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| 1 | RNA N^6-methyladenosine modification in cancers: current status and perspectives显示文摘 | Xiaolan Deng Rui Su Hengyou Weng Huilin Huang Zejuan Li Jianjun Chen | 2018 | Cell Research2018，28，5： | 55 |
| 2 | Quantitative relationship between pollen and vegetation in northern China显示文摘205 surface pollen samples from different communities in Northern China were analyzed to understand the quantitative relationship between pollen and its original vegetation. Pollen analysis and vegetation investigation show that the pollen assemblages differ a lot in different vegetation regions. Arboreal pollen account for more than 30% in temperate broad-deciduous forests region. In temperate steppe regions, herb pollen percentages are more than 90%, where Artemisia and Chenopodiaceae are domi- nant pollen types with Artemisia percentages more than 30%. In temperate desert, Chenopodiaceae pollen percentages are more than Artemisia, where ferns are rare. Cyperaceae pollen percentages are more than 20% in sub-alpine or cold meadows. The relations between pollen percentages and vegeta- tion cover indicate that most arboreal pollen shows a close relationship with parent plant covers, most shrubby pollen types have more or less correlations, but most herbs do not show clear correlations. For arboreal pollen types, Picea pollen shows the closest correlation with spruce trees coverage, then is Quercus and Carpinus. Betula, Larix and Juglans have also high correlation coefficients with their plants coverage, but Betula pollen is of overrepresented pollen type and more than 40% in birch forest, while Larix and Juglans pollen is underrepresented and pollen percentages are more than 10% in Larix or Juglans pure forests. Pinus is of overrepresented pollen type, and pollen percentages have some relations with plants cover. Pine forest might present when Pinus pollen percentages are more than 30%. The relations between Ulmus and Populus pollen percentages and vegetation cover are not close, where they are mixed with other arbors, they cannot be recorded easily, but if their pollen percentages are more than 1%, Ulmus or Populus trees should exist. For shrubby pollen types, the correlation be- tween Vitex pollen percentages and vegetation cover is the highest, then is Corylus, Tamariaceae and Nitraria, and their pollen percentages are less than 1% where original plant are absent. Caragana and Spiraea pollen percentages have some relations with vegetation cover. The relations between pollen percentages and vegetation cover are not clear for Rosaceae and Saxifragaceae. For herb pollen types, Cyperaceae pollen has the closest correlation with vegetation cover, where pollen percentages are more than 20% when Cyperaceae are constructive or dominant species in vegetation, and pollen per- centages are less than 5% where Cyperaceae are not constructive or dominant species (cover less than 30%). Artemisia and Chenopodiaceae pollen percentages mainly have close relations with ecological regions. The relations between pollen percentages and cover are not clear for Gramineae, Legumi- nosae and Compositae. | XU QingHai LI YueCong YANG XiaoLan ZHENG ZhenHua | 2007 | Science China Earth Sciences2007，50，4： | 41 |
| 3 | miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A显示文摘增加的证据建议 hsa-miR-126 (miR-126 ) 在房间衬里的非小的房间肺癌症(NSCLC ) 是下面调整的, miR-126 的恢复由指向特定的分子损害肿瘤房间增长,移植,侵略,和幸存。这里,我们第一次报导 miR-126 涉及调整 NSCLC 房间的反应到癌症化疗。在有 miR-126 的房间模仿的 transfected A549 或禁止者以后,我们发现 miR-126 的提高的水平显著地与减少的一半被联系 adriamycin ( ADM )和长春新碱的最大的禁止的集中, ADM 的增加的累积,脉管的 endothelial 生长因素 A ( VEGFA )和 multidrug 的下面规定联系抵抗的蛋白质 1 ( MRP1 ),并且 Akt 的 inactivation 发信号的小径。而且,提高了 miR-126 的表示压制了 A549 异种皮移植的生长并且禁止了 VEGFA 和 MRP1 的表示。miR-126 能高效地通过和 VEGFA 3-untranslated 区域的相互作用的下面调整 VEGFA 表示,而 VEGFA 的恢复能部分由 miR-126 稀释 MRP1 的抑制。然而, LY294002,表明小径的 PI3K/Akt 的一个禁止者,减少这效果,建议 miR-126 的那提高的表情通过发信号的 VEGF/PI3K/Akt/MRP1 的否定规定增加了 NSCLC 房间的敏感到 anticancer 代理人小径。 | Xiaolan Zhu Hao Li Lulu Long Lulu Hui Haining Chen Xuefeng Wang Huiling Shen Wenlin Xu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，6： | 23 |
