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| 1 | Enhancing sewage sludge dewaterability by bioleaching approach with comparison to other physical and chemical conditioning methods显示文摘The sewage sludge conditioning process is critical to improve the sludge dewaterability prior to mechanical dewatering.Traditionally,sludge is conditioned by physical or chemical approaches,mostly with the addition of inorganic or organic chemicals.Here we report that bioleaching,an efficient and economical microbial method for the removal of sludge-borne heavy metals,also plays a significant role in enhancing sludge dewaterability.The effects of bioleaching and physical or chemical approaches on sludge dewaterability were compared.The conditioning result of bioleaching by Acidithiobacillus thiooxidans and Acidithiobacillus ferrooxidans on sludge dewatering was investigated and compared with the effects of hydrothermal(121°C for 2 hr),microwave(1050 W for 50 sec),ultrasonic(250 W for 2 min),and chemical conditioning(24% ferric chloride and 68% calcium oxide;dry basis).The results show that the specific resistance to filtration(SRF) or capillary suction time(CST) of sludge is decreased by 93.1% or 74.1%,respectively,after fresh sludge is conditioned by bioleaching,which is similar to chemical conditioning treatment with ferric chloride and calcium oxide but much more effective than other conditioning approaches including hydrothermal,microwave,and ultrasonic conditioning.Furthermore,after sludge dewatering,bioleached sludge filtrate contains the lowest concentrations of chroma(18 times),COD(542 mg/L),total N(TN,300 mg/L),NH 4 +-N(208 mg/L),and total P(TP,2 mg/L) while the hydrothermal process resulted in the highest concentration of chroma(660 times),COD(18,155 mg/L),TN(472 mg/L),NH 4 +-N(381 mg/L),and TP(191 mg/L) among these selected conditioning methods.Moreover,unlike chemical conditioning,sludge bioleaching does not result in a significant reduction of organic matter,TN,and TP in the resulting dewatered sludge cake.Therefore,considering sludge dewaterability and the chemical properties of sludge filtrate and resulting dewatered sludge cakes,bioleaching has potential as an approach for improving sludge dewaterability and reducing the cost of subsequent reutilization or disposal of dewatered sludge. | Fenwu Liu Jun Zhou Dianzhan Wang Lixiang Zhou | 2012 | Journal of Environmental Sciences2012，24，8： | 26 |
| 2 | Cadmium transport mediated by soil colloid and dissolved organic matter:A field study显示文摘This study investigated the potential role of soil colloids and dissolved organic matter (DOM) in transporting Cd through in situ undisturbed paddy soil monoliths. Brilliant Blue was used as a tracer to assess the effect of preferential flow on Cd down migration. Experimental results showed that deep penetration of Cd and Brilliant Blue into the soil profile took place due to the preferential flow through macropores, mainly earthworm channels, with much of chemicals thus bypassing the soil matrix. Dye tracer and Cd distribution within the soil matrix was fairly restricted to several centimeters. Colloid restrained the migration of both dye and Cd in the matrix and preferential flow area. DOM facilitated the transport of Cd and Brilliant Blue in matrix and macropores by about 10 cm over that of the control. Pearson's is correlation analysis revealed strong associations between Brilliant Blue concentrations, exchangeable Cd and total Cd concentrations in three studied plots indicating that they had taken the same preferential flow pathway. | Zhaoli Li, Lixiang Zhou College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. | 2010 | Journal of Environmental Sciences2010，22，1： | 24 |
