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| 1 | Tetramethylpyrazine suppresses HIF-1α,TNF-α,and activated caspase-3 expression in middle cerebral artery occlusion-induced brain ischemia in rats显示文摘瞄准:检验详细机制位于禁止的效果 oftetramethylpyrazine (TMPZ ) 下面在煽动性并且 apoptotic 回答在 rats.Methods 由中间的服的 arteryocclusion (MCAO ) 导致了:在老鼠的导致 MCAO 的焦点的服的局部缺血在 thisstudy.The 被使用组织缺氧可诱导的 factor-1alpha (HIF-1alpha ) , caspase-3 的激活,和在 ischemic 区域的 TNF-alpha mRNAtranscription 被 immunoblotting andRT-PCR 检测, respectively.Anti 氧化的活动用 thiobarbituric acid-reactivesubstance (TBARS ) 被调查老鼠大脑 homogenate preparations.Results 的测试:我们显示出溶剂的梗塞区域的 statisticalresults --并且 TMPZ ( 20 mg/kg )在在在有 TMPZ ( 20 mg/kg )的 rats.Treatment 的 导致MCAO 的焦点的服的局部缺血的正面的杆显著地减少了的各种各样的 distancesfrom 对待组在所有区域的梗塞区域,在特别,第三显著地与 ischemic regions.These expressionswere 的 caspase-3 ,以及 TNF-alpha 抄写的 HIF-1alpha 和 theactivation 的增加被联系到 导致fifthsections.MCAO 的焦点的服的局部缺血我 neuroprotective effectof TMPZ 可以至少被 EOF-1alpha 和 TNF-alphaactivations 的抑制的部分调停,由 apoptosis 形成(活跃 caspase-3 )的抑制列在后面,在 ischemia-reperfusion 大脑 injury.Thus 在梗塞体积导致 areduction , TMPZ 处理 mayrepresent 在 ischemia-reperfusionbrain 降低风险或改善功能的一条理想的途径损害相关的混乱。 | Yi CHANG George HSIAO Seu-hwa CHEN Yi-cheng CHEN Jiing-han LIN Kuang-hung LIN Duen-suey CHOU Joen-rong SHEU | 2007 | Acta Pharmacologica Sinica2007，28，3： | 30 |
| 2 | Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bone morphogenetic protein-2/ mitogen-activated protein kinases pathways in mice显示文摘 | SHEU Shiow-yunn TSAI Chia-chung SUN Jui-sheng CHEN Ming-hong LIU Man-hai SUN Man-ger | 2012 | Chinese Medical Journal2012，，20： | 17 |
| 3 | Detection of YMDD mutation using mutant-specific primers in chronic hepatitis B patients before and after lamivudine treatment显示文摘AIM: To develop a PCR assay using mutant-specific primers to detect mutation of tyrosine-methionine-aspartate-aspartate (YMDD) motif of HBV to tyrosine-valine-aspartate-aspartate (YVDD) or tyrosine-isoleucine-aspartate-aspartate (YIDD).METHODS: Cloned wild-type and mutant HBV sequences were used as templates to test the sensitivity and specificity of the assay. A variety of primer construction, primer concentration, dNTP concentration, and annealing temperature of primers were systematically examined. Pair primers specifi c to rtL180M and rtM204V were selected for YVDD detection. Primer specif ic to rtM204I with an additional 3’-penultimate base mismatched to both the mutant and wild-type sequence was selected for YIDD detection. We applied this assay to study YMDD mutants in 28 chronic hepatitis B patients before and after lamivudine treatment.RESULTS: We could detect as little as 0.001%-0.00001% of mutant viruses coexisting in 108-109 copies of wild-type HBV using this assay. YMDD mutants were detected in 8 of 12 HBeAg-positive patients and 8 of 16 HBeAg-negative patients before lamivudine treatment. After treatment, two more patients in HBeAg-positive patients and seven more patients in HBeAg-negative patients developed YMDD mutations. CONCLUSION: We developed a highly sensitive and specifi c assay for detecting YMDD mutants. This assay can be applied to monitor chronic hepatitis B patients before and during lamivudine treatment. | Cha-Ze Lee Hsuan-Shu Lee Guan-Tarn Huang Jin-Chuan Sheu | 2006 | World Journal of Gastroenterology2006，12，33： | 13 |
