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| 1 | Nitrogen deposition as an important nutrient from the environment and its impact on ecosystems in China显示文摘As an example of atmospheric nitrogen(N) deposition,the paper summarizes the definition,form and amount of nutrient from the environment(NFE) and the relationship between NFE and anthro-pogenic reactive N emission.Based on our own study and published articles,we find that N wet and dry deposition has been an important nutrient resource in agricultural and natural ecosystems in China.The total amount of N deposition and other environment-derived N in China was up to 18 Tg N/a,equal to ap-proximately 60% of the national N fertilizer consumption.Nitrogen deposition is expected to contribute substantially to nutrient cycling and net primary productivity in various ecosystems.Therefore,it is crucial to utilize this environment-derived nutrient resource by integrated nutrient resource management in order to realize the sustainable development of both agricultural and non-agricultural ecosystems. | Liu, XueJun Song, Ling He, ChunE Zhang, FuSuo | 2010 | Journal of Arid Land2010，2，2： | 15 |
| 2 | Precipitation Chemistry and Corresponding Transport Patterns of Influencing Air Masses at Huangshan Mountain in East China显示文摘One hundred and ten samples of rainwater were collected for chemical analysis at the summit of Huangshan Mountain, a high-altitude site in East China, from July 2010 to June 2011. The volume-weighted-mean(VWM) pH for the whole sampling period was 5.03. SO2-4and Ca2+were the most abundant anion and cation, respectively. The ionic concentrations varied monthly with the highest concentrations in winter/spring and the lowest in summer. Evident inter-correlations were found among most ions, indicating the common sources for some species and fully mixing characteristics of the alpine precipitation chemistry. The VWM ratio of [SO2-4]/[NO-3] was 2.54, suggesting the acidity of rainwater comes from both nitric and sulfuric acids. Compared with contemporary observations at other alpine continental sites in China, the precipitation at Huangshan Mountain was the least polluted, with the lowest ionic concentrations. Trajectories to Huangshan Mountain on rainy days could be classified into six groups. The rainwater with influencing air masses originating in Mongolia was the most polluted with limited effect. The emissions of Jiangxi, Anhui, Zhejiang and Jiangsu provinces had a strong influence on the overall rain chemistry at Huangshan Mountain. The rainwater with influencing air masses from Inner Mongolia was heavily polluted by anthropogenic pollutants. | SHI ChunE DENG Xueliang YANG Yuanjian HUANG Xiangrong WU Biwen | 2014 | Advances in Atmospheric Sciences2014，31，5： | 9 |
| 3 | Development of composite PLGA microspheres containing exenatide-encapsulated lecithin nanoparticles for sustained drug release显示文摘This study aimed to prepare poly(D, L-lactic-co-glycolic acid) microspheres(PLGA-Ms)by a modified solid-in-oil-in-water(S/O/W) multi-emulsion technique in order to achieve sustained release with reduced initial burst and maintain efficient drug concentration for a prolonged period of time. Composite PLGA microspheres containing exenatideencapsulated lecithin nanoparticles(Ex-NPs-PLGA-Ms) were obtained by initial fabrication of exenatide-loaded lecithin nanoparticles(Ex-NPs) via the alcohol injection method,followed by encapsulation of Ex-NPs into PLGA microspheres. Compared to Ms prepared by the conventional water-in-oil-in-water(W/O/W) technique(Ex-PLGA-Ms), Ex-NPs-PLGAMs showed a more uniform particle size distribution, reduced initial burst release, and sustained release for over 60 d in vitro. Cytotoxicity studies showed that Ms prepared by both techniques had superior biocompatibility without causing any detectable cytotoxicity.In pharmacokinetic studies, the effective drug concentration was maintained for over 30 d following a single subcutaneous injection of two types of Ms formulation in rats, potentially prolonging the therapeutic action of Ex. In addition, administration of Ex-NPs-PLGA-Ms resulted in a more smooth plasma concentration-time profile with a higher area under the curve(AUC) compared to that of Ex-PLGA-Ms. Overall, Ex-NPs-PLGA-Ms prepared by the novel S/O/W method could be a promising sustained drug release system with reduced initial burst release and prolonged therapeutic efficacy. | Ni Dong Chune Zhu Junhuang Jiang Di Huang Xing Li Guilan Quan Yang Liu Wen Tan Xin Pan Chuanbin Wu | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 7 |