| 4 | Curative effect of warming kidney and fortifying spleen recipe on diarrhea-predominant irritable bowel syndrome显示文摘OBJECTIVE:To observe the curative effect of a recipe for warming the kidney and fortifying the spleen on diarrhea-predominant irritable bowel syndrome(IBS-D).METHODS:This multi-center,double-blind,randomized,and controlled trial included 240 patients that met the inclusion criterion and were then divided into two groups of 120.Patients in the treatment group(group A)took modified Sishen Wan orally for warming the kidney and fortifying the spleen and patients in the control group(group B)took a placebo,Chao Maiya,for 4 weeks.28 days after withdrawal,there was a 6-month follow-up to observe patient recurrence condition.The total effective rate,curative effect,and recurrence rate were evaluated after treatment.RESULTS:There was statistical difference(P<0.01)between the two groups in total effective rate(92.24%in the treatment group and 49.07%in the control group),in curative effect of TCM syndrome(90.52%and 47.22%,respectively),and in the recurrence rate(15.79%and 56.86%,respectively)within6 months after treatment.CONCLUSION:Modified Sishen Wan,for warming the kidney and fortifying the spleen,can effectively treat IBS-D and better control its recurrence. | Xiaolan Su Yanping Tang Jing Zhang Yuebin Dong Wei Wei Yibing Bai Yong Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 22 |
| 5 | Review on photocatalytic and electrocatalytic artificial nitrogen fixation for ammonia synthesis at mild conditions: Advances,challenges and perspectives显示文摘The ammonia synthesis from nitrogen and water under ambient conditions is one of the most inviting but challenging reaction routes.Although nitrogen is abundant in the atmosphere and the ammonia synthesis reaction is exothermic on the thermodynamics,the conversion of N2 to ammonia is actually hard to proceed owing to the chemical inertness and stability of N2 molecules.In industry,ammonia synthesis is carried out by the Haber-Bosch process under harsh conditions (300-500 ℃,20-30 MPa) associated with the requirement of substantial energy input and the enormous emission of greenhouse gases (e.g.,CO2).Recently,a growing number of studies on photo(electro)catalytic and electrocatalytic nitrogen reduction reaction (NRR) in aqueous solution have attracted extensive attention,which holds great promise for nitrogen fixation under room temperature and atmospheric pressure.However,the very low efficiency and ambiguous mechanism still remain as the major hurdles for the development of photochemical and electrochemical NRR systems.Here we provide an overview of the latest progresses,remaining challenges and future prospects in photocatalytic and electrocatalytic nitrogen fixation.Moreover,this review offers a helpful guidance for the reasonable design of photocatalysts and electrocatalysts towards NRR by combining theory predictions and experiment results.We hope this review can stimulate more research interests in the relatively understudied but highly promising research field of NRR. | Xiaolan Xue Renpeng Chen Changzeng Yan Peiyang Zhao Yi Hu Wenjun Zhang Songyuan Yang Zhong Jin | 2019 | Nano Research2019，12，6： | 20 |
| 6 | Pollen indication to source plants in the eastern desert of China显示文摘In order to investigate the indication of major pollen types to source plants, 39 surface pollen samples are collected from 39 plant communities. The results show that diversity of pollen assemblages presents in different commu-nities. Chenopodiaceae pollen percentages are highest in Kalidium communities and Ceratoides communities (higher than 45%, average is 63.4%), but high Ephedra pollen per-centages (higher than 3.3%, average is 16.5%)in Ceratoides communities make it distinguished from Kalidium communi-ties. Artemisia pollen percentages (more than 50%) are much higher than Chenopodiaceae (less than 35%) in Artemisia Communities. Nitraria pollen