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| 1 | Oxidative damage in the progression of chronic liver disease to hepatocellular carcinoma:An intricate pathway显示文摘The histo-pathologic and molecular mechanisms leading to initiation and progression of hepatocellular carcinoma(HCC)are still ill-defined;however,there is increasing evidence that the gradual accumulation of mutations,genetic and epigenetic changes which occur in preneoplastic hepatocytes results in the development of dysplastic foci,nodules,and finally,overt HCC.As well as many other neoplasias,liver cancer is considered an'inflammatory cancer',arising from a context of inflammation,and characterized by inflammation-related mechanisms that favor tumor cell survival,proliferation,and invasion.Molecular mechanisms that link inflammation and neoplasia have been widely investigated,and it has been well established that inflammatory cells recruited at these sites with ongoing inflammatory activity release chemokines that enhance the production of reactive oxygen species.The latter,in turn,probably have a major pathogenic role in the continuum starting from hepatitis followed by chronic inflammation,and ultimately leading to cancer.The relationship amongst chronic liver injury,free radical production,and development of HCC is explored in the present review,particularly in the light of the complex network that involves oxidative DNA damage,cytokine synthesis,telomere dysfunction,and microRNA regulation. | Romilda Cardin Marika Piciocchi Marina Bortolami Andromachi Kotsafti Luisa Barzon Enrico Lavezzo Alessandro Sinigaglia Kryssia Isabel Rodriguez-Castro Massimo Rugge Fabio Farinati | 2014 | World Journal of Gastroenterology2014，20，12： | 14 |
| 2 | 促进弱势群体参与体育锻炼的干预研究——以听力残疾学生为例显示文摘以150名听力残疾学生为研究对象,以阶段变化模型为理论框架,采用准实验不等同比较组前后测设计,使用散页印刷品为主要干预方式,对其进行了12周针对性的干预实验。研究结果表明,干预对实验组听力残疾学生的锻炼行为水平未产生影响;接受干预前后,实验组学生在不同锻炼阶段的人数分布发生了改变,且具有统计学上的意义(χ2=4.048,P=0.044<0.05),这一结果部分证明了干预措施的有效性;接受干预后,仅实验组学生的意识提高(t=-3.35,P=0.001<0.01)和刺激控制(t=-6.94,P=0.000<0.01)因素的均值相对于对照组学生出现了非常显著的提高,以阶段变化模型为理论基础的此干预实验并未有效地影响实验组听力残疾学生锻炼行为各心理决定因素的变化;锻炼收益、锻炼弊端和变化过程因素成功地预测了实验组听力残疾学生锻炼行为从预期阶段向准备阶段的转换。通过12周基于TTM模型的干预研究,部分证明了以阶段变化模型为理论基础的干预措施有效影响了听力残疾学生锻炼阶段变化的准备水平及心理决定因素,但完全没有影响到其锻炼行为水平。针对听力残疾学生这类特殊人群,有必要进行促进其锻炼行为水平的后续干预研究。 | 司琦 陈红玉 刘海群 Cardinal B | 2010 | 体育科学2010，30，7： | 14 |
| 3 | 阶段变化模型在身体活动领域应用研究的综述:1998年至2012年显示文摘阶段变化模型于1998年首次引入我国,至今尚没有对基于该模型的身体活动研究成果进行过系统综述。对1998—2012年间,我国以此模型为基础进行的身体活动研究进行了综述;并论证了基于该模型,制订促进青少年每天锻炼一小时干预策略的可行性。在对知网等数据库的期刊论文进行计算机检索,并对符合检索条件论文的全文和参考文献进行人工检索后,114篇论文进入综述。论文被编码、分类,并使用半定量方法进行了分析。结果显示:阶段变化模型虽是我国锻炼心理学领域内备受关注的理论模型之一,但前期基于整体模型的研究和干预(或纵向)研究较少,模型在我国的适用性和应用性仍有待进一步检验。12项涉及青少年身体活动的研究中,基于整体模型的研究和干预研究各占不到一成,为后续研究提供的可参考结果极其有限。与青少年身体活动具有稳定关系的因素是性别、年级(年龄)和均衡决策。后续应考虑关注纵向设计、检验测量工具、针对不同性质被试以及基于整体模型进行研究;研究需明确界定身体活动和变化阶段的划分标准。基于阶段变化模型制定促进青少年参与体育锻炼干预策略的证据有限。 | 司琦 于可红 陈谦 汪霖之 Cardinal Bradley 林盈盈 | 2013 | 体育科学2013，33，5： | 6 |
| 4 | Oxidative damage,pro-inflammatory cytokines,TGF-αand c-myc in chronic HCV-related hepatitis and cirrhosis显示文摘AIM: To assess whether a correlation exists between oxidative DNA damage occurring in chronic HCV-related hepatitis and expression levels of pro-inflammatory cytokines, TGF-αand c-myc. METHODS: The series included 37 patients with chronic active HCV-related hepatitis and 11 with HCV-related compensated cirrhosis. Eight-hydroxydeoxyguanosine in liver biopsies was quantified using an electrochemical detector. The mRNA expression of TIMF-α, IL-1β, TGF-αand c-myc in liver specimens was detected by semi-quantitative comparative RT-PCR. RESULTS: TNF-αlevels were significantly higher in hepatitis patients than in cirrhosis patients (P=0.05). IL-1βwas higher in cirrhosis patients (P=0.05). A significant correlation was found between TNF-αand staging (P=0.05) and between IL-1βlevels and grading (P=0.04). c-myc showed a significantly higher expression in cirrhosis patients (P=0.001). Eight-hydroxydeoxyguanosine levels were significantly higher in cirrhosis patients (P=0.05) and in HCV genotype 1 (P=0.03). Considering all patients, 8-hydroxydeoxyguanosine levels were found to be correlated with genotype (P=0.04) and grading (P=0.007). Also multiple logistic regression analysis demonstrated a significant correlation among the number of DNA adducts, TNF-αexpression and HCV genotype (P=0.02). CONCLUSION: In chronic HCV-related liver damage, oxidative DNA damage correlates with HCV genotype, grading and TNF-αlevels. As HCV-related liver damage progresses, TNF-αlevels drop while IL-1βand c-myc levels increase, which may be relevant to liver carcinogenesis. | Fabio Farinati Romilda Cardin Marina Bortolami Maria Guido Massimo Rugge | 2006 | World Journal of Gastroenterology2006，12，13： | 5 |