| 3 | siRNA-mediated inhibition of HBV replication and expression显示文摘AIM: RNA interference (RNAi) is a newly discovered phenomenon provoked by dsRNA. The dsRNA is initially cleaved by Dicer into 21-23 nt small interfering RNA (siRNA) and can then specifically target homologous mRNA for degradation by cellular ribonucleases. RNAi has been successfully utilized to down-regulate the endogenous gene expression or suppress the replication of various pathogens in mammalian cells. In this study, we investigated whether vector-based siRNA promoted by U6 (pSilencer1.0-U6) could efficiently inhibit HBV replication in cell culture. METHODS: pSilencer vectors with inserts targeting on different regions of HBV genome were constructed. These plasmids were co-transfected with pHBV3.8 into Huh-7 cells via lipofection and viral antigens were measured by ELISA. Viral RNA was analyzed by Northern blot. The mRNA of MxA and 2'-5'OAS was reverse transcribed and quantified by real-time PCR.RESULTS: Vector-based siRNA could potently reduce hepatitis 13 virus antigen expression in transient replicative cell culture. Furthermore, Northern blot analysis showed that viral RNA was effectively degraded, thus eliminating the messengers for protein expression as well as template for reverse transcription. Real-time PCR analysis of cellular MxA and 2'-5'OAS gene expression revealed that vectorbased siRNA did not provoke the interferon pathway which reassured the specificity of the vector-based RNA interference technique. CONCLUSION: Our results indicate that RNA interference may be a potential tool to control HBV infection. | Xiao-NanZhang WeiXiong Jia-DongWang Yun-WenHu LiXiang Zheng-HongYuan | 2004 | World Journal of Gastroenterology2004，10，20： | 19 |
| 4 | Gut microbes in cardiovascular diseases and their potential therapeutic applications显示文摘Microbial ecosystem comprises a complex community in which bacteria interact with each other. The potential roles of the intestinal microbiome play in human health have gained considerable attention. The imbalance of gut microbial community has been looked to multiple chronic diseases. Cardiovascular diseases (CVDs) are leading causes of morbidity worldwide and are influenced by genetic and environmental factors. Recent advances have provided scientific evidence that CVD may also be attributed to gut microbiome. In this review, we highlight the complex interplay between microbes, their metabolites, and the potential influence on the generation and development of CVDs. The therapeutic potential of using intestinal microbiomes to treat CVD is also discussed. It is quite possible that gut microbes may be used for clinical treatments of CVD in the near future. | Ling Jin Xiaoming Shi Jing Yang Yangyu Zhao Lixiang Xue Li Xu Jun Cai | 2021 | Protein & Cell2021，12，5： | 14 |
| 5 | Occurrence of Neoproterozoic low-grade metagranite in the western Beihuaiyang zone,the Dabie orogen显示文摘Based on detailed field investigations and petrographic observations,we discovered Neoproterozoic-emplaced granite from the metavolcanics of the Dingyuan Formation in the western Beihuaiyang zone,the Dabie orogen. This study reports the results of zircon U-Pb dating and preliminary petrographic observations on two metagranite samples. The studied rocks experienced epidote-amphibolite facies metamorphism and strong structural deformation. Their U-Pb ages are 726 ± 6 and 758 ± 12 Ma,respectively,similar to those for the Luzhenguan complex in the eastern segment of the Beihuaiyang zone. In combination with previously determined 635 ± 5 Ma low-grade metagabbro,this study suggests the occurrence of at least two types of Neoproterozoic intrusive rocks in the Beihuaiyang zone,the northern margin of the South China Block (SCB):726-758 Ma metagranite and 635 Ma metagabbro. These rocks occur within the metamorphosed Ordovician volcanic zone (originally named the Dingyuan Formation) and are in tectonic contact to each other,but they formed in different tectonic settings. The protolith ages for the Neoproterozoic low-grade metaigneous rocks are in good agreement not only with ages for two episodes of mid-and late-Neoproterozoic mafic and felsic magmatism in the Suizhou and Zaoyang area,Hubei Province,but also agree with protolith ages of ultrahigh-pressure metaigneous rocks in the Dabie-Sulu orogenic belt. In view of their tectonic relationships to country rocks,it appears that these Neoproterozoic low-grade rocks are exotic and they may have been detached and scraped from subducting SCB crust in the early Triassic during the initial continental subduction,and thrusted over Paleozoic metamorphosed rocks in the southern margin of the North China Block during continental collision. | LIU YiCan LIU LiXiang GU XiaoFeng LI ShuGuang SONG Biao | 2010 | Chinese Science Bulletin2010，55，30： | 10 |
