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| 1 | Trabecular Plate Loss and Deteriorating Elastic Modulus of Femoral Trabecular Bone in Intertrochanteric Hip Fractures显示文摘Osteoporotic hip fracture is associated with significant trabecular bone loss,which is typically characterized as low bone density by dual-energy X-ray absorptiometry(DXA)and altered microstructure by micro-computed tomography(μCT).Emerging morphological analysis techniques,e.g.individual trabecula segmentation(ITS),can provide additional insights into changes in plate-like and rod-like trabeculae,two major micro-structural types serving different roles in determining bone strength.Using ITS,we evaluated trabecular microstructure of intertrochanteric bone cores obtained from 23 patients undergoing hip replacement surgery for intertrochanteric fracture and 22 cadaveric controls.Micro-finite element(μFE)analyses were performed to further understand how the abnormalities seen by ITS might translate into effects on bone strength.ITS analyses revealed that,near fracture site,plate-like trabeculae were seriously depleted in fracture patients,but trabecular rod volume was maintained.Besides,decreased plate area and rod length were observed in fracture patients.Fracture patients also showed decreased elastic moduli and shear moduli of trabecular bone.These results provided evidence that in intertrochanteric hip fracture,preferential loss of plate-like trabeculae led to more rod-like microstructure and deteriorated mechanical competence adjacent to the fracture site,which increased our understanding of the biomechanical pathogenesis of hip fracture in osteoporosis. | Ji Wang Bin Zhou Ian Parkinson C.David L.Thomas John G.Clement Nick Fazzalari X.Edward Guo | 2013 | Bone Research2013，1，4： | 4 |
| 2 | Histone methylation versus histone acetylation: new insights into epigenetic regulation显示文摘 | Judd C Rice C.David Allis | 2001 | Current Opinion in Cell Biology2001，，3： | 1 |
| 3 | A comprehensive framework for service quality: an investigation of critical conceptual and measurement issues through a longitudinal study显示文摘 | Pratibha A Dabholkar C.David Shepherd Dayle I Thorpe | 2000 | Journal of Retailing2000，，2： | 1 |
| 4 | 大马尼拉市需水预测的批评性评价显示文摘城市需水预测是供水规划、多部门配水决策和制订水价的重要基础.但是,目前普遍认为城市需水预测有被夸大的趋势(Young 1996年,Munas-inghe 1992年).例如,1970年美国完成的需水预测,预计二十世纪90年代需水将有较大增长,这与1990年以来实际出现的新鲜水取用量不断减少形成了强烈的对比.(Rogers 1993年,Solley等1993年).欧洲在广泛采取用水计量设备和提高水价之后,需水也出现了下降的趋势(Bower等1984年).因为对水污染的严格控制和高昂的排污费,发达国家的工业用水也采用水循环利用等节水技术减少了用水. | Cristina C.David 石海峰 | 2003 | 水利规划与设计2003，，2： | 1 |
| 5 | 查看详情显示文摘 | C.David B.Kaulich R.Medenwaldt | | 0，，： | 1 |
| 6 | Split ADC calibration for all-digital correction of time-interleaved ADC errors显示文摘 | J.McNeill C.David M.Coln | | 0，，： | 1 |
| 7 | Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience显示文摘 | Matthias Pfisterer Jafna L Cox Christopher B Granger Sorin J Brener C.David Naylor Robert M Califf Frans van de Werf Amanda L Stebbins Kerry L Lee Eric J Topol Paul W Armstrong | 1998 | Journal of the American College of Cardiology1998，，3： | 1 |
| 8 | Hyperglycemia During Nomaothermic Cardiopulmonary Bypass: The Role of the Kidney显示文摘 | Hal Braden Surinder Cheerna-Dhadli C.David Mazer | | 0，，： | 1 |
| 9 | Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14显示文摘 | Wan-Sheng Lo Raymond C Trievel Jeannie R Rojas Laura Duggan Jer-Yuan Hsu C.David Allis Ronen Marmorstein Shelley L Berger | 2000 | Molecular Cell2000，，6： | 1 |
