|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies显示文摘Rheumatoid arthritis(RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages:(i) triggering,(ii) maturation,(iii) targeting, and(iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies(including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA. | Qiang Guo Yuxiang Wang Dan Xu Johannes Nossent Nathan J.Pavlos Jiake Xu | 2018 | Bone Research2018，6，2： | 71 |
| 2 | Effect of non-point source pollution on water quality of the Weihe River显示文摘非点来源污染是影响 Weihe 河的水质量的一个重要因素。为了在非洪水期间在 Weihe 河,五个洪水事件和三个正常分泌物事件的水质量上学习污染的效果,时期在 2006 从 7 月被监视到 12 月,在 Lin-tong 节。以便识别沉积怎么影响了河的水质量,未加工并且从监视事件拿的上层清液样品被分析。上层清液样品以后在实验室在未加工的样品的水表面下面从 5 厘米被吸未加工的样品被重组并且在烧杯为 30 放分钟。结果显示了那 1 ) 在从洪水事件的未加工的样品的 SS,货到付款, TP 和 TN 的集中比从正常分泌物事件的那些高。在未加工的样品的 COD, TP 和 TN 的更高的价值从自然的腐殖的事导致了表面土壤。2 ) 分析的水质量索引的负担运输率逐渐地增加了到它的最大值然后落下在下面,在分泌物自记水位计匹配那。在未加工的样品的 SS, NH3-N, NO2-N, NO3-N,货到付款,和 TP 的集中开始增加了然后减少,当在未加工的样品的溶解 orthophosphate 和 TN 的集中逐渐地减少了然后增加时。集中的黄金时间和在未加工的样品的 SS 以及货到付款, TP 和 TN 的负担运输率接近了或落后于山峰流动的时间。通常,集中的黄金时间和负担运输溶解 orthophosphate 评价,溶解全部磷酸盐, NH3-N, NO2-N,和 NO3-N 发生在山峰流动的时间以前。3 ) 吝啬的集中方法被用来在 Lin-tong 节计算 NPS 污染负担,并且结果是可信的。在 2006,到为货到付款, TP, TN 和无机的氮的全部的负担的 NPS 污染负担的比例是超过 30% 。 | LI Jiake LI Huaien SHEN Bing LI Yajiao | 2011 | International Journal of Sediment Research2011，26，1： | 11 |
| 3 | 3D graphene foam-supported cobalt phosphate and borate electrocatalysts for high-efficiency water oxidation显示文摘The cobalt phosphate-/cobalt borate-based oxygen-evolving catalysts(OECs) are the important class of earth-abundant electrocatalysts that can operate with high activity for water splitting under benign conditions.This article reports the integration of cobalt phosphate(CoPi) and cobalt borate(Co-Bi) OECs with three-dimensional(3D) graphene foam(GF) for the electrocatalytic water oxidation reaction. The GF showed a unique advantage to serve as a highly conductive 3D support with large capacity for anchoring and loading Co-OECs, thereby facilitating mass and charge transfer due to the large amount of active sites provided by the 3D graphene scaffold. As a result, this integrated system of GF and Co-OECs exhibits synergistically enhanced catalytic activity. The overpotential(g) of Co-Pi and Co-Bi/graphene catalysts is about 0.390 and0.315 V in neutral solutions, respectively. Besides, the integrated Co-OECs/graphene catalysts have also exhibited improved and stable oxygen evolution catalytic ability in alkaline solution. | Min Zeng Hao Wang Chong Zhao Jiake Wei Wenlong Wang Xuedong Bai | 2015 | Science Bulletin2015，60，16： | 10 |
| 4 | Current research on pharmacologic and regenerative therapies for osteoarthritis显示文摘Osteoarthritis(OA)is a degenerative joint disorder commonly encountered in clinical practice,and is the leading cause of disability in elderly people.Due to the poor self-healing capacity of articular cartilage and lack of specific diagnostic biomarkers,OA is a challenging disease with limited treatment options.Traditional pharmacologic therapies such as acetaminophen,non-steroidal anti-inflammatory drugs,and opioids are effective in relieving pain but are incapable of reversing cartilage damage and are frequently associated with adverse events.Current research focuses on the development of new OA drugs(such as sprifermin/recombinant human fibroblast growth factor-18,tanezumab/monoclonal antibody againstβ-nerve growth factor),which aims for more effectiveness and less incidence of adverse effects than the traditional ones.Furthermore,regenerative therapies(such as autologous chondrocyte implantation(ACI),new generation of matrix-induced ACI,cell-free scaffolds,induced pluripotent stem cells(iPS cells or iPSCs),and endogenous cell homing)are also emerging as promising alternatives as they have potential to enhance cartilage repair,and ultimately restore healthy tissue.However,despite currently available therapies and research advances,there remain unmet medical needs in the treatment of OA.This review highlights current research progress on pharmacologic and regenerative therapies for OA including key advances and potential limitations. | Wei Zhang Hongwei Ouyang Crispin R Dass Jiake Xu | 2015 | Bone Research2015，3，4： | 9 |