| 6 | Interactive effect of dissolved organic matter and phenanthrene on soil enzymatic activities显示文摘The investigation of dissolved organic matter(DOM) on urease,catalase and polyphenol oxidase activity in a phenanthrene(Phe)contaminated soil was conducted under laboratory incubation conditions.Values of soil enzymatic activity depended mainly on incubation time.In the initial 16 days,urease activity increased,and was followed by a decrease.In the initial 8 days,catalase activity decreased and then increased.Variation of polyphenol oxidase activity was just the reverse of catalase activity.After 30 days of incubation,no pronounced difference among treatments with Phe,Phe and DOM,and control were detected in urease,catalase and polyphenol oxidase activity.Phe might inhibit urease and catalase,and stimulate polyphenol oxidase.DOM could improve inhibition of Phe in soil urease and catalase activity during the initial period of applying DOM.Nevertheless,DOM had no significant effect on polyphenol oxidase activity in the Phe contaminated soil.There was a negative correlation between catalase and polyphenol oxidase(r =-0.761***),and catalase and urease(r =-0.554**).Additionally,a positive correlation between polyphenol oxidase and urease was also detected(r = 0.701***).It is implied that the formed DOM after application of organic wastes into soils may counteract the inhibition of polycyclic aromatic hydrocarbons in soil enzyme activities. | Xinhua Zhan,Wenzhu Wu,Lixiang Zhou,Jianru Liang,Tinghui Jiang College of Resources and Environmental Sciences,Nanjing Agricultural University,Nanjing 210095,China.Greenstar Plant Products Inc.,9430 198 St,Langley,BC,Canada V1M3C8. | 2010 | Journal of Environmental Sciences2010，22，4： | 10 |
| 7 | Biodegradation of aniline by Candida tropicalis AN1 isolated from aerobic granular sludge显示文摘Aniline-degrading microbes were cultivated and acclimated with the initial activated sludge collected from a chemical wastewater treatment plant. During the acclimation processes, aerobic granular sludge being able to effectively degrade aniline was successfully formed, from which a preponderant bacterial strain was isolated and named as AN1. Effects of factors including pH, temperature, and second carbon/nitrogen source on the biodegradation of aniline were investigated. Results showed that the optimal conditions for the biodegradation of aniline by the strain AN1 were at pH 7.0 and 28-35°C. At the optimal pH and temperature, the biodegradation rate of aniline could reach as high as 17.8 mg/(L·hr) when the initial aniline concentration was 400 mg/L. Further studies revealed that the addition of 1 g/L glucose or ammonium chloride as a second carbon or nitrogen source could slightly enhance the biodegradation efficiency from 93.0% to 95.1%-98.5%. However, even more addition of glucose or ammonium could not further enhance the biodegradation process but delayed the biodegradation of aniline by the strain AN1. Based on morphological and physiological characteristics as well as the phylogenetic analysis of 26S rDNA sequences, the strain AN1 was identified as Candida tropicalis. | Dianzhan Wang Guanyu Zheng Shimei Wang Dewei Zhang Lixiang Zhou | 2011 | Journal of Environmental Sciences2011，23，12： | 10 |
