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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Preparation and Mechanical Properties of-SiC Nanoparticle Reinforced Aluminum Matrix Composite by a Multi-step Powder Metallurgy Process显示文摘β-SiC nanoparticle reinforced Al matrix(nano-SiCp/Al) composite was prepared by a multi- step powder metallurgy strategy including presureless sintering, hot compacting process and hot extrusion. The microstructures of the as-prepared composites were observed by scanning electronic microscopy(SEM), and the mechanical properties were characterized by tensile strength measurement and Brinell hardness test. The experimental results revealed that the tensile strength of the composite with the addition of 5wt%-SiC nanoprticles could be increased to 215 MPa, increasing by 110% compared with pure Al matrix. Comparative experiments reflected that the-SiC nanoprticles showed significant reinforcement effect than traditional-SiC micro-sized particles. The preparation process and sintering procedure were investigated to develop a cost effective preparation strategy to fabricate nano-SiCp/Al composite. | WANG Linong WU Hao WU Xingping CHEN Minghai LIU Ning | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，6： | 5 |
| 3 | Negative association of time in range and urinary albumin excretion rate in patients with type 2 diabetes mellitus:a retrospective study of inpatients显示文摘Background:Time in range(TIR)refers to the time an individual spends within their target glucose range,which now has been popularized as an important metric to classify glycemic management and also recognized as an important outcome of current diabetes therapies.This study aimed to investigate the association between TIR and the severity of the urinary albumin excretion rate(UAER)in patients with type 2 diabetes mellitus(T2DM).Methods:We retrospectively analyzed the data of 1014 inpatients with T2DM at the Department of Endocrinology and Metabolism of Peking University International Hospital,China.TIR was defined as the percentage of blood glucose within the target range of 3.90-10.00 mmol/L.Urine samples for assessment of UAER were collected for 3 consecutive days from the start of hospitalization.Results:The TIR values for patients with normal urine levels of albumin,microalbuminuria,and macroalbuminuria were 70%±20%,50%±20%,and 30%±20%,respectively(allP<0.001).The patients were stratified according to quartiles of TIR as follows:quartile(Q)1,<55%;Q2,55%-72%;Q3,73%-83%;and Q4,>83%.The incidences of microalbuminuria in Q1,Q2,Q3,and Q4 were 41.1%,21.6%,7.1%,and 5.5%(allP<0.001),respectively.The respective incidences of macroalbuminuria were 24.2%,1.1%,1.4%,and 0%(allP<0.001).In multinomial logistic regression analyses,TIR was significantly correlated with microalbuminuria(odds ratio[OR]0.58,95%confidence interval[CI]:0.52-0.65,P<0.001)and macroalbuminuria(OR 0.26,95%CI:0.18-0.38,P<0.001)after adjusting for age,sex,body mass index,diabetes duration,systolic blood pressure,and levels of triglycerides,glycosylated hemoglobin A1c,and creatinine.Conclusion:The proportion of blood glucose in TIR is closely related to the severity of UAER in patients with T2DM. | Sanbao Chai Shanshan Wu Sixu Xin Ning Yuan Jianbin Sun Xiaomei Zhang Linong Ji | 2022 | Chinese Medical Journal2022，，9： | 3 |
| 4 | NUMERICAL MODEL FOR DYNAMIC SIMULATION OF TRAFFIC FLOW显示文摘NUMERICALMODELFORDYNAMICSIMULATIONOFTRAFFICFLOWWuZheng;ZengLi-nong(DepartmentAppliedMechanics,FudanUniversity,Shaghai200433,P... | Wu, Zheng Zeng, Linong | 1994 | Journal of Hydrodynamics1994，6，1： | 2 |
| 5 | A systematic literature review of risk factors for stroke in China 显示文摘 | Yong H Foody J Linong J | 2013 | Cardiol Rev2013，21，2： | 1 |
| 6 | A systematic literature review of risk factors for stroke in China显示文摘 | Yong H Foody J Linong J | 2013 | Cardiol Rev2013，21，2： | 1 |
| 7 | A systematic literature review of risk factors for stroke in China 显示文摘 | Yong H Foody J Linong J | 2013 | Cardiol Rev2013，21，2： | 1 |