| 4 | Herz type Besov and Triebel-Lizorkin spaces with variable exponent显示文摘 | Chune SHI Jingshi XU | 2013 | Frontiers of Mathematics in China2013，8，4： | 5 |
| 5 | TPGS/hyaluronic acid dual-functionalized PLGA nanoparticles delivered through dissolving microneedles for markedly improved chemo-photothermal combined therapy of superficial tumor显示文摘Nanoparticles(NPs)have shown potential in cancer therapy,while a single administration conferring a satisfactory outcome is still unavailable.To address this issue,the dissolving microneedles(DMNs)were developed to locally deliver functionalized NPs with combined chemotherapy and photothermal therapy(PTT).α-Tocopheryl polyethylene glycol succinate(TPGS)/hyaluronic acid(HA)dualfunctionalized PLGA NPs(HD10 NPs)were fabricated to co-load paclitaxel and indocyanine green.HD10 NPs significantly enhanced the cytotoxicity of low-dose paclitaxel because of active and mitochondrial targeting by HA and TPGS,respectively.PTT could further sensitize tumor cells toward chemotherapy by promoting apoptosis into the advanced period,highly activating caspase 3 enzyme,and significantly reducing the expression of survivin and MMP-9 proteins.Further,the anti-tumor effects of HD10 NPs delivered through different administration routes were conducted on the 4 T1 tumorbearing mice.After a single administration,HD10 NPs delivered with DMNs showed the best antitumor effect when giving chemotherapy alone.As expected,the anti-tumor effect was profoundly enhanced after combined therapy,and complete tumor ablation was achieved in the mice treated with DMNs and intra-tumor injection.Moreover,DMNs showed better safety due to moderate hyperthermia.Therefore,the DMNs along with combined chemo-photothermal therapy provide a viable treatment option for superficial tumors. | Tingting Peng Yao Huang Xiaoqian Feng Chune Zhu Shi Yin Xinyi Wang Xuequn Bai Xin Pan Chuanbin Wu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 4 |
| 6 | Nitrogen deposition and its ecological impact in China: An overview显示文摘 | Xuejun Liu Lei Duan Jiangming Mo Enzai Du Jianlin Shen Xiankai Lu Ying Zhang Xiaobing Zhou Chune He Fusuo Zhang | 2010 | Environmental Pollution2010，，10： | 4 |
| 7 | Comparison of Clinical and Epidemiological Characteristics of Asymptomatic and Symptomatic SARS-CoV-2 Infection in Children显示文摘To understand the epidemiological and clinical features of the symptomatic and asymptomatic pediatric cases of COVID-19,we carried out a prospective study in Shanghai during the period of January 19 to April 30,2020.A total of 49 children(mean age 11.5±5.12 years)confirmed with SARS-CoV-2 infection were enrolled in the study,including 11(22.4%)domestic cases and 38(77.6%)imported cases.Nine(81.8%)local cases and 12(31.6%)imported cases had a definitive epidemiological exposure.Twenty-eight(57.1%)were symptomatic and 21(42.9%)were asymptomatic.Neither asymptomatic nor symptomatic cases progressed to severe diseases.The mean duration of viral shedding for SARS-CoV-2 in upper respiratory tract was 14.1±6.4 days in asymptomatic cases and 14.8±8.4 days in symptomatic cases(P>0.05).Forty-five(91.8%)cases had viral RNA detected in stool.The mean duration of viral shedding in stool was 28.1±13.3 days in asymptomatic cases and 30.8±18.6 days in symptomatic participants(P>0.05).Children<7 years shed viral RNA in stool for a longer duration than school-aged children(P<0.05).Forty-three(87.8%)cases had seropositivity for antibodies against SARS-CoV-2 within 1–3 weeks after confirmation with infection.In conclusion,asymptomatic SARS-CoV-2 infection may be common in children in the community during the COVID-19 pandemic wave.Asymptomatic cases shed viral RNA in a similar pattern as symptomatic cases do.It is of particular concern that asymptomatic individuals are potentially seed transmission of SARS-CoV-2 and pose a challenge to disease control. | Jiehao Cai Xiangshi Wang Jun Zhao Yanling Ge Jin Xu He Tian Hailing Chang Aimei Xia Jiali Wang Jinqiang Zhang Zhongqiu Wei Jingjing Li Chuning Wang Jianshe Wang Qirong Zhu Xiaowen Zhai Mei Zeng | 2020 | Virologica Sinica2020，35，6： | 4 |