percentages (higher than 2%, average is 13.6%) are highest in Nitraria communities com-pared with those in other community patterns. Tamariceae pollen percentages (higher than 2%, average is 8.6%) are highest both in Tetraena and Reaumuria communities com-pared with those in other community patterns. But in Reau-muria communities, Artemisia pollen percentages are higher than Chenopodiaceae with some other pollen types such as Gramineae, Compositae, Leguminosae; on the contrary, in Tetraena communities, Artemisia pollen percentages are less than Chenopodiaceae with few other pollen types. Calli-gonum pollen only appears in Calligonum communities (higher than 2%,average is 5%). The results of cluster analysis (CLA) and detrended correspondence analysis (DCA) show that the pollen indication to source plants can be reflected by association indices (A), over-representation in-dices (O), under-representation indices (U), R-value, the av-erage pollen percentages where parent plants are absent (Xa) and the average pollen percentages where parent plants are present (Xp). Zygophyllum, Calligonum, Tetraena, Tribulus and Tamariceae can indicate source plants very well, owing to high A scores. Artemisia, Chenopodiaceae and Gramineae have high R-values, and Nitraria, Cruciferae and sedum have high O scores, so they are over-represented types, but the higher Xp and the lower Xa values make that these pollen types can also indicate source plants moderately. Allium, Leguminosae, Roseceae, Pedicularis and Compositae have low A scores (less than 0.5), high O and/or U scores, so they cannot indicate source plants clearly. Some other pollen types, such as Pinus, Picea, Betula, Quercus, Ulmus, Ephedra, Elaegnaceae, Ranunculaceae, Caryophyllaceae, Polygona-ceae, Saxifragaceae, only appear in pollen assemblages, so their indication cannot be decided. Just like the pollen per-centage ratios of Artemisia and Chenopodiaceae (A/C), the ratios of Ephedra and Artemisia (E/A), Nitraria and Ephedra (N/E) can also indicate the aridity of environment. In typical desert communities, A/C ratios are less than 0.5, E/A ratios are more than 0.1, and N/E ratios are less than 1. In steppe desert, A/C ratios are 0.5―2, E/A ratios are less than 0.1, and N/E ratios are more than 1. | LI Yuecong XU Qinghai ZHAO Yinclkui YANG Xiaolan XIAO Jule CHEN Hui Lü Xinmiao | 2005 | Chinese Science Bulletin2005，50，15： | 17 |
| 7 | Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin显示文摘Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model establishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang's regulation of Ghrelin-Ghrelin receptors. | Liye Wang Yuehan Song Feng Li Yan Liu Jie Ma Meng Mao Fengzhi Wu Ying Wu Sinai Li Binghe Guan Xiaolan Liu | 2014 | Neural Regeneration Research2014，9，2： | 16 |
| 8 | Carbon and Oxygen Isotopic Compositions: How Lacustrine Environmental Factors Respond in Northwestern and Northeastern China显示文摘Surface lake sediments,28 from Hoh Xil,24 from northeastern China,99 from Lake Bosten,31 from Ulungur and 26 from Heihai were collected to determine δ13C and δ18O values.Considering the impact factors,conductivity,alkalinity,pH,TOC,C/N and carbonate-content in the sediments,Cl,P,S,and metal element ratios of Mg/Ca,Sr/Ca,Fe/Mn of bulk sediments as environmental variables enable evaluation of their influences on δ13C and δ18O using principal component analysis(PCA) method.The closure and residence time of lakes can influence the correlation between δ13C and δ18O.Lake water will change from fresh to brackish with increasing reduction and eutrophication effects.Mg/Ca in the bulk sediment indicates the characteristic of residence time,Sr/Ca and Fe/Mn infer the salinity of lakes.Carbonate formation processes and types can influence the δ13C–δ18O correlation.