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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | 新加坡最大回用水处理厂污水短程硝化厌氧氨氧化脱氮工艺显示文摘总结了新加坡樟宜回用水处理厂4次采样的结果,该厂日处理城市污水80万t.在好氧区很好地实现了部分硝化和亚硝酸盐积累,其中好氧氨氧化率平均为72.2%,亚硝酸盐积累率平均为76.0%.在缺氧区氨氮和亚硝酸盐得到了同步去除(厌氧氨氧化).物料衡算结果表明:初沉池的出水总氮的37.5%是通过自养脱氮去除,27.1%是通过传统的硝化/反硝化脱氮去除,其余部分总氮则存在于活性污泥和出水中.微生物和动力学研究表明:短悬浮或游离的厌氧氨氧化菌可存在于污泥龄较短的污水处理系统.最后从出水氮质量浓度、pH、碱度、曝气能耗及反应器容积等方面,将樟宜回用水处理厂的分段进水活性污泥法工艺与新加坡其他3个回用水处理厂的MEL/LE工艺进行了对比分析. | Cao Yeshi Kwok Bee Hong Yan Zhou Yu Liu He Jianzhong Chua Seng Chye Wah Yuen Long Yahya Ghani | 2015 | 北京工业大学学报2015，41，10： | 32 |
| 3 | The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC) is closely associated with Epstein-Barr virus(EBV) infection. EBV episomes are detected in almost all NPC cells. The role of EBV in NPC pathogenesis has long been postulated but remains enigmatic. In contrast to infection of B lymphocytes, EBV infection does not directly transform nasopharyngeal epithelial cells into proliferative clones with malignant potential. EBV infection of normal pharyngeal epithelial cells is predominantly lytic in nature. Genetic alterations in premalignant nasopharyngeal epithelium, in combination with inflammatory stimulation in the nasopharyngeal mucosa, presumably play essential roles in the establishment of a latent EBV infection in infected nasopharyngeal epithelial cells during the early development of NPC. Establishment of latent EBV infection in premalignant nasopharyngeal epithelial cells and expression of latent viral genes, including the BART transcripts and BART-encoded micro RNAs, are crucial features of NPC. Expression of EBV genes may drive further malignant transformation of premalignant nasopharyngeal epithelial cells into cancer cells. The difficulties involved in the establishment of NPC cell lines and the progressive loss of EBV epsiomes in NPC cells propagated in culture strongly implicate the contribution of host stromal components to the growth of NPC cells in vivo and maintenance of EBV in infected NPC cells. Defining the growth advantages of EBV-infected NPC cells in vivo will lead to a better understanding of the contribution of EBV infection in NPC pathogenesis, and may lead to the identification of novel therapeutic targets for NPC treatment. | Chi Man Tsang Sai Wah Tsao | 2015 | Virologica Sinica2015，30，2： | 26 |
| 4 | 大型风电场雷击防护研究面临的关键问题显示文摘从风电场雷击现场观测与长间隙放电实验模拟、叶片雷击接闪放电、风电机组雷击风险评估与防雷系统优化设计、叶片雷击损伤机制、雷击电磁暂态与防护、叶片防雷系统测试方法、海洋环境风机防雷新问题等方面,对风电场雷击防护技术领域的国内外研究现状进行了总结。梳理出5个亟待解决的问题:风机旋转对叶片附近空间电荷的影响;叶片接闪的极性效应与负极性上行先导物理模型;多先导起始竞争机制及风机群屏蔽效应;雷击桨叶损伤机制与冲击爆裂动力学建模;风电机组雷击风险评估方法。对这些问题的有效解决将从理论基础、设计原则、评估测试体系等多个层面,提升对风电场雷击现象的认知水平,指导风机桨叶和防雷系统的优化设计。 | 李庆民 郭子炘 张黎 Siew Wah Hoon | 2018 | 中国电机工程学报2018，38，18： | 24 |
| 5 | 基于雷电上行先导起始物理机制的风机叶片雷击概率评估模型显示文摘风机叶片雷击损伤事故严重威胁风电场正常运行,传统分析方法无法给出叶片表面任意点雷击概率,现有叶片防雷系统设计尚无成熟理论作为指导。该文基于上行先导起始物理机制,提出了风机叶片表面任意位置雷击概率计算方法,建立了风机叶片雷击概率评估模型。考虑不同叶片姿态、下行先导侧面距离、接闪器布置方式等因素,分析了1.5MW典型风机在不同工况下雷击概率分布,并与试验结果相对照,验证了模型的有效性。结果表明:接闪器保护范围随叶片角度变化而变化,呈现不对称的特点,雷电下行先导侧面距离对接闪器保护范围的影响具有方向性,叶尖接闪器的防护效果优于叶身接闪器。该评估模型可为叶片防雷系统优化设计提供理论分析工具。 | 郭子炘 李庆民 任瀚文 张黎 王国政 马宇飞 闫江燕 SIEW Wah Hoon 方致阳 | 2018 | 中国电机工程学报2018，38，2： | 16 |
| 6 | 基于改进叶素动量理论的水平轴风电机组气动性能计算显示文摘综合考虑到风剪切、塔影效应、三维旋转效应的影响,本文对传统的叶素动量理论(blade element momentum,BEM)进行改进,建立风电机组气动性能计算模型,基于该模型编制计算程序,以商用1.5 MW风电机组为计算实例,计算出其在不同的风速、转速和桨距角配置下的轴向和切向气动荷载分布,以及推力、功率和风能利用系数,与传统BEM模型及风电设计分析软件FOCUS5计算值对比,验证了该模型的正确性和优越性。 | 曾庆川 刘浩 LIM Che Wah 罗维奇 杨云胜 | 2011 | 中国电机工程学报2011，31，23： | 15 |