| 8 | Cardiovascular safety and glycemic control of glucagon-like peptide-1 receptor agonists for type 2 diabetes mellitus: A pairwise and network meta-analysis显示文摘 | Feng Sun Kai Yu Shanshan Wu Yuan Zhang Zhirong Yang Luwen Shi Linong Ji Siyan Zhan | 2012 | Diabetes Research and Clinical Practice2012，，3： | 1 |
| 9 | 3D wavefield extrapolation with optimum split-step Fourier method显示文摘 | LIU Linong ZHANG Jianfeng | 2006 | Geophysics2006，71，3： | 1 |
| 10 | Frequency, Immunogenetics, and Clinical Characteristics of Latent Autoimmune Diabetes in China (LADA China Study): A Nationwide, Multicenter, Clinic-Based Cross-Sectional Study显示文摘 | Zhou Zhiguang Xiang Yufei Ji Linong Jia Weiping Ning Guang Huang Gan Yang Lin Lin Jian Liu Zhenqi Hagopian William A Leslie R David | 2013 | Diabetes2013，，2： | 1 |
| 11 | First in- sulinization with basal insulin in patients with Type 2 di- abetes in a real-world setting in Aisa显示文摘 | Shih-Tzer TSAI Faruque PATHAN Linong JI | 2011 | J Diabetes2011，3，： | 1 |
| 12 | Prevalence of diabetes among menand women in China显示文摘 | Yang Wenying Lu Juming Weng Jianping Jia Weiping Ji Linong Xiao Jianzhong Shan Zhongyan Liu Jie Tian Ha- oming Ji Qiuhe Zhu Dalong Ge Jiapu Lin Lixiang Chen Li Guo Xiaohui Zhao Zhigang Li Qiang Zhou Zhiguang Shan Guangliang He Jiang | 2010 | N Engl J Med2010，362，： | 1 |
| 13 | A systematic literature review of risk factors for stroke in China显示文摘 | Yong H Foody J Linong J | 2013 | Cardiol Rev2013，21，2： | 1 |
| 14 | Prevalence and associated factors of obstructive sleep apnea in hospitalized patients with type 2 diabetes in B eijing, C hina 对中国北京住院2型糖尿病患者的阻塞性睡眠呼吸暂停患病率的调查与相关因素分析显示文摘 | Rui Zhang Xiaohui Guo Lixin Guo Juming Lu Xianghai Zhou Linong Ji | 2015 | Journal of Diabetes2015，，： | 1 |
| 15 | Epigenetic Disorder Plays a Fundamental Role in the Etiology of Type 2 Diabetes显示文摘Type 2 diabetes (T2D) is now considered a pandemic noncommunicable disease, and the prevalence is still increasing steadily worldwide. Several lines of evidence, including T2D, is an aging-related disease, and the phenomenon of the metabolic memory and developmental origins of adult diabetes argues that epigenetic disorder plays critical roles in the development of T2D. Environmental factors can affect epigenetics during early fetal life until adulthood. Altered epigenetics can be maintained during mitosis and meiosis, so that the subsequent response to environmental cue in later life has also been altered. Epigenetic aberra-tions affect miRNA expression and functions, and altered miRNA expression can also affect expression of many genes including those relevant to epigenetics. Thus, the development of T2D is an accumulative process that may involve complex interactions between altered transcription factors, miRNA functions, and increased epigenetics disorder in response to environmental stimuli during different stages of life. | ZHANG Junlong XIAO Xinhua JI Linong | 2013 | Wuhan University Journal of Natural Sciences2013，18，1： | 1 |
| 16 | A systematic literature review of riskfactor for stroke in China显示文摘 | Yong H Foody J Linong J | 2013 | Cardiol Rev2013，21，2： | 1 |
| 17 | Serum Lipids and Lipoproteins in Chinese Men and Women显示文摘 | Wenying Yang Jianzhong Xiao Zhaojun Yang Linong Ji Weiping Jia Jianping Weng Juming Lu Zhongyan Shan Jie Liu Haoming Tian Qiuhe Ji Dalong Zhu Jiapu Ge Lixiang Lin Li Chen Xiaohui Guo Zhigang Zhao Qiang Li Zhiguang Zhou Guangliang Shan Jiang He | 2012 | Circulation2012，，18： | 1 |
| 18 | Dapagliflozin as Monotherapy in Drug-Naive Asian Patients With Type 2 Diabetes Mellitus: A Randomized, Blinded, Prospective Phase III Study显示文摘 | Linong Ji Jianhua Ma Hongmei Li Traci A. Mansfield Caroline L. T’joen Nayyar Iqbal Agata Ptaszynska James F. List | 2013 | Clinical Therapeutics2013，，： | 1 |
| 19 | Thickness optimization study of constrained damping plate显示文摘 | Wan Haochuan Zheng Ling Li Linong | 2012 | Applied Mechanics and Materials2012，，226228： | 1 |
| 20 | Understanding the standard of care in the treatment of type 2 diabetes in China: results from a national survey显示文摘 | Ji Linong Julliana Newman Lu Juming Cai Xiaoling | 2014 | Chinese Medical Journal2014，，20： | 1 |
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