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| 1 | Transforming growth factor-β and fibrosis显示文摘Transforming growth factor-β (TGF-β), a prototype of multifunctional cytokine, is a key regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-β isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Elevated TGF-β expression in affected organs, and subsequent deregulation of TGF-β functions, correlates with the abnormal connective tissue deposition observed during the onset of fibrotic diseases. During the last few years, tremendous progress has been made in the understanding of the molecular aspects of intracellular signaling downstream of the TGF-β receptors. In particular, Smad proteins, TGF-β receptor kinase substrates that translocate into the cell nucleus to act as transcription factors, have been studied extensively. The role of Smad3 in the transcriptional regulation of typeⅠcollagen gene expression and in the development of fibrosis, demonstrated both in vitro and in animal models with a targeted deletion of Smad3, is of critical importance because it may lead to novel therapeutic strategies against these diseases. This review focuses on the mechanisms underlying Smad modulation of fi brillar collagen expression and how it relates to fi brotic processes. | Franck Verrecchia Alain Mauviel | 2007 | World Journal of Gastroenterology2007，13，22： | 113 |
| 2 | 喀喇昆仑断裂的变形特征及构造演化显示文摘喀喇昆仑断裂的变形特征、形成时代、构造演化以及它的构造意义一直存在着争议。在喀喇昆仑断裂东南段阿伊拉日居山地区,沿断裂出露具右旋剪切应变的糜棱岩和糜棱岩化片麻岩-花岗岩,显微构造研究表明其存在高温右旋剪切变形特征,并伴随淡色同构造花岗岩的产生,同构造结晶锆石所记录的U-Pb同位素年龄,暗示了喀喇昆仑断裂的形成时代在23-25Ma以前,其连续变形作用持续到-12Ma,之后伴随阿伊拉日居山的快速隆升以及噶尔盆地开始形成。综合分析表明喀喇昆仑断裂生长过程可能是由南东向北西扩展的过程,是印度板块与欧亚大陆持续碰撞的结果。断裂的累积位移量至少为280km,其长期平均滑移速率约为11mm/a。通过块体间运动学分析,表明在-23-25Ma以后青藏高原物质以约16.2mmn/a的速率向-N108°方向挤出。 | 李海兵 Franck Valli 许志琴 杨经绥 Paul Tapponnier Robin Lacassin 陈松永 戚学祥 Marie-Luce Chevalier | 2006 | 中国地质2006，33，2： | 64 |
| 3 | 喀喇昆仑断裂的形成时代:锆石SHRIMP U-Pb年龄的制约显示文摘喀喇昆仑断裂的形成时代对青藏高原形成演化、变形过程的研究具有重要意义.在断裂东南段阿伊拉日居山地区,沿断裂出露具高温右旋剪切应变特征的糜棱岩和糜棱岩化片麻岩-花岗岩,因此,利用变形岩石中锆石的SHRIMP U-Pb年龄来制约断裂的形成时代和变形历史.变形岩石中同构造结晶锆石的U-Pb同位素年龄,暗示了喀喇昆仑断裂的形成时代至少为距今约27Ma以前,比前人观点至少早约10Ma;大规模的高温右旋剪切活动至少在距今27~20Ma期间,并且伴随同构造淡色花岗岩的产生;剪切变形过程中伴随大量热液流体作用时限至少在距今25-13Ma期间.喀喇昆仑断裂的生长可能是由南东向北西扩展的过程,是印度板块与欧亚大陆持续碰撞的结果. | 李海兵 Franck Valli 刘敦一 许志琴 杨经绥 Nicolas Arnaud Paul Tapponnier Robin Lacassin 陈松永 戚学祥 | 2007 | 科学通报2007，52，4： | 26 |
| 4 | 气象因素与心脑血管疾病急诊人次的时间序列分析显示文摘目的探讨日均气温、相对湿度和风速与医院日心脑血管疾病急诊就诊人次的相关性。方法收集北京市某三级甲等医院日心脑血管疾病急诊就诊人次和该地区日均气温、相对湿度和风速的时间序列数据。收集北京市该城区PM10、SO2和NO2日均浓度的时间序列数据。利用立方平滑样条函数将日均气温、相对湿度和风速以及作为潜在混杂因素的PM10、SO2和NO2日均浓度引入,同医院日心脑血管疾病急诊就诊人次间建立Poisson广义相加模型。根据AIC最小的原则,选择最终进入模型的变量,并确定其立方平滑样条函数自由度取值。结果医院日心脑血管疾病急诊就诊人次与日均气温和相对湿度表现出一定的非线性相关趋势,但无统计学意义(P>0.1);与日均风速表现出负相关趋势,但无统计学意义(P>0.1)。结论北京市某城区气温、相对湿度和风速与医院心脑血管疾病急诊人次的相关性不明显。 | 刘利群 潘小川 郑亚安 Wichmann HE Franck U | 2008 | 环境与健康杂志2008，25，7： | 22 |
