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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation显示文摘尽管为有类型 1 糖尿病的个人的小岛移植被显示了产出优异的血葡萄糖控制,它为长期的控制仍然保持不适当。这是部分,由于小岛损害和压力,那能导致贝它房间损失。过量 IL-1β 的抑制;活动可能最小化小岛损害,因此保存工作。IL-1 受体对手(IL-1Ra ) , IL-1β 的一个内长的禁止者;,保护小岛免受导致 cytokine 的坏死和 apoptosis 的伤害。因此,在 IL-1β 之间的不平衡;并且 IL-1Ra 可能影响到小岛的 allogeneic 和自体免疫的回答的功课。我们的组以前证明传播丝氨酸朊酶禁止者人 alpha-1-antitrypsin (hAAT ) ,以及 immunomodulatory 活动。在现在的学习,我们寻求了决定是否胰腺的小岛 hAAT 的 allograft 保护的活动被 IL-1Ra 调停感应。我们的结果证明 hAAT 在刺激巨噬细胞在 IL-1Ra 表示导致了 2.04 褶层增加并且 hAAT-pre-treated 小岛接枝在 IL-1Ra 抄本层次展出了 4.851 褶层增加,它与中等煽动性的侧面被联系。出人意料地,从 IL-1Ra-knockout 鼠标被孤立并且在 grafting 前与 hAAT 预先对待进野类型的鼠标的小岛在大概从渗入主机房间被导出的 intragraft IL-1Ra 表示产出增加,当主机的 hAAT 处理不在时的虽然。确实, hAAT-pre-treated 小岛产生了能在有教养的巨噬细胞导致 IL-1Ra 生产的 hAAT 免费的调节媒介。最后,我们证明 hAAT 为 p65 支持了不同 phosphorylation 和原子 translocation 模式,为 IL-1Ra 要求的一个关键抄写因素表示。 | Avishag Abecassis Ronen Schuster Galit Shahaf Eyal Ozeri Ross Green David E Ochayon Peleg Rider Eli C Lewis | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 3 | Impact of three-dimensional parametric modeling of buildings on productivity in structural engineering practice显示文摘 | Rafael Sacks Ronen Barak | 2007 | Automation in Construction2007，，4： | 2 |
| 4 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 5 | Coming challenges in microarchi-tecture and architecture 显示文摘 | RONEN R | 2001 | Proceedings of the IEEE2001，89，3： | 1 |
| 6 | Friction - reducing surface - texturing in reciprocating automotive component显示文摘 | Ronen A Etsion I Kligerman Y | 2001 | Trib Trans2001，44，3： | 1 |
| 7 | Wave equation trace interpolation显示文摘 | Joshua Ronen | 1987 | Geophysics1987，52，7： | 1 |
| 8 | Ship routing and scheduling: status and perspectives 显示文摘 | CHRISTIAN M FAGERHOLT K RONEN D | 2004 | Transportation Sci2004，38，1： | 1 |
| 9 | Alertness maintaining tasks(AMTs)while driving显示文摘 | ORON-GILAD T RONEN A SHINAR D | 2008 | Accident Analysis and Prevention2008，40，3： | 1 |
| 10 | Microvascular Obstruction and the No-Reflow Phenomenon After Percutaneous Coronary Intervention显示文摘 | Ronen J Thierry Ch Geoffrey P | 2008 | Cir- culation2008，117，24： | 1 |
| 11 | Friction Reducing Surface Texturing in Reciprocating Automotive Components 显示文摘 | A Ronen I Etsion Y Kligerman | 2001 | Tribology Transactions2001，44，3： | 1 |
| 12 | The Intel Pentium M processor: microarchitecture and performance 显示文摘 | GOCHMAN S RONEN R ANATI I | 2003 | Intel Technology Journal2003，7，2： | 1 |
| 13 | Spreadsheet Analysis and Design显示文摘 | Ronen B Palley M A Lucas H C J R | 1989 | Communications of the ACM1989，32，1： | 1 |
| 14 | Critical Chain:A New Project Management Paradigm or Old Wine in New Bottles?显示文摘 | LECHLER T G RONEN B EDWARDA S | 2005 | Engineering Management Journal2005，17，4： | 1 |
| 15 | Parameter Estimation of Dependence Tree Models Using the EM Algorithm 显示文摘 | RONEN O ROHLICEK J OSTENDORF M | 1995 | IEEE Signal Processing Letters1995，2，8： | 1 |
| 16 | Health-related quality of life in children with epilepsy: development and validation of self-report and parent proxy measure显示文摘 | Ronen GM Streiner DL Rosenbaum P | 2003 | Epilepsia2003，44，4： | 1 |
| 17 | Presence of JC virus DNAin the tumor tissue and normal mucosa of patients with spo-radic colorectal cancer (CRC) or with positive family historyand Bethesda criteria 显示文摘 | Vilkin A Ronen Z Levi Z | 2012 | Dig Dis Sci2012，57，1： | 1 |
| 18 | Choline metabolism in malignant transformation显示文摘 | Glunde K Bhujwalla ZM Ronen SM | 2011 | Nat Rev Cancer2011，11，12： | 1 |
| 19 | Pancreaticoduodenectomy in Elderly Adults: Is It Justified in Terms of Mortality, Long‐Term Morbidity, and Quality of Life?显示文摘 | Fabian Gerstenhaber Julie Grossman Nir Lubezky Eran Itzkowitz Ido Nachmany Ronen Sever Menahem Ben‐Haim Richard Nakache Joseph M. Klausner Guy Lahat | 2013 | J Am Geriatr Soc2013，，8： | 1 |
| 20 | Road Characteristics and Driver Fatigue: A Simulator Study 显示文摘 | ORON-GILAD T RONEN A | 2007 | Traffic Injury Prevention2007，8，3： | 1 |
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