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| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | TEMPERATURE EFFECT ON LOW-CYCLE FATIGUE BEHAVIOR OF NICKEL-BASED SINGLE CRYSTALLINE SUPERALLOY显示文摘基于镍的单个水晶 superalloy 与的低周期的疲劳(LCF ) 行为[001 ] 取向在 T0 掳 C 的中间的温度和 T0 + 的更高的温度被学习在 10 的经常的低紧张率下面的 250 掳 C ? 3 s ? 1 在周围的空气。superalloy 展出了依赖于温度并且使用紧张振幅的周期的紧张压缩不对称现象。破裂表面上的分析证明表面和表面下的扔 micropores 是主要裂缝开始地点。内部 Ta 富有的碳化物经常在所有标本被观察。骨折的二种不同类型被 frac-togaphy 建议。一种类型被模式描绘 -- 我与一台用显微镜裂开在 T0 + 的不平的表面 250 掳 C。而在更低的温度 T0C 的另外的类型赞成了中的一个或几八面 { 111 } 飞机,与正常模式相对照 -- 我生长模式典型地在低装载观察了频率(几 Hz ) 。为二个裂开的模式的失败机制纬鈥 ? 正在砍在 T0 + 在矩阵和纬 / 纬鈥 ? 接口在 T0 掳 C 和裂开的反对 ned 和矩阵猛抛 250 掳 C。 | Xianfeng Ma Huiji Shi Jialin Gu Zhaoxi Wang Harald Harders Thomas Malow | 2008 | Acta Mechanica Solida Sinica2008，21，4： | 4 |
| 3 | 心肺移植患者巨细胞病毒耐更昔洛韦基因突变研究显示文摘目的 建立并应用人巨细胞病毒 (HCMV)行列探针检测 (LiPA)技术 ,快速检测心肺移植患者HCMV耐更昔洛韦 (GCV)基因突变。方法 以HCMV UL97基因为靶序列 ,设计 13条特异性寡核苷酸探针 ,用Nested PCR扩增目的基因 ,LiPA技术检测与耐药有关的碱基突变。并对Nested PCR产物平行做直接序列测定 ,与LiPA结果比较。结果 16例心肺移植患者 ,LiPA技术检测发现 4例患者存在HCMV UL97基因突变 ,突变分别发生在编码子 5 2 0 ,5 95及 6 0 3,与直接序列测定比较 ,两者完全吻合。结论 长期应用GCV预防及治疗HCMV感染可以诱导病毒耐药 ,LiPA技术可作为检测HCMV基因突变的一种有效手段。 | 周琳 钱景 蔡挺 TC Harder P Rautenberg | 2002 | 中华传染病杂志2002，20，1： | 3 |
| 4 | Signaling Pathways in Cardiac Myocyte Hypertrophy显示文摘 | Martin A. Hefti Beatrice A. Harder Hans M. Eppenberger Marcus C. Schaub | 1997 | Journal of Molecular and Cellular Cardiology1997，，11： | 2 |
| 5 | Review methylotrophic yeasts as factories for the production of foreign proteins显示文摘 | Faber KN Harder W Ab G | 1995 | Yeast1995，11，14： | 2 |
| 6 | Long-term outcomes of breast cancer patients after endoscopic axillary lymph node dissection: a prospective analysis of 52 patients显示文摘 | I. Langer T. Kocher U. Guller J. Torhorst D. Oertli F. Harder M. Zuber | 2005 | Breast Cancer Research and Treatment2005，，1： | 2 |
| 7 | Extrusion Based Additive Manufacturing of Metal Parts显示文摘 | Clemens Lieberwirth Arne Harder Hermann Seitz | 2017 | Journal of Mechanics Engineering and Automation2017，7，2： | 2 |
| 8 | Microstructure segmentation with deep learning encoders pre-trained on a large microscopy dataset显示文摘This study examined the improvement of microscopy segmentation intersection over union accuracy by transfer learning from a large dataset of microscopy images called MicroNet.Many neural network encoder architectures were trained on over 100,000 labeled microscopy images from 54 material classes.These pre-trained encoders were then embedded into multiple segmentation architectures including UNet and DeepLabV3+to evaluate segmentation performance on created benchmark microscopy datasets.Compared to ImageNet pre-training,models pre-trained on MicroNet generalized better to out-of-distribution micrographs taken under different imaging and sample conditions and were more accurate with less training data.When training with only a single Ni-superalloy image,pre-training on MicroNet produced a 72.2%reduction in relative intersection over union error.These results suggest that transfer learning from large in-domain datasets generate models with learned feature representations that are more useful for downstream tasks and will likely improve any microscopy image analysis technique that can leverage pre-trained encoders. | Joshua Stuckner Bryan Harder Timothy M.Smith | 2022 | npj Computational Materials2022，，1： | 2 |
| 9 | Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice显示文摘 | HARDER C LAU P MENG A | 2007 | Arterioscler Thromb Vasc Biol2007，27，4： | 1 |
| 10 | Correlation between clinical, angiographic and transcranial Doppler sonographic findings in patients with moyamoya disease显示文摘 | Harders A Klimex L | 1993 | Neurol Res1993，15，： | 1 |
| 11 | Play for Pay:Effects of Inequity in a Pay-For-Performance Context显示文摘 | | 1992 | Administrative Science Quarterly1992，37，2： | 1 |
| 12 | Design and validation of a microarray for detection, hemagglutinin subtyping, and pathotyping of avian influenza viruses显示文摘 | Gall A Hoffmann B Harder T | 2009 | J Clin Microbiol2009，47，2： | 1 |
| 13 | Esomeprazole reduces gastroe- sophageal reflux after beer consumption in healthy volunteers 显示文摘 | Franke A Hepp C Harder H | 2008 | Seand J Gastroenterol2008，43，12： | 1 |
| 14 | Perinatal ‘programming' of insulin resistance in childhood: critical impact of neonatal insulin and low birth weight in a risk population显示文摘 | Harder T Kohlhoff R Domer G | 2001 | Diabet Med2001，18，8： | 1 |
| 15 | A peptide antibiotic from human skin显示文摘 | HARDER J BARTELS J CHRISTOPHERS E | 1997 | Nature1997，387，6636： | 1 |
| 16 | Canine distemper virus from diseased large felids:biological properties and polygenetic relationships显示文摘 | Harder T C Kenter M Vos H | 1996 | J Gen Virol1996，77，： | 1 |
| 17 | Noise equivalent circuit of a semiconductor laser diode显示文摘 | HARDER C KATZ J MARGALIT S | 1982 | IEEE Journal of Quantum Electronics1982，18，3： | 1 |
| 18 | Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type Ⅲ receptor-deficient embryos 显示文摘 | Stenvers KL Tursky ML Harder KW | 2003 | Mol Cell Biol2003，23，12： | 1 |
| 19 | Mineralizationof the deep gray matter with age: A retrospective review with Susceptibility weighted MR imaging显示文摘 | Harder SL HoppKM Ward H | 2008 | American Journal of Neuroradiology2008，29，1： | 1 |
| 20 | The epidemiology of fractures of the distal femur显示文摘 | Martinet O Cordey J Harder Y | 2000 | Injury2000，313，： | 1 |
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