| 8 | Liuwei Dihuang pill suppresses metastasis by regulating the wnt pathway and disrupting β-catenin/T cell factor interactions in a murine model of triple-negative breast cancer显示文摘OBJECTIVE:To investigate if the Liuwei Dihuang pill(LWDHP)can inhibit metastasis to the liver and lungs in mice bearing triple-negative breast cancer(TNBC),and the molecular mechanism underpinning this action.METHODS:Ninety-nine TNBC bearing-mice were distributed randomly to five groups:control(Con),paclitaxel(PTX),low-dose LWDHP(LLP,2.3 g·kg^-1·d^-1),middle-dose LWDHP(MLP,4.6 g·kg^-1·d^-1)and high-dose LWDHP(HLP,9.2 g·kg^-1·d^-1).The LWDHP were administered(p.o.)to the agonal stage.The morphology of BC cells was observed by hematoxylin&eosin staining.Expression of axin-2,β-catenin,T cell factor(TCF),cyclin-D1 and vascular endothelial growth factor(VEGF)was detected by western blotting or immunofluorescence.β-catenin/TCF-1 interaction was measured using a co-immunoprecipitation assay.RESULTS:After LWDHP treatment,metastasis of BC cells to the lungs and liver was inhibited,expression of axin-2 was increased,expression of TCF-1,β-catenin,cyclin-D1 and VEGF was decreased,andβ-catenin/TCF-1 interaction was disrupted.CONCLUSION:The LWDHP could inhibit metastasis of BC cells to the liver and lungs.The molecular mechanism underlying this action may be regulation of protein expression andβ-catenin/TCF-1 interactions in the Wnt pathway. | Zheng Lixiang Zheng Qing Yu Zhipeng Wang Jian Ren Xiaoying Gong Yan Yang Xue Hunag Ping Weng Meizhi Liu Hongning Liu Haizhou | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 9 |
| 9 | HPRF pulse Doppler stepped frequency radar显示文摘Stepped frequency radar is a well known scheme to generate high range resolution profile(HRRP) of targets. Through appropriate radar parameter design,the radar enables both unambiguous velocity measurement and high resolution ranging within a single dwell in a high pulse repetition frequency(HPRF) mode. This paper analyzes in detail the design principle of the HPRF stepped frequency radar system,the solution to its ambiguity issue,as well as its signal processing method. Both theoretical analysis and simulation results demonstrate that the proposed radar scheme can work independently to solve the problem of motion compensation,and is therefore highly applicable to many new types of radar. | LONG Teng REN LiXiang | 2009 | Science in China(Series F)2009，52，5： | 8 |
| 10 | Using repeated precise gps campaigns for research of present-day crustal movement and strain in the Qinghai-Tibetan Plateau显示文摘The problem of crustal movement in the Qing-hai-Tibetan Plateau is a hotstopic of the present-day international geodetic world. GPS observations in 1993, 1995 and 1997 are used to survey the three-dimensional displacement of GPS monitoring station in the Qinghai-Tibetan Plateau, and to calculate and analyze the present-day crustal movement and strain in the Qinghai-Tibetan Plateau. The result of repeated campaign shows that the crustal movement in the Qinghai-Tibetan Plateau is still compressing in the north and south directions, extending in the west and east directions, and uplifting in the vertical direction. The relative convergence velocity of the Himalayan block is approximately (19.5±1.7)mm/a, the strain velocity is about (5.5±6.0) mm/a, and the uplifting velocity is some (7.6±5.2) mm/a. The compression velocity of the Tibet block relative to Golmud in the north and south directions is (9.3±4.6) mm/a, the strain velocity of the middle part in the west and east directions is (15.6±6.3) mm/a, | LIU Jingnan XU Caijun SONG Chenghua SHI Chuang JIANG Weiping DONG Lixiang | 2001 | Chinese Science Bulletin2001，46，8： | 8 |
