维普中文期刊产品整合服务
2754篇 您的检索式:作者名="Haiyan"
    题名 作者 年代 出处 被引量
1Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota.Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng 2019Cell Research2019,29,10:192
2Chemical composition of PM_(2.5) during winter in Tianjin,China显示文摘PM2.5 samples for 24 h were collected during winter in Tianjin,China. The ambient mass concentration and chemical composition of the PM2.5 were determined. Ionic species were analyzed by ion chromatog-raphy,while carbonaceous species were determined with the IMPROVE thermal optical reectance(TOR) method,and inorganic elements were measured by inductively coupled plasma-atomic emission spec-trometer. The daily PM2.5 mass concentrations ranged from 48.2 to 319.2 g/m3 with an arithmetic average of 144.6 g/m3. The elevated PM2.5 in winter was mostly attributed to combustion sources such as vehicle exhaust,heating,cooking and industrial emissions,low wind speeds and high relative humidity(RH) ,which were favorable for pollutant accumulation and formation of secondary pollutants. By chem-ical mass balance,it was estimated that about 89.1% of the PM2.5 mass concentrations were explained by carbonaceous species,secondary particles,crustal matters,sea salt and trace elements. Organic material was the largest contributor,accounting for about 32.7% of the total PM2.5 mass concentrations. SO42-,NO3-,Cl- and NH4+ were four major ions,accounting for 16.6%,11.5%,4.7% and 6.0%,respectively,of the total mass of PM2.5.Jinxia Gu Zhipeng Bai Weifang Li Liping Wu Aixia Liu Haiyan Dong Yiyang Xie 2011Particuology2011,9,3:60
3A software architecture centric engineering approach for Internetware显示文摘As a new software paradigm evolved by the Internet, Internetware brings many challenges for the traditional software development methods and techniques. Though architecture-based component composition (ABC) approach is originated in the traditional software paradigm, it supports the engineering of Internetware effectively due to its philosophy, rationales and mechanisms. ABC has three major contributions to the en- gineering of Internetware in detail. First, the feature oriented domain modeling method can structure the “disordered”“software entities” to “ordered Internetware” bottom-up in the problem space. Second, the architecture centric design and analysis method can support the development of self-adaptive Internetware. Third, the component operating platform is a reflective and self-adaptive middleware that not only provides Internetware with a pow- erful and flexible runtime infrastructure but also enables the self-adaptation of the structure and individual entities of Internetware.MEI Hong HUANG Gang ZHAO Haiyan JIAO Wenpin 2006Science in China(Series F)2006,49,6:37
4Plasma-assisted fabrication of monolayer phosphorene and its Raman characterization显示文摘Wanglin Lu Haiyan Nan Jinhua Hong Yuming Chen Chen Zhu Zheng Liang Xiangyang Ma Zhenhua Ni Chuanhong Jin Ze Zhang 2014Nano Research2014,7,6:36
5Strategies of minimally invasive treatment for intrahepatic and extrahepatic bile duct stones显示文摘Zongming Zhang Zhuo Liu Limin Liu Mengmeng Song Chong Zhang Hongwei Yu Baijiang Wan Mingwen Zhu Zixu Liu Hai Deng Haiming Yuan Haiyan Yang Wenping Wei Yue Zhao 2017Frontiers of Medicine2017,11,4:37
6Denitrification characteristics of a marine origin psychrophilic aerobic denitrifying bacterium显示文摘A psychrophilic aerobic denitrifying bacterium,strain S1-1,was isolated from a biological aerated filter conducted for treatment of recirculating water in a marine aquaculture system.Strain S1-1 was preliminarily identified as Psychrobacter sp.based on the analysis of its 16S rRNA gene sequence,which showed 100% sequence similarity to that of Psychrobacter sp.TSBY-70.Strain S1-1 grew well either in high nitrate or high nitrite conditions with a removal of 100% nitrate or 63.50% nitrite,and the total nitrogen removal rates could reach to 46.48% and 31.89%,respectively.The results indicated that nitrate was mainly reduced in its logarithmic growth phase with a very low leve1 accumulation of nitrite,suggesting that the aerobic denitrification process of strain S1-1 occurred mainly in this phase.The GC-MS results showed that N 2 O was formed as the major intermediate during the aerobic denitrifying process of strain S1-1.Finally,factors affecting the growth of strain S1-1 and its aerobic denitrifying ability were also investigated.Results showed that the optimum aerobic denitrification conditions for strain S1-1 were sodium succinate as carbon source,C/N ratio15,salinity 10 g/L NaCl,incubation temperature 20°C and initial pH 6.5.Haiyan Zheng Ying Liu Guangdong Sun Xiyan Gao Qingling Zhang Zhipei Liu 2011Journal of Environmental Sciences2011,23,11:32
7Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage显示文摘Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi(Radix Astragali seu Hedysari), Danggui(Radix Angelica sinensis), Chishao(Radix Paeoniae Rubra), Chuanxiong(Rhizoma Ligustici Chuanxiong), Honghua(Flos Carthami), Taoren(Semen Persicae) and Dilong(Pheretima), and identifies the therapeutic targets and underlying mechanisms that contribute to the neuroprotective properties of Buyang Huanwu decoction.Qingchun Mu Pengfei Liu Xitong Hu Haijun Gao Xu Zheng Haiyan Huang 2014Neural Regeneration Research2014,9,17:32
8Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules显示文摘In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them(kappa <0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions.Cuiying Li Haiyan Gong Lijun Ling Liwen Du Tong Su Shui Wang Jie Wang 2018The Journal of Biomedical Research2018,32,3:27
9A journey to understand wheat Fusarium head blight resistance in the Chinese wheat landrace Wangshuibai显示文摘Fusarium head blight(FHB) or scab caused by Fusarium graminearum is a major threat to wheat production in China as well as in the world. To combat this disease, multiple efforts have been carried out internationally. In this article, we review our long-time effort in identifying the resistance genes and dissecting the resistance mechanisms by both forward and reverse genetics approaches in the last two decades. We present recent progress in resistance QTL identification, candidate functional gene discovery, marker-assisted improvement of FHB resistant varieties, and findings in investigating association of signal molecules, such as Ca^(++),SA, JA, and ET, with FHB response, with the assistance from rapidly growing genomics platforms. The information will be helpful for designing novel and efficient approaches to curb FHB.Haiyan Jia Jiyang Zhou Shulin Xue Guoqiang Li Haisheng Yan Congfu Ran Yiduo Zhang Jinxing Shi Li Jia Xin Wang Jing Luo Zhengqiang Ma 2018The Crop Journal2018,6,1:24
10Advances in dynamics and control of tethered satellite systems显示文摘拴住的卫星系统(TSS ) 的概念答应革命化空间探索和利用的许多方面。它提供不仅众多的可能、珍贵的应用程序,而且与他们的动力学,控制,和物理实现有关的挑战性、有趣的问题。在过去的十年,这个令人激动的话题从许多研究人员吸引了重要注意并且与动力学和控制的二个必要方面的一个焦点获得了分析、数字、试验性的成就的一个广阔数字。这篇评论文章介绍历史性的背景和最近的热话题因为空间拴住,并且以一种进步方式介绍 TSS 的动力学和控制给最先进的成就,从基本操作原则。Dongping P.Jin Haiyan Y.Hu 2008Acta Mechanica Sinica2008,24,3:23
11Major ozonated autohemotherapy promotes the recovery of upper limb motor function in patients with acute cerebral infarction显示文摘Major ozonated autohemotherapy is classically used in treating ischemic disorder of the lower limbs. In the present study, we performed major ozonated autohemotherapy treatment in patients with acute cerebral infarction, and assessed outcomes according to the U.S. National Institutes of Health Stroke Score, Modified Rankin Scale, and transcranial magnetic stimulation motor-evoked potential. Compared with the control group, the clinical total effective rate and the cortical potential rise rate of the upper limbs were significantly higher, the central motor conduction time of upper limb was significantly shorter, and the upper limb motor-evoked potential amplitude was significantly increased, in the ozone group. In the ozone group, the National Institutes of Health Stroke Score was positively correlated with the central motor conduction time and the motor-evoked potential amplitude of the upper limb. Central motor conduction time and motor-evoked potential amplitude of the upper limb may be effective indicators of motor-evoked potentials to assess upper limb motor function in cerebral infarct patients. Furthermore, major ozonated autohemotherapy may promote motor function recovery of the upper limb in patients with acute cerebral infarction.Xiaona Wu Zhensheng Li Xiaoyan Liu Haiyan Peng Yongjun Huang Gaoquan Luo Kairun Peng 2013Neural Regeneration Research2013,8,5:23
