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| 1 | Bone Morphogenetic Protein (BMP) signaling in development and human diseases显示文摘Bone Morphogenetic Proteins(BMPs)are a group of signaling molecules that belongs to the Transforming Growth Factor-b(TGF-b)superfamily of proteins.Initially discovered for their ability to induce bone formation,BMPs are now known to play crucial roles in all organ systems.BMPs are important in embryogenesis and development,and also in maintenance of adult tissue homeostasis.Mouse knockout models of various components of the BMP signaling pathway result in embryonic lethality or marked defects,highlighting the essential functions of BMPs.In this review,we first outline the basic aspects of BMP signaling and then focus on genetically manipulated mouse knockout models that have helped elucidate the role of BMPs in development.A significant portion of this review is devoted to the prominent human pathologies associated with dysregulated BMP signaling. | Richard N.Wang Jordan Green Zhongliang Wang Youlin Deng Min Qiao Michael Peabody Qian Zhang Jixing Ye Zhengjian Yan Sahitya Denduluri Olumuyiwa Idowu Melissa Li Christine Shen Alan Hu Rex C.Haydon Richard Kang James Mok Michael J.Lee Hue L.Luu Lewis L.Shi | 2014 | Genes & Diseases2014，1，1： | 47 |
| 2 | Insulin-like growth factor(IGF)signaling in tumorigenesis and the development of cancer drug resistance显示文摘One of the greatest obstacles to current cancer treatment efforts is the development of drug resistance by tumors.Despite recent advances in diagnostic practices and surgical interventions,many neoplasms demonstrate poor response to adjuvant or neoadjuvant radiation and chemotherapy.As a result,the prognosis for many patients afflicted with these aggressive cancers remains bleak.The insulin-like growth factor(IGF)signaling axis has been shown to play critical role in the development and progression of various tumors.Many basic science and translational studies have shown that IGF pathway modulators can have promising effects when used to treat various malignancies.There also exists a substantial body of recent evidence implicating IGF signaling dysregulation in the dwindling response of tumors to current standard-of-care therapy.By better understanding both the IGF-dependent and-independent mechanisms by which pathway members can influence drug sensitivity,we can eventually aim to use modulators of IGF signaling to augment the effects of current therapy.This review summarizes and synthesizes numerous recent investigations looking at the role of the IGF pathway in drug resistance.We offer a brief overview of IGF signaling and its general role in neoplasia,and then delve into detail about the many types of human cancer that have been shown to have IGF pathway involvement in resistance and/or sensitization to therapy.Ultimately,our hope is that such a compilation of evidence will compel investigators to carry out much needed studies looking at combination treatment with IGF signaling modulators to overcome current therapy resistance. | Sahitya K.Denduluri Olumuyiwa Idowu Zhongliang Wang Zhan Liao Zhengjian Yan Maryam K.Mohammed Jixing Ye Qiang Wei Jing Wang Lianggong Zhao Hue H.Luu | 2015 | Genes & Diseases2015，2，1： | 21 |
| 3 | Forest Ecosystem Services and Their Values in Beijing显示文摘As the most important ecosystem in Beijing, the forest supports a lot of ecosystem services to local and around communities, which plays a key role in the maintenance of urban ecological security.However, the valuation on the forest ecosystem services based on regional scale could not provide precise and reasonable values for forestry sector management.In this study, we estimated the magnitudes and economic values of the forest ecosystem services in Beijing at sublot level.The economic value of forest ecosystem services in Beijing was estimated to be 19 339.71×10 6 yuan(RMB) in 2004.Among all the ecosystem services indicators we estimated in this study, only fruit, timber and part of the recreation(which only include the tourism income from the forest parks and scenic areas, but not include that from other forest types) were measured in the social economic system.As estimated in this study, more than 82.19% of the economic value of forest ecosystem services could not be measured in the socio-economic statistical system.The importance of forest ecosystem services in Beijing to human welfare was underestimated by the socio-economic system.Therefore, the policies about the eco-compensation of forest ecosystem services should be established to maintain the sustainable supply of the forest ecosystem services in Beijing. | XIE Gaodi LI Wenhua XIAO Yu ZHANG Biao LU Chunxia AN Kai WANG Jixing XU Kang WANG Jinzeng | 2010 | Chinese Geographical Science2010，20，1： | 18 |