| 11 | Effect of Liuweidihuang pill and Jinkuishenqi pill on inhibition of spontaneous breast carcinoma growth in mice显示文摘OBJECTIVE: To investigate the preventing and treating action of Liuweidihuang pill(LP) and Jinkuishenqi pill(JP) on spontaneous breast carcinoma in mice.METHODS: A model of spontaneous breast carcinoma was derived from 11.5-month-old female Kunming breeding mice following the delivery of several litters. The mice were randomly divided into five groups: model control group(C),Liuweidihuang pill high-dose group(LH; 4.6 g·kg1·d1),Liuweidihuang pill low-dose group(LL;2.3 g·kg1·d﹣1),Jinkuishenqi pill high-dose group(JH; 4.6 g·kg﹣1·d1) and Jinkuishenqi pill low-dose group(JL;2.3 g·kg﹣1·d﹣1). Cancer tissue volume was measured by water immersion. Histopathology was analyzed by hematoxylin and eosin staining. Vascular endothelial growth factor(VEGF),extracellular signal-regulated kinase(ERK) and cyclin D1 protein expression in cancer tissue was assayed by western blotting.RESULTS: Compared with the control group,cancer tissue volume and weight were lower in the LP and JP groups,and survival time was longer. The expression of VEGF,ERK and Cyclin D1 were inhibited in the LP and JP groups(P < 0.05),and cell differentiation was increased. Tumor weights and volumes and VEGF,ERK and Cyclin D1 expression in LL or LH were significantly lower than in JL and JH(P < 0.01).CONCLUSION: Both LP and JP could restrain cancer growth and promote cancer cell differentiation;moreover,LP was more effective than JP The likely mechanism of action was via inhibition of VEGF,ERK and cyclin D1. | Zheng Lixiang Liu Hongning Gong Yan Meng Xianming Jiang Runde Wang Xiaomin Wang Qiaofeng Wang Yue | 2015 | Journal of Traditional Chinese Medicine2015，35，4： | 8 |
| 12 | A GmNINa-miR172c-NNC1 Regulatory Network Coordinates the Nodulation and Autoregulation of Nodulation Pathways in Soybean显示文摘Symbiotic root nodules are root lateral organs of plants in which nitrogen-fixing bacteria(rhizobia)convert atmospheric nitrogen to ammonia.The formation and number of nodules in legumes are precisely controlled by a rhizobia-induced signal cascade and host-controlled autoregulation of nodulation(AON).However,how these pathways are integrated and their underlying mechanisms are unclear.Here,we report that microRNA172c(miR172c)activates soybean(Glycine max)R hizobia-induced CLE1(GmRICI)and GmRIC2 by removing the transcriptional repression of these genes by Nodule Number Control 1(NNC1),leading to the activation of the AON pathway.NNC1 interacts with GmNINa,the soybean ortholog of Lotus NODULE INCEPTION(NIN),and hampers its transcriptional activation o i G m RICI and GmRIC2.Importantly,GmNINa acts as a transcriptional activator of miR172c.Intriguingly,NNC1 can transcriptionally repress miR172c expression,adding a negative feedback loop into the NNC1 regulatory network.Moreover,GmNINa interacts with NNC1 and can relieve the NNC1-mediated repression of miR172c transcription.Thus,the GmNINa-miR172c-NNC1 network is a master switch that coordinately regulates and optimizes NF and AON signaling,supporting the balance between nodulation and AON in soybean. | Lixiang Wang Zhengxi Sun Chao Su Yongliang Wang Qiqi Yan Jiahuan Chen Thomas Ott Xia Li | 2019 | Molecular Plant2019，12，9： | 7 |
| 13 | Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis显示文摘AIM: To investigate the effects of melatonin (MT) on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in rat models of colitis.
METHODS: Healthy adult Sprague-Dawlay (SD) rats of both sexes, weighing 280±30 g, were employed in the present study. The rat models of colitis were induced by either acetic acid or 2,4,6-trinitrobenzene sulfonic acid (TNBS) enemas. The experimental animals were randomly divided into melatonin treatment and model control group that were intracolicly treated daily with melatonin at doses of 2.5, 5.0, 10.0 mg.kg-1 and equal amount of saline respectively from 24 h following induction of colitis in rats inflicted with acetic acid enema and the seventh day in rats with TNBS to the end of study. A normal control group of rats treated with neither acetic acid nor TNBS but saline enema was also included in the study. On the 28th day of the experiment, the rat colon mucosal damage index (CDMI) was calculated, and the colonic prostaglandin E2(PGE2), nitric oxide (NO), as well as the iNOS and COX-2expression were also determined biochemically or immunohistochemically.