| 4 | Eradication of Helicobacter pylori increases childhood growth and serum acylated ghrelin levels显示文摘AIM: To determine whether Helicobacter pylori (H. pylori)infected children have reduced body weight (BW) and height (BH) growth, and if H. pylori eradication may restore growth while improving serum acylated ghrelin. METHODS: This longitudinal cohort study with oneyear follow-up enrolled 1222 children aged 4 to 12 years old into an observation cohort (18 with and 318 without H. pylori ) and intervention cohort (75 with and 811 without). The 7-d triple therapy was used for eradication in the intervention cohort. The net increases of BW and BH as well serum acylated ghrelin after oneyear follow-up were compared between successful eradicated H. pylori-infected children and controls. RESULTS: In the observation cohort, the H. pylori - infected children had lower z score of BW (-1.11 ± 0.47 vs 0.35 ± 0.69, P = 0.01) and body mass index (BMI) (0.06 ± 0.45 vs 0.44 ± 0.73, P = 0.02) at enrollment and lower net BW gain after one-year follow-up (3.3 ± 2.1 kg vs 4.5 ± 2.4 kg, P = 0.04) than the non-infected controls. In the intervention cohort, the H. pylori - infected children had lower z score of BMI (0.25 ± 1.09 vs 0.68 ± 0.87, P = 0.009) and serum acylated ghrelin levels (41.8 ± 35.6 pg/mL vs 83.6 ± 24.2 pg/mL, P < 0.001) than the non-infected controls. In addition to restoring decreased serum ghrelin levels (87.7 ± 38.0 pg/mL vs 44.2 ± 39.0 pg/mL, P < 0.001), the H. pylori - infected children with successful eradication had higher net gains (P < 0.05) and increase of z scores (P < 0.05) of both BW and BH as compared with non-infected controls after one-year follow-up. CONCLUSION:H. pylori-infected children are associated with low serum acylated ghrelin and growth retardation. Successful eradication of H. pylori restores ghrelin levels and increases growth in children. | Yao-Jong Yang Bor-Shyang Sheu Hsiao-Bai Yang Cheng-Chan Lu Ching-Chun Chuang | 2012 | World Journal of Gastroenterology2012，18，21： | 12 |
| 5 | Gadoxetic acid-enhanced magnetic resonance imaging can predict the pathologic stage of solitary hepatocellular carcinoma显示文摘BACKGROUND Although important for determining long-term outcome, pathologic stage of hepatocellular carcinoma (HCC) is difficult to predict before surgery. Current state-of-the-art magnetic resonance imaging (MRI) using gadoxetic acid provides many imaging features that could potentially be used to classify single HCC as pT1 or pT2. AIM To determine which gadoxetic acid-enhanced MRI (EOB-MRI) findings predict pathologic stage T2 in patients with solitary HCC (cT1). METHODS Pre-operative EOB-MRI findings were reviewed in a retrospective cohort of patients with solitary HCC. The following imaging features were examined: Hyperintensity in unenhanced T2-weighted images, hypointensity in unenhanced T1-weighted images, arterial enhancement, corona enhancement, washout appearance, capsular appearance, hypointensity in the tumor tissue during the hepatobiliary (HB) phase, peritumoral hypointensity in the HB phase, hypointense rim in the HB phase, intratumoral fat, hyperintensity on diffusionweighted imaging, hypointensity on apparent diffusion coefficient map, mosaic appearance, nodule-in-nodule appearance, and the margin (smooth or irregular). Surgical pathology was used as the reference method for tumor staging. Univariate and multivariate analyses were performed to identify predictors of microvascular invasion or satellite nodules. RESULTS There were 39 (34.2%;39 of 114) and 75 (65.8%;75 of 114) pathological stage T2 and T1 HCCs, respectively. Large tumor size (≥ 2.3 cm) and two MRI findings, i.e., corona enhancement [odds ratio = 2.67;95% confidence interval: 1.101-6.480] and peritumoral hypointensity in HB phase images (odds ratio = 2.203;95% confidence interval: 0.961-5.049) were associated with high risk of pT2 HCC. The positive likelihood ratio was 6.25 (95% confidence interval: 1.788-21.845), and sensitivity of EOB-MRI for detecting pT2 HCC was 86.2% when two or three of these MRI features were present. Small tumor size and hypointense rim in the HB phase were regarded as benign features. Small HCCs with hypointense rim but not associated with aggressive features were mostly pT1 lesions (specificity, 100%). CONCLUSION Imaging features on EOB-MRI could potentially be used to predict the pathologic stage of solitary HCC (cT1) as pT1 or pT2. | Yi-Chen Chou I-Ha Lao Pei-Ling Hsieh Ying-Ying Su Chee-Wai Mak Ding-Ping Sun Ming-Jen Sheu Hsing-Tao Kuo Tzu-Ju Chen Chung-Han Ho Yu-Ting Kuo | 2019 | World Journal of Gastroenterology2019，25，21： | 10 |
