | Yiping Li Raymond Lap Bong Lo | 2004 | Tourism Management2004，25，： | 1 |
| 8 | Apoptosis and Other Cell Death Mechanisms after Retinal Detachment: Implications for Photoreceptor Rescue显示文摘 | Lo Amy C Y Woo Tiffany T Y Wong Raymond L M Wong David | 2011 | 2011，，： | 1 |
| 9 | Changes in Arterial Oxygen Ssturation (SaO2) Befoer,During,and After Measls in Storke Patients in a Rehbilitation Setting显示文摘 | Simon YP Raymond S Lo K | 2009 | Dysphagia2009，24，： | 1 |
| 10 | Phenolic compounds from the leaf extract of artichoke(Cynarascolymus L) and their an- timicrobial activities显示文摘 | Xianfeng Zhu Hongxun Zhang Raymond LO | 2004 | Agricultural and food chemistry2004，，52： | 1 |
| 11 | Modified clays for waste containment and pollutant attenuation显示文摘 | Lo Irene M C Raymond Mak K M Lee Samuel C H | 1997 | Journal of Environmental Engineering1997，123，1： | 1 |
| 12 | Opportunities and constraints of heritage tourism in Hong Kong's changing cultural landscape 显示文摘 | Yiping Li Lap Bang Raymond Lo | 2005 | Tourism and Hospitality Research2005，5，4： | 1 |
| 13 | Modified Clays for Waste Containment and Pollutant Attenuation显示文摘 | Irene M C Lo Raymond K M Mak Samuel C H Lee | 1997 | Journal of Environmental Engineering1997，123，1： | 1 |
| 14 | Guideline on targets for solute and fluid removal in adult patients on chronic peritoneal di alysis显示文摘 | Lo W K Bargman J M Burkart J Raymond T K Carol P Hideki K | 2006 | Petit Dial Int2006，26，： | 1 |
| 15 | Modified clays for waste containment and pollutant attenuation 显示文摘 | Irene M C Lo Raymond K M Mak Samuel C H Lee | 1997 | Journal of Environmentar Engineering1997，123，1： | 1 |
| 16 | Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14显示文摘 | Wan-Sheng Lo Raymond C Trievel Jeannie R Rojas Laura Duggan Jer-Yuan Hsu C.David Allis Ronen Marmorstein Shelley L Berger | 2000 | Molecular Cell2000，，6： | 1 |
| 17 | Improving Visible Light Sensitization of Luminescent Europium Complexes显示文摘 | Pascal Kadjane Lo?c Charbonnière Franck Camerel Philippe P. Lainé Raymond Ziessel | 2008 | Journal of Fluorescence2008，，1： | 1 |
| 18 | Pediatric liver transplantation in Hong Kong—a domain with scarce deceased donors显示文摘 | Kwong Leung Chan Sheung Tat Fan Chung Mau Lo William I. Wei Raymond Wai Man Ng Ho Yu Chung Kelvin Kwok Chai Ng See Ching Chan Kwok Wah Chan Wai Kuen Tso Nai Shun Tsoi Paul Kwong Hang Tam John Wong | 2009 | Journal of Pediatric Surgery2009，，12： | 1 |
| 19 | Vascular burden and Alzheimer disease pathologic progression显示文摘 | Raymond Y. Lo William J. Jagust Michael Weiner Paul Aisen Michael Weiner Paul Aisen Ronald Petersen Clifford R. Jack William Jagust John Q. Trojanowki Arthur W. Toga Laurel Beckett Robert C. Green Andrew J. Saykin John Morris Enchi Liu Robert C. Green Tom | 2012 | Neurology2012，，13： | 1 |
| 20 | Measurement properties of the English and Chinese versions of the Functional Assessment of Cancer Therapy—Breast (FACT-B) in Asian breast cancer patients显示文摘 | Raymond Ng Chun Fan Lee Nan Soon Wong Nan Luo Yoon Sim Yap Soo Kien Lo Whay Kuang Chia Alethea Yee Lalit Krishna Cynthia Goh Yin Bun Cheung | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员