|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gut flora and bacterial translocation in chronic liver disease显示文摘增加的证据建议内脏植物群的精神错乱具有到有肝硬化的病人的实质的临床的关联。特别地,肠的细菌的增生和从肠的腔的内脏植物群的增加的细菌的易位在这个组为细菌的感染预先安排到一个增加的潜力。最近的研究建议除了他们在公开易传染的事件的致病和败血的临床的后果的角色,内脏植物群甚至当公开感染不在时贡献肝硬化的支持 inflammatory 状态。而且,内脏植物群的操作可以有利在肝脏硬化症的病人影响肝功能与更病原的潜力在损坏另外的内脏植物群种类的情况下扩充乳的酸类型的细菌的肠的内容。这里,我们在这个组考察在内脏植物群,细菌的易位,细菌的感染,支持 inflammatory cytokine 生产和肝功能之间的各种各样的相互关系的当前的概念。 | John Almeida Sumedha Galhenage Jennifer Yu Jelica Kurtovic Stephen M Riordan | 2006 | World Journal of Gastroenterology2006，12，10： | 37 |
| 2 | Adenovirus-mediated gene delivery:Potential applications for gene and cell-based therapies in the new era of personalized medicine显示文摘With rapid advances in understanding molecular pathogenesis of human diseases in the era of genome sciences and systems biology,it is anticipated that increasing numbers of therapeutic genes or targets will become available for targeted therapies.Despite numerous setbacks,efficacious gene and/or cell-based therapies still hold the great promise to revolutionize the clinical management of human diseases.It is wildly recognized that poor gene delivery is the limiting factor for most in vivo gene therapies.There has been a long-lasting interest in using viral vectors,especially adenoviral vectors,to deliver therapeutic genes for the past two decades.Among all currently available viral vectors,adenovirus is the most efficient gene delivery system in a broad range of cell and tissue types.The applications of adenoviral vectors in gene delivery have greatly increased in number and efficiency since their initial development.In fact,among over 2000 gene therapy clinical trials approved worldwide since 1989,a significant portion of the trials have utilized adenoviral vectors.This review aims to provide a comprehensive overview on the characteristics of adenoviral vectors,including adenoviral biology,approaches to engineering adenoviral vectors,and their applications in clinical and preclinical studies with an emphasis in the areas of cancer treatment,vaccination and regenerative medicine.Current challenges and future directions regarding the use of adenoviral vectors are also discussed.It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine. | Cody S.Lee Elliot S.Bishop Ruyi Zhang Xinyi Yu Evan M.Farina Shujuan Yan Chen Zhao Zongyue Zeng Yi Shu Xingye Wu Jiayan Lei Yasha Li Wenwen Zhang Chao Yang Ke Wu Ying Wu Sherwin Ho Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Russell R.Reid Tong-Chuan He | 2017 | Genes & Diseases2017，4，2： | 19 |
| 3 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 4 | RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis显示文摘Histone ubiquitination 调整为许多生物过程是重要的染色质结构。最近, histones 的 ubiquitination 在 DNA 损坏反应(DDR ) 期间被观察,并且这修正被确实有趣的新基因(戒指) 控制领域 E3 ligase, RNF8。和结合酶 UBC13 的 E2, RNF8 在 DDR 期间催化 histones H2A 和 H2AX 的 ubiquitination,因此便于 DDR 因素的下游的招募,例如 p53 绑定蛋白质 1 (53BP1 ) 并且乳癌类型 1 危险性蛋白质(BRCA1 ) ,到损坏地点。因此, RNF8 猛烈鼠标显示与没有通过的 DDR 联系的显型,包括到电离的超敏性放射, V (D) J 再结合缺乏,和倾向到癌症。除了 DDR 显型, RNF8 猛烈老鼠没能在精子发生期间产生成熟精子,导致男绝育。RNF8 猛烈老鼠也在睾丸在 histone ubiquitination 有激烈的减小。这些调查结果显示 histone ubiquitination 的角色能被 RNF8 依赖的机制在染色质在二个不同生物事件改变期间连接。这里,我们在 DDR 和精子发生两个都考察 RNF8 依赖的 histone ubiquitination 的分子的机制。 | Teng Ma Jennifer A. Keller Xiaochun Yu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 6 |
| 5 | Sources and environmental fate of pyrogenic polycyclic aromatic hydrocarbons(PAHs)in the Arctic显示文摘Polycyclic aromatic hydrocarbons(PAHs)are large class of hydrophobic,semi-volatile organic contaminants that may enter the environment from both natural sources and anthropogenic activities.Pyrogenic PAHs arise from the incomplete combustion of fossil fuels and organic matter and following dispersal via long-range transport and may subsequently deposit in surface waters,soils and sediments of remote regions,including the Arctic.The current review summarizes and discusses Arctic data that is available for combustion-derived PAHs between 2004 and early 2018,focusing largely on data collected from remote,unexploited Arctic regions and from studies that provide some evidence of a pyrogenic origin.The increasing use of attribution ratios,which aid in discriminating PAHs from petrogenic or pyrogenic sources,suggest PAHs found in Arctic marine waters and sediment predominantly originate from natural underwater seeps,while those measured in air,freshwater,and terrestrial environments are likely to have originated from atmospheric and combustion-derived sources.Modeling efforts indicate that atmospheric PAHs in the Canadian and Norwegian Arctic are likely to have originated in the northern hemisphere e predominantly from Western Russia,northern Europe,and North America.East Asia appears to be a minor source of PAHs to the Arctic,despite contributing more than 50%of global PAH emissions.In comparison to the growing data for atmospheric PAHs,environmental data for these compounds in terrestrial