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| 1 | The basics of epithelial-mesenchymal transition显示文摘 | Kalluri Raghu Weinberg Robert A | 2009 | Journal of Clinical Investigation2009，，6： | 17 |
| 2 | 结膜滤过泡组织病理学特性显示文摘目的:描述并比较在修复小梁切除术和由于疏忽造成的滤过泡时得到的的结膜的组织学特征并评价抗纤维变性药物的作用。方法:我们对经过晚期滤过泡修复的28只眼的结膜标本采用常规石蜡制作的方法和光学显微镜下检查进行仔细观察:19只眼为渗漏的小梁切除术滤过泡,5只眼为无渗漏的小梁切除术滤过泡,4只眼为由于疏忽造成的滤过泡。定量分析的组织学特征包括结膜上皮的厚度,基质血管供应,鳞状组织化生,基质炎症细胞浸润和杯状细胞的密度。并且分析了手术类型,存在渗漏,先前的局部用药,应用抗纤维化药物都与组织学检查所见并置对比。结果:与由于疏忽造成的滤过泡的对照组相比,小梁切除术的滤过泡(渗漏的和无渗漏的)显示上皮的厚度(P〈0.02),杯状细胞的密度(P〈0.001)和血管供应(P〈0.001)全部降低。接受过抗纤维化药物的结膜比先前未受抗纤维化药物影响的结膜的上皮细胞层数更少(P〈0.05)。结论:小梁切除术后切除的薄的滤过泡的组织学分析证明上皮的厚度和杯状细胞的密度与由于疏忽造成的滤过泡相比均降低。与正常结膜相比。 | Brian A. Francis Lee T. Du Kathryn Najafi Raghu Murthy Usha Kurumety Narsing Rao Don S. Minckler 李航(译) 申敏如(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，3： | 8 |
| 3 | Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation显示文摘The integrity of the basal stem cell layer is critical for epithelial homoeostasis.In this paper,we review the expression of oral mucosal stem cell markers(OM-SCMs)in oral submucous fibrosis(OSF),oral potentially malignant disorders(OPMDs)and oral squamous cell carcinoma(OSCC)to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF.While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF,the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness.The vacillating expression patterns of OM-SCMs confirm the role of keratins 5,14,19,CD44,β1-integrin,p63,sex-determining region Y box(SOX2),octamer-binding transcription factor 4(Oct-4),c-MYC,B-cell-specific Moloney murine leukaemia virus integration site 1(Bmi-1)and aldehyde dehydrogenase 1(ALDH1)in OSF,OPMDs and OSCC.The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review. | Mohit Sharma Felipe Paiva Fonseca Keith D.Hunter Raghu Radhakrishnan | 2020 | International Journal of Oral Science2020，12，3： | 7 |
| 4 | Conversion of confined metal@ZIF-8 structures to intermetallic nanoparticles supported on nitrogen-doped carbon for electrocatalysis显示文摘 | Zhiyuan Qi Yuchen Pei Tian Wei Goh Zhaoyi Wang Xinle Li Mary Lowe Raghu V. Maligal-Ganesh Wenyu Huang | 2018 | Nano Research2018，11，6： | 6 |
| 5 | Role of tissue microenvironment resident adipocytes in colon cancer显示文摘Colorectal cancer(CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment(TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors(angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, neoangiogenesis, evasion of immune surveillance and therapy resistance. Furthermore, adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells. Interestingly, a relationship between obesity and molecular variants in CRC has recently been identified. Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored. This editorial highlights the major findings related to crosstalk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression. Furthermore, we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells. This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression. | Maria Tabuso Shervanthi Homer-Vanniasinkam Raghu Adya Ramesh P Arasaradnam | 2017 | World Journal of Gastroenterology2017，23，32： | 6 |
| 6 | An evolving function of DNA-containing exosomes in chemotherapy-induced immune response显示文摘 | Paul Kurywchak Raghu Kalluri | 2017 | Cell Research2017，27，6： | 6 |