| 7 | 旋转状态下风机叶片雷击接闪特性的实验研究显示文摘风机雷击事故频发,严重威胁风电场正常运行。现场观测数据表明,旋转风机更易遭受雷击。对此该文设计1:30缩比可旋转3MW风机模型,模拟真实风机旋转叶尖线速度,使用正负极性标准操作波,利用长间隙放电模拟真实雷电,开展旋转状态下风机叶片防雷装置接闪特性研究。实验结果表明,旋转会对接闪过程中叶片接闪点分布与接闪后放电通道产生影响,放电具有明显的极性效应。旋转使得正极性放电下叶片接闪器拦截效率下降;对负极性影响较小。正极性放电更易击中远离叶尖部位。成功接闪后,接闪点附近放电通道因叶片旋转发生偏移,产生"拉弧"现象,造成叶片损伤,并与实际风机受损情况相对应。所得结果为风机叶片防雷优化设计提供参考。 | 郭子炘 李庆民 于万水 张黎 王国政 马宇飞 WAQAS Arif SIEW Wah Hoon | 2018 | 中国电机工程学报2018，38，16： | 15 |
| 8 | 基于雷电物理的风机叶片动态击距与电气几何模型显示文摘风机叶片遭受雷击现已成为风电场亟需解决的问题之一。该文将电气几何方法与雷电先导发展的物理过程相结合,提出了针对风机叶片的电气几何分析模型。通过引入风机叶片动态击距的概念及分析方法,模拟了雷电先导的发展过程,使得击距的物理意义更加清晰,并进一步推导了叶片防雷系统效率的计算方法,最后基于风机叶片长间隙下击穿实验验证了该模型的有效性。利用提出的风机叶片电气几何模型,分析了叶片角度、雷电流幅值和接闪器布置对防雷系统效率的影响,分析发现叶片越接近水平、雷电流幅值越小叶片防雷系统效率越低,增设叶片侧接闪器能够有效提高防雷系统效率。该文提出的方法拟为风机叶片的防雷设计与评估提供理论依据。 | 王国政 张黎 郭子炘 马宇飞 李庆民 闫江燕 赵彤 邹亮 SIEW Wah Hoon | 2017 | 中国电机工程学报2017，37，21： | 14 |
| 9 | Relationship between hepatitis C virus infection and type 2 diabetes mellitus:Meta-analysis显示文摘AIM:To investigate the association between hepatitis C infection and type 2 diabetes mellitus.METHODS:Observational studies assessing the relationship between hepatitis C infection and type 2 diabetes mellitus were identified via electronic and hand searches.Studies published between 1988 to March 2011 were screened,according to the inclusion criteria set for the present analysis.Authors performed separate analyses for the comparisons between hepatitis C virus(HCV) infected and not infected,and HCV infected and hepatitis B virus infected.The included studies were further subgrouped according to the study design.Heterogenity was assessed using I2 statistics.The summary odds ratios with their corresponding 95% CIs were calculated based on a random-effects model.The included studies were subgrouped according to the study design.To assess any factor that could potentially affect the outcome,results were further stratified by age group(proportion of ≥ 40 years),gender(proportion of male gender),body mass index(BMI)(pro-portion of BMI ≥ 27),and family history of diabetes(i.e.,self reported).For stability of results,a sensitivity analysis was conducted including only prospective studies.RESULTS:Combining the electronic database and hand searches,a total of 35 observational studies(in 31 articles) were identified for the final analysis.Based on random-effects model,17 studies(n = 286 084) compared hepatitis C-infected patients with those who were uninfected [summary odds ratio(OR):1.68,95% CI:1.15-2.45].Of these 17 studies,7 were both a cross-sectional design(41.2%) and cohort design(41.2%),while 3 were case-control studies(17.6%).Nineteen studies(n = 51 156) compared hepatitis C-infected participants with hepatitis B-infected(summary OR:1.92,95% CI:1.41-2.62).Of these 19 studies,4(21.1%),6(31.6%) and 9(47.4%) were cross-sectional,cohort and case-control studies,respectively.A sensitivity analysis with 3 prospective studies indicated that hepatitis C-infected patients had a higher risk of developing type 2 diabetes compared with uninfected controls(summary odds ratio:1.41,95% CI:1.17-1.7;I2 = 0%).Among hepatitis C-infected patients,male patients(OR:1.26,95% CI:1.03-1.54) with age over 40 years(summary OR:7.39,95% CI:3.82-9.38) had an increased frequency of type 2 diabetes.Some caution must be taken in the interpretation of these results because there may be unmeasured confounding factors which may introduce bias.CONCLUSION:The findings support the association between hepatitis C infection and type 2 diabetes mellitus.The direction of association remains to be determined,however.Prospective studies with adequate sample sizes are recommended. | Cho Naing Joon Wah Mak Syed Imran Ahmed Mala Maung | 2012 | World Journal of Gastroenterology2012，18，14： | 12 |
