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| 1 | The Stripe Rust Resistance Gene Yr10 Encodes an Evolutionary-Conserved and Unique CC-NBS-LRR Sequence in Wheat显示文摘对用一条基于地图的克隆途径从摩洛人小麦(Triticum aestivum L.) 孤立的条纹锈的第一棵幼苗或所有阶段抵抗(R) R 基因作为 Yr10 被识别。这基因的克隆 4B 编码一高度,进化保存和唯一的 CCNBSLRR 定序。克隆 4E, Yr10 的一个相当或相同的事物,而是缺乏的抄写开始地点(TSS ) 和通常认为的 TATA 盒子和 CAAT 盒子,是可能的非表示的 pseudogene。克隆 4B 和 4E 是 84% 在 intron 和 LRR 领域相同、分叉。基因 silencing 和 transgenesis 与无毒害、剧毒的条纹锈尽力表明 Yr10 功能的差别与接种一起被使用。Yr10 CCNBSLRR 顺序在在小麦的已知的 CCNBSLRR R 基因之中是唯一的,但是高度保存相当或相同的事物(E = 0.0 ) 包括 Hordeum vulgare 和 Brachypodium distachyon 在 Aegilops tauschii 和另外的 monocots 被识别。相关序列也在玉米的 genomic 数据库被识别,米饭,并且在里面蜀黍。这是在有在它的本国的主人的有限相同,但是与在为条纹锈是主人或非主人的相关 monocots 的众多的相应 R 基因的植物的 CCNBSLRR 抵抗基因的第一份报告。这些结果越过种类代表基因进化和分散的一个唯一的例子。 | Wei Liu Michele Frick Rene Huel Cory L. Nykiforuk Xiaomin Wang Denis A. Gaudet Francois Eudes Robert L. Conner Alan Kuzyk Zhensheng Kang Andre Laroche | 2014 | Molecular Plant2014，7，12： | 21 |
| 2 | Association of comorbidities with increasing severity of peripheral neuropathy in diabetes mellitus显示文摘AIM: To analyze a large population of patients with diabetes and peripheral neuropathy(PN) to determine other meaningful comorbid etiologies for PN.METHODS: Peripheral Neuropathy is a common complication of type 1 and 2 diabetes mellitus;however,other potential causes for PN may be co-existing in patients with diabetes.A prospective cohort study was performed to assess patients with diabetes and PN.We compared patients having PN due solely to diabetes with patients possessing co-existing comorbidities,performing clinical(Toronto Clinical Scoring System and the Utah Early Neuropathy Scale),laboratory and electrophysiological assessments in all patients.RESULTS: Patients with either type 1 or 2 diabetes mellitus and co-existing comorbidities did not have more severe clinical or electrophysiological PN phenotypes overall.However,in patients with type 1 diabetes,presence of a lipid disorder was associated with greater PN severity.In type 2 diabetes patients,both a lipid disorder and cobalamin deficiency were associated with greater PN severity.There was no additive effect upon PN severity with presence of three or more comorbid etiologies.CONCLUSION: The presence of specific,and not general,comorbidities in patients with type 1 or 2 diabetes corresponds with greater PN severity. | Shafna Sachedina Cory Toth | 2013 | World Journal of Diabetes2013，4，4： | 7 |
| 3 | Physical activity after total knee arthroplasty: A critical review显示文摘Total knee arthroplasty(TKA) is the most commonly performed elective surgery in the United States. TKA typically improves functional performance and reduces pain associated with knee osteoarthritis. Little is known about the influence of TKA on overall physical activity levels. Physical activity, defined as 'any bodily movement produced by skeletal muscles that results in energy expenditure', confers many health benefits but typically decreases with endstage osteoarthritis. The purpose of this review is to describe the potential benefits(metabolic, functional, and orthopedic) of physical activity to patients undergoing TKA, present results from recent studies aimed to determine the effect of TKA on physical activity, and discuss potential sources of variability and conflicting results for physical activity outcomes. Several studies utilizing self-reported outcomes indicate that patients perceive