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| 1 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 2 | To inhibit coffee ring effect in inkjet printing of light-emitting polymer films by decreasing capillary force显示文摘Polymer thin film with uniform thickness and flat surface profile is the key point for polymer light emitting diodes(PLEDs) by inkjet printing. However, the coffee ring effect is usually observed due to the mismatch between the evaporation of the solvent and the decrease of solution volume, which promotes the formation of radial flow from the interior of the drop to the edge. In this paper, coffee ring effects of inkjet printed poly(spirobifluorene) films were proposed to be restrained by decreasing capillary force by adding co-solvent with high boiling point and high viscosity to the main solvent. The low evaporation rate of the co-solvent can reduce the driving force of the radial flow; meanwhile the high viscosity of the co-solvent can increase the resistance of the radial flow. Thus, polymer films with improve uniformity can be obtained due to the suppression of the radial flow. The device performance was greatly improved under the condition of proper film thickness and film uniformity and the maximum luminous efficiency of devices with inkjet printed poly(spirobifluorene) can reach 80% of the spin-coated devices. | Xinhong Yu Rubo Xing Zhongxiang Peng Yangming Lin Zhonghui Du Junqiao Ding Lixiang Wang Yanchun Han | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 3 | Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington’s Disease显示文摘Huntington's disease(HD) is a deadly neurodegenerative disease with abnormal expansion of CAG repeats in the huntingtin gene. Mutant Huntingtin protein(m HTT) forms abnormal aggregates and intranuclear inclusions in specific neurons, resulting in cell death. Here,we tested the ability of a natural heat-shock protein 90 inhibitor, Gedunin, to degrade transfected m HTT in Neuro-2 a cells and endogenous m HTT aggregates and intranuclear inclusions in both fibroblasts from HD patients and neurons derived from induced pluripotent stem cells from patients. Our data showed that Gedunin treatment degraded transfected m HTT in Neuro-2 a cells, endogenous m HTT aggregates and intranuclear inclusions in fibroblasts from HD patients, and in neurons derived from induced pluripotent stem cells from patients in a dose-and time-dependent manner, and its activity depended on the proteasomal pathway rather than the autophagy route. These findings also showed that although Gedunin degraded abnormal m HTT aggregates and intranuclear inclusions in cells from HD patient, it did not affect normal cells, thus providing a new perspective for using Gedunin to treat HD. | Weiqi Yang Jingmo Xie Qiang Qiang Li Li Xiang Lin Yiqing Ren Wenlei Ren Qiong Liu Guomin Zhou Wenshi Wei Hexige Saiyin Lixiang Ma | 2019 | Neuroscience Bulletin2019，35，6： | 2 |
| 4 | The S 1P, receptor-selective agonist CYM-5442 reduces the severity of acute GVHD byinhibiting macrophage recruitment显示文摘FTY720,为五已知的 sphingosine-1-phosphate (S1P ) 中的四个的收缩筋受体,被报导了禁止尖锐 graft-versus-host 疾病(aGVHD ) 。因为 FTY720 通过多重 S1P 受体工作,通过至少一这些受体的行动的机制可以说明它的副作用。因此,更选择的 S1P 受体调节的人被需要评估不同 S1P 受体和他们的治疗学的功效的角色。在这研究,我们调查了 S1P 1-selective 收缩筋的效果, CYM-5442,在 aGVHD 的前进上。我们显示出显著地禁止的那 CYM-5442 但是没阻止 aGVHD。CYM-5442 没影响施主 T 细胞的渗入进目标器官,当在 GVHD 器官的巨噬细胞的数字被 CYM-5442 处理显著地减少时。在 vivo 增长,试金证明巨噬细胞的增长没被 CYM-5442 压制。用人的 endothelial 房间的进一步的研究在 endothelial 房间表明了那 CYM-5442 处理 downregulated CCL2 和 CCL7 表情,因此减少单核白血球,从纸巾,巨噬细胞发源的迁居。我们的数据在 aGVHD 和它行动的可能的机制表明 S1P 1-selective 收缩筋的治疗学的功效。结果建议进一步的调查为 aGVHD 作为潜在的治疗学的政体关于 CYM-5442 被需要。 | Qiao Cheng Shoubao Ma Dandan Lin Yu Mei Huanle Gong Lei Lei Yuanyuan Chen Ye Zhao Bo Hut Yan Wu Xiao Yu Lixiang Zhao Haiyan Liu | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 5 | Overweight, obesity, and their associations with insulin resistance and β -cell function among Chinese: a cross-sectional study in China显示文摘 | Gang Chen Chune Liu Jin Yao Qiqin Jiang Nianhui Chen Huibin Huang Jixing Liang Liantao Li Lixiang Lin | 2010 | Metabolism2010，，12： | 1 |