| 5 | Detection of the critical micelle concentration of cationic and anionic surfactants based on aggregation-induced emission property of hexaphenylsilole derivatives显示文摘We report a fluorescence 'turn-on' method to detect the critical micelle concentration (CMC) of surfactants. This method works well for both cationic and anionic surfactants. It employs an unprecedented mechanism (aggregation-induced emission, or AIE) to determine the CMC values, and the results are consistent with the data obtained by the classical techniques. In addition, this method renders the convenient detection of the CMC values. Any large and professional instruments are unnecessary, instead, a portable UV lamp and an ultrasonic generator are enough to carry out the detection in an ordinary laboratory. Considering that micelles are interesting entities and have found applications in many important fields such as emulsion polymerization, template of nanosized materials synthesis, controllable drug delivery and macromolecular self-assembling. Our experimental results may offer a facile, sensitive and promising method to detect the formation of micelles constructed by the new amphiphilic molecules and macromolecules. | TANG Li JIN JiaKe ZHANG Shuang MAO Yu SUN JingZhi YUAN WangZhang ZHAO Hui XU HaiPeng QIN AnJun TANG Ben Zhong | 2009 | Science China Chemistry2009，52，6： | 6 |
| 6 | Pathological mechanisms and therapeutic outlooks for arthrofibrosis显示文摘Arthrofibrosis is a fibrotic joint disorder that begins with an inflammatory reaction to insults such as injury,surgery and infection.Excessive extracellular matrix and adhesions contract pouches,bursae and tendons,cause pain and prevent a normal range of joint motion,with devastating consequences for patient quality of life.Arthrofibrosis affects people of all ages,with published rates varying.The risk factors and best management strategies are largely unknown due to a poor understanding of the pathology and lack of diagnostic biomarkers.However,current research into the pathogenesis of fibrosis in organs now informs the understanding of arthrofibrosis.The process begins when stress signals stimulate immune cells.The resulting cascade of cytokines and mediators drives fibroblasts to differentiate into myofibroblasts,which secrete fibrillar collagens and transforming growth factor-β(TGF-β).Positive feedback networks then dysregulate processes that normally terminate healing processes.We propose two subtypes of arthrofibrosis occur:active arthrofibrosis and residual arthrofibrosis.In the latter the fibrogenic processes have resolved but the joint remains stiff.The best therapeutic approach for each subtype may differ significantly.Treatment typically involves surgery,however,a pharmacological approach to correct dysregulated cell signalling could be more effective.Recent research shows that myofibroblasts are capable of reversing differentiation,and understanding the mechanisms of pathogenesis and resolution will be essential for the development of cell-based treatments.Therapies with significant promise are currently available,with more in development,including those that inhibit TGF-βsignalling and epigenetic modifications.This review focuses on pathogenesis of sterile arthrofibrosis and therapeutic treatments. | Kayley M.Usher Sipin Zhu Georgios Mavropalias John A.Carrino Jinmin Zhao Jiake Xu | 2019 | Bone Research2019，7，1： | 5 |