themselves to be more physically active after TKA than they were before surgery. Accelerometry-based outcomes indicate that physical activity for patients after TKA remains at or below pre-surgical levels. Several different factors likely contributed to these variable results, including the use of different instruments, duration of follow-up, and characteristics of the subjects studied. Comparison to norms, however, suggests that daily physical activity for patients following TKA may fall short of healthy agematched controls. We propose that further study of the relationship between TKA and physical activity needs to be performed using accelerometry-based outcome measures at multiple post-surgical time points. | Roger J Paxton Edward L Melanson Jennifer E Stevens-Lapsley Cory L Christiansen | 2015 | World Journal of Orthopedics2015，6，8： | 5 |
| 4 | C:N:P stoichiometry in soil: is there a “Redfield ratio” for the microbial biomass?显示文摘 | Cory C. Cleveland Daniel Liptzin | 2007 | Biogeochemistry2007，，3： | 4 |
| 5 | 多年生黑麦草、雀麦根系形态和生长对土壤干旱的适应性显示文摘为了研究牧草根系对干旱环境的适应性,选择多年生黑麦草(Lolium perenne)和雀麦(Bromus valdivianus)进行盆栽试验,给予80%~85%有效水(PAW)充分供水和20%~25%PAW极端干旱两种水分模式,通过对两种牧草的根系外形、干物质积累和根系形态学分析,探求两牧草在极干旱胁迫下的有效生产策略。研究表明,两种牧草的根尖外形略有不同。雀麦根毛长而密,分生区细胞致密,伸长区较长;多年生黑麦草根毛稀疏,伸长区短。20%~25%PAW极干旱胁迫使黑麦草根系粗细不匀,出现畸形;而雀麦根系未见明显受害。两种牧草生物量在茎叶和根的积累无显著的种间差异和水分处理间的组间差异。雀麦和多年生黑麦草单株根系的总长度、根面积、根平均直径、根尖数和分叉数存在极显著差异。多年生黑麦草根量显著高于雀麦(至少P≤0.01),根长和面积是雀麦的1.5倍左右,根尖数和分叉数是雀麦的2倍以上。雀麦根系末端侧根分枝密度高,短且粗;多年生黑麦草侧根细而长。干旱胁迫显著减少了两种牧草的总根长度,促进了雀麦根的径向生长。总之,雀麦根毛区较多年生黑麦草发达,多年生黑麦草根量显著多于雀麦。黑麦草主要以根数量(量)取胜,采取广泛吸水的适应策略;雀麦以根毛发达,侧根分枝密度高(质)为主,采用确保有效吸水的适应策略。 | 张咏梅 胡海英 白小明 Matthew Cory García-Favre Javier Ordóñez Iván P | 2022 | 中国生态农业学报(中英文)2022，30，11： | 3 |
| 6 | Genome and metabolic engineering in non-conventional yeasts:Current advances and applications显示文摘Microbial production of chemicals and proteins from biomass-derived andwaste sugar streams is a rapidly growing area of research and development.While the model yeast Saccharomyces cerevisiae is an excellent host for the conversion of glucose to ethanol,production of other chemicals from alternative substrates often requires extensive strain engineering.To avoid complex and intensive engineering of S.cerevisiae,other yeasts are often selected as hosts for bioprocessing based on their natural capacity to produce a desired product:for example,the efficient production and secretion of proteins,lipids,and primary metabolites that have value as commodity chemicals.Even when using yeasts with beneficial native phenotypes,metabolic engineering to increase yield,titer,and production rate is essential.The non-conventional yeasts Kluyveromyces lactis,K.marxianus,Scheffersomyces stipitis,Yarrowia lipolytica,Hansenula polymorpha and Pichia pastoris have been developed as eukaryotic hosts because of their desirable phenotypes,including thermotolerance,assimilation of diverse carbon sources,and high protein secretion.However,advanced metabolic engineering in these yeasts has been limited.This review outlines the challenges of using non-conventional yeasts for strain and pathway engineering,and discusses the developed solutions to these problems and the resulting applications in industrial biotechnology. | Ann-Kathrin Lobs Cory Schwartz Ian Wheeldon | 2017 | Synthetic and Systems Biotechnology2017，2，3： | 3 |