δ18O will be heavier from Mg-calcite and aragonite formed in a high-salinity water body than calcite formed in freshwater conditions.When carbonate content is less than 30%,there is no relationship with either δ13C or δ18O,and also none between δ13C and δ18O.More than 30%,carbonate content,however,co-varies highly to δ13C and δ18O,and there is also a high correlation between δ13C and δ18O.Vegetation conditions and primary productivity of lakes can influence the characteristics of δ13C and δ18O,and their co-variance.Total organic matter content(TOC) in the sediments is higher with more terrestrial and submerged plants infilling.In northeastern and northwestern China,when organic matter in the lake sediments comes from endogenous floating organisms and algae,the δ13C value is high.δ13C is in the range of 4‰ to 0‰ when organic matter comes mainly from floating organisms(C/N<6);in the range of 4‰ to 8‰ when organic matter comes from diatoms(C/N=6 to 8);and 8‰ to 4‰ when organic matter comes from aquatic and terrestrial plants(C/N>8). | ZHANG Chengjun FAN Rong LI Jun Steffen MISCHKE laise DEMBELE HU Xiaolan | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 13 |
| 9 | Efficient InGaN-based yellow-light-emitting diodes显示文摘Realization of efficient yellow-light-emitting diodes(LEDs) has always been a challenge in solid-state lighting.Great effort has been made, but only slight advancements have occurred in the past few decades. After comprehensive work on InGaN-based yellow LEDs on Si substrate, we successfully made a breakthrough and pushed the wall-plug efficiency of 565-nm-yellow LEDs to 24.3% at 20 A∕cm^2 and 33.7% at 3 A∕cm^2. The success of yellow LEDs can be credited to the improved material quality and reduced compressive strain of InGaN quantum wells by a prestrained layer and substrate, as well as enhanced hole injection by a 3 D pn junction with V-pits. | FENGYI JIANG JIANLI ZHANG LONGQUAN XU JIE DING GUANGXU WANG XIAOMING WU XIAOLAN WANG CHUNLAN MO ZHIJUE QUAN XING GUO CHANGDA ZHENG SHUAN PAN JUNLIN LIU | 2019 | Photonics Research2019，7，2： | 13 |
| 10 | Exosomes derived from human amniotic epithelial cells accelerate diabetic wound healing via PI3K-AKT-mTOR-mediated promotion in angiogenesis and fibroblast function显示文摘Background:Diabetic wounds are one of the most common and serious complications of diabetes mellitus,characterized by the dysfunction of wound-healing-related cells in quantity and quality.Our previous studies revealed that human amniotic epithelial cells(hAECs)could promote diabetic wound healing by paracrine action.Interestingly,numerous studies demonstrated that exosomes derived from stem cells are the critical paracrine vehicles for stem cell therapy.However,whether exosomes derived from hAECs(hAECs-Exos)mediate the effects of hAECs on diabetic wound healing remains unclear.This study aimed to investigate the biological effects of hAECs-Exos on diabetic wound healing and preliminarily elucidate the underlying mechanism.Methods:hAECs-Exos were isolated by ultracentrifugation and identified by transmission electron microscopy,dynamic light scattering and flow cytometry.A series of in vitro functional analyses were performed to assess the regulatory effects of hAECs-Exos on human fibroblasts(HFBs)and human umbilical vein endothelial cells(HUVECs)in a high-glycemic microenvironment.Highthroughput sequencing and bioinformatics analyses were conducted to speculate the related mechanisms of actions of hAECs-Exos on HFBs and HUVECs.Subsequently,the role of the candidate signaling pathway of hAECs-Exos in regulating the function of HUVECs and HFBs,as well as in diabetic wound healing,was assessed.Results:hAECs-Exos presented a cup-or sphere-shaped morphology with a mean diameter of 105.89±10.36 nm,were positive for CD63 and TSG101 and could be internalized by HFBs and HUVECs.After that,hAECs-Exos not only significantly promoted the proliferation and migration of HFBs,but also facilitated the angiogenic activity of HUVECs in vitro.High-throughput sequencing revealed enriched miRNAs of hAECs-Exos involved in wound healing.Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses have shown that the target genes of the top 15 miRNAs were highly enriched in the PI3K-AKT pathway.Further functional studies demonstrated that the PI3K-AKT-mTOR pathway was necessary for the induced biological effects of hAECs-Exos on HFBs and HUVECs,as well as on wound healing,in diabetic mice.Conclusions:Our findings demonstrated that hAECs-Exos represent a promising,novel strategy for diabetic wound healing by promoting angiogenesis and fibroblast function via activation of the PI3K-AKT-mTOR pathway. | Pei Wei Chenjian Zhong Xiaolan Yang Futing Shu Shichu Xiao Teng Gong Pengfei Luo Li Li Zhaohong Chen Yongjun Zheng Zhaofan Xia | 2020 | Burns & Trauma2020，8，1： | 12 |