| 7 | Real-time in situ TEM studying the fading mechanism of tin dioxide nanowire electrodes in lithium ion batteries显示文摘在锂离子电池的电极很吸引了的锡二氧化物(SnO2 ) 的褪色的机制注意,它为电池应用很重要。在这份报纸,单个 SnO2 nanowires 的电气化学的 lithiation-delithiation 周期在高分辨率的传播电子显微镜学(TEM ) 在 situ 被进行。在有 SnO2 nanowire 电极上的 170%300% 的扩大的体积的主要变化在电气化学的骑车在第一 lithiation 进程期间被观察,包括到 Li2O 矩阵和活跃的锂的 SnO2 先锋的变换反应与李一起招待 Sn 的 Sn,和 alloying 形成易碎的 Li-Sn 合金。SnO2 nanowire 电极被使倾向在开始的二个周期受不了热逃走的状况。在骑车期间,形态学和 SnO2 nanowire 电极的作文进化被记录。电极的周期的 lithiation 和 delithiation 表明了在 Li13Sn5 和 Sn 之间的阶段转变。金属性的 Sn 簇被形成,他们与增加扩大的尺寸骑车乘。Sn 簇的有害聚集在 SnO2 nanowire 电极引起了弄成粉,它为电子和锂离子打破了传导和运输路径。在 situ TEM 即时揭示褪色的机制在锂离子电池为 SnO2 nanowire 电极的可行设计提供重要指南。 | WANG LiFen XU Zhi YANG ShiZe TIAN XueZeng WEI JiaKe WANG WenLong BAI XueDong | 2013 | Science China(Technological Sciences)2013，56，11： | 5 |
| 8 | Filament growth dynamics in solid electrolyte-based resistive memories revealed by in situ TEM显示文摘底抵抗的记忆被考虑了是有在非不稳定的存储器,逻辑电路和 neuromorphic 计算的应用程序的未来信息技术的一个潜在的候选人的稳固的电解质。一个传导性的细丝模型通常被接受了是为抵抗切换的内在的机制。然而,如此的传导性的细丝的生长动力学仍然不充分被理解。这里,我们与电场分发和几个另外的因素由细丝生长的相关观察探索细丝生长的可控制性。细丝生长行为被记录了在 situ 传播电子显微镜学使用。由学习即时记录细丝生长行为和形态学,我们能根据我们的观察模仿电场分发。另外的因素也被显示了影响细丝生长,例如加热的朱尔和电解质基础结构。这个工作提供卓见进进 nanoionic 的进一步的功能的传导性的细丝和愿望帮助指南研究的可控制的生长抵抗记忆。 | Xuezeng Tian Lifen Wang Jiake Wei Shize Yang Wenlong Wang Zhi Xu Xuedong Bai | 2014 | Nano Research2014，7，7： | 4 |
| 9 | Effect of preparation methods on the hydrocracking performance of NiMo/Al_(2)O_(3) catalysts显示文摘In this work,NiMo catalysts with various contents of MoO_(3)were prepared through incipient wetness impregnation by a twostep method(NMxA)and onepot method(NMxB).The catalysts were then characterized by XRD,XPS,NH3TPD,H_(2)TPR,HRTEM,and N_(2)adsorptiondesorption technologies.The performance of the NiMo/Al_(2)O_(3) catalysts was investigated by hydrocracking lowtemperature coal tar.When the MoO3 content was 15 wt%,the interaction between Ni species and Al_(2)O_(3) on the NM15B catalyst was stronger than that on the NM15A catalyst,resulting in the poor performance of the former.When the MoO^(3) content was 20 wt%,MoO_(3) agglomerated on the surface of the NM20A catalyst,leading to decreased number of active sites and specific surface area and reduced catalytic performance.The increase in the number of MoS_(2) stack layers strengthened the interaction between Ni and Mo species of the NM20B catalyst and consequently improved its catalytic performance.When the MoO_(3) content reached 25 wt%,the active metals agglomerated on the surface of the NiMo catalysts,thereby directly decreasing the number of active sites.In conclusion,the twostep method is suitable for preparing catalysts with large pore diameter and low MoO_(3) content loading,and the onepot method is more appropriate for preparing catalysts with large specific surface area and high MoO_(3) content.Moreover,the NMxA catalysts had larger average pore diameter than the NMxB catalysts and exhibited improved desulfurization performance. | Jiake Yang Tongjiu Zuo Jiangyin Lu | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 4 |
| 10 | Deep eutectic solvents eutectogels:progress and challenges显示文摘Deep eutectic solvents(DESs)have received widespread attention for their advantages of good electrical conductivity,stability,environmental friendliness,and easy preparation with a wide range of applications.However,it was not until recent years that DESs were used as gel electrolytes as environmentally friendly alternatives to ionic liquids(ILs).In this mini review,we first introduce the DESs related eutectogels(or ion gels),then introduce the types and applications of the gels,the opportunities and challenges of them are also summarized. | Jiake Wang Shangzhong Zhang Zhongzheng Ma Lifeng Yan | 2021 | Green Chemical Engineering2021，2，4： | 4 |
