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| 1 | Simultaneous in-situ determination of U-Pb age and trace elements in zircon by LA-ICP-MS in 20 μm spot size显示文摘Simultaneous in-situ determination of U-Pb ages and 20 trace elements of three international zircon standards(91500,GJ1 and TEMORA 1) and one laboratory zircon standard(SK10-2) separated from Cenozoic fine-grained gabbro was carried out on quadrupole ICP-MS equipped with 193 nm excimer laser in 20 μm spot size. The weighted mean 206Pb/238U ages of 91500,GJ1 and TEMORA 1 are 1064.4±4.8 Ma(2σ ),603.2±2.4 Ma(2σ ) and 418.2±2.4 Ma(2σ ),respectively. The relative standard de-viations(RSDs) of 206Pb/238U ages(2σ ) are less than 2.2% for single measurements and 0.6% for weighted means. The obtained weighted mean 206Pb/238U ages of three standard zircons agree with the recommended values within 2σ error. The weighted mean 206Pb/238U age of SK10-2 is 31.42±0.25 Ma(2σ ) and the RSDs of 206Pb/238U ages(2σ ) are between 2.4% and 5.7% for single measurements and less than 0.8% for weighted mean. The obtained weighted mean 206Pb/238U age is in good agreement with the age obtained by Yuan(2004). Trace element concentrations of NIST612 and NIST614 obtained under the same LA-ICP-MS operating conditions agree with the recommended values within analytical error. The results indicate that it is possible to measure U-Pb age and trace elements simultaneously by LA-ICP-MS in a small spot size of 20 μm. | LIU XiaoMing GAO Shan DIWU ChunRong YUAN HongLin HU ZhaoChu | 2007 | Chinese Science Bulletin2007，52，9： | 107 |
| 2 | Reappraisement and refinement of zircon U-Pb isotope and trace element analyses by LA-ICP-MS显示文摘A protocol was established for simultaneous measurements of zircon U-Pb ages and trace elements by LA-ICP-MS at spot sizes of 16 32 μm.This was accomplished by introducing N 2 into ICP to increase the sensitivity.The obtained U-Pb ages for zircon standards GJ-1,TEMORA and SK10-2 are consistent with the preferred values within about 1% uncertainty (2σ) by simple external calibration against zircon standard 91500.Different data reduction softwares could yield different uncertainties for calculation of U-Pb ages.The commercially available program GLITTER4.4 could apply an improper uncertainty calculation strategy,but it may yield artificial high precisions for single analyses.Our trace element analyses indicate that Si is not an ideal internal standard for zircon when calibrated against the NIST glasses.Calibration against the NIST glasses using Si as an internal standard,a systematic deviation of 10% 30% was found for most trace elements including Zr.However,the trace element compositions of zircon can be accurately measured by calibration against multiple reference materials with natural compositions (e.g.,BCR-2G,BHVO-2G and BIR-1G),or calibration against NIST SRM 610 and using Zr as an internal standard.Analyses of two pieces of GJ-1 demonstrate that it is relatively homogenous for most trace elements (except for Ti). | LIU YongSheng HU ZhaoChu ZONG KeQing GAO ChangGui GAO Shan XU Juan CHEN HaiHong | 2010 | Chinese Science Bulletin2010，55，15： | 1011 |
| 3 | Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul... | WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 | 1998 | World Journal of Gastroenterology1998，4，4： | 295 |