| 11 | The computations of Einstein-Khler metric of Cartan-Hartogs domain显示文摘In this paper, we compute the complete Einstein-Kahler metric with explicit formula for the Cartan-Hartogs domain of the fourth type in some cases. Under this metric the holomorphic sectional curvature is given, which intervenes between -2k and -1. This is the sharp estimate. | YIN Xiaolan & ZHAO Xiaoxia Institute of Software, Chinese Academy of Sciences, Beijing 100080, China Department of Computer Science, Beijing Language and Culture University, Beijing 100083, China | 2005 | Science China Mathematics2005，48，z1： | 12 |
| 12 | Effect of Jinhua Qinggan granules on novel coronavirus pneumonia in patients显示文摘OBJECTIVE: To evaluate the effectiveness and safety of Jinhua Qinggan granules in the treatment of patients with novel coronavirus pneumonia(COVID-19).METHODS: Eighty cases of COVID-19 diagnosed from January 24 to February 17, 2020 in Beijing YouAn Hospital Affiliated to Capital Medical University were retrospectively analyzed. All 80 patients received symptomatic and supportive treatment.Among them, 44 patients took Jinhua Qinggan granules(treatment group) within 24 h of admission, and the remaining 36 patients either did not take Jinhua Qinggan granules or took the granules for less than 2 d(control group). In this study, we compared the duration of viral nucleic acid detection and of pneumonia absorption improvement between the two groups.RESULTS: Among the 80 cases, 37 were male(46%)and 43 were female(54%) with age ranging from15 to 86 years, with an average age of 51.19 years.The average duration of viral nucleic acid detection was(7 ± 4) d in the Jinhua Qinggan administration group and(10 ± 4) d for the control group(P =0.010), following which, nucleic acid tests were negative. Of the two groups, 56.82% in the Jinhua Qinggan treatment group and 27.78% in the control group demonstrated negative nucleic acid tests within 7 d or less. The 7-day viral clearance rate was significantly higher in the Jinhua Qinggan group compared with the control group(P = 0.009). Furthermore, the pneumonia recovery time indicated by chest CT was(8 ± 4) d in the Jinhua Qinggan group, which was significantly shorter than the control group, at(10 ± 5) d(P = 0.021). No adverse reactions were found in the treatment group after taking this medicine.CONCLUSION: In patients with COVID-19, Jinhua Qinggan granules can effectively shorten the duration of nucleic acid detection and promote the absorption of pneumonia inflammatory exudate without obvious adverse reactions. | Liu Zengli Li Xiuhui Gou Chunyan Li Li Luo Xiaolan Zhang Chun Zhang Yin Zhang Jiaying Jin Aihua Li Hongyan Zeng Yuan Li Tongzeng Wang Xiaojun | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 11 |
| 13 | Temperature Variable Optimization for Precision Machine Tool Thermal Error Compensation on Optimal Threshold显示文摘Machine tool thermal error is an important reason for poor machining accuracy.Thermal error compensation is a primary technology in accuracy control.To build thermal error model,temperature variables are needed to be divided into several groups on an appropriate threshold.Currently,group threshold value is mainly determined by researchers experience.Few studies focus on group threshold in temperature variable grouping.Since the threshold is important in error compensation,this paper arms to find out an optimal threshold to realize temperature variable optimization in thermal