| 11 | PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation显示文摘PIP5k1βis crucial to the generation of phosphotidylinosotol(4,5)P2.PIP5k1βparticipates in numerous cellular activities,such as B cell and platelet activation,cell phagocytosis and endocytosis,cell apoptosis,and cytoskeletal organization.In the present work,we aimed to examine the function of PIP5k1βin osteoclastogenesis and osteogenesis to provide promising strategies for osteoporosis prevention and treatment.We discovered that PIP5k1β deletion in mice resulted in obvious bone loss and that PIP5k1β was highly expressed during both osteoclast and osteoblast differentiation.Deletion of the gene was found to enhance the proliferation and migration of bone marrow-derived macrophage-like cells to promote osteoclast differentiation.PIP5k1β-/-osteoclasts exhibited normal cytoskeleton architecture but stronger resorption activity.PIP5kip deficiency also promoted activation of mitogen-activated kinase and Akt signaling,enhanced TRAF6 and c-Fos expression,facilitated the expression and nuclear translocation of NFATC1,and upregulated Grb2 expression,thereby accelerating osteoclast differentiation and function.Finally,PIP5k1β enhanced osteoblast differentiation by upregulating master gene expression through triggering smad1/5/8 signaling.Therefore,PIP5k1βmodulates bone homeostasis and remodeling. | Xiaoying Zhao Penglei Cui Guoli Hu Chuandong Wang Lei Jiang Jingyu Zhao Jiake Xu Xiaoling Zhang | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 12 | Electrochemical solid-state amorphization in the immiscible Cu-Li system显示文摘As a typical immiscible binary system, copper (Cu) and lithium (Li) show no alloying and chemical intermixing under normal circumstances. Here we show that, when decreasing Cu nanoparticle sizes into ultrasmall range, the nanoscale size effect can play a subtle yet critical role in mediating the chemical activity of Cu and therefore its miscibility with Li, such that the electrochemical alloying and solidstate amorphization will occur in such an immiscible system. This unusual observation was accomplished by performing in-situ studies of the electrochemical lithiation processes of individual CuO nanowires inside a transmission electron microscopy (TEM). Upon lithiation, CuO nanowires are first electrochemically reduced to form discrete ultrasmall Cu nanocrystals that, unexpectedly, can in turn undergo further electrochemical lithiation to form amorphous Cu Lixnanoalloys. Real-time TEM imaging unveils that there is a critical grain size (ca. 6 nm), below which the nanocrystalline Cu particles can be continuously lithiated and amorphized. The possibility that the observed solid-state amorphization of Cu-Li might be induced by electron beam irradiation effect can be explicitly ruled out; on the contrary, it was found that electron beam irradiation will lead to the dealloying of as-formed amorphous Cu Lixnanoalloys. | Muhua Sun Jiake Wei Zhi Xu Qianming Huang Yu Zhao Wenlong Wang Xuedong Bai | 2018 | Science Bulletin2018，63，18： | 3 |