| 5 | Rice CYP703A3, a cytochrome P450 hydroxylase, is essential for development of anther cuticle and pollen exine显示文摘Anther cuticle and pollen exine act as protective envelopes for the male gametophyte or pollen grain, but the mechanism underlying the synthesis of these lipidic polymers remains unclear. Previously, a tapetum‐expressed CYP703A3, a putative cytochrome P450 fatty acid hydroxylase, was shown to be essential for male fertility in rice(Oryza sativa L.). However,the biochemical and biological roles of CYP703A3 has not been characterized. Here, we observed that cyp703a3‐2 caused by one base insertion in CYP703A3 displays defective pollen exine and anther epicuticular layer, which differs from Arabidopsis cyp703a2 in which only defective pollen exine occurs. Consistently, chemical composition assay showed that levels of cutin monomers and wax components were dramatically reduced in cyp703a3‐2 anthers. Unlike the wide range of substrates of Arabidopsis CYP703A2, CYP703A3 functions as an in‐chain hydroxylase only for a specific substrate, lauric acid, preferably generating 7‐hydroxylated lauric acid. Moreover, chromatin immunoprecipitation and expression analyses revealed that the expression of CYP703A3 is directly regulated by Tapetum Degeneration Retardation, a known regulator of tapetum PCD and pollen exine formation. Collectively, our results suggest that CYP703A3 represents a conserved and diversified biochemical pathway for in‐chain hydroxylation of lauric acid required for the development of male organ in higher plants. | Xijia Yang Di Wu Jianxin Shi Yi He Franck Pinot Bernard Grausem Changsong Yin Lu Zhu Mingjiao Chen Zhijing Luo Wanqi Liang Dabing Zhang | 2014 | Journal of Integrative Plant Biology2014，56，10： | 21 |
| 6 | 妊娠期乳腺癌9例的诊断和综合治疗显示文摘目的 :研究妊娠期乳腺癌在诊断和手术、化疗、放疗综合治疗方面的特殊性。方法 :1992年 12月—1999年 6月 ,法国巴黎第十二大学附属HenriMondor医院放疗科收治 9例妊娠期乳腺癌患者 ,其中 3例诊断于妊娠期 ,6例诊断于分娩后 1年内。 5例行乳房保留治疗 ,4例改良根治术。所有病例行术后放疗。 7例接受化疗。结果 :9例钼靶摄片中 7例和所有的 5例超声检查提示肿瘤征象 ,诊断时总体病期晚 ,Ⅰ、Ⅱ、、Ⅲ期比例分别为11%、44 %和 44 %。中位随访 6 0月 (9— 89月 )时 ,6例无病生存 ,3例在治疗结束后 14月— 48月出现局部复发或远处转移。结论 :妊娠期乳腺癌诊断延误较为常见 ,对分娩后确诊的患者 ,应重视妊娠、哺乳期乳房体检和超声检查在鉴别诊断乳房肿块中的作用。治疗原则必须兼顾疾病的迫切性和胎儿的安全性。在可以及时开展化疗和放疗的综合治疗的前提下 。 | 陈佳艺 林原 Youlia KIROVA Franck FEUILLADE Jean-Paul Le BOURGEOIS | 2001 | 中国癌症杂志2001，11，5： | 21 |
| 7 | 大气污染物与呼吸系统疾病急诊就诊关系的病例交叉研究显示文摘目的 分析大气污染急性暴露对呼吸系统疾病急诊人次的影响.方法 收集2004年1月1日至2005年12月31日北京大学第三医院急诊科呼吸系统疾病急诊资料和北京市环境监测中心大气污染物数据,应用时间分层的病例交叉设计研究方法进行数据分析,同时比较单向回顾性对照设计和双向对照设计研究结果的差异.结果 在调整气象因素并采用单向回顾性(多污染物)模型中,无滞后大气可吸入颗粒物(PM10)、二氧化硫(SO2)、滞后2 d二氧化氮(NO2)日平均浓度每增加10 μg/m^3,呼吸系统疾病总急诊的OR值(95%CI)分别为1.010(1.005~1.014)、1.010(1.001~1.018)、0.996(0.983~1.009);双向对称性(多污染物)模型中,其相应OR值(95%CI)分别为1.002(0.998~1.005)、1.011(1.003~1.018)、1.012(1.001~1.022).采用不同对照选择方案,病例交叉设计的研究结果有变化.结论 区域内大气污染物暴露对居民呼吸系统疾病急诊人次有急性效应. | 苏畅 郭玉明 Ulrich Franck 潘小川 | 2010 | 中华流行病学杂志2010，31，8： | 20 |