12Analyses on the tectonic thermal evolution and influence factors in the deep-water Qiongdongnan Basin显示文摘To reveal the tectonic thermal evolution and influence factors on the present heat flow distribution, based on 154 heat flow data, the present heat flow distribution features of the main tectonic units are first analyzed in detail, then the tectonic thermal evolution histories of 20 profiles are reestablished crossing the main deep-water sags with a structural, thermal and sedimentary coupled numerical model. On the basis of the present geothermal features, the Qiongdongnan Basin could be divided into three regions: the northern shelf and upper slope region with a heat flow of 50–70 m W/m2, most of the central depression zone of 70–85 m W/m2, and a NE trending high heat flow zone of 85–105 m W/m2 lying in the eastern basin. Numerical modeling shows that during the syn-rift phase, the heat flow increases generally with time, and is higher in basement high area than in its adjacent sags. At the end of the syn-rift phase, the heat flow in the deepwater sags was in a range of 60–85 m W/m2, while in the basement high area, it was in a range of 75–100 m W/m2. During the post-rift phase, the heat flow decreased gradually, and tended to be more uniform in the basement highs and sags. However, an extensive magmatism, which equivalently happened at around 5 Ma, has greatly increased the heat flow values, and the relict heat still contributes about 10–25 m W/m2 to the present surface heat flow in the central depression zone and the southern uplift zone. Further analyses suggested that the present high heat flow in the deep-water Qiongdongnan Basin is a combined result of the thermal anomaly in the upper mantle, highly thinning of the lithosphere, and the recent extensive magmatism. Other secondary factors might have affected the heat flow distribution features in some local regions. These factors include basement and seafloor topography, sediment heat generation, thermal blanketing, local magmatic injecting and hydrothermal activities related to faulting and overpressure.WANG Zhenfeng SHI Xiaobin YANG Jun HUANG Baojia SUN Zhen WANG Yahui JIANG Haiyan YU Chuanhai YANG Xiaoqiu 2014Acta Oceanologica Sinica2014,33,12:22
13Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies显示文摘Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction,angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action,and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke.We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research.Guihong Li Fengbo Yu Ting Lei Haijun Gao Peiwen Li Yuxue Sun Haiyan Huang Qingchun Mu 2016Neural Regeneration Research2016,11,6:22
14Sequencing of Cultivated Peanut, Arachis hypogaea, Yields Insights into Genome Evolution and Oil Improvement显示文摘Cultivated peanut (Arachis hypogaea) is an allotetraploid crop planted in Asia, Africa, and America for edible oil and protein. To explore the origins and consequences of tetraploidy, we sequenced the allotetraploid A. hypogaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes. We annotated 39 888 A-subgenome genes and 41 526 B-subgenome genes in allotetraploid peanut. The A. hypogaea subgenomes have evolved asymmetrically, with the B subgenome resembling the ancestral state and the A subgenome undergoing more gene disruption, loss, conversion, and transposable element proliferation, and having reduced gene expression during seed development despite lacking genome-wide expression dominance. Genomic and transcriptomic analyses identified more than 2 500 oil metabolism-related genes and revealed that most of them show altered expression early in seed development while their expression ceases during desiccation, presenting a comprehensive map of peanut lipid biosynthesis. The availability of these genomic resources will facilitate a better understanding of the complex genome architecture, agronomically and economically important genes, and genetic improvement of peanut.Xiaoping Chen Qing Lu Hao Liu Jianan Zhang Yanbin Hong Haofa Lan Haifen Li Jinpeng Wang Haiyan Liu Shaoxiong Li Manish K.Pandey Zhikang Zhang Guiyuan Zhou Jigao Yu Guoqiang Zhang Jiaqing Yuan Xingyu Li Shijie Wen Fanbo Meng Shanlin Yu Xiyin Wang Kadambot H.M.Siddique Zhong-Jian Liu Andrew H.Paterson Rajeev K.Varshney Xuanqiang Liang 2019Molecular Plant2019,12,7:23