RESULTS: CDMI increased to 2.87±0.64 and 3.12±1.12respectively in rats treated with acetic acid and TNBS enema,which was in accordance with the significantly elevated colonic NO and PGE2 contents, as well as the up-regulated colonic iNOS and COX-2 expression in both of the two rat models of colitis. With treatment by melatonin at the doses of 5.0 and 10.0 mg@kg-1, CDMI in both models of rat colitis was significantly decreased (P<0.05-0.01), which accorded synchronously and unanimously with the reduced colonic NO and PGE2 content, as well as the down-regulated expression of colonic iNOS and COX-2.
CONCLUSION: Melatonin has a protective effect on colonic injury induced by both acetic acid and TNBS enemas, which is probably via a mechanism of local inhibition of iNOS and COX-2 expression in colonic mucosa. | Wei-GuoDong QiaoMei Jie-PingYu Jian-MingXu LiXiang YuXu | 2003 | World Journal of Gastroenterology2003，9，6： | 7 |
| 14 | Novel way to research nonlinear feedback shift register显示文摘In this paper,we regard the nonlinear feedback shift register(NLFSR)as a special Boolean network,and use semi-tensor product of matrices and matrix expression of logic to convert the dynamic equations of NLFSR into an equivalent algebraic equation.Based on them,we propose some novel and generalized techniques to study NLFSR.First,a general method is presented to solve an open problem of how to obtain the properties(the number of fixed points and the cycles with different lengths)of the state sequences produced by a given NLFSR,i.e.,the analysis of a given NLFSR.We then show how to construct all 22n-(l-n)/22n-lshortest n-stage feedback shift registers(nFSR)and at least 22n-(l-n)-1/22n-l-1shortest n-stage nonlinear feedback shift registers(nNLFSR)which can output a given nonperiodic/periodic sequence with length l.Besides,we propose two novel cycles joining algorithms for the construction of full-length nNLFSR.Finally,two algorithms are presented to construct 22n-2-1different full-length nNLFSRs,respectively. | ZHAO DaWei PENG HaiPeng LI LiXiang HUI SiLi YANG YiXian | 2014 | Science China(Information Sciences)2014，57，9： | 7 |
| 15 | Experimental Study of Effects of Tip Geometry on the Flow Field in a Turbine Cascade Passage显示文摘This study investigates the effects of blade tip geometry on the flow field of a turbine cascade at the incidence angle of 0 degree experimentally. The tests were performed in a low-speed turbine cascade wind tunnel. The Reynolds number based on the blade chord was about 172300 at the exit. Traverses of the exit flow field were made in order to measure the overall performance. The effects of using flat tip and grooved tip with a chord-wise channel were studied. The case with the flat tip is referenced as the baseline. The tip clearances are all 1 mm measuring 0.84 percent of the blade span. The depth of channel is 2mm.The flow field at 10% chord downstream from the cascade trailing edge was measured at 38 span-wise positions and 26 pitch-wise positions using a mini five-hole pressure probe. The static pressure distribution on the tip end wall is measured at 16 pitch-wise stations and 17 chord-wise stations. Results show that there exists great pressure gradient in the pressure side for the flat tip and the pressure side squealer tip, which means strong leakage flow. The pressure gradient from the pressure side to the suction side is greatly decreased for the grooved tip, and the resulting leakage flow is weaker. The core of the leakage vortex moves closer to the suction side for the pressure side squealer tip and farther away from the suction side for the suction side squealer tip. The pressure side squealer has little advantages over the flat tip in improving the flow capacity and reducing the overall losses. The suction side squealer tip and grooved tip can effectively decrease the intensity of the tip leakage vortex, improve the flow capacity and reduce loss of the turbine cascade passage and the grooved tip performs the best. | MA Hongwei WANG Lixiang | 2015 | Journal of Thermal Science2015，24，1： | 6 |
