|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Wastewater analysis for nicotine,cocaine,amphetamines,opioids and cannabis in New York City显示文摘According to current surveys and overdoses data,there is a drug crisis in the USA.Wastewater-based epidemiology(WBE)is an evolving discipline that analyses wastewater samples to detect drugs and metabolites to estimate drug consumption in a certain community.This study demonstrates how drug relative presence could be tracked by testing wastewater,providing real-time results,in different boroughs in New York City throughout 1 year.We developed and fully validated two analytical methods,one for 21 drugs and metabolites,including nicotine,cocaine,amphetamines,opioids and cannabis markers;and another for the normalization factor creatinine.Both methods were performed by liquid chromatography tandem mass spectrometry(LC-MS/MS)using positive electrospray ionization,achieving a limit of quantification of 5–10 ng/L for drugs and metabolites,and 0.01 mg/L for creatinine.These methods were applied to 48 one-time grab wastewater samples collected from six wastewater treatment plants in New York City(Manhattan,The Bronx,Queens and Brooklyn),eight different times throughout 2016,before and after major holidays,including Memorial Day,4th of July,Labour Day and New Year’s.In this study,the drug group normalized concentrations present in the wastewater samples,in decreasing order,were cocaine,nicotine,opioids,cannabis and amphetamines.When looking at individual compounds,the one with the highest normalized concentration was benzoylecgonine(BE),followed by cotinine,morphine and 11-nor-9-carboxy-tetrahydrocannabinol(THCCOOH).To estimate community use,these concentrations were multiplied by the corresponding correction factor,and the most present were THCCOOH,followed by BE,cotinine and morphine.When comparing the treatment plants by drug group(nicotine,cocaine,amphetamines,opioids and cannabis),samples collected from The Bronx had the highest normalized concentrations for nicotine,cocaine and opioids;The Bronx and Manhattan for cannabis;and Manhattan and Queens for amphetamines.In most of the cases,no effect due to holiday was observed.This study provides the first snapshot of drug use in New York City and how that changes between key calendar dates employing wastewater analysis. | Nicole Centazzo Bonnie-Marie Frederick Alethea Jacox Shu-Yuan Cheng Marta Concheiro-Guisan | 2019 | Forensic Sciences Research2019，4，2： | 7 |
| 2 | Quantitative analysis of opioids and cannabinoids in wastewater samples显示文摘Wastewater-based epidemiology is an innovative approach that uses the analysis of human excretion products in wastewater to obtain information about exposure to drugs in defined population groups.We developed and validated an analytical method for the simultaneous determination of opioids(morphine,oxycodone,hydrocodone,oxymorphone and hydromorphone),and cannabinoids(△9-tetrahydrocannabinol,11-nor-9-carboxy-tetrahydrocannabinol(THCCOOH)and THCCOOH-glucuronide)in raw-influent wastewater samples by ultra-high performance liquid chromatography-tandem mass spectrometry.Method validation included linearity(5-1000 ng/L for opioids,10-1000 ng/L for cannabinoids),imprecision(<21.2%),accuracy(83%-131%),matrix effect(from-35.1%to-14.7%)and extraction efficiency(25%-84%),limit of detection(1-5 ng/L)and quantification(5-10 ng/L)and auto-sampler stability(no loss detected).River and wastewater samples were collected in triplicate from different locations in New York City and stored at-20℃until analysis.Water from sewage overflow location tested positive for morphine(10.7 ng/L),oxycodone(4.2-23.5 ng/L),oxymorphone(4.8 ng/L)and hydromorphone(4.2 ng/L).Raw influent wastewater samples tested positive for morphine(133.0-258.3 ng/L),oxycodone(31.1-63.6 ng/L),oxymorphone(16.0-56.8 ng/L),hydromorphone(6.8-18.0 ng/L),hydrocodone(4.0-12.8 ng/L)and THCCOOH(168.2-772.0 ng/L).This method is sensitive and specific for opioids and marijuana determination in wastewater samples. | Alethea Jacox Jillian Wetzel Shu-Yuan Cheng Marta Concheiro | 2017 | Forensic Sciences Research2017，2，1： | 3 |
| 3 | The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with men显示文摘 | Alethea WM Walensky RP Lipsitch M | 2007 | Clin Infect Dis2007，44，9： | 1 |
| 4 | Observing nonreactively: A con- ditional process model linking mindfulness facets,cognitive emotion regulation strategies, and depression and anxiety symptoms显示文摘 | Alethea D Vera V Joshua C | 2014 | J Affect Disord2014，165，： | 1 |
| 5 | A practical Manual of Di ahetic Foot Care显示文摘 | Miehaebel E Alethea V Lee J | 2004 | Blackwell Publishing2004，56，5： | 1 |
| 6 | Effects of sample storage conditions on glycated hemoglobin measurement: evaluation of five different high performance liquid chromatography methods显示文摘 | RaMie RL Curt LR Alethea LT | 2007 | Diabetes Technol Ther2007，9，： | 1 |
| 7 | Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantation显示文摘 | Vincent C Emery Caroline A Sabin Alethea V Cope Dehila Gor Aycan F Hassan-Walker Paul D Griffiths | 2000 | The Lancet2000，，9220： | 1 |
| 8 | Plantar pressures are elevated in the neuroischemic and the neuropathic diabetic foot显示文摘 | Marilyn L Alethea F | 1999 | Diabetes Care1999，22，： | 1 |
| 9 | Columnar joints in the Patino Formation sandstones, Eastern Paraguay: a dynamic interaction between dyke intrusion, quartz dissolution and cooling-induced fractures显示文摘 | Victor Fernandez Velazquez Paulo Cesar Fonseca Giannini Claudio Riccomini Alethea Ernandes Martins Sallun Jorge Hachiro Celso de Barros Gomes | 2008 | Episodes2008，31，3： | 1 |
| 10 | The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with men 显示文摘 | Alethea WM Walensky RP Lipsitch M | 2007 | Clin Infect Dis2007，44，9： | 1 |
| 11 | A practical Manual of Diabetic Foot Care显示文摘 | Miehaebel E Alethea V Lee J | 2004 | Blackwell Publishing2004，56，： | 1 |
| 12 | Mechanics of linear cellular alloys显示文摘 | Alethea M Hayes Aijun Wang Benjamin M Dempsey | 2004 | Mechanics of Materials2004，36，8： | 1 |
| 13 | Investigating users' intuitive with interaction complex artefacts显示文摘 | Alethea Blackler Vesna Popovic Doug Mahar | 2010 | Applied Ergonomics2010，41，1： | 1 |
| 14 | Measurement properties of the English and Chinese versions of the Functional Assessment of Cancer Therapy—Breast (FACT-B) in Asian breast cancer patients显示文摘 | Raymond Ng Chun Fan Lee Nan Soon Wong Nan Luo Yoon Sim Yap Soo Kien Lo Whay Kuang Chia Alethea Yee Lalit Krishna Cynthia Goh Yin Bun Cheung | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员