| 4 | The novel quantitative trait locus GL3.1 controls rice grain size and yield by regulating Cyclin-T1;3显示文摘增加的庄稼收益被要求支持世界范围的快速的人口生长。谷物重量是米饭产量的一个关键部件,但是控制它的内在的分子的机制留下逃犯。这里,我们报导为米饭谷物长度,重量和产量的控制克隆和一个新量的特点地点(QTL ) 的描述。这个地点, GL3.1,编码蛋白质磷酸酶 kelch (PPKL ) 家庭 —Ser/Thr 磷酸酶。GL3.1 是大谷物 WY3 变化的一个成员,它比小谷物 FAZ1 变化与更弱的 dephosphorylation 活动被联系。GL3.1-WY3 在小穗状花小穗影响蛋白质 phosphorylation 加速房间分割,从而导致更长的谷物和更高的收益。进一步的研究直接显示出那 GL3.1 dephosphorylates 它的底层, Cyclin-T1; 3,它很少仅仅在植物被学习了。Cyclin-T1 的 downregulation; 3 在更短的谷物导致了米饭,它在房间周期规定为 Cyclin-T 显示新奇功能。我们的调查结果为通过影响 Cyclin-T1 的 phosphorylation 的新奇调停磷酸酶的进程被驾驶的谷物尺寸和产量的规定建议新机制; 3 在房间周期前进期间,并且这样提供新卓见进位于庄稼种子开发下面的机制。我们引起了包含表明了增加的谷物产量的自然 GL3.1 等位基因的一个新变化,它显示 GL3.1 是为引起产量很高的庄稼的一个强大的工具。 | Peng Qi You-Shun Lin Xian-Jun Song Jin-Bo Shen Wei Huang Jun-Xiang Shan Mei-Zhen Zhu Liwen Jiang Ji-Ping Gao Hong-Xuan Lin | 2012 | Cell Research2012，22，12： | 132 |
| 5 | The Chinese Society of Clinical Oncology(CSCO):clinical guidelines for the diagnosis and treatment of gastric cancer显示文摘China is one of the countries with the highest incidence of gastric cancer.There are differences in epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selection between gastric cancer patients from the Eastern and Western countries.Non-Chinese guidelines cannot specifically reflect the diagnosis and treatment characteristics for the Chinese gastric cancer patients.The Chinese Society of Clinical Oncology(CSCO)arranged for a panel of senior experts specializing in all sub-specialties of gastric cancer to compile,discuss,and revise the guidelines on the diagnosis and treatment of gastric cancer based on the findings of evidence-based medicine in China and abroad.By referring to the opinions of industry experts,taking into account of regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted experts’consensus judgement on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes.This guideline uses tables and is complemented by explanatory and descriptive notes covering the diagnosis,comprehensive treatment,and follow-up visits for gastric cancer. | Feng-Hua Wang Lin Shen Jin Li Zhi-Wei Zhou Han Liang Xiao-Tian Zhang Lei Tang Yan Xin Jing Jin Yu-Jing Zhang Xiang-Lin Yuan Tian-Shu Liu Guo-Xin Li Qi Wu Hui-Mian Xu Jia-Fu Ji Yuan-Fang Li Xin Wang Shan Yu Hao Liu Wen-Long Guan Rui-Hua Xu | 2019 | Cancer Communications2019，39，1： | 127 |
| 6 | Determination of U-Pb age and rare earth element concentrations of zircons from Cenozoic intrusions in northeastern China by laser ablation ICP-MS显示文摘Using the in situ zircon U-Pb dating method of LA-ICPMS, we analyzed the 31 Ma old SHRIMP U-Pb age of the Yongsheng nepheline syenite from southern Jilin Province under different spot sizes. The obtained ages are comparable with that of SHRIMP in both accuracy and precision. The age is also identical to that of the Yinmawanshan gabbro from the Liaodong Peninsula within error. Both the Yongsheng nepheline syenite and the Yinmawanshan gabbro represent the youngest known exposed intrusions in northeastern and even eastern China. The results indicate the Eocene mantle-derived magmatic underplating, and the rapid crustal uplifting of this region since 30 Ma. The analyses also document extremely high LREE concentrations and relatively flat REE patterns for the zircons from the Yongsheng nepheline syenite, which represent a new type of zircon REE pattern. | YUAN Honglin WU Fuyuan GAO Shan LIU Xiaoming XU Ping SUN Deyou | 2003 | Chinese Science Bulletin2003，48，22： | 252 |
| 7 | North Qinling Paleozoic granite associations and their variation in space and time: Implications for orogenic processes in the orogens of central China显示文摘Integrated zircon U-Pb dating and whole rock geochemical analyses have been carried out for two typical S-and I-type granitoids in the north Qinling. Zircon dating by SIMS of the Piaochi S-type grani- toids yields an emplacement age of 495±6 Ma. The granitoids show whole-rock εNd(t)=-8.2--8.8, zircon εHf(t)=-6―-39. The Huichizi I-type granitoids have emplacement ages of 421±27 Ma and 434±7 Ma es- tablished by LA-ICP-MS and SIMS