| 10 | PKM2: A gatekeeper between growth and survival显示文摘 | Isaac Harris Susan McCracken Tak Wah Mak | 2012 | Cell Research2012，22，3： | 11 |
| 11 | Acute-on-chronic liver failure in a multi-ethnic Asian city:A comparison of patients identified by Asia-Pacific Association for the Study of the Liver and European Association for the Study of the Liver definitions显示文摘AIM To explore the applicability of the Asia-Pacific Association for the Study of the Liver(APASL) and European Association for the Study of the Liver(EASL) guidelines for acute-on-chronic liver failure(ACLF) in profiling patients and determining the outcome.METHODS Patients admitted to a tertiary hospital in Singapore with acute decompensation of liver disease from January 2004to July 2014 are screened for ACLF according to the APASL and EASL criteria. The patients' data(including basic demographics, information about existing chronic liver disease, information about the acute decompensation, relevant laboratory values during admission, treatment, and outcome) are retrospectively analyzed to determine the background, precipitating factors and outcome.RESULTS A total of 458 liver patients is analyzed, and 78 patients with ACLF are identified. Sixty-three patients(80.8%) meet the APASL criteria, 64 patients(82.1%) meet the EASL criteria, and 49 patients(62.8%) fulfilled both criteria. The most common causes of acute liver injury are bacterial infections(59.0%), hepatitis B flare(29.5%), and variceal bleeding(24.4%). The common aetiologies of the underlying chronic disease included hepatitis B(43.6%), alcoholic(20.5%) and cryptogenic(11.5%) liver disease. The overall mortality rate is 61.5%. Increased age, the number of organ failures(as per CLIF-SOFA score), peak creatinine, INR, and amylase levels are associated with increased mortality or the need for liver transplantation. 14.3% of patients undergo liver transplantation with a 100% 1-year survival rate. CONCLUSION Both APASL and EASL criteria have identified ACLF patients with high three-month mortality, but those who fulfill APASL criteria alone have a better survival. | Anandraj Selva Rajoo Seng-Gee Lim Wah Wah Phyo Thandar Tun Yock-Young Dan Yin-Mei Lee How-Cheng Low Kieron Lim Poh-Seng Tan Guan-Huei Lee | 2017 | World Journal of Hepatology2017，9，28： | 10 |
| 12 | Meeting the communicative demands in academic and professional training curricula: An overview of ELT in tertiary institutions in Singapore显示文摘This paper focuses on the upper end of the formal Singapore educational spectrum,providing an overview of ELT in polytechnics and universities. It is in four parts.In order to show continuity between ELT in schools and tertiary institutions,Part 1 explains briefly the nation’s language policy in education.In Part 2,an attempt is made to delineate the main trends in ELT in universities and polytechnics and the approaches to ELT generally adopted for mature learners. Part 3 draws attention to the changing emphases in tertiary education in Singapore and to how students are being prepared in innovative ways in ELT for a globalised world and a knowledge based economy. Part 4 provides a summary of the paper. | Ho Wah Kam | 2001 | 外语教学与研究2001，33，4： | 10 |