| 7 | Dietary zinc and metallothionein on small intestinal disaccharidases activity in mice显示文摘AIM: To examine the effect of increasing dietary zinc (Zn) intake and the lack of metallothionein (MT) expression on activity of small intestinal disaccharidases. METHODS: MT-Ⅰ and Ⅱ knockout (MT-/-) and wild-type (MT+/+) female mice at 3.5 wk of age were randomly fed with a diet containing 2 (2 Zn), 15 (15 Zn) or 50 (50 Zn) mg Zn/kg (n = 8/group/genotype) for 5 wk. Small intestinal segments (duodenum, jejunum and ileum) were collected and either fixed in 10% formalin for histological analysis or snap frozen in liquid nitrogen for sucrase, lactase and maltase activity analyses.RESULTS: Plasma Zn was significantly (P < 0.05) lower (33%) in MT-/- compared with MT+/+ mice fed the 2 Zn diet. Villus height and crypt depth were increased by approximately 15% in MT+/+ mice compared with MT-/- mice. Duodenal disaccharidase activities were significantly higher in MT+/+ compared with MT-/- mice particularly in those fed the 2 Zn diet. For the 50 Zn diet, jejunal sucrase and lactase activities were significantly higher in MT-/- (13 313 ± 2314; 4107 ± 364 μmol glucose/well/min/g tissue, respectively) compared with MT+/+ mice (7054 ± 608; 1818 ± 174). Similarly, ileal lactase activities were higher in MT-/- (1480 ± 192) compared with MT+/+ (629 ± 353) mice particularly those fed the 2 Zn diet. CONCLUSION: Increasing dietary Zn has little effect on disaccharidases activity in MT wild-type mice. The presence of MT may enhance morphological and functional development of the gut. | Cuong D Tran Johanna Cool Cory J Xian | 2011 | World Journal of Gastroenterology2011，17，3： | 2 |
| 8 | Outcomes of Minimally Invasive Plate Osteosynthesis for Metaphyseal Distal Tibia Fractures显示文摘 | Cory Collinge Robert Protzman | 2010 | Journal of Orthopaedic Trauma2010，，1： | 2 |
| 9 | The Bcl-2 family:roles in cell survival and oncogenesis显示文摘 | Cory S Huang DC Adams JM | | 0，，53： | 2 |
| 10 | Bcl-2-regulated apoptosis: mechanism and therapeutic potential显示文摘 | Jerry M Adams Suzanne Cory | 2007 | Current Opinion in Immunology2007，，5： | 2 |
| 11 | Safety and efficacy of sofosbuvir/velpatasvir/voxilaprevir in postliver transplant patients with previous direct-acting antiviral failure:Six case reports显示文摘BACKGROUND Direct-acting antiviral(DAA)therapy regimens are highly effective at eliminating hepatitis C virus(HCV)infection but rates of sustained virologic response(SVR)are lower in patients with decompensated cirrhosis or hepatocellular carcinoma.Since many of these patients will be referred for liver transplant,they will require retreatment after transplantation.Sofosbuvir/velpatasvir/voxilaprevir(SOF/VEL/VOX)is recommended by guidelines as the preferred regimen to treat HCV in DAA-experienced patients following liver transplant however there is limited data.CASE SUMMARY We present the cases of six liver transplant recipients who had previous treatment failure with sofosbuvir-based DAA therapy prior to transplantation and who then received SOF/VEL/VOX after transplant.CONCLUSION This case series demonstrate the real-world efficacy and safety of SOF/VEL/VOX in the post liver transplant setting.Treatment was successful with all patients achieving SVR,it was well tolerated,and there were minimal drug-drug interactions with their immunosuppressants. | Cory Higley Christine C Hsu Coleman Smith Sandeep Nadella Alexander T.Lalos | 2020 | World Journal of Hepatology2020，12，12： | 2 |