methods, respectively. Their whole-rock εNd(t)=-0.9-0.9 and zircon εHf(t)=-11-8.4. Combined with statistical analyses of 28 zircon ages of granitoid plutons collected from the literature, Paleozoic magmatism in the north Qinling can be divided into three stages. The first-stage magmatism (~505-470 Ma) mainly occurred in the east part of the north Qinling and has features of an I-type arc, associated with which are S-type granitoids such as Piaochi pluton. The early granitoids (~505-490 Ma) have close spatio-temporal relations to ultra-high-pressure (UHP) rocks, and thus are interpreted as an oceanic subduction system along a continental margin. The second-stage magmatism (~450-422 Ma) occured through the whole north Qinling, and is characterized by I-type granitoids represented by the Huichizi pluton. The magma is interpreted as partial melting of lower crust mixed by mantle-derived magma in a collisional setting with the uplift of terranes. The third-stage magmatism (~415-400 Ma) is dominated by I-type granitoids and only took place in the middle part of the north Qinling, and is regarded as a late-stage collision. The spatial and temporal variations of the Qinling Paleozoic magmatism reveal protracted subduction/collision. The subduction was initiated from the east part of the north Qinling, earlier than that in the Qilian-northern Qaidam, Kunlun, and northern Dabie regions. This demonstrates variations in time of subduction, accretion and collision of separate blocks or terranes in the orogenic systems in central China. | WANG Tao WANG XiaoXia TIAN Wei ZHANG ChengLi LI WuPing LI Shan | 2009 | Science China Earth Sciences2009，52，9： | 79 |
| 8 | Peer-to-Peer环境下多粒度Trust模型构造显示文摘信任是多方面的,在不同的应用场景中,同一节点在不同领域具有不同的可信度.现有信任模型粒度过于粗糙,不能很好地解决同一Peer节点在不同领域、不同方面的可信度计算问题.据此,提出一种新的Peer-to-Peer环境下的多粒度信任模型,并给出该模型的数值分析和分布式实现方法.分析及仿真结果表明,该模型与已有模型相比,在可信度计算的粒度、模型的安全性等方面有较大的提高. | 张骞 张霞 文学志 刘积仁 Ting Shan | 2006 | 软件学报2006，17，1： | 71 |
| 9 | 我国5城市合格献血者血液HIV及HCV残余风险研究显示文摘目的研究我国献血者血液HIV及HCV残余风险;评估我国开展血液核酸检测(NAT)的可行性和必要性。方法采集乌鲁木齐、昆明、北京、广州、杭州5城市献血者血样,用Chiron Procleix HIV-1/HCV Assay血液核酸检测体系,对各项血清学筛查均合格的89 467份血液作16人份混合血样NAT检测,凡筛查不合格血样再作单人份检测;对于抗-HCV阴性而HCV RNA NAT阳性者,用备用管作抗-HCV、ALT、及HCV RNA NAT复检。结果共检出HCV RNA NAT阳性但抗-HCV EIA阴性标本3例,未检出HIV RNA NAT阳性但抗-HIV EIA阴性标本;在87 034份血清学筛查合格献血者中,检出HCV NAT阳性2例,其中1例复检ALT为254U/L,未检出HIVNAT阳性;在2 613份血清学筛查不合格者中,检出1例HCV NAT阳性但抗-HCV EIA阴性标本,该献血者抗-HIV阳性、ALT 372U/L;未检出HIV NAT阳性但抗-HIV EIA阴性的标本。结论血清学筛查使我国的血液安全性已有相当高的保障;而NAT技术可进一步提高血液的安全性,但在我国是否可应用于常规血液筛查,需考虑成本与效益比。此外,ALT筛查对排除抗-HCV漏检血液仍有一定的作用。 | 任芙蓉 王憬惺 赵海燕 文国新 张远志 姚富柱 高国静 严力行 江朝富 白旭华 美黑丽.铁木尔 涂源泉 朱发明 郑优荣 崔莉 龚晓燕 吕秋霜 刘长利 郑鹏 NESS Paul SHAN Hua | 2007 | 中国输血杂志2007，20，6： | 66 |
| 10 | Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial显示文摘 | CUI Li-ying ZHUYi-cheng GAO Shan WANG Jian-ming PENG Bing NI Jun ZHOU Li-xin HE Jia MA Xiu-qiang | 2013 | Chinese Medical Journal2013，，18： | 71 |
| 11 | Opportunities and challenges of the Sponge City construction related to urban water issues in China显示文摘Waterlogging is one of the major water issues in most cities of China and directly restricts their urbanization processes.The construction of Sponge City is an effective approach to solving the urban water issues,particularly for the waterlogging.In this study,both the urban issues emerged at the stage of rapid urbanization in China and the demands as well as problems of Sponge City construction related with the water issues were investigated,and the opportunities and challenges for the Sponge City construction in the future were also proposed.It was found that the current stormwater management focused on the construction of gray infrastructures(e.g.,drainage network and water tank) based on the fast discharge idea,which