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| 1 | Ureteral stent technology:Drug-eluting stents and stent coatings显示文摘Ureteral stents are commonly used following urological procedures to maintain ureteral patency.However,alongside the benefits of the device,indwelling stents frequently cause significant patient discomfort(pain,urgency,frequency)and can become encrusted and infected.The importance of these sequelae is that they are not only bothersome to the patient but can lead to significant morbidity,urinary retention,ureteral damage,recurrent infections,pyelonephritis and sepsis.When these problems occur,stent removal or replacement alongside antibiotic,analgesic and/or other symptom-modifying therapies are essential to successfully treat the patient.In an attempt to prevent such morbidity,numerous approaches have been investigated over the past several decades to modify the stent itself,thereby affecting changes locally within the urinary tract without significant systemic therapy.These strategies include changes to device design,polymeric composition,drug-elution and surface coatings.Of these,drug-elution and surface coatings are the most studied and display the most promise for advancing ureteral stent use and efficacy.This article reviews these two strategies in detail to determine their clinical potential and guide future research in the area. | Luo Yang Samantha Whiteside Peter A.Cadieux John D.Denstedt | 2015 | Asian Journal of Urology2015，2，4： | 4 |
| 2 | Prevalence and clinical characteristics associated with left atrial thrombus detection: Apixaban显示文摘BACKGROUND The prevalence of left atrial appendage(LAA) thrombus detection by transesophageal echocardiogram(TEE) in patients with non-valvular atrial fibrillation(AF) anticoagulated with apixaban is not well defined and identification of additional risk factors may help guide the selection process for pre-procedural TEE. The purpose of our study was to retrospectively analyze the prevalence of LAA thrombus detection by TEE in patients continuously anticoagulated with apixaban for ≥ 4 wk and evaluate for any cardiac risk factors or echocardiographic characteristics which may serve as predictors of thrombus formation.AIM To retrospectively analyze the prevalence of LAA thrombus detection by TEE in patients continuously anticoagulated with apixaban.METHODS Clinical and echocardiographic data for 820 consecutive patients with AF undergoing TEE at Augusta University Medical Center over a four-year period were retrospectively analyzed. All patients(apixaban: 226) with non-valvular AF and documented compliance with apixaban for ≥ 4 wk prior to index TEE were included.RESULTS Following ≥ 4 wk of continuous anticoagulation with apixaban, the prevalence ofLAA thrombus and LAA thrombus/dense spontaneous echocardiographic contrast was 3.1% and 6.6%, respectively. Persistent AF, left ventricular ejection fraction < 30%, severe LA dilation, and reduced LAA velocity were associated with thrombus formation. Following multivariate logistic regression, persistent AF(OR: 7.427; 95%CI: 1.02 to 53.92; P = 0.0474), and reduced LAA velocity(OR:1.086; 95%CI: 1.010 to 1.187; P = 0.0489) were identified as independent predictors of LAA thrombus. No Thrombi were detected in patients with a CHA2 DS2-VASc score ≤ 1.CONCLUSION Among patients with non-valvular AF and ≥ 4 wk of anticoagulation with apixaban, the prevalence of LAA thrombus detected by TEE was 3.1%. This suggests that continuous therapy with apixaban does not completely eliminate the risk of LAA thrombus and that TEE prior to cardioversion or catheter ablation may be of benefit in patients with multiple risk factors. | Hoyle L Whiteside Arun Nagabandi Kristen Brown Deepak N Ayyala Gyanendra K Sharma | 2019 | World Journal of Cardiology2019，11，2： | 2 |
| 3 | Synthesis of CMP-NeuAc from N-acetylglucosamine: Generation of CTP from CMP using adenylate kinase 显示文摘 | Simon E S Bednarski M D Whitesides G M | 1988 | J Am Chem Soc1988，110，： | 2 |
| 4 | What are regulatory T cells (Treg) regulating in cancer and why?显示文摘 | Theresa L. Whiteside | 2012 | Seminars in Cancer Biology2012，，4： | 2 |
| 5 | Exercise lowers pain thresholdin chronic fatigue syndrome显示文摘 | Whiteside A Hansen S Chaudhuri A | 2004 | Pain2004，109，3： | 1 |
| 6 | The role of natural killer cells in human disease 显示文摘 | Whiteside TL Herberman RB | 1989 | Clin Immunol1989，53，1： | 1 |
| 7 | Chronic Overexpression of Proinflammatory Cytokines and Histopathology in the Brains of Rats Infected With Trypanosoma brucei显示文摘 | Quan N Mhlanga J D M Whiteside M B | 1999 | The Journal of Comparative Neurology1999，414，： | 1 |
| 8 | Soft lithography for micro-and nanoscale patterning显示文摘 | Qin D Xia Y N Whitesides G M | 2010 | Nature Protocols2010，5，3： | 1 |
| 9 | Solvent-assisted microcontact molding: A convenient method for fabricating three-dimensional structures of polymeric materials 显示文摘 | Kim E Xia T Zhao X H Whitesides G M | 1997 | Adv Mater1997，9，： | 1 |
| 10 | Solid-state structures of hydrogen-bonded tapes based on cyclic secondary diamides显示文摘 | MacDonald J C Whitesides G M | 1994 | Chem Rev1994，94，： | 1 |
| 11 | Printing,molding, and near-field photolitho graphic methods for patterning organic lasers, smart pixels and simple circuits 显示文摘 | Rogers J A Whitesides G M | 2000 | Synthetic Metals2000，，115： | 1 |
| 12 | Fabrication of arrays of two-dimensional micropatterns using microspheres as lenses for projection photolithography显示文摘 | Wu Ming-Hsien George M Whitesides | 2000 | Applied Physics Letter2000，78，6： | 1 |
| 13 | Diagnostics for the developing world:microfluidic paper-based analytical devices显示文摘 | Martinez A W Phillips S T Whitesides G M | 2010 | Anal Chem2010，82，1： | 1 |
| 14 | Preparation of phosphoenol-pyruvate from D-O-3-phosphoglyceric acid for use in regeneration of ATP显示文摘 | SIMON E S GRABOWSKI S WHITESIDES G M | 1989 | Journal of the American Chemical Society1989，111，24： | 1 |
| 15 | Diagnostics for the developing world: microfluidic paper-based analytical de- vices显示文摘 | Martinez AW Phillips ST Whitesides GM | 2010 | AnalChem2010，82，1： | 1 |
| 16 | 显示文摘 | Rasmussen J R Stedronsky E R Whitesides G M | 2007 | J Am Chem Soe2007，99，14： | 1 |
| 17 | Determination of the compartment pressure threshold of muscle ischemia in a canine model显示文摘 | Matava M J Whitesides T E Jr Seiler J G 3rd | 1994 | J Trauma1994，37，： | 1 |
| 18 | Functional and pheno- typic characteristics of CD4 ICD25 high Foxp3+ Treg clones obtained from peripheral blood of patients with cancer显示文摘 | Strauss L Bergrnann C Whiteside TL | 2007 | Int J Cancer2007，，： | 1 |
| 19 | Control of NF-kappa activity by the I kappa Bβinhibitor显示文摘 | WEIL R WHITESIDE S T ISRAL A | 1997 | Immunobiology1997，198，123： | 1 |
| 20 | A pilot study of the effects of phytoestrogen supplem en tation on postmenopausal endometrium显示文摘 | Balk JL Whiteside DA Naus G | 2002 | JSoc Gynecol Investig2002，9，4： | 1 |
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