| 6 | Enhancement of insulin-producing cell differentiation from embryonic stem cells using pax4-nucleofection method显示文摘AIM: To enhance the differentiation of insulin producing cell (IPC) ability from embryonic stem (ES) cells in vitro. METHODS: Four-day embryoid body (EB)-formatted ES cells were dissociated as single cells for the followed plasmid DNA delivery. The use of NucleofectorTM electroporator (Amaxa biosystems, Germany) in combination with medium-contained G418 provided a high efficiency of gene delivery for advanced selection. Neucleofected cells were plated on the top of fibronectincoated Petri dishes. Addition of Ly294002 and raised the glucose in medium at 24 h before examination.The differentiation status of these cells was monitored by semi-quantitative PCR (SQ-PCR) detection of the expression of relative genes, such as oct-4, sox-17, foxa2, mixl1, pdx-1, insulin 1, glucagons and somatostatin. The percentage of IPC population on d 18 of the experiment was investigated by immunohistochemistry (IHC), and the content/secretion of insulin was estimated by ELISA assay. The mice with severe combined immunodeficiency disease (SCID) pretreated with streptozotocin (STZ) were used to eliminate plasma glucose restoration after pax4+ ES implantation. RESULTS: A high efficiency of gene delivery was demonstrated when neucleofection was used in the present study; approximately 70% cells showed DsRed expression 2 d after neucleofection. By selection of medium-contained G418, the percentage of DsRed expressing cells kept high till the end of study. The pancreatic differentiation seemed to be accelerated by pax4 nucleofection. When compared to the group of cells with mock control, foxa2, mixl1, pdx1, higher insulin and somatostatin levels were detected by SQ-PCR 4 d after nucleofection in the group of pax4 expressing plasmid delivery. Approximately 55% of neucleofected cells showed insulin expression 18 d after neucleofection, and only 18% of cells showed insulin expression in mock control. The disturbance was shown by nucleofected pax4 RNAi vector; only 8% of cells expressed insulin 18 d after nucleofection. A higher IPC population was also detected in the insulin content by ELISA assay, and the glucose dependency was demonstrated in insulin secretion level. In the animal model, improvement of average plasma glucose concentration was observed in the group of pax-4 expressed ES of SCID mice pretreated with STZ, but no significant difference was observed in the group of STZ-pretreated SCID mice who were transplanted ES with mock plasmid. CONCLUSION: Enhancement of IPC differentiation from EB-dissociated ES cells can be revealed by simply using pax4 expressing plasmid delivery. Not only more IPCs but also pancreatic differentiation-related genes can be detected by SQ-PCR. Expression of relative genes, such as foxa 2, mixl 1, pdx-1, insulin 1 and somatostatin after nucleofection, suggests that pax4 accelerates the whole differentiation progress. The higher insulin production with glucose dependent modulation suggests that pax4 expression can drive more mature IPCs. Although further determination of the entire mechanism is required, thepotential of pax-4-nucleofected cells in medical treatment is promising. | Han-Tso Lin Chung-Lan Kao Kun-Hsiung Lee Yuh-Lih Chang Shih-Hwa Chiou Fu-Ting Tsai Tung-Hu Tsai Dey-Chyi Sheu Larry LT Ho Hung-Hai Ku | 2007 | World Journal of Gastroenterology2007，13，11： | 10 |