was costly and hard to catch up with the rapid expansion of city and its impervious surface,while green infrastructures(e.g.,river,lake and wetland)were ignored.Moreover,the current construction of Sponge City was still limited to low impacted development(LID) approach which was concentrated on source control measures without consideration of the critical functions of surrounding landscapes(i.e.,mountain,river,wetland,forest,farmland and lake),while application of the integrated urban water system approach and its supported technologies including municipal engineering,urban hydrology,environmental science,social science and ecoscape were relatively weak and needed to be improved.Besides,the lack of special Sponge City plan and demonstration area was also a considerable problem.In this paper,some perspectives on Good Sponge City Construction were proposed such as the point that idea of urban plan and construction should conform to the integral and systematic view of sustainable urban development.Therefore,both the basic theoretical research and the basic infrastructure construction such as monitoring system,drainage facility and demonstration area should be strengthened,meanwhile,the reformation and innovation in the urban water management system and the education system should also be urgently performed.The study was expected to provide a deeper thinking for the current Sponge City construction in China and to give some of suggestions for the future directions to urban plan and construction,as well as urban hydrology discipline. | XIA Jun ZHANG YongYong XIONG LiHua HE Shan WANG LongFeng YU ZhongBo | 2017 | Science China Earth Sciences2017，60，4： | 65 |
| 12 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 13 | Fecal microbiota transplantation broadening its application beyond intestinal disorders显示文摘Intestinal dysbiosis is now known to be a complication in a myriad of diseases.Fecal microbiota transplantation(FMT),as a microbiota-target therapy,is arguably very effective for curing Clostridium difficile infection and has good outcomes in other intestinal diseases.New insights have raised an interest in FMT for the management of extra-intestinal disorders associated with gut microbiota.This review shows that it is an exciting time in the burgeoning science of FMT application in previously unexpected areas,including metabolic diseases,neuropsychiatric disorders,autoimmune diseases,allergic disorders,and tumors.A randomized controlled trial was conducted on FMT in metabolic syndrome by infusing microbiota from lean donors or from self-collected feces,with the resultant findings showing that the lean donor feces group displayed increased insulin sensitivity,along with increased levels of butyrate-producing intestinal microbiota.Case reports of FMT have also shown favorable outcomes in Parkinson's disease,multiple sclerosis,myoclonus dystonia,chronic fatigue syndrome,and idiopathic thrombocytopenic purpura.FMT is a promising approach in the manipulation of the intestinal microbiota and has potential applications in a variety of extra-intestinal conditions associated with intestinal dysbiosis. | Meng-Que Xu Hai-Long Cao Wei-Qiang Wang Shan Wang Xiao-Cang Cao Fang Yan Bang-Mao Wang | 2015 | World Journal of Gastroenterology2015，21，1： | 63 |