| 10 | Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation显示文摘 | Peter Cheung Kirk G Tanner Wang L Cheung Paolo Sassone-Corsi John M Denu C.David Allis | 2000 | Molecular Cell2000，，6： | 1 |
| 11 | Subgroups, treatment effects, and baseline risks: Some lessons from major cardiovascular trials显示文摘 | Andrea B. Parker C.David Naylor | 2000 | American Heart Journal2000，，6： | 1 |
| 12 | The changes of oligodendrocytes induced by anesthesia during brain development显示文摘With the advent of modern techniques,drugs,and monitoring,general anesthesia has come to be considered an unlikely cause of harm,particularly for healthy patients.While this is largely true,newly emerging clinical and laboratory studies have suggested that exposure to anesthetic agents during early childhood may have long-lasting adverse effects on cognitive function.This concern has been the focus of intense study in the field | Danye Jiang Sanghee Lim Minhye Kwak Yun Kyoung Ryu C.David Mintz | 2015 | Neural Regeneration Research2015，10，9： | 1 |
| 13 | Hypofractionated radiotherapy for invasive bladder cancer显示文摘 | Astrid N. Scholten Jan-Willem H. Leer C.David Collins Jan Wondergem Jo Hermans Adrian Timothy | 1997 | Radiotherapy and Oncology1997，，2： | 1 |
| 14 | AF9YEATS结构域在分子层面偶联组蛋白巴豆酰化和活跃转录显示文摘染色质结合蛋白质模块(“阅读器”)识别组蛋白共价修饰构成表观遗传调控的主要方式之一,例如溴域识别乙酰化赖氨酸修饰。除乙酰化之外,近来研究发现组蛋白赖氨酸还能发生巴豆酰化、丁酰化、丙酰化等酰基化修饰.但能够偏好识别这些新型酰基化修饰的阅读器尚未见报道。 | Yuanyuan Li Benjamin R.Sabari Tatyana Panchenko Hong Wen Dan Zhao Haipeng Guan Liling Wan He Huang Zhanyun Tang Yingming Zhao Robert G.Roeder Xiaobing Shi C.David Allis 李海涛 | 2017 | 科学新闻2017，19，4： | 0 |
| 15 | 组蛋白修饰通过促成相分离机制来调节染色质区室化显示文摘文章简介真核染色体包含各种功能的区室,这些区室由特定的组蛋白修饰标记。但是,人们对这些组蛋白标记在染色体区室化中起作用的分子机制了解甚少。组成型异染色质是一个高度沉默的染色体区室,部分特征在于组蛋白H3K9的二甲基化和三甲基化修饰标记(H3K9me2/3)。 | 王亮 郜一飞 郑向东 Cuifang Liu Shuangshuang Dong Ru Li Guanwei Zhang Yixuan Wei Hongyuan Qu Yuhan Li C.David Allis Guohong Li 李海涛 李丕龙 | 2020 | 科学新闻2020，，2： | 0 |
| 16 | Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells显示文摘While Mek1/2 and Gsk3βinhibition('2i')supports the maintenance of murine embryonic stem cells(EsCs)in a homogenous naive state,prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmental potential.Additionally,2i fails to support derivation and culture of fully potent female ESCs.Here we find that mouse ESCs cultured in 2i/LIF supplemented with lipid-rich albumin(AlbuMAx)undergo pluripotency transition yet maintain genomic stability and full potency over long-term culture.Mechanisticaily,lipids in AlbuMAx impact intracellular metabolism including nucleotide biosynthesis,lipid biogenesis,and TCA cycle intermediates,with enhanced expression of DNMT3s that prevent DNA hypomethylation.Lipids induce a formative-like pluripotent state through direct stimulation of Erk2 phosphorylation,which also alleviates X chromosome loss in female ESCs.Importantly,both male and female'all-ESc'mice can be generated from de novo derived ESCs using AlbuMAXbased media.Our findings underscore the importance of lipids to pluripotency and link nutrient cues to genome integrity in early development. | Liangwen Zhong Miriam Gordillo Xingyi Wang Yiren Qin Yuanyuan Huang Alexey Soshnev Ritu Kumar Gouri Nanjangud Daylon James C.David Allis Todd Evans Bryce Carey Duancheng Wen | 2023 | Protein & Cell2023，14，8： | 0 |
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