error modeling.Firstly,correlation coefficient is used to express membership grade of temperature variables,and the theory of fuzzy transitive closure is applied to obtain relational matrix of temperature variables.Concepts as compact degree and separable degree are introduced.Then evaluation model of temperature variable clustering is built.The optimal threshold and the best temperature variable clustering can be obtained by setting the maximum value of evaluation model as the objective.Finally,correlation coefficients between temperature variables and thermal error are calculated in order to find out optimum temperature variables for thermal error modeling.An experiment is conducted on a precise horizontal machining center.In experiment,three displacement sensors are used to measure spindle thermal error and twenty-nine temperature sensors are utilized to detect the machining center temperature.Experimental result shows that the new method of temperature variable optimization on optimal threshold successfully worked out a best threshold value interval and chose seven temperature variables from twenty-nine temperature measuring points.The model residual of z direction is within 3 m.Obviously,the proposed new variable optimization method has simple computing process and good modeling accuracy,which is quite fit for thermal error compensation. | ZHANG Ting YE Wenhua LIANG Ruijun LOU Peihuang YANG Xiaolan | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 11 |
| 14 | Efficient emission of InGaN-based light-emitting diodes:toward orange and red显示文摘Indium gallium nitride(InGaN)-based light-emitting diodes(LEDs)are considered a promising candidate for red-green-blue(RGB)micro displays.Currently,the blue and green LEDs are efficient,while the red ones are inefficient for such applications.This paper reports our work of creating efficient InGaN-based orange and red LEDs on silicon(111)substrates at low current density.Based on the structure of InGaN yellow LEDs,by simply reducing the growth temperature of all the yellow quantum wells(QWs),we obtained 599 nm orange LEDs with peak wall-plug efficiency(WPE)of 18.1%at 2 A/cm^2.An optimized QW structure was proposed that changed two of the nine yellow QWs to orange ones.Compared with the sample containing nine orange QWs,the sample with two orange QWs and seven yellow QWs showed similar emission spectra but a much higher peak WPE up to 24.0%at 0.8 A/cm^2 with a wavelength of 608 nm.The improvement of peak WPE can be attributed to the improved QW quality and the reduced active recombination volume.Subsequently,a series of efficient InGaN-based orange and red LEDs was demonstrated.With further development,the InGaN-based red LEDs are believed to be attainable and can be used in micro LED displays. | Shengnan Zhang Jianli Zhang Jiangdong Gao Xiaolan Wang Changda Zheng Meng Zhang Xiaoming Wu Longquan Xu Jie Ding Zhijue Quan Fengyi Jiang | 2020 | Photonics Research2020，8，11： | 10 |
| 15 | Decolorization on Indigo Dyeing Wastewater by Laccase from Coriolus versicolor显示文摘[Object]The study aimed to discuss the decolorization on indigo dyeing wastewater by laccase from Coriolus versicolor.[Method]Firstly,the effects of temperature,pH,indigo concentration,HBT concentration,laccase dosage on the decolorization of indigo dyeing wastewater by laccase /HBT,and then the synergism of laccase and acid cellulase was analyzed.[Result]Using ABTS as the substrate,the kinetic parameters,K m and V max,were 0.318 mmol/L and 0.035 5 mmol/(L·min) respectively.The decolorization rate of indigo reached 96.5% when the laccase acted on indigo for 40 min with HBT as an introducer at temperature 50 ℃,pH =4.5,indigo concentration 100 mg /L,HBT concentration 0.1% and laccase dosage 100 IU /L.Due to the synergism of laccase and acid cellulase during the bio-finishing of blue jeans,the backstaining degree of blue jeans reduced by 85% when the amount of laccase added was 15 000 IU /kg.Menawhile,the synergism of the laccase and acid cellulase decreased indigo concentration in wastewater by 83.8%.[Conclusion] The laccase from Coriolus versicolor had a good prospect in the bio-finishing of blue jeans and the decolorization of indigo dyeing wastewater. | Enli Gao Weijia Zhong Xiaolan Fu Fushan Chen Zhigang Ye | 2013 | Meteorological and Environmental Research2013，4，1： | 10 |