| 14 | Preventive treatments for recurrence after curative resection of hepatocellular carcinoma-A literature review of randomized control trials显示文摘To review the inhibitory effect of preventive approaches on recurrence after operation in patients with hepatocellular carcinoma (HCC), we summarized all available publications. reporting randomized control trial indexed in PubMed. The treatment approaches presented above included preoperative transcatheter arterial chemoembolization (TACE),post-operative TACE, systemic or locoregional chemotherapy,immunotherapy, Interferons and acyclic retinoic acid Although no standard treatment has been established,several approaches presented promising results, which were both effective and tolerable in post-operative patients. Preoperative TACE was not effective on prolonging survivals,while post-operative TACE was shown with both diseasefree survival and overall survival benefits in some papers,however, it was also questioned by others. Systemic chemotherapy was generally not effective on prolonging survival but also poorly tolerated for its significant toxicities.Adoptive immunotherapy using LAK cells was proved to be beneficial to patients' survival in a recent paper. Interferon and Interferon β can inhibit recurrence in HCC patients with HCV infection background, though the mechanism is not fully understood. Acyclic retinoic acid was shown to decrease multi-centric recurrence after operation, which was reported by only one group. In conclusion, several adjuvant approaches have been studied for their efficacy on recurrence in HCC patients in randomized control trials; however, multi-centric randomized control trial is still needed for further evaluation on their efficacy and systemic or local toxicities;in addition, new adjuvant treatment should be investigated to provide more effective and tolerable methods for the patients with HCC after operation. | Hui-Chuan Sun Zhao-You Tang Liver Cancer Institute and Zhong Shan Hospital,Fudan University,Shanghai 200032,China | 2003 | World Journal of Gastroenterology2003，9，4： | 63 |
| 15 | Improved quality of life in patients with gastric cancer after esophagogastrostomy reconstruction显示文摘AIM:To compare postoperative quality of life (QOL) in patients with gastric cancer treated by esophagogastrostomy reconstruction after proximal gastrectomy.METHODS: QOL assessments that included functional outcomes (a 24-item survey about treatment-specific symptoms) and health perception (Spitzer QOL Index) were performed in 149 patients with gastric cancer in the upper third of the stomach, who had received proximal gastrectomy with additional esophagogastrostomy.RESULTS: Fifty-four patients underwent reconstruction by esophagogastric anterior wall end-to-side anastomosis combined with pyloroplasty (EA group); 45 patients had reconstruction by esophagogastric posterior wall end-to-side anastomosis (EP group); and 50 patients had reconstruction by esophagogastric end-to-end anastomosis (EE group). The EA group showed the best postoperative QOL, such as recovery of body weight, less discomfort after meals, and less heart burn or belching at 6 and 24 mo postoperatively. However, the survival rates, surgical results and Spitzer QOL index were similar among the three groups.CONCLUSION: Postoperative QOL was better in the EA than EP or EE group. To improve QOL after proximal gastrectomy for upper third gastric cancer, the EA procedure using a stapler is safe and feasible for esophagogastrostomy. | Hao Zhang Zhe Sun Hui-Mian Xu Ji-Xian Shan Shu-Bao Wang Jun-Qing Chen | 2009 | World Journal of Gastroenterology2009，15，25： | 54 |
| 16 | Delamination and destruction of the North China Craton显示文摘This article presents an overview on recent developments in studies of chemical and physical processes of lithospheric delamination with respect to destruction of the North China Craton. It is emphasized that the pyroxenite source resulting from interaction between eclogite-derived melt and peridotite is a direct consequence of delamination. The pyroxenite source thus formed has unique mineralogical and geochemical features, which characterize Mesozoic basalts of the North China Craton. Melt-peridotite interaction played an important role in refertilization of cratonic lithospheric mantle, leading to density increase, weakening and final destabilization of the North China Craton. The nature of the melt is the key to distinguish mechanisms of destructing this craton. | GAO Shan ZHANG JunFeng XU WenLiang LIU YongSheng | 2009 | Chinese Science Bulletin2009，54，19： | 53 |