| 13 | On Density-Based Data Streams Clustering Algorithms: A Survey显示文摘Clustering data streams has drawn lots of attention in the last few years due to their ever-growing presence. Data streams put additional challenges on clustering such as limited time and memory and one pass clustering. Furthermore, discovering clusters with arbitrary shapes is very important in data stream applications. Data streams are infinite and evolving over time, and we do not have any knowledge about the number of clusters. In a data stream environment due to various factors, some noise appears occasionally. Density-based method is a remarkable class in clustering data streams, which has the ability to discover arbitrary shape clusters and to detect noise. Furthermore, it does not need the number of clusters in advance. Due to data stream characteristics, the traditional density-based clustering is not applicable. Recently, a lot of density-based clustering algorithms are extended for data streams. The main idea in these algorithms is using densitybased methods in the clustering process and at the same time overcoming the constraints, which are put out by data stream's nature. The purpose of this paper is to shed light on some algorithms in the literature on density-based clustering over data streams. We not only summarize the main density-based clustering algorithms on data streams, discuss their uniqueness and limitations, but also explain how they address the challenges in clustering data streams. Moreover, we investigate the evaluation metrics used in validating cluster quality and measuring algorithms' performance. It is hoped that this survey will serve as a steppingstone for researchers studying data streams clustering, particularly density-based algorithms. | Amineh Amini Teh Ying Wah Hadi Saboohi | 2014 | Journal of Computer Science & Technology2014，29，1： | 9 |
| 14 | Epstein-Barr virus infection and persistence in nasopharyngeal epithelial cells显示文摘Epstein-Barr virus(EBV) infection is closely associated with undifferentiated nasopharyngeal carcinoma(NPC), strongly implicating a role for EBV in NPC pathogenesis; conversely, EBV infection is rarely detected in normal nasopharyngeal epithelial tissues. In general, EBV does not show a strong tropism for infecting human epithelial cells, and EBV infection in oropharyngeal epithelial cells is believed to be lytic in nature. To establish life-long infection in humans, EBV has evolved efficient strategies to infect B cells and hijack their cellular machinery for latent infection. Lytic EBV infection in oropharyngeal epithelial cells, though an infrequent event, is believed to be a major source of infectious EBV particles for salivary transmission. The biological events associated with nasopharyngeal epithelial cells are only beginning to be understood with the advancement of EBV infection methods and the availability of nasopharyngeal epithelial cell models for EBV infection studies. EBV infection in human epithelial cells is a highly inefficient process compared to that in B cells, which