15Overview of Mechanism and Mitigation Measures on Multi-frequency Oscillation Caused by Large-scale Integration of Wind Power显示文摘In recent years,the large-scale integration of re-newable energy sources represented by wind power and the widespread application of power electronic devices in power systems have led to the emergence of multi-frequency oscillation problems covering multiple frequency segments,which seriously threaten system stability and restrict the accommodation of renewable energy.The oscillation problems related to renewable energy integration have become one of the most popular topics in the field of wind power integration and power system stability research.It has received extensive attention from both academia and industries with many promising research results achieved to date.This paper first analyzes several typical multi-frequency oscillation events caused by large-scale wind power integration in domestic and foreign projects,then studies the multi-frequency oscillation problems,including wind turbine’s shafting torsional oscillation,sub/super-synchronous oscillation and high frequency resonance.The state of the art is systematically summarized from the aspects of oscillation mechanism,analysis methods and mitigation measures,and the future research directions are explored.Yongning Chi Bingjie Tang Jiabing Hu Xinshou Tian Haiyan Tang Yan Li Sujuan Sun Lei Shi Lei Shuai 2019CSEE Journal of Power and Energy Systems2019,5,4:23
16The effects of probiotics administration on the milk production,milk components and fecal bacteria microbiota of dairy cows显示文摘Probiotics administration can improve host health.This study aims to determine the effects of probiotics(Lactobacillus casei Zhang and Lactobacillus plantarum P-8) administration on milk production,milk functional components,milk composition,and fecal microbiota of dairy cows.Variations in the fecal bacteria microbiota between treatments were assessed based on 16 S rRNA profiles determined by Pac Bio single molecule real-time sequencing technology.The probiotics supplementation significantly increased the milk production and the contents of milk immunoglobulin G(IgG),lactoferrin(LTF),lysozyme(LYS)and lactoperoxidase(LP),while the somatic cell counts(SCC) significantly decreased(P < 0.01).However,no significant difference was found in the milk fat,protein and lactose contents(P > 0.05).Although the probiotics supplementation did not change the fecal bacteria richness and diversity,significantly more rumen fermentative bacteria(Bacteroides,Roseburia,Ruminococcus,Clostridium,Coprococcus and Dorea) and beneficial bacteria(Faecalibacterium prausnitzii) were found in the probiotics treatment group.Meanwhile,some opportunistic pathogens e.g.Bacillus cereus,Cronobacter sakazakii and Alkaliphilus oremlandii,were suppressed.Additionally,we found some correlations between the milk production,milk components and fecal bacteria.To sum up,our study demonstrated the beneficial effects of probiotics application in improving the quality and quantity of cow milk production.Haiyan Xu Weiqiang Huang Qiangchuan Hou Lai-yu Kwok Zhihong Sun Huimin Ma Feiyan Zhao Yuan-Kun Lee Heping Zhang 2017Science Bulletin2017,62,11:21