and freshwater environments remain scarce.PAHs have been detected in Arctic biota from terrestrial,freshwater and marine environments,indicating exposure,however,levels are generally low,as most organisms efficiently metabolize parent PAHs.Globally,PAH emissions are expected to decline in the future,however models suggest the Arctic may not experience the same magnitude of decline projected for other world regions.Furthermore,future changes in climate may contribute to a re-volatilization of environmental PAHs,providing a source of secondary emissions to the Arctic atmosphere,emphasizing the importance of future monitoring for understanding the sources,fate and impacts of PAHs in the Arctic. | Jennifer E.Balmer Hayley Hung Yong Yu Robert J.Letcher Derek C.G.Muir | 2019 | Emerging Contaminants2019，5，1： | 4 |
| 6 | Receptor-type protein tyrosine phosphatases in cancertype protein tyrosine phosphatases in cancer显示文摘Protein tyrosine phosphatases(PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases(PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different types of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches. | Yu Du Jennifer R.Grandis | 2015 | Chinese Journal of Cancer2015，34，2： | 4 |
| 7 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 8 | The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism显示文摘Dear Editor,Japanese encephalitis(JE)is a mosquito-borne acute neurological infectious disease caused by the Japanese encephalitis virus(JEV).Globally,68,000 cases of the disease are estimated each year,with a fatality rate of as high as 30%and with approximately 30%-50%of survivors suffering from severe neurological sequelae(WHO,2015). | Xinyu Liu Xin Zhao Rui Na Lili Li Eberhard Warkentin Jennifer Witt Xu Lu Yongxin Yu Yuquan Wei Guohong Peng Yuhua Li Junzhi Wang | 2019 | Protein & Cell2019，10，2： | 3 |
| 9 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 10 | Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies显示文摘 | Lehmann Brian D Bauer Joshua A Chen Xi Sanders Melinda E Chakravarthy A Bapsi Shyr Yu Pietenpol Jennifer A | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 11 | Long-term Prognosis of Patients Presenting With ST-Segment Elevation Myocardial Infarction With No Significant Coronary Artery Disease (from The HORIZONS-AMI Trial)显示文摘 | Alf Inge Larsen Dennis W.T. Nilsen Jennifer Yu Roxana Mehran Eugenia Nikolsky Alexandra J. Lansky Adriano Caixeta Helen Parise Martin Fahy Ecaterina Cristea Bernhard Witzenbichler Giulio Guagliumi Jan Z. Peruga Bruce R. Brodie Dariusz Dudek Gregg W. Stone | 2013 | The American Journal of Cardiology2013，，： | 2 |
| 12 | Regulation of mitochondrial fission by intracellular Ca 2+ in rat ventricular myocytes显示文摘 | Jennifer Hom Tianzheng Yu Yisang Yoon George Porter Shey-Shing Sheu | 2010 | BBA - Bioenergetics2010，，6： | 2 |
| 13 | Rethinking virtual network embedding显示文摘 | Minlan Yu Yung Yi Jennifer Rexford Mung Chiang | 2008 | ACM SIGCOMM Computer Communication Review2008，，： | 2 |
| 14 | Rethinking vir- tual network embedding:substrate support for path splitting and migration 显示文摘 | Yu Minlan Yi Yung Rexford Jennifer | 2008 | ACM SIGCOMM Computer Communica- tion Review2008，38，2： | 1 |
| 15 | IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy显示文摘 | MIKE W HELMS JENNIFER A PRESCHER CAO YU′AN | 2010 | Cancer Immunology Immunotherapy2010，59，9： | 1 |
| 16 | EGFL7 Is Expressed in Bone Microenvironment and Promotes Angiogenesis via ERK, STAT3, and Integrin Signaling Cascades显示文摘 | Shek Man Chim Vincent Kuek Siu To Chow Bay Sie Lim Jennifer Tickner Jinmin Zhao Rosa Chung Yu‐Wen Su Ge Zhang Wendy Erber Cory J. Xian Vicki Rosen Jiake Xu | 2015 | Physiol2015，，1： | 1 |
| 17 | Activated Akt and Erk Expression and Survival After Surgery in Pancreatic Carcinoma显示文摘 | Krishdeep S. Chadha MD Thaer Khoury MD Jihnhee Yu PhD Jennifer D. Black PhD John F. Gibbs MD Boris W. Kuvshinoff MD Dongfeng Tan MD Michael G. Brattain PhD Milind M. Javle MD | 2006 | Annals of Surgical Oncology2006，，7： | 1 |
| 18 | Risk factors for surgical site infection in pediatric cardiac surgery patients undergoing delayed sternal closure显示文摘 | Erika E. Harder Michael G. Gaies Sunkyung Yu Janet E. Donohue David A. Hanauer Caren S. Goldberg Jennifer C. Hirsch | 2013 | The Journal of Thoracic and Cardiovascular Surgery2013，，2： | 1 |
| 19 | Outcomes associated with balloon angioplasty for recurrent coarctation in neonatal univentricular and biventricular norwood‐type aortic arch reconstructions显示文摘 | Wendy Whiteside Jennifer Hirsch‐Romano Sunkyung Yu Sara K. Pasquali Aimee Armstrong | 2014 | Cathet. Cardiovasc. Intervent2014，，： | 1 |
| 20 | Comparative effectiveness of upfront treatment strategies in elderly women with ovarian cancer显示文摘 | Jason D. Wright Cande V. Ananth Jennifer Tsui Sherry A. Glied William M. Burke Yu‐Shiang Lu Alfred I. Neugut Thomas J. Herzog Dawn L. Hershman | 2014 | Cancer2014，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员