express the complement receptor type 2(CR2) to mediate EBV infection. Although receptor(s) on the epithelial cell surface for EBV infection remain(s) to be identified, EBV infection in epithelial cells could be achieved via the interaction of glycoproteins on the viral envelope with surface integrins on epithelial cells, which might trigger membrane fusion to internalize EBV in cells. Normal nasopharyngeal epithelial cells are not permissive for latent EBV infection, and EBV infection in normal nasopharyngeal epithelial cells usually results in growth arrest. However, genetic alterations in premalignant nasopharyngeal epithelial cells, including p16 deletion and cyclin D1 overexpression, could override the growth inhibitory effect of EBV infection to support stable and latent EBV infection in nasopharyngeal epithelial cells. The EBV episome in NPC is clonal in nature, suggesting that NPC develops from a single EBV-infected nasopharyngeal epithelial cell, and the establishment of persistent and latent EBV infection in premalignant nasopharyngeal epithelium may represent an early and critical event for NPC development. | Chi Man Tsang Wen Deng Yim Ling Yip Mu-Sheng Zeng Kwok Wai Lo Sai Wah Tsao | 2014 | Chinese Journal of Cancer2014，33，11： | 8 |
| 15 | Awareness and knowledge of hepatitis B infection and prevention and the use of hepatitis B vaccination in the Hong Kong adult Chinese population显示文摘背景肝炎 B 病毒( HBV )感染仍然是一个全球公共健康问题,它是尖锐、长期、暴发性的肝炎,肝肝硬化和在在在 10 点未改变的仍然是的过去的十年的香港的 HBV 感染的 hepatocellular carcinoma.The 流行的一个重要原因,尽管有实现通用新生并且当前的局势对 HBV 传播和预防的不适当的了解和知识可归因的成年 vaccination.We | Wah, Chung Pui Hung, Suen Sik Ka, Chan Oi Hsi, Lao Tzu Yeung, Leung Tak | 2012 | Chinese Medical Journal2012，，3： | 8 |
| 16 | 风力发电机接闪系统失效风险定量评估方法研究显示文摘雷害问题严重影响风机的正常运行,但针对风机接闪系统的失效风险,目前鲜有定量的分析和评估方法。基于先导发展物理模型,提出风机接闪系统雷击屏蔽失效率的定义和计算方法,并通过叶片雷击模拟实验验证了方法的有效性。比较分析了不同接闪系统型式叶片的雷击屏蔽失效率,并考虑了风机旋转角度和海洋盐雾附着对雷击屏蔽失效率的影响。分析表明,相比于接闪器–引下线结构型式和叶尖包覆铜网型式,采用主梁包覆铜网型式的叶片雷击屏蔽失效率最小,但综合考虑经济性和易维护性,推荐采用叶尖包覆铜网的接闪系统型式。提出的定量分析方法可为风机叶片接闪系统的优化设计和失效风险评估提供依据。 | 于万水 李庆民 张敏昊 郭子炘 刘亮 Siew Wah Hoon 王健 | 2019 | 中国电机工程学报2019，39，12： | 7 |
| 17 | 以慢性咳嗽为主要表现的儿童多发性抽动症的临床诊治显示文摘目的探讨以慢性咳嗽为主要表现的儿童多发性抽动症儿童的临床特征,提高慢性咳嗽中多发性抽动症的诊断准确率,减少误诊率。方法回顾性分析24例以慢性咳嗽为表现的多发性抽动症患儿的临床特点、咳嗽症状积分、视觉模拟评分(VAS)、误诊误治情况,并对其进行治疗和随访分析。结果 24例多发性抽动症患儿咳嗽表现为清咽样10例次(41.7%),干咳14例次(58.3%),咽部不适14例次(58.3%)。抽动表现频繁眨眼21例次,耸肩3例次,面部局部抽动6例次,缩鼻3例次。误诊为咳嗽变异性哮喘者7例,变应性咳嗽5例,肺炎3例,反复呼吸道感染4例,过敏性结膜炎5例。咳嗽症状总积分和VAS评分在治疗前后差异有统计学意义(P<0.05)。结论发声性抽动是引起儿童慢性咳嗽的原因之一,常规治疗效果差的慢性咳嗽患儿应排除多发性抽动症可能。 | Kenny Lan Cheng Wah 于兴梅 郝创利 汤继宏 | 2014 | 中华肺部疾病杂志(电子版)2014，7，5： | 6 |
| 18 | Prehospital system delay in patients with ST-segment elevation myocardial infarction in Singapore显示文摘BACKGROUND: Timely reperfusion in ST-segment elevation myocardial infarction(STEMI)improves outcomes. System delay is that between first medical contact and reperfusion therapy,comprising prehospital and hospital components. This study aimed to characterize prehospital system delay in Singapore.METHODS: A retrospective chart review was performed for 462 consecutive STEMI patients presenting to a tertiary hospital from December 2006 to April 2008. Patients with cardiac arrest secondarily presented were excluded. For those who received emergency medical services(EMS),ambulance records were reviewed. Time intervals in the hospital were collected prospectively. The patients were