| 4 | A numerically stable coupled-mode formulation for acoustic propagation in range-dependent waveguides显示文摘In this paper,a stepwise coupled-mode model with the use of the direct global matrix approach is proposed.This method is capable of handling two-dimensional problems with either a point source in cylindrical geometry or a line source in plane geometry.With the use of the direct global matrix approach,this method is numerically stable.In addition,by introducing appropriately normalized range solutions,this model is free from the numerical overflow problem.Furthermore,we put forward source conditions appropriate for the line-source problem in plane geometry.As a result,this method is capable of addressing the scenario with a line source on top of a sloping bottom.Closed-form expressions for coupling matrices are derived and applied in this paper for handling problems with pressure-release boundaries and a homogeneous water column.The numerical simulations indicate that the proposed model is accurate,efficient,and numerically stable.Consequently,this model can serve as a benchmark model in range-dependent propagation modeling.Although this method is verified by an ideal wedge problem in this paper,the formulation applies to realistic problems as well. | LUO WenYu YANG ChunMei QIN JiXing ZHANG RenHe | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，4： | 13 |
| 5 | Multifaceted signaling regulators of chondrogenesis:Implications in cartilage regeneration and tissue engineering显示文摘Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature.Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue.Here,we review the current understanding of the most important biological regulators of chondrogenesis and their interactions,to provide insight into potential applications for cartilage tissue engineering.These include various signaling pathways,including fibroblast growth factors(FGFs),transforming growth factor b(TGF-b)/bone morphogenic proteins(BMPs),Wnt/b-catenin,Hedgehog,Notch,hypoxia,and angiogenic signaling pathways.Transcriptional and epigenetic regulation of chondrogenesis will also be discussed.Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering. | Jordan D.Green Viktor Tollemar Mark Dougherty Zhengjian Yan Liangjun Yin Jixing Ye Zachary Collier Maryam K.Mohammed Rex C.Haydon Hue H.Luu Richard Kang Michael J.Lee Sherwin H.Ho Tong-Chuan He Lewis L.Shi Aravind Athiviraham | 2015 | Genes & Diseases2015，2，4： | 9 |
| 6 | Effect of mixed rare earth oxides and CaCO_3 modification on the microstructure of an in-situ Mg_2Si/Al-Si composite显示文摘The effects of mixed rare earth oxides and CaCO3 on the microstructure of an in-situ Mg2Si/Al-Si hypereutectic alloy composite were investigated by optical microscope,scanning electron microscope,and energy dispersive spectrum analysis. The results showed that the morphol-ogy of the primary Mg2Si phase particles changed from irregular or crosses to polygonal shape,their sizes decreased from 75 μm to about 25 μm,and the compound of both the oxide and CaCO3 was better than either the single mixed rare earth oxides or CaCO3. | Liu, Zheng Lin, Jixing Jing, Qingxiu | 2009 | Rare Metals2009，28，2： | 9 |