| 17 | Stress changes on major faults caused by M_w7.9 Wenchuan earthquake,May 12,2008显示文摘On May 12,2008,a magnitude 7.9 earthquake ruptured the Longmenshan fault system in Sichuan Province,China,collapsing buildings and killing tens of thousands people.As predicted,aftershocks may last for at least one year,and moreover,large aftershocks are likely to occur.Therefore,it is critical to outline the areas with potential aftershocks before reconstruction and resettling people as to avoid future disasters.It is demonstrated that the redistribution of stress induced by an earthquake should trigger successive seismic activity.Based on static stress triggering theory,we calculated the coseismic stress changes on major faults induced by the Wenchuan earthquake,with elastic dislocation the-ory and the multilayered crustal model.We also discuss the stress distribution and its significance for future seismic activity under the impact of the Wenchuan earthquake.It is shown that coulomb failure stress(CFS) increases obviously on the Daofu-Kangding segment of the Xianshuihe Fault,the Maqu and Nanping segment of the Eastern Kunlun Fault,the Qingchuan Fault,southern segment of the Min-jiang Fault,Pengxian-Guanxian Fault,Jiangyou-Guangyuan Fault,and Jiangyou-Guanxian Fault.The increased stress raises the probability of earthquake occurrence on these faults.Since these areas are highly populated,earthquake monitoring and early disaster alarm system are needed.CFS increases with a magnitude of 0.03―0.06 MPa on the Qingchuan Fault,which is close to the northern end of the rapture of Wenchuan earthquake.The occurrence of some strong aftershocks,including three events with magnitude higher than 5.0,indicates that the seismic activities have been triggered by the main shock.Aftershocks seem to migrate northwards.Since the CFS change on the Lueyang-Mianxian Fault located on the NEE of the Qingchuan Fault is rather small(±0.01 MPa),the migration of aftershocks might be terminated in the area near Hanzhong City.The CFS change on the western Qinling Fault is around 10 Pa,and the impact of static triggering can be neglected.The increment of CFS on the Pengxian-Guanxian Fault and Beichuan-Yingxiu Fault southwest to the main rupture is 0.005―0.015 MPa,which would facilitate earthquake triggering in these areas.Very few aftershocks in these areas indicate that the accumulated stress has not been released sufficiently.High seismic risk is predicated in these areas due to coseismic CFS loading.The Wenchuan earthquake released the accumulated CFS on the Fubianhe Fault,the Huya Fault,the Ha'nan-Qingshanwan Fault,and the Diebu-Bailongjiang Fault.The decrement of CFS changes on the Longquanshan Fault east to Chengdu City is about 0.002 MPa.The seismic activity will be depressed by decrement of CFS on these faults. | SHAN Bin XIONG Xiong ZHENG Yong DIAO FaQi | 2009 | Science China Earth Sciences2009，52，5： | 47 |