| 5 | 5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis显示文摘AIM:To compare the mucosal concentrations of 5-aminosalicylic acid(5-ASA)resulting from different pharmaceutical formulations and analyse the influence of inflammation on the mucosal concentrations.METHODS:The study included 130 inflammatory bowel disease(IBD)patients receiving 5-ASA as pH-dependent-release formulations(73 patients),time-dependent-release formulations(11 patients),or pro-drugs(18patients).In addition,28 patients were receiving topical treatment(2-4 g/d)with pH-dependent-release formulations.Endoscopic biopsies were obtained from the sigmoid region during the colonoscopy.The 5-ASA concentrations(ng/mg)were measured in tissue homogenatesusing high-pressure liquid chromatography with electrochemical detection.The t test and Mann-Whitney test,when appropriate,were used for statistical analysis.RESULTS:Patients receiving pH-dependent-release formulations showed significantly higher mucosal concentrations of 5-ASA(51.75±5.72 ng/mg)compared with patients receiving pro-drugs(33.35±5.78 ng/mg,P=0.01)or time-dependent-release formulations(38.24±5.53 ng/mg,P=0.04).Patients with endoscopic remission had significantly higher mucosal concentrations of5-ASA than patients with active disease(60.14±7.95ng/mg vs 35.66±5.68 ng/mg,P=0.02).Similar results were obtained when we compared patients with the histological appearance of remission and patients with active histological inflammation(67.53±9.22 ng/mg vs 35.53±5.63 ng/mg,P<0.001).Significantly higher mucosal concentrations of 5-ASA were detected in patients treated with both oral and topical treatments in combination compared with patients who received oral treatment with pH-dependent-release formulations alone(72.33±11.23 ng/mg vs 51.75±5.72 ng/mg,P=0.03).CONCLUSION:IBD patients showed significant variability in mucosal 5-ASA concentrations depending on the type of formulation,and the highest mean concentration was achieved using pH-dependent-release formulations. | Renata D’Incà Martina Paccagnella Romilda Cardin Surajit Pathak Vincenzo Baldo Maria Cecilia Giron Giacomo Carlo Sturniolo | 2013 | World Journal of Gastroenterology2013，19，34： | 4 |
| 6 | Interferon regulatory factor-1 mediates the release of high mobility group box-1 in endotoxemia in mice显示文摘 | PAN Pin-hua Jon Cardinal LI Mo-li HU Cheng-ping Allan Tsung | 2013 | Chinese Medical Journal2013，，5： | 3 |
| 7 | Monolithic crystalline silicon solar cells with SiN_x layers doped with Tb^(3+) and Yb^(3+) rare-earth ions显示文摘In this study, we propose the fabrication of monolithic crystalline silicon solar cells with Tb^(3+) and Yb^(3+)-doped silicon nitride(SiN_x) layers by low-cost screen-printing methods. The performances of c-Si solar cells can be enhanced by rare-earth ions doped SiN_x layers via the mechanism of spectrum conversion.These SiN_x doped and codoped thin films were deposited by reactive magnetron co-sputtering and integrated as the antireflection coating layers in c-Si solar cells. The characterizations of SiN_x, SiN_x:Tb^(3+) tand SiN_x:Tb^(3+)-Yb^(3+) thin films were conducted by means of photoluminescence, Rutherford backscattering spectroscopy, Ellipsometry spectroscopy and Fourier transform infrared measurements. Their composition and refractive index was optimized to obtain good anti-reflection coating layer for c-Si solar cells.Transmission electron microscopy performs the uniform coatings on the textured emitter of c-Si solar cells. After the metallization process, we demonstrate monolithic c-Si solar cells with spectrum conversion layers, which lead to a relative increase by 1.34% in the conversion efficiency. | Ing-Song Yu Shao-Chun Wu Lucile Dumont Julien Cardin Christophe Labbé Fabrice Gourbilleau | 2019 | Journal of Rare Earths2019，37，5： | 3 |