| 8 | Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis显示文摘The adenoma-carcinoma sequence is a well-accepted roadmap for the development of sporadic colorectal cancer.However,cellular heterogeneity in aberrant epithelial cells limits our understanding of carcinogenesis in colorectal tissues.Here,we performed a single-cell RNA sequencing survey of 54,788 cells from patient-matched tissue samples,including blood,normal tissue,para-cancer,polyp,and colorectal cancer. | Xiaobo Zheng Jinen Song Chune Yu Zongguang Zhou Xiaowei Liu Jing Yu Guangchao Xu Jiqiao Yang Xiujing He Xin Bai Ya Luo Yu Bao Huifang Li Lie Yang Mingqing Xu Nan Song Xiaodong Su Jie Xu Xuelei Ma Hubing Shi | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 9 | Anti-enrofloxacin Antibody Production by Using Enrofloxacin-screened HSA as an Immunogen显示文摘A two-step zero-length cross-linking procedure using active esters was successfully adopted for conjugating en-rofloxacin (EF) to human serum albumin (HSA). The derived conjugate was characterized by UV spectrum and then usedfor immunization of BALB/C mice. In enzyme-linked immunosorbent assay (ELISA) and competitive inhibition ELISA ex-periments, the derived antiserum exhibited high antibody titer (greater than 1: 250 000) as well as varied cross-reactivity(from 97.8% to 161.7%) to three analogs of EF belonging to fluoroquinolones family. But over the concentration rangestudied, no significant cross-reactivity was observed to other group of antibiotics (chloramphenicol, oxytetracycline, sul-phamethoxazole and nysfungin). It was confirmed that the synthesized immunogen was highly antigenic and elicited specificantibody responses in BALB/C mice against EF. | LIU Chune LIN Hong CAO Limin JIANG Jie | 2005 | Journal of Ocean University of China2005，4，3： | 2 |
| 10 | Spectroscopic study of conformation changes of bovine serum albumin in aqueous environment显示文摘The secondary structural changes of bovine serum albumin (BSA) aqueous solutions with and without calcium cations were investigated by attenuated total reflection-Fourier transform infrared (ATR-FTIR) technology. The spectra of BSA solution and BSA dry powder were mainly reflected the formation of hydrogen bonds between water and BSA. Further investigation indicated that the concentrations of calcium cations in BSA aqueous solution also affected the secondary structural change of the protein. Amide I band was red shifted and amide II band was blue shifted in aqueous environment compared with the dry BSA powder, and the addition of calcium cations further changed the amide bands position, which led to the change of the secondary structure. The result was coinciding with the Raman spectroscopy. | Chune Guo Xiaomi Guo Wubo Chu Nan Jiang He Li | 2019 | Chinese Chemical Letters2019，30，6： | 2 |
| 11 | Study on the synthetic process of calcium borate 显示文摘 | Cao Chune Wang Yingjun Zheng Naizhang | 2005 | Key Engineering Materials2005，，280283： | 1 |
| 12 | Overweight, obesity, and their associations with insulin resistance and β -cell function among Chinese: a cross-sectional study in China显示文摘 | Gang Chen Chune Liu Jin Yao Qiqin Jiang Nianhui Chen Huibin Huang Jixing Liang Liantao Li Lixiang Lin | 2010 | Metabolism2010，，12： | 1 |
| 13 | Hewei Jiangni granule alleviates visceral hypersensitivity in a rat model of non-erosive reflux disease via transient receptor potential channel signaling显示文摘Objective:To uncover the underlying mechanism of Hewei Jiangni granule(HWJNG)on non-erosive reflux disease(NERD)treatment by examining histological changes,gastrointestinal neurochemicals release and visceral hypersensitivity-related receptor expression in NERD model rats.Methods:A NERD rat model was established via a combination of basal sensitization and acid perfusion.HWJNG treatments at different doses were then administered.Pathological changes to tissues,mast cell(MC)activation,serum levels of esophageal visceral hypersensitivity-related neurochemicals,and transient receptor potential(TRP)receptor mRNA and protein levels were investigated.Results:Compared with the control group,the expression of tryptase in MCs,the changes of intercellular space,and the serum levels