| 7 | Synthesis and kinetics investigation of meso-microporous Cu-SAPO-34 catalysts for the selective catalytic reduction of NO with ammonia显示文摘A series of meso-microporous Cu-SAPO-34 catalysts were successfully synthesized by a one-pot hydrothermal crystallization method, and these catalysts exhibited excellent NH_3-SCR performance at low temperature. Their structure and physic chemical properties were characterized by means of X-ray diffraction patterns(XRD), Scanning electron microscopy(SEM), Transmission electron microscopy(TEM), N_2 sorption-desorption, nuclear magnetic resonance(NMR), Inductively Coupled Plasma-Atomic Emission spectrometer(ICP-AES), X-ray absorption spectroscopy(XPS),Temperature-programmed desorption of ammonia(NH_3-TPD), Ultraviolet visible diffuse reflectance spectroscopy(UV-Vis DRS) and Temperature programmed reduction(TPR).The analysis results indicate that the high activities of Cu-SAPO-34 catalysts could be attributed to the enhancement of redox property, the formation of mesopores and the more acid sites. Furthermore, the kinetic results verify that the formation of mesopores remarkably reduces diffusion resistance and then improves the accessibility of reactants to catalytically active sites. The 1.0-Cu-SAPO-34 catalyst exhibited the high NO conversion(> 90%) among the wide activity temperature window in the range of 150–425℃. | Jixing Liu Fuhong Yu Jian Liu Lifeng Cui Zhen Zhao Yuechang Wei Qianyao Sun | 2016 | Journal of Environmental Sciences2016，28，10： | 8 |
| 8 | Si/C Composites as Negative Electrode for High Energy Lithium Ion Batteries显示文摘硅很为因为它的高特定的能力,中等潜力,环境友好,和低费用,改进锂离子电池(解放) 的精力密度正在答应否定电极材料。然而, Si 否定电极的体积变化在导致弄成粉,低骑车效率,和永久能力损失的 lithiation/delithiation 过程期间是巨大的。以便克服这个问题,巨大的努力被尝试了。在他们之中,最成功的策略是把另外的部件合并到硅形成合成的,特别碳媒介。在这微型评论,用作解放的否定电极的 Si/C 材料上的最近的进步被总结例如 Si/amorphous 碳合成, Si/graphene composites, Si/carbon nanotubes 或纤维 composites。制造,结构,不同 Si/C composites 的电气化学的表演被讨论。另外,一些未来方向被指出。 | Yi Zhang Yusong Zhu Lijun Fu Jixing Meng Nengfei Yu Jing Wang Yuping Wu | 2017 | Chinese Journal of Chemistry2017，35，1： | 8 |
| 9 | A Nonlinear Observer Approach of SOC Estimation Based on Hysteresis Model for Lithium-ion Battery显示文摘In this paper, a state of charge(SOC) estimation approach for lithium-ion battery based on equivalent circuit model and the input-to-state stability(ISS) theory has been proposed. According to the electrochemical performance of lithiumion battery, the equivalent circuit model with two RC networks is established, which includes hysteresis characteristic in inner electrochemical response process. The nonlinear relation between open circuit voltage(OCV) and SOC is obtained from a rapid test. Exponential fitting method is used to identify the parameters of the model. A novel state observer based on ISS theory is designed for lithium-ion battery SOC estimation. The designed observer is tested on AMESim and Simulink co-simulation. The simulation results show that the proposed method has a high SOC estimation accuracy with an error of about 2 percent. | Yan Ma Bingsi Li Guangyuan Li Jixing Zhang Hong Chen | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，2： | 7 |
| 10 | Study on S-shaped characteristic of Francis reversible unit by on-site test and CFD simulation显示文摘The operation parameters (vibration, shaft displacement and pressure fluctuation) of No. 1 Francis reversible unit of Baoquan pumped-storage power station were measured on site in the no-load mode at net heads of 518.04, 522.01 and 530.38 m, respectively. The rotational speed fluctuations in the no-load mode at three net heads were beyond synchronization requirement with obvious S-shaped characteristic, and misaligned guide vanes (MGV) had to be put into use for synchronization. Further analysis demonstrated that the rotating frequency signal was generally dominant in vibration and shaft displacement mixing signal in the no-load mode, while the frequency domain was wide without an obvious main frequency in pressure fluctuation mixing signal. Besides, the SST k-ω turbulence model was adopted to simulate the four quadrant characteristic curves of Baoquan model pump-turbine at three gate openings, and the relative error between simulation results and model test data was within ±6%, indicating that the simulation method in this paper is feasible and S-shaped characteristic of the pump-turbine can be simulated with CFD method. | LI JinWei HU QingJuan YU JiXing LI QiZhang | 2013 | Science China(Technological Sciences)2013，56，9： | 5 |