| 16 | A high-precision phase-derived range and velocity measurement method based on synthetic wideband pulse Doppler radar显示文摘Development of radar technology needs to address the two-dimensional high resolution of range and velocity simultaneously for high-speed targets. Taking advantage of the superior coherent performance of synthetic wideband pulse Doppler radar, this paper elaborates the principles of phase-derived range and velocity measurements. Moreover, this paper explores the key technologies of unwrapping phase ambiguity, and discusses the phase unwrapping strategy at a low signal-to-noise ratio(SNR). The proposed method can be applied to the conditions of low SNR and has comparatively strong practicality in engineering. Both the ejection ball and civil aircraft experiments have validated the correctness and feasibility of the proposed method. In particular,the experimental results reveal that the accuracy of phase-derived range and velocity measurement has reached a level of submillimeter or millimeter and centimeter/second or submillimeter/second, respectively. | Huayu FAN Lixiang REN Teng LONG Erke MAO | 2017 | Science China(Information Sciences)2017，60，8： | 6 |
| 17 | Conjugated polymers containing B←N unit as electron acceptors for all-polymer solar cells显示文摘Polymer electron acceptors are the key materials in all-polymer solar cells(all-PSCs).In this review,we focused on introducing the principle of boron-nitrogen coordination bond(B←N),and summarizing our recent research on polymer electron acceptors containing B←N unit for efficient all-PSC devices.Two approaches have been reported to design polymer electron acceptors using B←N unit.One is to replace a C-C unit by a B←N unit in conjugated polymers to transform a polymer electron donor to a polymer electron acceptor.The other approach is to construct novel electron-deficient building block based on B←N unit for polymer electron acceptors.The polymer electron acceptors containing B←N unit showed tunable lowest unoccupied molecular orbital(LUMO) energy levels and exhibited excellent all-PSC device performance with power conversion efficiency of exceeding6%.These results indicate that organic boron chemistry is a new toolbox to develop functional polymer materials for optoelectronic device applications. | Chuandong Dou Jun Liu Lixiang Wang | 2017 | Science China Chemistry2017，60，4： | 5 |
| 18 | FREQUENCY RESPONSE ANALYSIS IN INTERNAL FLOWS显示文摘FREQUENCYRESPONSEANALYSISININTERNALFLOWS￥ZhangLi-xiang(YunnanPolytechnicUniversity,ElectricEngineering,Kunming650051,P.R.Chin... | Zhang, Lixiang Tijsseling, A.S. Vardy, A.E. | 1995 | Journal of Hydrodynamics1995，7，3： | 5 |
| 19 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 20 | Rice productivity and profitability with slow-release urea containing organic-inorganic matrix materials显示文摘Applying slow-release fertilizers is possible means for reducing nitrogen(N) loss in rice production. Matrix-based fertilizers represent novel slow-release fertilizers. To date, there is little consensus about the effect of combined addition of organic and inorganic matrix materials on rice production. We developed a slow-release urea fertilizer with selected organic and inorganic matrix materials. The study aimed to: i) determine the effect of the slow-release urea on rice yield, profit, and agronomic efficiency and ii) elucidate its possible mechanisms. A two-year field experiment was conducted during 2015–2016. Besides,laboratory experiments were conducted to determine the potential N loss risk. Three treatments were set up: control without N application(CK), regular urea treatment(RU, 150 kg N ha^(-1)), and slow-release urea treatment(SU, 150 kg N ha^(-1)). The results showed that rice biomass and grain yield were significantly higher in SU than in RU(P < 0.05). The higher panicle density in SU was largely responsible for the greater grain yield. Net profit in SU was US$450 ha^(-1), higher than in RU. Agronomic efficiency was significantly greater in SU than in RU(P < 0.05). Rice height, root area, leaf chlorophyll, leaf nitrate reductase activity, and leaf glutamine synthetase activity were larger in SU than in RU. Less N loss and greater soil N availability were partly responsible for the improvements in rice growth traits and physiological parameters in SU. Overall, the slow-release urea is a promising fertilizer for rice production. | Yang YANG Binmei LIU Xiaoyu NI Liangzhi TAO Lixiang YU Ye YANG Mengxi FENG Wenjin ZHONG Yuejin WU | 2021 | Pedosphere2021，31，4： | 5 |
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