| 6 | Alkyl-chain branched effect on the aggregation and photophysical behavior of polydiarylfluorenes toward stable deep-blue electroluminescence and efficient amplified spontaneous emission显示文摘The control of the condensed superstructure of light-emitting conjugated polymers(LCPs)is a crucial factor to obtain high performance and stable organic optoelectronic devices.Side-chain engineering strategy is an effective platform to tune inter chain aggregation and photophysical behaviour of LCPs.Herein,we systematically investigated the alkyl-chain branched effecton the conformational transition and photophysical behaviour of polydiarylfluorenes toward efficient blue optoelectronic devices.The branched side chain will improve materials solubility to inhibit interchain aggregation in solution according to DLS and optical analysis,which is useful to obtain high quality film.Therefore,our branched PEODPF,POYDPF pristine film present high luminance efficiency of 36.1%and 39.6%,enhanced about 20%relative to that of PODPF.Compared to the liner-type sides'chain,these branched chains also suppress chain planarization and improve film morphological stability effectively.Interestingly,the branched polymer also had excellent stable amplified spontaneous emission(ASE)behaviour with low threshold(4.72μJ/cm2)and a center peak of 465 nm,even thermal annealing at 220℃in the air atmosphere.Therefore,side-chain branched strategy for LCPs is an effective means to control interchain aggregation,film morphology and photophysical property of LCPs. | Lili Sun Ning Sun Lubing Bai Xiang An Bin Liu Chen Sun Lixiang Fan Chuanxin Wei Yamin Han Mengna Yu Jinyi Lin Dan Lu Ning Wang Linghai Xie Kang Shen Xinwen Zhang Yanan Xu Juan Cabanillas-Gonzalez Wei Huang | 2019 | Chinese Chemical Letters2019，30，11： | 1 |
| 7 | Prevalence of diabetes among menand women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping Jia Weiping Ji Linong Xiao Jianzhong Shan Zhongyan Liu Jie Tian Ha- oming Ji Qiuhe Zhu Dalong Ge Jiapu Lin Lixiang Chen Li Guo Xiaohui Zhao Zhigang Li Qiang Zhou Zhiguang Shan Guangliang He Jiang | 2010 | N Engl J Med2010，362，： | 1 |
| 8 | Serum Lipids and Lipoproteins in Chinese Men and Women显示文摘 | Wenying Yang Jianzhong Xiao Zhaojun Yang Linong Ji Weiping Jia Jianping Weng Juming Lu Zhongyan Shan Jie Liu Haoming Tian Qiuhe Ji Dalong Zhu Jiapu Ge Lixiang Lin Li Chen Xiaohui Guo Zhigang Zhao Qiang Li Zhiguang Zhou Guangliang Shan Jiang He | 2012 | Circulation2012，，18： | 1 |
| 9 | Isolation of Endophytic Actinomycetes From Roots and Leaves of Banana (Musa Acuminata) Plants and Their Activities Against Fusarium oxysporumf. sp. cubense显示文摘 | Lixiang Cao Zhiqi Qiu Xin Dai Hongming Tan Yongcheng Lin Shining Zhou | 2004 | World Journal of Microbiology and Biotechnology2004，，5： | 1 |
| 10 | Review on Enhancement of Nitridation of Si Powder显示文摘This paper reviewed the effect of powder characteristics and additives including metals,rare earth oxides,and ZrO_2 on nitridation of Si powder.The decrease of particle size of Si powder increased nitridation.Most of metal additives inhibited nitridation,while some metal additives such as Fe,Cu,Cr,and Ca increased nitrida—tion.Otherwise,the addition of metals might lead to the degradation of physical and mechanical properties of Si_3N_4.All the rare earth oxides,especially CeO_2 and Eu_2O_3,showed nitridation enhancing effect.In addition,ZrO_2 with small particle size showed a stronger enhancing effect. | GUO Weiming WU Lixiang LIN Huatay ZHANG Guojun | 2015 | China's Refractories2015，24，3： | 1 |
| 11 | Frequency upconversion detection of rotational Doppler effect显示文摘We demonstrated an efficient scheme of measuring the angular velocity of a rotating object with the detection light working at the infrared regime.Our method benefits from the combination of second-harmonic generation(SHG)and rotational Doppler effect,i.e.,frequency upconversion detection of rotational Doppler effect.In our experiment,we use one infrared light as the fundamental wave(FW)to probe the rotating objects while preparing the other FW to carry the desired superpositions of orbital angular momentum.Then these two FWs are mixed collinearly in a potassium titanyl phosphate crystal via typeⅡphase matching,which produces the visible secondharmonic light wave.The experimental results show that both the angular velocity and geometric symmetry of rotating objects can be identified from the detected frequency-shift signals at the photon-count level.Our scheme will find potential applications in infrared monitoring. | HAOXU GUO XIAODONG QIU SONG QIU LING HONG FEI LIN YUAN REN LIXIANG CHEN | 2022 | Photonics Research2022，10，1： | 1 |
| 12 | Attenuation of hearing loss in DBA/2J mice by anti-apoptotic treatment显示文摘 | Linlin Yang Heng Zhang Xu Han Xin Zhao Fangyuan Hu Ping Li Gang Xie Lixiang Gao Lin Cheng Xicheng Song Fengchan Han | 2015 | Hearing Research2015，，： | 1 |