17GRAIN INCOMPLETE FILLING 2 regulates grain filling and starch synthesis during rice caryopsis development显示文摘Rice grain filling determines grain weight,final yield and grain quality.Here,a rice defective grain filling mutant,gif2,was identified.Grains of gif2 showed a slower filling rate and a significant lower final grain weight and yield compared to wild-type.The starch content in gif2 was noticeably decreased and its physicochemical properties were also altered.Moreover,gif2 endosperm cells showed obvious defects in compound granule formation.Positional cloning identified GIF2 to encode an ADP-glucose pyrophosphorylase(AGP) large subunit,AGPL2;consequently,AGP enzyme activity in gif2 endosperms was remarkably decreased.GIF2 is mainly expressed in developing grains and the coded protein localizes in the cytosol.Yeast two hybrid assay showed that GIF2 interacted with AGP small subunits Os AGPS1,Os AGPS2a and Os AGPS2 b.Transcript levels for granule-bound starch synthase,starch synthase,starch branching enzyme and starch debranching enzyme were distinctly elevated in gif2 grains.In addition,the level of nucleotide diversity of the GIF2 locus was extremely low in both cultivated and wild rice.All of these results suggest that GIF2 plays important roles in the regulation of grain filling and starch biosynthesis during caryopsis development,and that it has been preserved during selection throughout domestication of modern rice.Xiangjin Wei Guiai Jiao Haiyan Lin Zhonghua Sheng Gaoneng Shao Lihong Xie Shaoqing Tang Qingguo Xu Peisong Hu 2017Journal of Integrative Plant Biology2017,59,2:20
18Discovery of the marine Eocene in the northern South China Sea显示文摘The nature of the Eocene stratigraphy of the South China Sea(SCS)has been a mystery for decades.In the southern SCS,the Eocene system with marine deposits is often considered as representing part of the‘Proto-South China Sea’[1].In the northern SCS,however,the Eocene is dominated by non-marine sequences of South China origin[2],probably also related to the Proto-SCS[3].Zhimin Jian Haiyan Jin Michael A Kaminski Fabricio Ferreira Baohua Li Pai-Sen Yu 2019National Science Review2019,6,5:20
19肾脏病学的新创意:“肾脏疾病:改善全球预后”(KDIGO)显示文摘慢性肾脏病(CKD)是世界范围的医疗和公共卫生问题,并开始呈现流行性的特点.美国肾脏数据系统(USRDS)的数据提示,终末期肾衰的发病率呈上升趋势,因此对于这一问题的重视日益增加.根据近期USRDS登记系统提供的资料,世界范围内需要肾脏替代治疗(RRT)的终末期肾病(ESRD)患者数目持续上升,其中我国台湾、美国和日本最多(254~365人/100万人)[1].卡塔尔和巴斯克地区的儿童患病率最高,分别为33.7人/100万人和22.7人/100万人;在大于等于20岁患者中患病率最高的是卡塔尔、美国和台湾.在欧洲,德国的患病率最高,2000年为175人/100万人.在RRT仍在发展中的东欧,报道的患病率低于西欧[2].Norbert Lameire Garabed Eknoyan Rashad Barsoum Kai-Uwe Eckardt Adeera Levin Nathan Levin Francesco Locatelli Alison Macleod Raymond Vanholder Rowan Walker Haiyan Wang 张路霞 王海燕 2005中华肾脏病杂志2005,21,12:19
20Degradation of pyrene by immobilized microorganisms in saline-alkaline soil显示文摘Biodegradation of polycyclic aromatic hydrocarbons(PAHs) is very difficult in saline-alkaline soil due to the inhibition of microbial growth under saline-alkaline stress.The microorganisms that can most effectively degrade PAHs were screened by introducing microorganisms immobilized on farm byproducts and assessing the validity of the immobilizing technique for PAHs degradation in pyrene-contaminated saline-alkaline soil.Among the microorganisms examined,it was found that Mycobacterium sp.B2 is the best,and can degrade 82.2% and 83.2% of pyrene for free and immobilized cells after 30 days of incubation.The immobilization technique could increase the degradation of pyrene significantly,especially for fungi.The degradation of pyrene by the immobilized microorganisms Mucor sp.F2,fungal consortium MF and co-cultures of MB+MF was increased by 161.7%(P < 0.05),60.1%(P < 0.05) and 59.6%(P < 0.05) after 30 days,respectively,when compared with free F2,MF and MB+MF.Scanning electron micrographs of the immobilized microstructure proved the positive effects of the immobilized microbial technique on pyrene remediation in salinealkaline soil,as the interspace of the carrier material structure was relatively large,providing enough space for cell growth.Co-cultures of different bacterial and fungal species showed different abilities to degrade PAHs.The present study suggests that Mycobacterium sp.B2 can be employed for in situ bioremediation of PAHs in saline-alkaline soil,and immobilization of fungi on farm byproducts and nutrients as carriers will enhance fungus PAH-degradation ability in saline-alkaline soil.Shanxian Wang Xiaojun Li Wan Liu Peijun Li Lingxue Kong Wenjie Ren Haiyan Wu Ying Tu 2012Journal of Environmental Sciences2012,24,9:19
返回顶部 每页显示:
共138页 首页 上一页 第1页 下一页 末页 /138 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费