| 12 | A vital sugar code for ricin toxicity显示文摘 | Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger | 2017 | Cell Research2017，27，11： | 2 |
| 13 | Scaling diode-pumped, high energy picosecond lasers to kilowatt average powers显示文摘Recent results in the development of diode-driven high energy, high repetition rate, picosecond lasers, including the demonstration of a cryogenic Yb:YAG active mirror amplifier that produces 1.5 J pulses at 500 Hz repetition rate(0.75 kW average power) are reviewed. These pulses are compressed resulting in the generation of ~5 ps duration,1 J pulses with 0.5 kW average power. A full characterization of this high power cryogenic amplifier, including atwavelength interferometry of the active region under >1 kW average power pump conditions, is presented. An initial demonstration of operation at 1 kW average power(1 J, 1 k Hz) is reported. | Brendan A.Reagan Cory Baumgarten Elzbieta Jankowska Han Chi Herman Bravo Kristian Dehne Michael Pedicone Liang Yin Hanchen Wang Carmen S.Menoni Jorge J.Rocca | 2018 | High Power Laser Science and Engineering2018，6，1： | 2 |
| 14 | Production of Gene‐Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient i PSC s After Genome Editing of the Sickle Point Mutation显示文摘 | Xiaosong Huang Ying Wang Wei Yan Cory Smith Zhaohui Ye Jing Wang Yongxing Gao Laurel Mendelsohn Linzhao Cheng | 2015 | Stem Cells2015，，5： | 2 |
| 15 | Esophageal lichen planus:A case report and review of the literature显示文摘Esophageal involvement by lichen planus(ELP),previously thought to be quite rare,is a disease much more common in women and frequently the initial manifestation of mucocutaneous lichen planus(LP).Considering that the symptoms of ELP do not present in a predictable manner,ELP is perhaps more under-recognized than rare.To date,four cases of squamous cell carcinoma in association with ELP have been reported,suggesting that timely and accurate diagnosis of ELP is of importance for appropriate follow-up.In this case report,a 69-year-old female presented with dysphagia and odynophagia.She reported a history of oral LP but had no active oral or skin lesions.Endoscopic examination revealed severe strictures and web-like areas in the esophagus.Histologic examination demonstratedextensive denudation of the squamous epithelium,scattered intraepithelial lymphocytes,rare eosinophils and dyskeratotic cells.Direct immunofluorescence showed rare cytoid bodies and was used to exclude other primary immunobullous disorders.By using clinical,endoscopic,and histologic data,a broad list of differential diagnoses can be narrowed,and the accurate diagnosis of ELP can be made,which is essential for proper treatment and subsequent follow-up. | Jennifer A Nielsen Robert M Law Keith H Fiman Cory A Roberts | 2013 | World Journal of Gastroenterology2013，19，14： | 1 |
| 16 | The Bcl-2 protein family arbiters of cell survival 显示文摘 | Adams JM Cory S | 1998 | Science1998，281，： | 1 |
| 17 | The Bcl-2 apoptotic switch in cancer development and therapy显示文摘 | ADAMS JM CORY S | 2007 | Oncogene2007，26，9： | 1 |
| 18 | The Bcl-2 apoptotic switch in cancer development and therapy显示文摘 | ADAMS J M CORY S | 2007 | Oncogene2007，26，9： | 1 |
| 19 | Bcl - 2 - regulated apoptosis : mechanism and therapeutic potential 显示文摘 | Adams JM Cory S | 2007 | Curr Opin Immunol2007，19，5： | 1 |
| 20 | The Bcl-2 protein family: Arbiters of cell survival显示文摘 | Adams JM Cory S | 1998 | Science1998，281，5381： | 1 |
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