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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Role of proteasome inhibition in sensitized transplant candidates显示文摘 | Matthew J. Everly Jason J. Everly Paul I. Terasaki | 2011 | Chinese Medical Journal2011，，5： | 4 |
| 3 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 4 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 5 | Automatic Tracing and Segmentation of Rat Mammary Fat Pads in MRI Image Sequences Based on Cartoon-Texture Model显示文摘The growth patterns of mammary fat pads and glandular tissues inside the fat pads may be related with the risk factors of breast cancer.Quantitative measurements of this relationship are available after segmentation of mammary pads and glandular tissues.Rat fat pads may lose continuity along image sequences or adjoin similar intensity areas like epidermis and subcutaneous regions.A new approach for automatic tracing and segmentation of fat pads in magnetic resonance imaging(MRI) image sequences is presented,which does not require that the number of pads be constant or the spatial location of pads be adjacent among image slices.First,each image is decomposed into cartoon image and texture image based on cartoon-texture model.They will be used as smooth image and feature image for segmentation and for targeting pad seeds,respectively.Then,two-phase direct energy segmentation based on Chan-Vese active contour model is applied to partitioning the cartoon image into a set of regions,from which the pad boundary is traced iteratively from the pad seed.A tracing algorithm based on scanning order is proposed to accurately trace the pad boundary,which effectively removes the epidermis attached to the pad without any post processing as well as solves the problem of over-segmentation of some small holes inside the pad.The experimental results demonstrate the utility of this approach in accurate delineation of various numbers of mammary pads from several sets of MRI images. | 涂圣贤 张素 陈亚珠 Freedman Matthew T WANG Bin XUAN Jason WANG Yue | 2009 | Transactions of Tianjin University2009，15，3： | 3 |
| 6 | Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection显示文摘 | Matthew J. Everly Jason J. Everly Brian Susskind Paul Brailey Lois J. Arend Rita R. Alloway Prabir Roy-Chaudhury Amit Govil Gautham Mogilishetty Adele H. Rike Michael Cardi George Wadih Amit Tevar E Steve Woodle | 2008 | Transplantation2008，，12： | 2 |
| 7 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 8 | Reduced Acute Bowel Toxicity in Patients Treated With Intensity-Modulated Radiotherapy for Rectal Cancer显示文摘 | Jason M. Samuelian Matthew D. Callister Jonathan B. Ashman Tonia M. Young-Fadok Mitesh J. Borad Leonard L. Gunderson | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 2 |
| 9 | Response of borderline resectable pancreatic cancer to neoadjuvant therapy is not reflected by radiographic indicators显示文摘 | Matthew H. G. Katz Jason B. Fleming Priya Bhosale Gauri Varadhachary Jeffrey E. Lee Robert Wolff Huamin Wang James Abbruzzese Peter W. T. Pisters Jean‐Nicolas Vauthey Chusilp Charnsangavej Eric Tamm Christopher H. Crane Aparna Balachandran | 2012 | Cancer2012，，23： | 2 |
| 10 | Borderline Resectable Pancreatic Cancer: The Importance of This Emerging Stage of Disease显示文摘 | Matthew H.G. Katz Peter W.T. Pisters Douglas B. Evans Charlotte C. Sun Jeffrey E. Lee Jason B. Fleming J. Nicolas Vauthey Eddie K. Abdalla Christopher H. Crane Robert A. Wolff Gauri R. Varadhachary Rosa F. Hwang | 2008 | Journal of the American College of Surgeons2008，，5： | 1 |
| 11 | When Outgroups Fail; Phylogenomics of Rooting the Emerging Pathogen, Coxiella burnetii显示文摘 | Talima Pearson Heidie M. Hornstra Jason W. Sahl Sarah Schaack James M. Schupp Stephen M. Beckstrom-Sternberg Matthew W. O’Neill Rachael A. Priestley Mia D. Champion James S. Beckstrom-Sternberg Gilbert J. Kersh James E. Samuel Robert F. Massung Paul Keim | 2013 | Systematic Biology2013，，5： | 1 |
| 12 | Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Predictor of Outcome in Head-and-Neck Squamous Cell Carcinoma Patients With Nodal Metastases显示文摘 | Amita Shukla-Dave Nancy Y. Lee Jacobus F.A. Jansen Howard T. Thaler Hilda E. Stambuk Matthew G. Fury Snehal G. Patel Andre L. Moreira Eric Sherman Sasan Karimi Ya Wang Dennis Kraus Jatin P. Shah David G. Pfister Jason A. Koutcher | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，： | 1 |
| 13 | Telaprevir: A Hepatitis C NS3/4A Protease Inhibitor显示文摘 | Samuel James Matthews Jason W. Lancaster | 2012 | Clinical Therapeutics2012，，9： | 1 |
| 14 | Does combined open and arthroscopic synovectomy for diffuse PVNS of the knee improve recurrence rates显示文摘 | Matthew WC Jason Y Kurt RW | 2013 | Clin Orthop Rel Res2013，471，3： | 1 |
| 15 | Carbon black thin films with tunable resistance and optical transparency显示文摘 | C. Jason Jan Matthew D. Walton Ethan P. McConnell Woo-Sik Jang Y.S. Kim Jaime C. Grunlan | 2006 | Carbon2006，，10： | 1 |
| 16 | Routine Contrast Imaging of Low Pelvic Anastomosis Prior to Closure of Defunctioning Ileostomy: is it Necessary?显示文摘 | Matthew F. Kalady Christopher R. Mantyh Jason Petrofski Kirk A. Ludwig | 2008 | Journal of Gastrointestinal Surgery2008，，7： | 1 |
| 17 | Current diagnosis and management of unusual pancreatic tumors显示文摘 | Melinda M. Mortenson Matthew H.G. Katz Eric P. Tamm Manoop S. Bhutani Huamin Wang Douglas B. Evans Jason B. Fleming | 2008 | The American Journal of Surgery2008，，： | 1 |
| 18 | Effect of Statins Alone Versus Statins Plus Ezetimibe on Carotid Atherosclerosis in Type 2 Diabetes显示文摘 | Jerome L. Fleg Mihriye Mete Barbara V. Howard Jason G. Umans Mary J. Roman Robert E. Ratner Angela Silverman James M. Galloway Jeffrey A. Henderson Matthew R. Weir Charlton Wilson Mario Stylianou Wm. James Howard | 2008 | Journal of the American College of Cardiology2008，，25： | 1 |
| 19 | Transient modeling of high- altitude rocket-stage separation 显示文摘 | Allen E Jason C Matthew B | 2008 | Journal of Spacecraft and Rockets2008，45，4： | 1 |
| 20 | Pancreatic neuroendocrine neoplasms: diagnosis and management显示文摘 | Aparna Balachandran Eric P. Tamm Priya R. Bhosale Madhavi Patnana Raghu Vikram Jason B. Fleming Matthew H. Katz Chuslip Charnsangavej | 2013 | Abdominal Imaging2013，，2： | 1 |
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