| 8 | 燃气轮机发电机组黑启动方案探讨显示文摘不同电厂的黑启动方案由于机型和系统接线的差异而千差万别,但黑启动过程设计中的关键因素如黑启动负荷加载顺序、黑启动柴油发电机组选型、死母线合闸、孤岛运行控制等却有着原理一致性和可归纳性。基于9E机组的黑启动成功案例,阐述燃气轮机电厂黑启动必须考虑的重要负荷顺序以及黑启动柴油机的选型计算过程。对死母线合闸、孤岛运行控制等黑启动方案中关键步骤进行原理描述和经验总结,并介绍了优化方法和现场经验及需要注意的特殊环节,为今后黑启动方案设计提供参考和借鉴。 | 余旭翔 Denicourt Franck | 2012 | 燃气轮机技术2012，25，1： | 14 |
| 9 | 喀喇昆仑断裂带走滑过程中伴随的快速隆升作用:热年代学证据显示文摘喀喇昆仑断裂带是青藏高原西部的一条大型右旋走滑断裂带,它是喜马拉雅山脉西段北侧重要的地质边界。本文在岩石学、变形构造的研究基础上,对喀喇昆仑断裂带东南段阿伊拉日居山—噶尔盆地地区的喀喇昆仑韧性剪切带中变质岩石的同构造矿物进行了^(40)Ar/^(39)Ar热年代学研究。显微构造研究表明,剪切带中的矿物记录了从高温(>600℃)到低温(<250℃)条件下的连续变形,表现为近水平的右旋剪切运动转变成斜向的右旋正滑,使绿片岩相的变形作用叠加在中-高温变形之上,暗示出走滑过程中存在隆升作用,热年代学结果显示其连续剪切变形作用从早中新世以来至少持续到4Ma,并且出现三个快速冷却阶段:第一个快速冷却阶段为从25~22Ma 到21~18Ma 期间,可能代表的是浅部高温剪切过程中变形局部停止或减慢的过程;第二个快速冷却时期为从15Ma 到12~10Ma,是喀喇昆仑断裂带走滑过程中,阿伊拉日居山的快速隆升、噶尔盆地开始形成以及主要河流深切过程阶段;9Ma 以来是第三个快速冷却过程,使阿伊拉日居山脉进一步快速隆升、噶尔盆地定形过程。根据不同年代地表地貌特征的右旋错位距离以及不同层次变形特征,估算出喀喇昆仑断裂带长期滑移速率为8~10mm/a,伴随的隆升速率为1mm/a。从显微构造和热年代学证据表明,晚第四纪以来该断裂经历了强烈的右旋走滑运动的同时伴随强烈的隆升作用。 | 李海兵 VALLI Franck ARNAUD Nicolas 陈松永 许志琴 TAPPONNIER Paul LACASSIN Robin 司家亮 邱祝礼 | 2008 | 岩石学报2008，24，7： | 14 |
| 10 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 11 | Inflammation and colorectal cancer, when microbiota-host mutualism breaks显示文摘Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal cancer.In this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic configuration.The possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically discussed.On the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is suggested.As a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory configuration.Consolidating inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting carcinogenesis.In this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset. | Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi | 2014 | World Journal of Gastroenterology2014，20，4： | 13 |
| 12 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 13 | 西菲律宾海末次冰期以来的浊流沉积及其古环境意义显示文摘菲律宾海西部吕宋岛岸外MD98-2188钻孔揭示末次冰期以来发生过数次浊流沉积事件。研究发现浊流沉积层具有密度高、颜色亮度大等物理特征,含有较多粗沉积组分和翼足类化石碎片,说明其来源于浅海沉积物。本文运用AMS ^(14)C测年和浮游有孔虫氧同位素建立精细的年龄模式,发现浊流沉积层段主要与末次盛冰期、冰期Heinrich变冷事件以及氧同位素4期等低海平面时期相对应,推测与千年尺度北半球气候冷期相关的海平面快速上升可能是西菲律宾海浊流沉积的触发原因。这对于认识快速气候变化的环境后果和开展西菲律宾海晚第四纪地层划分对比都有重要意义。 | 党皓文 翦知湣 Franck assinot | 2009 | 第四纪研究2009，29，6： | 9 |
| 14 | 混凝土气体渗透性测试技术研究显示文摘渗透性直接影响混凝土的耐久性能,是混凝土耐久性能的重要的评价指标。本文在对现有混凝土水渗透法、离子渗透法和气体渗透法的测试技术优缺点进行分析总结的基础上,提出了一种基于气压差值法的新型测试技术,并采用离子渗透法和气体渗透法对6组混凝土渗透性能进行测试研究。研究结果表明,气体渗透系数均随混凝土抗压强度、平均孔隙率的增长而增加,且与孔隙率呈现很好的线性相关性,与氯离子扩散系数呈现出一定的相关性。本文开发的基于气压差值新型测试技术可行,对提升混凝土耐久性能检测技术和发展桥梁长期性能研究具有重要的意义。 | 张国荣 韩依璇 Frédéric Skoczylas Franck Agostini 赵亮 | 2015 | 硅酸盐通报2015，34，S1： | 9 |