of substance P(SP),calcitonin gene-related peptides(CGRP)and proteinaseactivated receptor 2(PAR2)increased in the model group(all P<.05).The expression of TRP vanilloid 1(Trpv1)mRNA decreased in esophagus and dorsal root ganglia(DRG)of the model group(P=.030&P=.013),and the expression of TRP melastatin channel subfamily member 8(Trpm8)mRNA decreased in the esophagus of model group(P<.01).The level of esophageal TRPV1 protein increased in the model group(P<.01)and the level of TRPM8 protein decreased in esophagus and DRG of the model group(both P<.05).Compared with the model group,the serum levels of SP,CGRP,and PAR2 in the mediumdose HWJNG group showed significant decreases(all P<.05).The expression of Trpv1 mRNA in esophagus and DRG of the HWJNG groups and the Omeprazole group remarkably decreased(all P<.05),as was the expression of Trpm8 mRNA in esophagus of the HWJNG groups(all P<.05).Conclusion:HWJNG alleviated visceral hypersensitivity in NERD model rats by regulating TRP-mediated signaling.Our results indicate that HWJNG has potential as a therapeutic agent for NERD. | Jiali Liu Fushun Kou Xiang Tan Yi Dai Chune Xie Xiaohong Li Lei Shi Tangyou Mao Xiaojun Shi Junxiang Li | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 1 |
| 14 | FTIR-ATR study for adsorption of trypsin in aqueous environment on bare and TiO2 coated ZnSe surfaces显示文摘Undesired adsorption of proteins brings big troubles to marine structures.The settled proteins change the physical and chemical properties of the surfaces,which allow marine fouling organisms to settle down on the structures.Therefore,to understand the adsorption mechanism of proteins is very helpful to find an environment-friendly solution against biofouling.Many approaches have been developed to study protein adsorption,but most of them are insufficient to give the chemical interaction information between proteins and surfaces.Fourier transform infrared spectroscopy with attenuated total reflection(FTIR-ATR)is an efficient,fast and non-destructive method for in situ surface measurement,which greatly minimizes the interference of water to infra red spectra,because of the very small depth of penetration of the evanescent wave.In this paper,an in situ FTIR-ATR technology was used to investigate the adsorption process of trypsin on a bare ZnSe surface and on a TiO2 coated ZnSe surface,and the effect of calcium cation strength and ultraviolet light irradiation on the secondary structure of trypsin were also evaluated.FTIR spectra of trypsin showed that Amide I band red shift and AmideⅡband blue shift in aqueous environment on both surfaces compared with the dry trypsin powder,and the addition of calcium cations further changed the Amide bands position,which indicated that the change of the secondary structure could be interfered by the environment.The hydrogen bond formation between water and trypsin,the interaction between surface and trypsin,the interaction between hydrated calcium cations and trypsin,are major facto rs to change the secondary structure of trypsin,and UV light irradiation also showed its influence for the secondary structure. | Chune Guo Xiaomi Guo Wubo Chu Nan Jiang He Li | 2020 | Chinese Chemical Letters2020，31，1： | 1 |
| 15 | Successful removal of freckles in asian skin with a Q - switched alexandrite laser显示文摘 | Chune E C Choi J H | 2000 | Dermatol surg2000，26，3： | 1 |
| 16 | Impacts of ur- banization on long-term fog variation in Anhui Province, China 显示文摘 | Shi Chune Matthias Roth B Zhang Hao | 2008 | Atmos Environ2008，42，： | 1 |
| 17 | New mutants of speciality rice induced from pumbyeo, a high - quality rice cultivar, by MNU treatment on fertilized egg cells显示文摘 | Choi Hae Chune | 2006 | Korea Journal of Breeding2006，38，： | 1 |
| 18 | Single-mode Coupling Efficiencies of Type-Ⅱ Spontaneous Parametric Down-conversion:Collinear,Noncollinear,and Beamlike Phase Matching显示文摘 | HOU SHUN POH CHUNE YANG LUM IVAN MARCIKIC | | 0，，： | 1 |
| 19 | 3D model study on fog over complex terrain part Ⅰ:numerical study显示文摘 | Li Zihua Shi Chune | 1997 | Acta Meteorologica Sinica1997，10，1： | 1 |
| 20 | 3D model study on fog over complex terrain part Ⅰ: numerical study 显示文摘 | Li Zihua Shi Chune | 1997 | Acta Meteor Sinica1997，10，1： | 1 |
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