| 13 | Secreted IL‐1α promotes T‐cell activation and expansion of CD11b+Gr1+ cells in carbon tetrachloride‐induced liver injury in mice显示文摘 | Dandan Lin Lei Lei Yinsheng Zhang Bo Hu Guangming Bao Yonghao Liu Yuan Song Chunliang Liu Yan Wu Lixiang Zhao Xiao Yu Haiyan Liu | 2015 | Eur. J. Immunol2015，，： | 1 |
| 14 | Association study of genetic variants of 17 diabetes‐related genes/loci and cardiovascular risk and diabetic nephropathy in the C hinese S he population (中国畲族人群17个糖尿病相关基因位点的遗传变异与心血管风险和糖尿病肾病的相关性)显示文摘 | Gang Chen Yuan Xu Yinghua Lin Xiaolan Lai Jin Yao Baoying Huang Zichun Chen Huibin Huang Xianguo Fu Lixiang Lin Shenghan Lai Junping Wen | 2013 | Journal of Diabetes2013，，2： | 1 |
| 15 | Macroscopic assembled graphene nanofilms based room temperature ultrafast mid-infrared photodetectors显示文摘Graphene with linear energy dispersion and weak electron-phonon interaction is highly anticipated to harvest hot electrons in a broad wavelength range.However,the limited absorption and serious backscattering of hot-electrons result in inadequate quantum yields,especially in the mid-infrared range.Here,we report a macroscopic assembled graphene(nMAG)nanofilm/silicon heterojunction for ultrafast mid-infrared photodetection.The assembled Schottky diode works in 1.5-4.0μm at room temperature with fast response(20-30 ns,rising time,4 mm2 window)and high detectivity(1.61011 to 1.9109 Jones from 1.5 to 4.0μm)under the pulsed laser,outperforming single-layer-graphene/silicon photodetectors by 2-8 orders.These performances are attributed to the greatly enhanced photo-thermionic effect of electrons in nMAG due to its high light absorption(~40%),long carrier relaxation time(~20 ps),low work function(4.52 eV),and suppressed carrier number fluctuation.The nMAG provides a long-range platform to understand the hot-carrier dynamics in bulk 2D materials,leading to broadband and ultrafast MIR active imaging devices at room temperature. | Li Peng Lixiang Liu Sichao Du Srikrishna Chanakya Bodepudi Lingfei Li Wei Liu Runchen Lai Xiaoxue Cao Wenzhang Fang Yingjun Liu Xinyu Liu Jianhang Lv Muhammad Abid Junxue Liu Shengye Jin Kaifeng Wu Miao-Ling Lin Xin Cong Ping-Heng Tan Haiming Zhu Qihua Xiong Xiaomu Wang Weida Hu Xiangfeng Duan Bin Yu Zhen Xu Yang Xu Chao Gao | 2022 | InfoMat2022，4，6： | 1 |
| 16 | Screening for Anti-tumor Activity of Fractions from Buddleja officinalis Maxim显示文摘[Objectives]The anti-tumor activity of fractions from Buddleja officinalis Maxim.by petroleum ether,ethyl acetate,n-butanol and water solvent was studied.[Methods]The ethanol extract from B.officinalis Maxim.was extracted and then concentrated with petroleum ether,ethyl acetate,n-butanol and water,respectively,and the extracts were obtained.The inhibitory effects of the four different fractions on the growth of three tumor cell lines in vitro were detected by CCK-8 method,and the median inhibitory concentration(IC 50 value)was calculated.[Results]The four fractions inhibited the growth of the three tumor cell lines in vitro,among which the n-butanol fraction had the best anti-tumor activity.The IC 50 values of the n-butanol fraction on human gastric cancer(SGC-7901),human breast cancer(MCF-7)and human liver cancer(BEL-7404)cell lines were 0.08,1.58 and 0.12 mg/mL,respectively.[Conclusions]Petroleum ether,ethyl acetate,n-butanol and water fractions from the ethanol extract of B.officinalis Maxim.had certain anti-tumor effects,and the n-butanol fraction had the best anti-tumor activity. | Tong LI Xin XIE Liyuan LI Aipeng LI Zhidong LEI Tingting HE Sirui MO Shangfeng HUANG Yao LIN Suoyi HUANG Lixiang LU Shiyou ZHOU | 2024 | Medicinal Plant2024，15，2： | 0 |
| 17 | Specification Requirement for Thermal Stability of Sintered NdFeB Materials for Electrical Machines显示文摘Based on IEC standards and Chinese national standards of sintered NdFeB materials, in the paper the hightemperature, room-temperature properties and thermal stability of about one hundred samples of NdFeB materials for electrical machines were measured and analyzed.These materials are produced by ten representative manufactories in China.Combined with the analysis results, the paper points out that the magnetic properties of sintered NdFeB materials for electrical machines should meet not only the specific values in standards, such as Br, (BH)max ,HcJ ,but also the requirement of temperature coefficients a (Br) , a (HcJ). | Lin Yan Jiang Daiwei Chen Lixiang Chen Hailing Bi Haitao Tang Renyuan | 2004 | Journal of Rare Earths2004，22，z1： | 0 |
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