| 15 | 运行时软件体系结构的建模与维护显示文摘运行时体系结构是系统运行时刻的一个动态、结构化的抽象,描述系统当前的组成成分、各成分的状态和配置以及不同成分之间的关系.运行时体系结构与目标系统间具有动态的因果关联,即系统的变化及时体现在体系结构上,而对体系结构的修改及时影响当前系统.运行时体系结构允许开发者以读写体系结构的方式实现系统的监测和调整,是体系结构层次系统动态适应与在线演化的基础.构造运行时体系结构的关键是针对不同的目标系统和体系结构风格实现合适的基础设施,以维护二者之间的因果关联.由于目标系统和体系结构的多样性以及因果关联维护逻辑的复杂性,这一构造过程往往过于繁琐、易错、难以复用和维护.提出一种模型驱动的运行时体系结构构造方法.开发者只需针对目标系统、体系结构以及两者之间的关系分别进行建模,根据这些模型,支撑框架自动构造合法而高效的运行时体系结构基础设施.基于MOF和QVT标准建模语言定义了一组运行时体系结构建模语言,并基于通用的模型与系统间同步技术实现了相应的支撑框架.一系列实例研究表明,该方法具有广泛的适用性,并显著提高了运行时体系结构构造过程的效率与可复用性. | 宋晖 黄罡 武义涵 Franck CHAUVEL 孙艳春 邵维忠 梅宏 | 2013 | 软件学报2013，24，8： | 8 |
| 16 | Allogenic banking of dental pulp stem cells for innovative therapeutics显示文摘Medical research in regenerative medicine and cellbased therapy has brought encouraging perspectives for the use of stem cells in clinical trials. Multiple types of stem cells, from progenitors to pluripotent stem cells, have been investigated. Among these, dental pulp stem cells(DPSCs) are mesenchymal multipotent cells coming from the dental pulp, which is the soft tissue within teeth. They represent an interesting adult stem cell source because they are recovered in large amount in dental pulps with non-invasive techniques compared to other adult stem cell sources. DPSCs can be obtained from discarded teeth, especially wisdom teeth extracted for orthodontic reasons. To shift from promising preclinical results to therapeutic applications to human, DPSCs must be prepared in clinical grade lots and transformed into advanced therapy medicinal products(ATMP). As the production of patient-specific stem cells is costly and time-consuming, allogenic biobanking of clinical grade human leukocyte antigen(HLA)-typed DPSC lines provides efficient innovative therapeutic products. DPSC biobanks represent industrial and therapeutic innovations by using discarded biological tissues(dental pulps) as a source of mesenchymal stem cells to produce and store, in good manufacturing practice(GMP) conditions, DPSC therapeutic batches. In this review, we discuss about the challenges to transfer biological samples from a donor to HLA-typed DPSC therapeutic lots, following regulations, GMP guidelines and ethical principles. We also present some clinical applications, for which there is no efficient therapeutics so far, but that DPSCs-based ATMP could potentially treat. | Pierre-Yves Collart-Dutilleul Franck Chaubron John De Vos Frederic J Cuisinier | 2015 | World Journal of Stem Cells2015，7，7： | 7 |
| 17 | 毛皮鞣制中不同铝鞣剂的对比研究显示文摘通过对比试验研究了三甲酸铝和明矾鞣制毛皮的优缺点。试验证明,采用三甲酸铝为鞣剂,成品革在面积得革率、单位面积重量。 | Vasil kovac Dr. H. Francke | 1999 | 中国皮革1999，28，19： | 7 |