divided into two equal groups of high/low prehospital system delay using visual binning technique.RESULTS: Of 462 patients, 76 received EMS and 52 of the 76 patients were analyzed. The median system delay was 125.5 minutes and the median prehospital system delay was 33.5minutes(interquartile range [IQR]=27.0, 42.0). Delay between call-received-by-ambulance and ambulance-dispatched was 2.48 minutes(IQR=1.47, 16.55); between ambulance-dispatch and arrival-at-patient-location was 8.07 minutes(IQR=1.30, 22.13); between arrival-at- and departurefrom-patient-location was 13.12 minutes(IQR=3.12, 32.2); and between leaving-patient-location to ED-registration was 9.90 minutes(IQR=1.62, 32.92). Comparing patients with prehospital system delay of less than 35.5 minutes versus more showed that the median delay between ambulancedispatch and arrival-at-patient-location was shorter(5.75 vs. 9.37 minutes, P<0.01). The median delay between arrival-at-patient-location and leaving-patient-location was also shorter(10.78 vs.14.37 minutes, P<0.01).CONCLUSION: Prehospital system delay in our patients was suboptimal. This is the first attempt at characterizing prehospital system delay in Singapore and forms the basis for improving efficiency of STEMI care. | Andrew Fu Wah Ho Pin Pin Pek Stephanie Fook-Chong Ting Hway Wong Yih Yng Ng Aaron Sung Lung Wong Marcus Eng Hock Ong | 2015 | World Journal of Emergency Medicine2015，6，4： | 6 |
| 19 | Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong显示文摘Sewage discharge could be a major source of polycyclic aromatic hydrocarbons(PAHs) in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works(SCISTW and STSTW)in Hong Kong, adopted chemically enhanced primary treatment and biological treatment,respectively. This study aimed at(1) determining the removal efficiencies of PAHs,(2) comparing the capabilities in removing PAHs, and(3) characterizing the profile of each individual PAHs, in the two sewage treatment plants(STPs). Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes(from 301 ± 255 and 307 ± 217 ng/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively). It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal efficiency 94.4% ± 4.12% vs. 79.2% ± 7.48%(p < 0.05). The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples(dewatered sludge contained92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively) than liquid samples(final effluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively).Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs(1.85 and 39.3 kg/year, respectively for the two STPs) being discharged into Hong Kong coastal waters, which would be an environmental concern. | Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung Wong | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 20 | 儿童系统性红斑狼疮神经精神症状的研究(一)显示文摘目的通过分析儿童系统性红斑狼疮(SLE)神经精神症状的发病情况、临床及实验室表现、治疗等,探讨中国儿童神经精神性狼疮(NPSLE)的发病特点。方法回顾性研究1990-2006年诊断为SLE的62例中国儿童SLE患者。收集神经精神症状发病时的性别、年龄、病程、临床表现、实验室检查、影像学检查、治疗等资料,并与其他研究结果相对比。结果19例(31%)患者被诊断为NPSLE,共发生症状21次;最常见的神经精神症状是认知障碍(48%)、癫痫(43%)和头痛(29%)。单光子发射计算机断层成像(SPECT)的表现异常率达80%。86%的患者接受了甲泼尼龙治疗;大部分(74%)患者无神经精神系统后遗症。结论中国儿童SLE的神经精神症状是常见的,其发病特点与其他种族的报道有所不同;SPECT与MR是诊断NPSLE较敏感的辅助检查;儿童NPSLE的预后良好。 | 董静 王吉波 Yu Lung Lau Tsz Leung Lee Pamela Pui Wah Lee Wilfred Hing Sang Wong | 2008 | 中华风湿病学杂志2008，12，12： | 5 |
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