| 18 | Panax notogiseng saponin inhibits ischemia-induced apoptosis by activating PI3K/Akt signal pathway in cardiomyocytes显示文摘The panax notoginseng saponin(PNS) had been clinically used for the treatment of cardiovascular diseases and stroke in China.It had been demonstrated that PNS could protect cardiomyocytes from injury induced by ischemi- a,but the underlying molecular mechanisms of this protective effect were still unclear.This study was aimed to investigate the protective effect and molecular mechanisms of PNS on apoptosis in H9c2 cells in vitro and rat myocardial ischemia injury model in vivo.Annexin-V/PI assay shew that PNS could protect H9c2 cells from apoptosis induced by serum, glucose and oxygen deprivation(SGOD) in a dose-dependent manner.However,the anti-apoptotic effect of PNS was reversed by LY294002,a specific PI3K inhibitor.This antiapoptotic effect of PNS was confirmed by JC-1,a specific probe of mitochondrial membrane potential staining.PNS could significantly increase phos-Akt in H9c2 cells by Western blot assays and its effect could be inhibited by LY294002.Furthermore,PNS could improve ischemic-induced left ventricular function as reflected by EF,LVDd and LVDs.PNS could also inhibited cellular apoptosis in myocardial tissues in ischemic rats by TUNEL assay.PNS administration also increased the expression of phos-Akt in rat ischemic myocardial tissues.These results suggested that PNS could protect myocardial cells from apoptosis induced by ischemia in vitro model and in vivo model through activating-PI3K/Akt signal pathway which may be meaningful for further understanding the molecular mechanisms of cardiac protection of PNS.And the results might be useful in treatment of myocardial ischemia in future. | YANG Min,CHEN Shao-Xian,LIU Ju-Li,LIU Xiao-Ying,FU Yong-Heng,ZHANGMeng-zhen,LIN Qiu-Xiong,ZHU Jie-Ning, SHAN Zhi-Xin,YU Xi-yong (Medical Research Center,Guangdong General Hospital, Guangdong Academy of Medical Sciences,Guangzhou 510100,China) | 2011 | 岭南心血管病杂志2011，17，S1： | 47 |
| 19 | Polycyclic aromatic hydrocarbon in urban soil from Beijing, China显示文摘Polycyclic aromatic hydrocarbons (EPA-PAHs) in the urban surface soils from Beijing were determined using gas chromatography and mass spectrometry (GC-MS). It is significantly complementary for understanding the PAHs pollution in soil of integrated Beijing city on the basis of the information known in the outskirts. The total concentration of 16 EPA-PAH was from 0.467 to 5.470 ?滋g/g and was described by the contour map. Compound profiles presented that the 4-, 5- and 6-ring PAHs were major compositions. The correlation analysis showed that PAHs have the similar source in the most sampling sites and BaP might be considered as the indicator of PAHs. Characteristic ratios of anthracene (An)/(An+ phenanthrene (Phe)), fluoranthene (Flu)/(Flu+ pyrene (Pyr)) and benzo[a]pyrene (BaP)/benzo[g,h,i]perylene (BghiP) indicated that the PAHs pollutants probably mainly originated from the coal combustion and it was not negligible from vehicular emission. The level of PAHs in our study area was compared with other studies. | LI Xing-hong MA Ling-ling LIU Xiu-fen FU Shan CHENG Hang-xin XU Xiao-bai | 2006 | Journal of Environmental Sciences2006，18，5： | 50 |
| 20 | Plant Terpenoids: Biosynthesis and Ecological Functions显示文摘在植物之中,第二等的代谢物 terpenoids 是在结构上很多样的组;他们直接在植物作为 phytoalex 在里面工作防卫,或作为在包含草食动物和他们的天敌的间接防卫回答的信号。在最近的年里,越来越多的注意对植物 terpenoids 的生态的角色的调查被给予了。单音的萜烯, sesquiterpenes ,和 diterpenes 的 Thebiosynthesis 小径包括 C5precursor isopentenyl diphosphate ( IPP )和它的 allylic 异构体 dimethylallyl diphosphate ( DMAPP )的合成,立即的 diphosphate 先锋的合成,并且多样的 terpenoids.Terpene synthases ( TPS )的形成在不稳定的萜烯合成起一个关键作用。由 TPSgenes 的表示,重要成就在新陈代谢的工程上被做了增加 terpenoidproduction。这评论主要在阐明总结最近的研究进步 terpenoids 的生态的角色和酶的描述在 terpenoid 生合成包含了。terpenoids 新陈代谢的空间、时间的规定也被讨论…… | Ai-Xia Cheng Yong-Gen Lou Ying-Bo Mao Shan Lu Ling-Jian Wang Xiao-Ya Chen | 2007 | Journal of Integrative Plant Biology2007，49，2： | 45 |
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