| 7 | 特发性肺间质纤维化的发病率和患病率显示文摘背景和目的:特发性肺间质纤维化(IPF)是病因未明的慢性肺间质疾病,美国的IPF流行病学资料尚不完整。本研究的目的在于观察美国IPF的患病率及年发病率。方法:通过医疗保健系统的资料库,对1996年1月至2002年12月的数据进行回顾性队列研究,根据诊断及操作编码确定观察对象是否患IPF。结果:18—34岁人群的IPF患病率约为7/10万,75岁以上人群的IPF患病率为227.2/10万,年发病率约为1.2~76.4/10万; | Raghu G Weycker D Edelsberg J 蔡闯 | 2007 | 中华结核和呼吸杂志2007，30，4： | 5 |
| 8 | Refractory gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease(GERD)is a condition that develops when the reflux of stomach contents into the esophagus causes troublesome symptoms,esophageal injury,and/or complications.Use of proton pump inhibitors(PPI)remains the standard therapy for GERD and is effective in most patients.Those whose symptoms are refractory to PPIs should be evaluated further and other treatment options should be considered,according to individual patient characteristics.Response to PPIs could be total(no symptoms),partial(residual breakthrough symptoms),or absent(no change in symptoms).Patients experiencing complete response do not usually need further management.Patients with partial response can be treated surgically or by using emerging endoscopic therapies.Patients who exhibit no response to PPI need further evaluation to rule out other causes. | Charumathi Raghu Subramanian George Triadafilopoulos | 2015 | Gastroenterology Report2015，3，1： | 5 |
| 9 | Aerodynamics of high-speed railway train显示文摘 | Raghu S Raghunathan H.-D Kim T Setoguchi | 2002 | Progress in Aerospace Sciences2002，，6： | 4 |
| 10 | Cerium(Ⅳ) ammonium nitrate catalysed facile and efficient synthesis of polyhydroquinoline derivatives through Hantzsch multicomponent condensation显示文摘为 polyhydroquinoline 衍生物的合成的一条一般、方便的实际途径经由一个壶被完成了面对铈(IV ) 的催化数量的芳香的醛, dimedone,乙醇 acetoacetate 和铵醋酸盐的四部件的 Hantzsch 冷凝作用铵硝酸盐(罐头) ,在在周围的温度的乙醇溶剂。简单病情的检查,温和反应条件,便宜、无毒的催化剂,和优秀产品收益是这个方法的有益的特征。 | Cherkupally Sanjeeva Reddy Mekala Raghu | 2008 | Chinese Chemical Letters2008，19，7： | 4 |
| 11 | Accuracy of abdominal ultrasound for the diagnosis of small bowel obstruction in the emergency department显示文摘BACKGROUND: Emergency physicians frequently encounter patients with acute small bowel obstructions(SBO). Although computed tomography(CT) imaging is the current gold standard in the assessment of patients with suspected SBO in the emergency department, a few studies have examined the use of ultrasound as an alternative imaging technique. METHODS: We evaluated the accuracy of ultrasound performed in the ED by a variety of providers(physicians with various levels of training, physician assistants) compared to CT imaging in 47 patients with suspected SBOs. RESULTS: Our data demonstrated a sensitivity of 93.8% and a specificity of 93.3% when compared to abdominal CT, and a sensitivity of 94.3% and specificity of 95.2% using a composite endpoint of abdominal CT and discharge diagnosis. CONCLUSION: Ultrasound can play an important role in the identification of small bowel obstructions in ED patients. | Sarah E. Frasure Amy F. Hildrcth Raghu Seethala Heidi H. Kimberly | 2018 | World Journal of Emergency Medicine2018，9，4： | 4 |
| 12 | An official ATS/ERS/JRS/ALAT statement:idiopathic pulmonary fibrosis:evidence-based guidelines for diagnosis and management显示文摘 | Raghu G Collard HR Egan J J | | 0，，06： | 3 |
| 13 | Gastric digestion of pea ferritin and modulation of its iron bioavailability by ascorbic and phytic acids in caco-2 cells显示文摘瞄准:在 caco-2 房间线模型理解版本和豌豆含铁听铁的肠的举起的消化稳定性和机制。方法:豌豆种子含铁锡用分别由胶化过滤层析跟随了的盐被净化。含铁听铁的简历可获得性当面用联合在试管内 digestion/Caco-2 房间模型被估计或抗坏血酸和 phytic 的缺席。Caco-2 房间含铁听形成被用作铁举起的一个代理人标记。在模仿的胃的 pH 下面的豌豆含铁锡的结构的变化用电气泳动,胶化过滤和圆形的二色性光谱学被描绘。结果:caco-2 房间含铁听形成显著地被增加(P <