| 7 | 热力学遗传算法计算效率的改进显示文摘热力学遗传算法(thermodynamical genetic algorithms,简称TDGA)借鉴固体退火过程中能量与熵的竞争模式来协调GA中'选择压力'和'种群多样性'之间的冲突.然而TDGA目前极高的计算代价限制了其应用.为了提高TDGA的计算效率,首先定义一种等级熵(rating-based entropy,简称RE)度量方法,它能以较小的计算成本度量种群中个体适应值的分散程度.然后引入分量热力学替换规则(component thermodynamical replacement,简称CTR),有效地降低了替换规则的复杂度.同时也证明了CTR规则具有驱动种群自由能近似最速下降的能力.在0-1背包问题上的实验结果表明,RE方法和CTR规则在保持TDGA良好的性能与稳定性的同时,极大地提高了其计算效率. | 应伟勤 李元香 SHEU Phillip C-Y | 2008 | 软件学报2008，19，7： | 9 |
| 8 | 演化多目标优化中的几何热力学选择显示文摘热力学遗传算法(Thermodynamical Genetic Algorithms,TDGAs)借鉴热力学中的自由能极小过程来统一处理多目标优化在逼近性和多样性两方面的任务.为提高TDGA的运行效率和解集分布均匀性,提出了一种几何热力学选择.在该选择中首先定义角度熵通过扇形采样来度量种群逼近方向的多样性.然后利用距离精英定义距离能量来度量种群的逼近程度,避免了耗时的非劣分层操作.此外,引入分量热力学替换规则以较低计算代价驱动种群的几何自由能快速下降.在多目标0/1背包问题上的实验结果表明,几何热力学选择极大地提高了TDGA的运行效率和解集分布均匀性;采用该选择的TDGA算法可生成与NSGA-II在逼近性和分布多样性上性能相当的解,但在运行效率上明显优于NSGA-II. | 应伟勤 李元香 SHEU Phillip C-Y 吴昱 余法红 | 2010 | 计算机学报2010，33，4： | 8 |
| 9 | Risks of rapid decline renal function in patients with type 2 diabetes显示文摘Progressive rising population of diabetes and related nephropathy, namely, diabetic kidney disease and associated end stage renal disease has become a major global public health issue. Results of observational studies indicate that most diabetic kidney disease progresses over decades; however, certain diabetes patients display a rapid decline in renal function, which may lead to renal failure within months. Although the definition of rapid renal function decline remained speculative, in general,it is defined by the decrease of estimated glomerular filtration rate(e GFR) in absolute rate of loss or percent change. Based on the Kidney Disease: Improving Global Outcomes 2012 clinical practice guidelines, a rapid decline in renal function is defined as a sustained declinein e GFR of > 5 m L/min per 1.73 m2 per year. It has been reported that potential factors contributing to a rapid decline in renal function include ethnic/genetic and demographic causes, smoking habits, increased glycated hemoglobin levels, obesity, albuminuria, anemia, low serum magnesium levels, high serum phosphate levels, vitamin D deficiency, elevated systolic blood pressure, pulse pressure, brachial-ankle pulse wave velocity values, retinopathy, and cardiac autonomic neuropathy. This article reviews current literatures in this area and provides insight on the early detection of diabetic subjects who are at risk of a rapid decline in renal function in order to develop a more aggressive approach to renal and cardiovascular protection. | Yi-Jing Sheen Wayne HH Sheu | 2014 | World Journal of Diabetes2014，5，6： | 5 |
| 10 | Intravenous proton pump inhibitors for peptic ulcer bleeding:Clinical benefits and limits显示文摘Peptic ulcer bleeding is a common disease and recurrent bleeding is an independent risk factor of mortality.Infusion with proton pump inhibitors(PPIs) prevents recurrent bleeding after successful endoscopic therapy.A gastric acidic environment of less than pH 5.4 alters coagulation function and activates pepsin to disaggregate platelet plugs.Gastric acid is secreted by H+,K+-ATPase,naming the proton pump.This update review focuses on the mechanism and the role of PPIs in the clinical management of patients with peptic ulcer bleeding.An intravenous omeprazole bolus followed by high-dose continuous infusion for 72 h after successful endoscopic therapy can prevent the recurrent bleeding.In the Asian,however,the infusion dosage can possibly be diminished whilst preserving favorable control of the intragastric pH and thereby still decreasing rates of recurrent bleeding.Irrespective of the infusion dosage of PPIs,rates of recurrent bleeding remain high in patients with co-morbidities.Because recurrent peptic ulcer bleeding may be prolonged in those with co-morbidities,a lowdose infusion of IV PPIs for up to 7-day may result in better control of recurrent bleeding of peptic ulcers.Due to the inter-patient variability in CYP2C19 genotypes,the infusion form of new generation PPIs,such as esomeprazole,should be promising for the prevention of recurrent bleeding.This article offers a comprehensive review of clinical practice,highlighting the indication,the optimal dosage,the duration,and the potential limitation of PPIs infusion for peptic ulcer bleeding. | Hsiu-Chi Cheng Bor-Shyang Sheu | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，3： | 4 |