| 11 | Lignin-based carbon fibers: Formation, modification and potential applications显示文摘As an aromatic polymer in nature, lignin has recently attracted gross attention because of its advantages of high carbon content, low cost and bio-renewability. However, most lignin is directly burnt for power generation to satisfy the energy demand of the pulp mills. As a result, only a handful of isolated lignin is used as a raw material. Thus, increasing value addition on lignin to expand its scope of applications is currently a challenge demanding immediate attention. Many efforts have been made in the valorization of lignin, including the preparation of precursors for carbon fibers. However, its complex structure and diversity significantly restrict the spinnability of lignin. In this review, we provide elaborate knowledge on the preparation of lignin-based carbon fibers ranging from the relationships among chemical structures, formation conditions and properties of fibers, to their potential applications. Specifically, control procedures for different spinning methods of lignin, including melt spinning, solution spinning and electrospinning, together with stabilization and carbonization are deeply discussed to provide an overall understanding towards the formation of lignin-based carbon fibers. We also offer perspectives on the challenges and new directions for future development of lignin-based carbon fibers. | Shichao Wang Jixing Bai Mugaanire Tendo Innocent Qianqian Wang Hengxue Xiang Jianguo Tang Meifang Zhu | 2022 | Green Energy & Environment2022，7，4： | 5 |
| 12 | Sound propagation from the shelfbreak to deep water显示文摘Motivated by a phenomenon in an experiment conducted in the Northwestern Pacific indicating that the energy of the received signal around the sound channel axis is much greater than that at shallower depths,we study sound propagation from the transitional area(shelfbreak)to deep water.Numerical simulations with different source depths are first performed,from which we reach the following conclusions.When the source is located near the sea surface,sound will be strongly attenuated by bottom losses in a range-independent oceanic environment,whereas it can propagate to a very long range because of the continental slope.When the source is mounted on the bottom in shallow water,acoustic energy will be trapped near the sound channel axis,and it converges more evidently than the case where the source is located near the sea surface.Then,numerical simulations with different source ranges are performed.By comparing the relative energy level in the vertical direction between the numerical simulations and the experimental data,the range of the air-gun source can be approximated. | QIN JiXing ZHANG RenHe LUO WenYu PENG ZhaoHui LIU JianJun WANG DeJun | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，6： | 3 |
| 13 | Biodegradable Zn–3Cu and Zn–3Cu–0.2Ti alloys with ultrahigh ductility and antibacterial ability for orthopedic applications显示文摘Zinc(Zn) and its alloys have been proposed as biodegradable implant materials due to their unique combination of biodegradability, biocompatibility, and biofunctionality. However, the insufficient mechanical properties of pure Zn greatly limit its clinical application. Here, we report on the microstructure, mechanical properties, friction and wear behavior, corrosion and degradation properties, hemocompatibility, and cytocompatibility of Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys under three different conditions of as-cast(AC),hot-rolling(HR), and hot-rolling plus cold-rolling(HR + CR). The HR + CR Zn–3 Cu–0.2 Ti exhibited the best set of comprehensive properties among all the alloy samples, with yield strength of 211.0 MPa, ultimate strength of 271.1 MPa, and elongation of 72.1 %. Immersion tests of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution for 3 months indicated that the AC samples showed the lowest degradation rate,followed by the HR samples, and then the HR + CR samples, while the HR + CR Zn–3 Cu exhibited the highest degradation rate of 23.9 m/a. Friction and wear testing of the Zn–3 Cu and Zn–3 Cu–0.2 Ti alloys in Hanks’ solution indicated that the AC samples showed the highest wear resistance, followed by the HR samples, and then the HR + CR samples, while the AC Zn–3 Cu–0.2 Ti showed the highest wear resistance.The diluted extracts of HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti at a concentration of ≤25 % exhibited noncytotoxicity. Furthermore, both the HR + CR Zn–3 Cu and Zn–3 Cu–0.2 Ti exhibited effective antibacterial properties against S. aureus. | Jixing Lin Xian Tong Kun Wang Zimu Shi Yuncang Li Matthew Dargusch Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，9： | 3 |