0.001 ) 与 FeSO4 (19.3 +/- 9.8 ng/mg 蛋白质) 并且豌豆含铁锡(13.9 +/- 6.19 ng/mg 蛋白质) 与空白的文摘相比(3.7 +/- 1.8 ng/mg 蛋白质) 。当 phytic 减少了时,提高的抗坏血酸豌豆含铁听铁简历可获得性。然而,也当面或抗坏血酸的缺席, caco-2 房间的含铁听内容是显著地有豌豆含铁锡的更少比与 FeSO4。在胃的 pH,相应于含铁锡的乐队都没在本国的页或 SDS 页上面对胃朊酶任何一个被观察。胶化过滤层析和圆形的二色性光谱学揭示了第四级、第二等的结构的 pH 依赖者损失。结论:在胃的条件下面,豌豆含铁锡的铁核心由于酸被释放进消化媒介蛋白质的导致的结构的改变和分离。释放的铁与导致豌豆含铁听铁简历可获得性的调整的饮食的因素交往,类似于 non-heme 铁的典型特征。 | Satyanarayana Bejjani Raghu Pullakhandam Ravinder Punjal K Madhavan Nair | 2007 | World Journal of Gastroenterology2007，13，14： | 3 |
| 14 | Imaging of pancreatic ductal adenocarcinoma: State of the art显示文摘Significant advances in imaging technology have changed the management of pancreatic cancer. In computed tomography (CT), this has included development of multidetector row, rapid, thin-section imaging that has also facilitated the advent of advanced reconstructions, which in turn has offered new perspectives from which to evaluate this disease. In magnetic resonance imaging, advances including higher field strengths, thin-section volumetric acquisitions, diffusion weighted imaging, and liver specific contrast agents have also resulted in new tools for diagnosis and staging. Endoscopic ultrasound has resulted in the ability to provide high-resolution imaging rivaling intraoperative ultrasound, along with the ability to biopsy via real time imaging suspected pancreatic lesions. Positron emission tomography with CT, while still evolving in its role, provides whole body staging as well as the unique imaging characteristic of metabolic activity to aid disease management. This article will review these modalities in the diagnosis and staging of pancreatic cancer. | Eric Peter Tamm Priya Ranjit Bhosale Raghu Vikram Leonardo Pimentel de Almeida Marcal Aparna Balachandran | 2013 | World Journal of Radiology2013，5，3： | 3 |
| 15 | Prednisone,azathioprine,and N-acetylcysteine for pulmonary fibrosis显示文摘 | Raghu G Anstrom K J King TE Jr | | 0，，21： | 2 |
| 16 | Acetylcholinesterase based biosensor for monitoring of Malathion and Acephate in food samples: A voltammetric study显示文摘 | P. Raghu T. Madhusudana Reddy K. Reddaiah B.E. Kumara Swamy M. Sreedhar | 2013 | Food Chemistry2013，，： | 2 |
| 17 | Protective Actions of Globular and Full-Length Adiponectin on Human Endothelial Cells: Novel Insights into Adiponectin-Induced Angiogenesis显示文摘 | Adya Raghu Tan Bee K Chen Jing Randeva Harpal S | 2012 | Journal of Vascular Research2012，，6： | 2 |
| 18 | Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model显示文摘 | Janaiah Kota Raghu R. Chivukula Kathryn A. O’Donnell Erik A. Wentzel Chrystal L. Montgomery Hun-Way Hwang Tsung-Cheng Chang Perumal Vivekanandan Michael Torbenson K. Reed Clark Jerry R. Mendell Joshua T. Mendell | 2009 | Cell2009，，6： | 2 |
| 19 | Inhibition of Intercellular Adhesion Molecule-1 Protein Expression by Antisense Oligonucleotides Is Neuroprotective After Transient Middle Cerebral Artery Occlusion in Rat显示文摘 | Raghu Vemuganti Robert J. Dempsey Kellie K. Bowen | 2004 | Stroke: Journal of the American Heart Association2004，，1： | 2 |
| 20 | Marketing on the Internet- Who Can Benefit from an Online Marketing Approach显示文摘 | Melidy Y Kiang T S Raghu Kevin Huei-MinShang | 2000 | Decision Support System2000，27，： | 1 |
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