| 18 | Determination of trace PAHs in seawater and sediment pore-water by solid-phase microextraction (SPME) coupled with GC/MS显示文摘A fast and reliable method for the determination of trace PAHs (polynuclear aromatic hydrocarbons) in seawater by solid-phase microextraction (SPME) followed by gas chromatographic (GC) analysis has been developed. The SPME operational parameters have been optimized, and the effects of salinity and dissolved organic matter (DOM) on PAHs recoveries have been investigated. SPME measures only the portion of PAHs which are water soluble, and can be used to quantify PAH partition coefficient between water and DOM phases. The detection limits of the overall method for the measurement of sixteen PAHs range from 0.1 to 3.5 ng/g, and the precisions of individual PAH measurements range from 4% to 23% RSD. The average recovery for PAHs is 88.2±20.4%. The method has been applied to the determination of PAHs in seawater and sediment porewater samples collected in Jiaozhou Bay and Laizhou Bay in Shandong Peninsula, China. The overall levels of PAHs in these samples reflect moderate pollution compared to seawater samples reported elsewhere. The PAH distribution pattern shows that the soluble PAHs in seawater and porewater samples are dominated by naphthalenes and 3 ring PAHs. This is in direct contrast to those of the sediment samples reported earlier, in which both light and heavy PAHs are present at comparable concentrations. The absence of heavy PAHs in soluble forms (<0.1-3.5 ng/L) is indicative of the strong binding of these PAHs to the dissolved or solid matters and their low seawater solubility. | Lee Franck Sen-Chun | 2006 | Science China Chemistry2006，49，6： | 6 |
| 19 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 20 | Initial movement of the Karakorum Fault in western Tibet:constraints from SHRIMP U-Pb dating of zircons显示文摘The Karakorum Fault zone(KFZ)plays an important role in understanding the formation,evolvement and deformation of the Tibetan Plateau.The high-T dextral shearing metamorphic rocks,e.g.,mylonites or mylonitized gneisses-granites,locally crop out along the southeastern part of the KFZ in the Ayila Ri’gyüRange area.The SHRIMP U-Pb dating of the syn-kinematic crystallized zircons indicates that the initial age of the KFZ is^27 Ma,~10 Ma older than previous results.The extensive high-T dextral shearing along the KFZ started at least at 27-20 Ma,accompanied by the syn-kinematic emplacement of leuco-granites.Deformation and concomitant fluid circulation during shearing most likely occurred as early as at 25-13 Ma.The KFZ probably grew from southeast to northwest along the fault as a result of continuous convergence between the India plate and Eurasia plate. | LI HaiBing Franck VALLI LIU DunYi XU ZhiQin YANG JingSui Nicolas ARNAUD Paul TAPPONNIER Robin LACASSIN CHEN SongYong QI xuexiang | 2007 | Chinese Science Bulletin2007，52，8： | 6 |
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