| 16 | Characteristics of Boundary Layer Structure during a Persistent Haze Event in the Central Liaoning City Cluster, Northeast China显示文摘The characteristics of boundary layer structure during a persistent regional haze event over the central Liaoning city cluster of Northeast China from 16 to 21 December 2016 were investigated based on the measurements of particulate matter(PM) concentration and the meteorological data within the atmospheric boundary layer(ABL). During the observational period, the maximum hourly mean PM_(2.5) and PM10 concentrations in Shenyang, Anshan, Fushun, and Benxi ranged from 276 to 355 μg m–3 and from 378 to 442 μg m–3, respectively, and the lowest hourly mean atmospheric visibility(VIS) in different cities ranged from 0.14 to 0.64 km. The central Liaoning city cluster was located in the front of a slowly moving high pressure and was mainly controlled by southerly winds. Wind speed(WS) within the ABL(< 2 km) decreased significantly and WS at 10-m height mostly remained below 2 m s–1 during the hazy episodes, which was favorable for the accumulation of air pollutants. A potential temperature inversion layer existed throughout the entire ABL during the earlier hazy episode [from 0500 Local Time(LT) 18 December to 1100 LT 19 December], and then a potential temperature inversion layer developed with the bottom gradually decreased from 900 m to 300 m. Such a stable atmospheric stratification further weakened pollutant dispersion. The atmospheric boundary layer height(ABLH) estimated based on potential temperature profiles was mostly lower than 400 m and varied oppositely with PM_(2.5) in Shenyang. In summary, weak winds due to calm synoptic conditions, strong thermal inversion layer, and shallow atmospheric boundary layer contributed to the formation and development of this haze event.The backward trajectory analysis revealed the sources of air masses and explained the different characteristics of the haze episodes in the four cities. | Xiaolan LI Yangfeng WANG Lidu SHEN Hongsheng ZHANG Hujia ZHAO Yunhai ZHANG Yanjun MA | 2018 | Journal of Meteorological Research2018，32，2： | 10 |
| 17 | Exosomes: roles and therapeutic potential in osteoarthritis显示文摘Exosomes participate in many physiological and pathological processes by regulating cell–cell communication, which are involved in numerous diseases, including osteoarthritis(OA). Exosomes are detectable in the human articular cavity and were observed to change with OA progression. Several joint cells, including chondrocytes, synovial fibroblasts, osteoblasts, and tenocytes, can produce and secrete exosomes that influence the biological effects of targeted cells. In addition, exosomes from stem cells can protect the OA joint from damage by promoting cartilage repair, inhibiting synovitis, and mediating subchondral bone remodeling.This review summarizes the roles and therapeutic potential of exosomes in OA and discusses the perspectives and challenges related to exosome-based treatment for OA patients in the future. | Zhenhong Ni Siru Zhou Song Li Liang Kuang Hangang Chen Xiaoqing Luo Junjie Ouyang Mei He Xiaolan Du Lin Chen | 2020 | Bone Research2020，8，2： | 10 |