| 8 | Perirenal extra-adrenal myelolipoma显示文摘Myelolipomas are rare tumors consisting of both adipose and hematopoietic tissue and are typically found within the adrenal gland. Extra-adrenal involvement is rare, especially those tumors involving the perirenal space and collecting system. We report a case of a patient with an incidentally discovered perirenal mass that was initially concerning for a retroperitoneal liposarcoma. Following surgical resection and pathological analysis, the lesion was found to be an extra-adrenal myelolipoma. This case report and review of the literature demonstrates the importance of the proper workup and management of perirenal lipoma variants while addressing the issues of tissue biopsy, surgical intervention, and pre- and post-operative surveillance. | Ali Hajiran Chad Morley Robert Jansen Stanley Kandzari Patrick Bacaj Stanley Zaslau Jon Cardinal | 2014 | World Journal of Clinical Cases2014，2，7： | 3 |
| 9 | Littoral cell angioma: A case report显示文摘Primary splenic lesions are rare entities among which littoral cell angioma(LCA) is a recently described, uncommon vascular lesion that is unique to the spleen. It has heretofore been described primarily in pathologic series and has been found mostly to behave as a benign entity. A few reports of malignant variants have been reported. We present a case report of a solitary LCA discovered after splenectomy for an incidentally discovered splenic lesion, along with a literature review. | Amanda Bailey Jeffrey Vos Jon Cardinal | 2015 | World Journal of Clinical Cases2015，3，10： | 3 |
| 10 | Solute clearances during continuous venovenous heamofiltration at various ultrafiltration flow rates using multiflow-100 and HF1000 filters 显示文摘 | Troyanov S Cardinal J Geadah D | 2003 | Nephrol Dial Transplant2003，18，： | 2 |
| 11 | “肌腱软化(Tenomalacia)”:肌腱病变的一种新的超声征象?显示文摘本研究的目的是采用超声评估肘关节伸肌肌腱病与无症状肌腱的压缩性。8例临床诊断为单侧肱骨外上髁炎的病人行双肘超声检查,通过测量探头压迫前后的厚度评估肌腱的压缩性。彩色多普勒评价肌腱的血供情况时采用同样的手法操作。所有8个病例中,疼痛侧较无症状侧的肌腱有更大的压缩性,彩色多普勒也显示有更多可压缩的血管。 | V.Khoury .Cardinal 朱玉兆 | 2009 | 国际医学放射学杂志2009，32，2： | 2 |
| 12 | Arthrography of the shoulder: a simple fluoroseopically guided approach for targeting the rotator cuff interval显示文摘 | Depeheau H Bureau N J Cardinal E | 2004 | Am J Roentgenol2004，2，： | 1 |
| 13 | Intravascular ultrasound image segmentation: a three-dimensional fast-marching method based on gray level distributions 显示文摘 | Cardinal M H R Meunier J Soulez G | 2006 | IEEE Transactions on Medical Imaging2006，25，5： | 1 |
| 14 | Helicobacter pylori CagA status,mucosal oxidative damage and gastritis phenotype:a potential pathway to cancer?显示文摘 | Farinati F Cardin R Russo VM | 2003 | Helicobacter2003，8，3： | 1 |
| 15 | Correlation be- tween thermal fatigue and thermomechanical properties during the oxidation of multilayered TiSiN nanocomposite coatings synthesized by a hybrid physical/chemical vapour deposition process显示文摘 | A M~ge - Revil P Steyer S Cardinal | 2010 | Thin Solid Films2010，518，2010： | 1 |
| 16 | A non-invasive tape absorption method for recovery of inflammatory mediators to differentiate normal from compromised scalp conditions显示文摘 | Perkins MA Cardin CW Osterhues MA | 2002 | Skin Res Technol2002，8，3： | 1 |
| 17 | The use of knowledge for technological innovation within diversified firms显示文摘 | Miller D J Fern M J Cardinal L B | 2007 | Academy of Management Journal2007，50，2： | 1 |
| 18 | Serial surgical de-bridement: a retrospective study on clinical outcomes in chro-nic lower extremity wounds显示文摘 | Cardinal M Eisenbud DE Armstrong DG Zelen C DriverV Attinqer C Phillips T Harding K | 2009 | Wound Repair Reqen2009，17，3： | 1 |
| 19 | The genesis of strategy in new ventures : escaping the constraints of founder and team knowledge 显示文摘 | FERN M J CARDINAL L B NEILL H M | 2012 | Strategic Management Journal2012，33，4： | 1 |
| 20 | Transcatheter arterial chemoembolization(TACE) in hepatocellular carcinoma(HCC):The role of angiogenesis and invasiveness显示文摘 | Sergio A Cristofori C Cardin R | 2008 | Am J Gastroenterol2008，103，3： | 1 |
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