| 11 | Characterization of flgK gene and FlgK protein required for H pylori Colonization-from cloning to clinical relevance显示文摘瞄准:在 H 描绘 flgK 和它的蛋白质产品的角色。pylori 殖民。方法:克隆方法的 PCR 识别了 flgK 基因。isogenic flgK 异种被基因代替构造并且由南部的污点分析和 PCR 分析证实了。recombinant FlgK 蛋白质(r-FlgK ) 被净化。电子显微镜学(他们) 被使用表明 H 的毛虫。pylori。在试管内活动性测试在半固体媒介被估计。H 的密度。有野类型的紧张或它的 flgK 异种的 pylori 殖民与 r-FlgK 与或没有免疫前在 BALB/c 老鼠之中被作比较。对 r-FlgK 的血清学的回答与 H 的不同密度为 70 个临床的病人被分析。pylori 殖民。结果:从十二指肠溃疡紧张, flgK 基因被克隆,它包含了 1821 bp,与到出版序列的 95.7% 身份。没有毛虫为变异的紧张在他们下面被观察,它有活动性的损失。H。pylori 密度在异种接种的 BALB/c 老鼠是更低的或与有与 unimmunized 相比的 r-FlgK 的免疫前,老鼠或老鼠由野类型的紧张(P<0.05 ) 接种。在 H。感染 pylori 的病人,对 r-FlgK 的血清学的回答在效价是一致地低的。结论:flgK 编码的 FlgK 为毛虫形成和 H 是重要的。pylori 活动性。在到 r-FlgK 的 FlgK 或提高的血清学的回答的缺乏能防碍 H。pylori 殖民。H 的 FlgK。pylori 能是为种痘的一个新奇目标。 | Jiunn-Jong Wu Bor-Shyang Sheu Ay-Huey Huang Shin-Ting Lin Hsiao-Bai Yang | 2006 | World Journal of Gastroenterology2006，12，25： | 4 |
| 12 | An efficient semi-blind source extraction algorithm and its applications to biomedical signal extraction显示文摘In many applications, such as biomedical engineering, it is often required to extract a desired signal instead of all source signals. This can be achieved by blind source extraction (BSE) or semi-blind source extraction, which is a powerful technique emerging from the neural network field. In this paper, we propose an efficient semi-blind source extraction algorithm to extract a desired source signal as its first output signal by using a priori information about its kurtosis range. The algorithm is robust to outliers and spiky noise because of adopting a classical robust contrast function. And it is also robust to the estimation errors of the kurtosis range of the desired signal providing the estimation errors are not large. The algorithm has good extraction performance, even in some poor situations when the kurtosis values of some source signals are very close to each other. Its convergence stability and robustness are theoretically analyzed. Simulations and experiments on artificial generated data and real-world data have confirmed these results. | YE YaLan SHEU Phillip C-Y ZENG JiaZhi WANG Gang LUKe | 2009 | Science in China(Series F)2009，52，10： | 3 |
| 13 | Resistance switching for RRAM applications显示文摘Resistive random access memory (RRAM or ReRAM) is a non-volatile memory (NVM) technology that consumes minimal energy while offering sub-nanosecond switching. In addition, the data stability against high temperature and cycling wear is very robust, allowing new NVM applications in a variety of markets (au- tomotive, embedded, storage, RAM). Based on sudden conduction through oxide insulators, the characteristics of RRAM technology have still yet to be fully described. In this paper, we present our current understanding of this very promising technology. | CHEN Frederick T LEE HengYuan CHEN YuSheng HSU YenYa ZHANG LiJie CHEN PangShiu CHEN WeiSu GU PeiYi LIU WenHsing WANG SuMin TSAI ChenHan SHEU ShyhShyuan TSAI MingJinn HUANG Ru | 2011 | Science China(Information Sciences)2011，54，5： | 3 |
| 14 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 15 | Liver Resection Improves the Survival of Patients with Multiple Hepatocellular Carcinomas显示文摘 | Ming-Chih Ho Guan-Tarn Huang Yuk-Ming Tsang Po-Huang Lee Ding-Shinn Chen Jin-Chuan Sheu Chien-Hung Chen | 2009 | Annals of Surgical Oncology2009，，4： | 3 |