| 14 | Report of epibenthic macrofauna found from Haima cold seeps and adjacent deep-sea habitats,South China Sea显示文摘This work reports on a preliminary taxonomic study of epibenthic macroinvertebrates collected or observed by underwater video at the Haima cold seeps and in adjacent deep-sea habitats,including a mud volcano feld and Ganquan Plateau,during an expedition in the South China Sea by the Chinese-manned submersible Shenhai Yongshi in May 2018.A total of 41 species belonging to 6 phyla were identifed,among which 34 species were collected from the Haima cold seeps.Mollusks and crustaceans that are specialized in reducing habitats were predominant in biotopes of the Haima cold seeps,whereas sponges and cold-water corals and their commensals were prominent in communities of the mud volcano feld and the slopes of Ganquan Plateau.The distribution and faunal composition of each taxonomic group are discussed. | Dong Dong Xinzheng Li Mei Yang Lin Gong Yang Li Jixing Sui Zhibin Gan Qi Kou Ning Xiao Junlong Zhang | 2021 | Marine Life Science & Technology2021，3，1： | 3 |
| 15 | The earthquake precursor detected in a granular medium and a proposed model for the propagation of precursive stress-strain signal显示文摘A way to detect the seismic precursor in granular medium is described and a model of propagation for precursive stress-strain signals is proposed.A strain sensor buried in a sandpit is used to measure a seismic precursor signal.The signal has been investigated and confirmed to originate from a specific earthquake.A comparison of simulated and experimental signals indicates that the signal results from the strain in the earth's strata.Based on the behavioral characteristics of granular materials,an analysis of why this method can be so sensitive to the seismic strain signal is undertaken and a model for the propagation of this stress-strain signal is proposed.The Earth's lithosphere is formed of tectonic plates,faults and fault gouges at their boundaries.In the case of the quasi-static mechanics of seismic precursory stress-strain propagation,the crustal lithosphere should be treated as a large-scale granular system.During a seismogenic event,accumulated force generates the stick-slip motion of adjacent tectonic plates and incrementally pushes blocks farther apart through stick-slip shift.The shear force released through this plate displacement causes soil compression deformation.The discrete properties of the sand in the sandpit lead to the sensitive response of the sensor to the deformation signal which enables it to detect the seismic precursor.From the analysis of the mechanism of the stress-strain propagation in the lithosphere,an explanation is found for the lack of signal detection by sensors installed in rocks.The principles and method presented in this paper provide a new technique for investigating seismic precursors to shallow-source earthquakes. | LU KunQuan HOU MeiYing WANG Qiang PENG Zheng SUN Wei SUN XiaoMing WANG YuYing TONG XiaoHui JIANG ZeHui LIU JiXing | 2011 | Chinese Science Bulletin2011，56，11： | 2 |
| 16 | Analysis and comparison between two coupled-mode methods for acoustic propagation in range-dependent waveguides显示文摘Two coupled-mode methods,namely DGMCM(Direct-Global-Matrix CoupledMode Method)and CCMM(Consistent Coupled-Mode Method),are analyzed and compared.First,both of these two methods provide two-way solutions,and hence they are accurate models.Second、the series of local vertical modes in DGMCM converges as fast as that in CCMM,whereas DGMCM has a more tolerable requirement of the number of segments than CCMM.Third,these two models obtain the field solution by solving the coupled-mode system with different coefficient matrices,in which the computational etfort for the required parameters is almost the same.Finally,DGMCM can handle some problems which are difficult for CCMM,such as in a waveguide with a rough bottom,a line source located right on top of a sloping bottom,or in the presence of multiple sources.In DGMCM,closed-form expressions for coupling matrices in a two-layer waveguide are given.In addition.the formulation for the line-source problem in plane geometry is derived to update CCMM. | QIN Jixing LUO Wenyu ZHANG Renhe YANG Chunmei | 2014 | Chinese Journal of Acoustics2014，33，1： | 2 |