| 13 | Towards the controlled CVD growth of graphitic B-C-N atomic layer films: The key role of B-C delivery molecular precursor显示文摘象 Graphene 一样,第三的系统 B-C-N 原子层材料答应高度悦耳的电子性质和潜在的应用程序的过多。然而, B-C-N 原子层的这样远的、试验性的合成通常产出由纯 C 和 BN 领域组成的显微镜的分离阶段的结构。进一步,与同质的原子安排种真正第三的 B-C-N 阶段层证明了很挑战性。这里,在为化学蒸汽免职( CVD )设计一个 bettercontrolled 过程, B-C-N 原子层的生长与最小化的 C 和 BN 阶段分离拍摄,我们选择了 trimethyl borane ( TMB ),有先存在的气体的 organoboron 混合物 B-C 契约,作为分子的先锋到与氨反应(用作氮的硝化作用代理人的 NH 3)气体。这位唯一的 B-C 交货先锋的使用允许高质量、大区域的 B-C-N 原子层电影的成功的合成。而且, TMB/NH 3 反应物联合能由调整二气体的反应物的相对部分压力提供 tunability 的高水平和 B-C-N 原子层的全面化学作文的控制。有限精力差距能在成长得当的 B-C-N 原子层和它的 tunability 被打开的电的运输大小表演实质上依赖于到 BN 原子作文的相对 C。根据小心地控制的实验,我们证明在 TMB 分子的先锋的先存在的 B-C 契约在有效地减少 C 和 BN 阶段分离问题起了一个关键作用,从而便于真正第三的 B-C-N 的形成分阶段执行原子层。 | Hao Wang Chong Zhao Lei Liu Zhi Xu Jiake Wei Wenlong Wang Xuedong Bai Enge Wang | 2016 | Nano Research2016，9，5： | 2 |
| 14 | Effect of burn injury on apoptosis and expression of apoptosis-related genes/proteins in skeletal muscles of rats显示文摘 | Hongjie Duan Jiake Chai Zhiyong Sheng Yongming Yao Huinan Yin Liming Liang Chuanan Shen Jing Lin | 2009 | Apoptosis2009，，1： | 2 |
| 15 | The relationship between skeletal muscle proteolysis and ubiquitin–proteasome proteolytic pathway in burned rats显示文摘 | Jiake Chai Yanqiu Wu Zhiyong Sheng | 2002 | Burns2002，，6： | 2 |
| 16 | Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemia显示文摘 | Jiake Chai Yanqiu Wu Zhiyong Sheng (Zy Sheng) | 2003 | Critical Care Medicine2003，，6： | 2 |
| 17 | Versatile subtypes of pericytes and their roles in spinal cord injury repair,bone development and repair显示文摘Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit(NVU),pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury(SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics. | Sipin Zhu Min Chen Yibo Ying Qiuji Wu Zhiyang Huang Wenfei Ni Xiangyang Wang Huazi Xu Samuel Bennett Jian Xiao Jiake Xu | 2022 | Bone Research2022，10，2： | 2 |
| 18 | Recent development of studies on the mechanism of resistive memories in several metal oxides显示文摘Resistive switching random access memories(RRAM)have been considered to be promising for future information technology with applications for non-volatile memory,logic circuits and neuromorphic computing.Key performances of those resistive devices are approaching the realistic levels for production.In this paper,we review the progress of valence change type memories,including relevant work reported by our group.Both electrode engineering and in-situ transmission electron microscopy(TEM)high-resolution observation have been implemented to reveal the influence of migration of oxygen anions/vacancies on the resistive switching effect.The understanding of resistive memory mechanism is significantly important for device applications. | TIAN XueZeng WANG LiFen LI XiaoMin WEI JiaKe YANG ShiZe XU Zhi WANG WenLong BAI XueDong | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 2 |
| 19 | Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis显示文摘Breast cancer bone metastasis poses significant challenge for therapeutic strategies.Inside the metastatic environment,osteoclasts and tumor cells interact synergistically to promote cancer progression.In this study,the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function.Importantly,the furin inhibitor is specifically delivered by bone targeting superparamagnetic iron oxide(SPIO)nanoparticles.Our in vitro and in vivo data demonstrate that this system can effectively inhibit both osteoclastic bone resorption and breast cancer invastion,leading to alleviated osteolysis.Therefore,the bone targeting&furin inhibition nanoparticle system is a promising therapeutic and diagnostic strategy for breast cancer bone metastasis. | Yichuan Pang Li Su Yao Fu Fan Jia Chenxi Zhang Xiankun Cao Wenxin He Xueqian Kong Jiake Xu Jie Zhao An Qin | 2021 | Bioactive Materials2021，6，3： | 2 |
| 20 | Strategies for mass burn casualties transferred from a distance-clinical experience显示文摘 | Jiake Chai Zhiyong Sheng Hongming Yang | 2005 | Wehrmedizn and Wehrpharmazie2005，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员