| 18 | A computational cognition model of perception,memory,and judgment显示文摘The mechanism of human cognition and its computability provide an important theoretical foundation to intelligent computation of visual media.This paper focuses on the intelligent processing of massive data of visual media and its corresponding processes of perception,memory,and judgment in cognition.In particular,both the human cognitive mechanism and cognitive computability of visual media are investigated in this paper at the following three levels:neurophysiology,cognitive psychology,and computational modeling.A computational cognition model of Perception,Memory,and Judgment(PMJ model for short)is proposed,which consists of three stages and three pathways by integrating the cognitive mechanism and computability aspects in a unified framework.Finally,this paper illustrates the applications of the proposed PMJ model in five visual media research areas.As demonstrated by these applications,the PMJ model sheds some light on the intelligent processing of visual media,and it would be innovative for researchers to apply human cognitive mechanism to computer science. | FU XiaoLan CAI LianHong LIU Ye JIA Jia CHEN WenFeng YI Zhang ZHAO GuoZhen LIU YongJin WU ChangXu | 2014 | Science China(Information Sciences)2014，57，3： | 10 |
| 19 | Metal Sealing Performance of Subsea X-tree Wellhead Connector Sealer显示文摘The metal sealing performance of subsea X-tree wellhead connectors is crucial for the safety and reliability of subsea X-trees. In order to establish the theoretical relation between metal sealing ring's contact stress and its structural parameters and working pressure, a mechanical analysis method for double-cone sealing of high pressure vessels is applied in analyzing the metal sealing ring under the condition of preload and operation. As a result, the formula of the unit sealing load for the metal sealing ring under operation with residual preload is shown in this paper, which ensures that the metal sealing ring has an excellent sealing effect and can prevent the metal sealing ring from yielding. Besides, while analyzing the sealing process of the metal sealing ring, the change rule of contact stress and working pressure is concluded here, putting forward that the structural parameters of the metal sealing ring are the major factors affecting the change rule. Finally, the analytical solution through theoretical analysis is compared with the simulation result through finite element analysis in a force feedback experiment, and both are consistent with each other, which fully verifies for the design and calculation theory on metal sealing ring's contact stress and its structural parameters and working pressure deduced in this paper. The proposed research will be treated as an applicable theory guiding the design of metal seal for subsea X-tree wellhead connectors. | ZHAO Honglin CHEN Rui LUO Xiaolan DUAN Menglan LU Yinghui FU Guowei TIAN Hongping YE Daohui | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 9 |
| 20 | Functional Characterization of the Promoter and Second Intron of CUM1 During Flower Development in Cucumber(Cucumis sativus L.)显示文摘The characterization of flower specific promoter is critical during flower development by cucumber transformation technology.AGAMOUS(AG)is an organ identity gene that is required for carpel and stamen development in Arabidopsis.The promoter and second intron of AG contain multiple regulatory elements that confer proper spatial and temporal expression.Cucumber is an important vegetable with unisexual flowers.Cucumber MADS-box 1(CUM1)is the AG homolog in cucumber,belonging to the eu AG lineage along with AG.In situ hybridization showed that CUM1 was specifically expressed in the stamens and carpels of cucumber.GUS staining indicated that the second intron of CUM1 confers stamen-specific expression,while the promoter of CUM1 drives both stamen-and carpel-specific expression during the early stages of flower development,but is restricted to carpel-and connectivum-specific expression during the late stages of flower development.Furthermore,a yeast one-hybrid assay demonstrated that two auxin response factors(Cs ARF13 and Cs ARF17)had bound directly to the second intron of CUM1.Our data suggest that different regulatory circuits operate in AG homologs in plant species with distinct sex types. | GU Ran LIU Xiaofeng ZHAO Wensheng YAN Shuangshuang SUN Linhan WU Binning ZHANG Xiaolan | 2018 | Horticultural Plant Journal2018，4，3： | 9 |
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