| 16 | Prognosis and Treatment of Squamous Cell Carcinoma from a Mature Cystic Teratoma of the Ovary显示文摘 | Ruey-Jien Chen Ko-Yang Chen Ting-Chen Chang Bor-Ching Sheu Song-Nan Chow Su-Cheng Huang | 2008 | Journal of the Formosan Medical Association2008，，： | 3 |
| 17 | A High Performance Silicon-on-Insulator LDMOSTT Using Linearly Increasing Thickness Techniques显示文摘我们在场在侧面的双 diffused metal-oxide-semiconductor 晶体管完成一致侧面的电场和最大的故障电压的一种新技术在 silicon-on-insulator 上制作了底层。到排水管的从来源的线性地增加的飘移区域厚度被采用在设备改进电场分发。比作侧面的线性做技术和减少的表面地技术,新设备展出的二维的数字模拟表演减少了操作的特定的在抵抗上,最大的离开状态和在状态上故障电压,优异伪浸透特征和改进保险箱区域。[从作者抽象] | GUO Yu-Feng WANG Zhi-Gong SHEU Gene CHENG Jian-Bing | 2010 | Chinese Physics Letters2010，27，6： | 2 |
| 18 | One-year real-world outcomes of ranibizumab 0.5 mg treatment in Taiwan Residents patients with polypoidal choroidal vasculopathy: a subgroup analysis of the REAL study显示文摘AIM: To assess the effectiveness and safety of ranibizumab 0.5 mg in Taiwan Residents patients with polypoidal choroidal vasculopathy(PCV) by performing a retrospective exploratory subgroup analysis of the REAL study.METHODS: REAL was a 12-month, observational, prospective, non-interventional phase IV post-marketing surveillance study conducted at 9 centers in Taiwan. The study collected data as part of the routine patient visits from the medical records of patients with neovascular agerelated macular degeneration treated with ranibizumab 0.5 mg according to local standard medical practice and local label and/or reimbursement guidelines. The presence of PCV at baseline was determined using indocyanine green angiography. RESULTS: At baseline, PCV was diagnosed in 64 of the 303 enrolled patients(21.1%). Of these, 41 patients(64.1%) had received prior treatment; 15(23.4%) patients had received ranibizumab. The intent-to-treat population included 58 patients; 47(80%) who received ranibizumab and 11(20%) who received ranibizumab plus photodynamic therapy(PDT; 9 patients received once, 2 patients received twice). Bevacizumab was used as a concomitant medication in a similar percentage of patients who received ranibizumab(43%, n=20) or ranibizumab plus PDT(45%, n=5). In patients who received ranibizumab, visual acuity(VA) at baseline was 50.1±12.9 Early Treatment Diabetic Retinopathy Study letters, and the gain at month 12 was 1.1±17.8 letters. In patients who received ranibizumab plus PDT, VA at baseline was 51.4±15.9 letters, and there was a marked gain in VA at month 12(14.0±9.2 letters, P=0.0009). In the intent-totreat population, the reduction in central retinal subfield thickness from baseline at month 12 was 69.6±122.6 μm(baseline: 310.8±109.8 μm, P=0.0004). The safety results were consistent with the well-characterized safety profile of ranibizumab.CONCLUSION: In real-world settings, ranibizumab 0.5 mg treatment for 12 mo results in maintenance of VA and reduction in central retinal subfield thickness in Taiwan Residents patients with PCV. Improvements in VA are observed in patients who received ranibizumab plus PDT. There are no new safety findings. | San-Ni Chen Cheng-Kuo Cheng Ling Yeung Jiann-Torng Chen Wei-Chun Chan Jorn-Hon Liu Shwu-Jiuan Sheu Wen-Chuan Wu Chi-Chun Lai | 2018 | International Journal of Ophthalmology(English edition)2018，11，11： | 2 |
| 19 | Challenges of emergency logistics management显示文摘 | Jiuh-Biing Sheu | 2007 | Transportation Research Part E2007，，6： | 2 |
| 20 | Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway显示文摘 | Hsiu-Chung Ou Wen-Jane Lee Shin-Da Lee Chih-Yang Huang Tsan-Hung Chiu Kun-Ling Tsai Wen-Cheng Hsu Wayne Huey-Herng Sheu | 2010 | Toxicology and Applied Pharmacology2010，，2： | 2 |
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