| 17 | One pot synthesis, crystal structures and properties of two new MOFs with imidazole-containing tripodal ligand显示文摘Two new different Cu(Ⅱ) MOFs with the same 1,3,5-tris(1-imidazolyl) benzene(tib) ligand {[Cu(tib)2]·(H2O)2·Br2}n(1) and {[Cu2(tib)·Br·Cl]·2Br}n(2) were obtained by one pot synthesized of tib with CuBr in the presences of HCl and water. X-ray single crystal diffraction analyses indicate that both complexes 1 and 2 have two dimensional frameworks containing different building blocks. Each Cu(Ⅱ) atom in complex 1 is coordinated by four N atoms from different tib ligands. However, there are two different cryptographic Cu(Ⅱ) atoms in complex 2, one is four coordinated by two bromine atoms and two N atoms from different tib ligands, the other is six coordinated by two chloride atoms and four N atoms from different tib ligands. The thermal gravimetric analysis of complexes 1 and 2 are depicted in the paper. | TANG YunZhi YU YinMei XIONG JianBo YAO Qiong TAN YuHui GAO JiXing WEN HeRui | 2014 | Science China Chemistry2014，57，11： | 2 |
| 18 | Leakage current characteristics and ageing assessment technology of roof arrester under ultra harmonics overvoltage显示文摘The large leakage current of the roof arrester caused by the high‐frequency resonant overvoltage on the high‐speed train occurs intermittently,which will cause the arrester to overheat locally.In this work,the overheating issue of the arrester under Ultra Harmonics Overvoltage is studied.Then,the relationship between the active power and the voltage(including amplitude and frequency)of the arrester is investigated,and the impact mechanism of the harmonic voltage on the overheating fault of the arrester is analysed based on experiments in this work.It is found that the total leakage current of the arrester is proportional to the amplitude and frequency of the applied voltage.The internal resistance of the arrester is independent of the amplitude of the voltage,but it will decrease with the increase of the frequency.The main reason that leads to thermal breakdown of the arrester valve under high‐frequency harmonic voltage is the heating power elevation of the arrester valve.The research study can provide theoretical basis and data support for the design,type selection and monitoring of the high‐speed train roof arrester. | Jixing Sun Fan Ding Yunlong Lv Jiayi Ren Sibo Song Tiance Li Qingyun Zhi Changwang Guo | 2022 | High Voltage2022，7，2： | 1 |
| 19 | One-dimensional ZnSe@N-doped carbon nanofibers with simple electrospinning route for superior Na/K-ion storage显示文摘One-dimensional carbon nanofibers are widely applied as anode material in the energy storage field due to its unique structure and high conductivity. In this work, one-dimensional ZnSe@N-doped carbon nanofibers(ZnSe@NC NFs) are successfully synthesized by electrospinning and annealed without extra troublesome conditions. ZnSe nanocrystals are enfolded in the N-doped carbon nanofibers, which can act as a protective layer to avoid the volume expansion of active material and promote ion transport during the cycling process. More importantly, the as-synthesized ZnSe@NC NFs are served as the anode material and display the admirable storage properties for Na/K-ion batteries. The one-dimensional Zn Se@NC NFs material shows the high capacity of 237 mAh/g for Na-ion batteries at a current density of 1 A/g for 2000cycles. Meanwhile, it also delivers a high discharge capacity of 337 mAh/g for K-ion batteries at 0.2 A/g for 300 cycles. Additionally, it is confirmed that the pseudocapacitive contribution of the nano-structure material is up to 54.5% at a scan rate of 0.6 m V/s through the cyclic voltammetry(CV) measurement in K-ion batteries. | Di Huang Daxiong Wu Jixing Zhu Jinyu Xie Jipeng Wu Jiaojiao Liang | 2023 | Chinese Chemical Letters2023，34，2： | 1 |
| 20 | Molecules mimicking Smad1 interacting with Hox stimulate bone formation显示文摘 | LIU Z SHIW JIX | 2004 | J Biol Chem2004，279，11： | 1 |
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