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| 1 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 2 | Elucidation of the ‘Honeycrisp’ pedigree through haplotype analysis with a multi-family integrated SNP linkage map and a large apple (Malus×domestica) pedigree-connected SNP data set显示文摘The apple(Malus×domestica)cultivar Honeycrisp has become important economically and as a breeding parent.An earlier study with SSR markers indicated the original recorded pedigree of‘Honeycrisp’was incorrect and‘Keepsake’was identified as one putative parent,the other being unknown.The objective of this study was to verify‘Keepsake’as a parent and identify and genetically describe the unknown parent and its grandparents.A multi-family based dense and high-quality integrated SNP map was created using the apple 8 K Illumina Infinium SNP array.This map was used alongside a large pedigree-connected data set from the RosBREED project to build extended SNP haplotypes and to identify pedigree relationships.‘Keepsake’was verified as one parent of‘Honeycrisp’and‘Duchess of Oldenburg’and‘Golden Delicious’were identified as grandparents through the unknown parent.Following this finding,siblings of‘Honeycrisp’were identified using the SNP data.Breeding records from several of these siblings suggested that the previously unreported parent is a University of Minnesota selection,MN1627.This selection is no longer available,but now is genetically described through imputed SNP haplotypes.We also present the mosaic grandparental composition of‘Honeycrisp’for each of its 17 chromosome pairs.This new pedigree and genetic information will be useful in future pedigree-based genetic studies to connect‘Honeycrisp’with other cultivars used widely in apple breeding programs.The created SNP linkage map will benefit future research using the data from the Illumina apple 8 and 20 K and Affymetrix 480 K SNP arrays. | Nicholas P Howard Eric van de Weg David S Bedford Cameron P Peace Stijn Vanderzande Matthew D Clark Soon Li Teh Lichun Cai James J Luby | 2017 | Horticulture Research2017，4，1： | 9 |
| 3 | The Molecular Pathogenesis of Osteosarcoma: A Review显示文摘 | Matthew L. Broadhead Jonathan C. M. Clark Damian E. Myers Crispin R. Dass Peter F. M. Choong H. Kovar | 2011 | Sarcoma2011，，： | 4 |
| 4 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 5 | Structure-function studies of the human immunodeficiency virus type 1 matrix protein, pl7显示文摘 | Cannon P M Matthews S Clark N | 1997 | J Virol1997，71，5： | 1 |
| 6 | Dopamine D 2 -Receptor-Mediated Increase in Vascular and Endothelial NOS Activity Ameliorates Cerebral Vasospasm After Subarachnoid Hemorrhage In Vitro显示文摘 | Gail J. Pyne-Geithman Danielle N. Caudell Matthew Cooper Joseph F. Clark Lori A. Shutter | 2009 | Neurocritical Care2009，，2： | 1 |
| 7 | Randomized controlled trial of maintaining quality of life during radiotherapy for advanced cancer显示文摘 | Matthew M. Clark Teresa A. Rummans Pamela J. Atherton Andrea L. Cheville Mary E. Johnson Marlene H. Frost Janis J. Miller Jeff A. Sloan Karen M. Graszer Jean G. Haas Jean M. Hanson Yolanda I. Garces Katherine M. Piderman Maria I. Lapid Pamela J. Netzel Ja | 2012 | Cancer2012，，4： | 1 |
| 8 | Bisphosphonates: mechanism of action and role in clinical practice 显示文摘 | Matthew TD Clarke BL Khosla S | 2008 | Mayo Clin Proc2008，83，9： | 1 |
| 9 | High-precision U-series ages of transported coral blocks on Heron Reef (southern Great Barrier Reef) and storm activity during the past century显示文摘 | Kefu Yu Jianxin Zhao George Roff Matthew Lybolt Yuexing Feng Tara Clark Shu Li | 2012 | Palaeogeography, Palaeoclimatology, Palaeoecology2012，，： | 1 |
| 10 | A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68)显示文摘 | P. M. Clarke A. M. Gray A. Briggs A. J. Farmer P. Fenn R. J. Stevens D. R. Matthews I. M. Stratton R. R. Holman | 2004 | Diabetologia2004，，10： | 1 |
| 11 | The Ethical-politics of Teacher Identity 显示文摘 | Matthew Clarke | 2008 | Educational Philosophy and Theory2008，，3： | 1 |
| 12 | Photonic analog-to-digital conversion by distributed phase modulation显示文摘 | Marc Currie Thomas R Clark Paul J Matthews | 2000 | IEEE Photonics Technology Letters2000，12，12： | 1 |
| 13 | Conformational changes of fibrinogen after adsorption 显示文摘 | Matthew L Clarke Wang Jie Chen Zhan | 2005 | J Phys Chem B2005，109，22： | 1 |
| 14 | Photonic analog-to-digital conversion by distributed phase modulation 显示文摘 | Currie M Clark T R Matthews P J | 2000 | Photonics Technology Letters IEEE2000，12，12： | 1 |
| 15 | Impact of micro- wave synthesis conditions on the rechargeable capacity of LiCo- PO4 for lithium ion batteries显示文摘 | Rogers R E Clarke G M Matthew O N | 2013 | J Appl Electrochem2013，43，3： | 1 |
| 16 | The Molecular Pathogenesis of Osteosarcoma: A Review显示文摘 | Matthew L. Broadhead Jonathan C. M. Clark Damian E. Myers Crispin R. Dass Peter F. M. Choong H. Kovar | 2011 | Sarcoma2011，，： | 1 |
| 17 | First principles methods using CASTEP显示文摘 | Stewart J. Clark Matthew D. Segall Chris J. Pickard Phil J. Hasnip Matt I. J. Probert Keith Refson Mike C. Payne | 2005 | Zeitschrift für Kristallographie . 2005 (5/6/)2005，，5： | 1 |
| 18 | MRI segmentation using fuzzy clustering techniques显示文摘 | Clark Matthew C Hall Lawrence O | 1994 | IEEE Engineering in Medicine and Biology1994，13，5： | 1 |
| 19 | Automatic Tumor Segmentation Using knowledge-Based Technique显示文摘 | Clark Matthew C Hall Lawrence O | 1998 | IEEE Transactions on Medical Imaging1998，17，2： | 1 |
| 20 | Reporting Standards for Endovascular Treatment of Pulmonary Embolism显示文摘 | Filip Banovac Donna C. Buckley William T. Kuo Denver Matthew Lough Louis G. Martin Steven F. Millward Timothy W.I. Clark Sanjoy Kundu Dheeraj K. Rajan David Sacks John F. Cardella | 2010 | Journal of Vascular and Interventional Radiology2010，，1： | 1 |
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