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| 1 | 中国年轻乳腺癌发病危险因素——多中心十年回顾性研究显示文摘[目的]研究年轻乳腺癌与非年轻乳腺癌患者的临床病理特征差异,探寻年轻女性罹患乳腺癌的危险因素。[方法]数据来自于一项以医院为基础的10年(1999-2008)多中心回顾性研究。对年轻组(〈35岁)与非年轻组(≥35岁)患者的肿瘤大小、淋巴结转移状况和人口学信息进行统计分析。[结果]研究共纳入4211例患者。其中年轻乳腺癌患者(〈35岁)295例(7.06%)。年轻组与非年轻组患者在临床病理特征方面仅有肿瘤最大径(31.91mm vs.27.44mm,P=0.009)和淋巴结转移发生率(62.31%vs.49.01%,P〈0.001)存在统计学差异。此外,年轻乳腺癌患者的生产次数少(Ptrend〈0.001)、哺乳比例低(P〈0.001)。年轻患者中未婚者(P〈0.001)、使用口服避孕药者(P〈0.001)、饮酒者(P=0.006)均较非年轻组的比例高。年轻乳腺癌患者具有较高的脑力劳动比例(P=0.005)和较高的教育背景(Ptrend〈0.001)。[结论 ]年轻乳腺癌患者在临床病理特征以及人口学信息等方面与非年轻患者存在差异。其中一些在年轻乳腺癌患者中出现频率高的变量提示了年轻患者罹患乳腺癌的危险因素。 | 张柏林 张倩 Priya G.Sivasubramaniam 高纪东 方仪 王翔 张保宁 张斌 唐中华 谢小明 杨红建 何建军 李卉 李佳圆 范金虎 乔友林 | 2015 | 中国肿瘤2015，24，12： | 31 |
| 2 | Overexpression of TaNAC69 Leads to Enhanced Transcript Levels of Stress Up-Regulated Genes and Dehydration Tolerance in Bread Wheat显示文摘NAC 蛋白质是植物特定的抄写因素并且充实,成员们在对干旱应力的植物反应包含了。在这研究,我们用 Affymetrix 小麦染色体数组数据集和量的 RTPCR 在面包小麦分析了 TaNAC69 的表达式侧面。TaNAC69 表示断然与对不能生活、关於生命的压力的小麦回答被联系并且密切与很多个压力被相关起来调整的基因。在转基因的小麦的 TaNAC69 的功能的分析证明干旱可诱导的 HvDhn4s 倡导者导致了的一棵大麦驾驶的 TaNAC69 在转基因的线的叶子和根标记 TaNAC69 的干旱可诱导的 overexpression。HvDhn4s : 更生产的 TaNAC69 转基因的线在联合的温和的盐应力和水限制条件下面射击生物资源,在聚乙烯下面的有的更长的根和更多根生物资源导致乙二醇的脱水。有 TaNAC69 的组成的 overexpression 的转基因的线的分析证明提高的表示几个压力铺平起来调整的基因。DNA 有约束力的试金表明 TaNAC69 和它的米饭相当或相同的事物(ONAC131 ) 能够到三米饭基因的倡导者元素的绑定(chitinase, ZIM,和 glyoxalase 我) 并且 Arabidopsis glyoxalase 我家庭基因,它是 TaNAC69 起来调整的压力基因的相当或相同的事物。这些数据建议 TaNAC69 涉及调整应力起来调整的基因和小麦改编到干旱应力。 | Gang-Ping Xue Heather M. Way Terese Richardson Janneke Drenth Priya A. Joyce C.Lynne Mclntyre | 2011 | Molecular Plant2011，4，4： | 25 |
| 3 | 2017年哮喘研究进展:发病机制、生物制剂和遗传学显示文摘总结了近年来部分关于哮喘最重要的研究进展。首先,关注哮喘发展和加重机制的新发现,随后讨论了新的潜在的哮喘生物标志物,包括射线性标记物的使用。第二,过去一年里临床医师已经开始使用几种治疗哮喘的新型生物制剂,总结这些药物的应用进展及其对哮喘临床治疗的影响。第三,探讨了哮喘遗传学的重要发现和哮喘表型的异质性,如同环境因素一样,这些因素在哮喘的发展和急性发作过程中也发挥着重要的作用。最后,讨论了医学知识的进步以及它们将如何影响哮喘的防治。 | Mitchell H. Grayson Scott Feldman Benjamin T. Prince Priya J. Patel Elizabeth C. Matsui Andrea J. Apter 杨玲(翻译) 刘婷(翻译) 刘春涛(审校/点评) | 2018 | 中华临床免疫和变态反应杂志2018，12，6： | 13 |
| 4 | 新生儿早期基本保健:为西太平洋地区的每位新生儿创造健康的生命开端显示文摘为了提高新生儿存活率,确保每一位婴儿都拥有健康的生命开端,世界卫生组织成员国于2013年共同制定了《西太平洋地区健康新生儿行动计划(2014—2020)》,其重点是推行新生儿早期基本保健(early essential newborn care, EENC)技术。本文从以下四方面阐述西太平洋地区EENC实施现状—地区引入、维持和推广EENC的方法;EENC实施进展;开展社会动员支持新生儿保健;最佳实践、经验总结和未来方向。中国正积极采取行动,以实现可持续发展目标中的妇幼健康指标和全民健康覆盖。 | Priya Mannava Howard L.Sobel | 2019 | 中华围产医学杂志2019，22，8： | 11 |
| 5 | Active learning for accelerated design of layered materials显示文摘Hetero-structures made from vertically stacked monolayers of transition metal dichalcogenides hold great potential for optoelectronic and thermoelectric devices.Discovery of the optimal layered material for specific applications necessitates the estimation of key material properties,such as electronic band structure and thermal transport coefficients.However,screening of material properties via brute force ab initio calculations of the entire material structure space exceeds the limits of current computing resources.Moreover,the functional dependence of material properties on the structures is often complicated,making simplistic statistical procedures for prediction difficult to employ without large amounts of data collection.Here,we present a Gaussian process regression model,which predicts material properties of an input hetero-structure,as well as an active learning model based on Bayesian optimization,which can efficiently discover the optimal hetero-structure using a minimal number of ab initio calculations.The electronic band gap,conduction/valence band dispersions,and thermoelectric performance are used as representative material properties for prediction and optimization.The Materials Project platform is used for electronic structure computation,while the BoltzTraP code is used to compute thermoelectric properties.Bayesian optimization is shown to significantly reduce the computational cost of discovering the optimal structure when compared with finding an optimal structure by building a regression model to predict material properties.The models can be used for predictions with respect to any material property and our software,including data preparation code based on the Python Materials Genomics(PyMatGen)library as well as python-based machine learning code,is available open source. | Lindsay Bassman Pankaj Rajak Rajiv K.Kalia Aiichiro Nakano Fei Sha Jifeng Sun David J.Singh Muratahan Aykol Patrick Huck Kristin Persson Priya Vashishta | 2018 | npj Computational Materials2018，，1： | 10 |
| 6 | Differential changes in intrinsic innervation and interstitial cells of Cajal in small bowel atresia in newborns显示文摘AIM: To investigate morphological changes of the enteric nervous system (ENS) and the interstitial cells of Cajal (ICCs) in small bowel atresia.METHODS: Resected small bowel specimens from affected patients (n = 7) were divided into three parts (proximal, atretic, distal). Standard histology and enzyme immunohistochemistry anti-S100, anti-protein gene product (PGP) 9.5, anti-neurofilament (NF), antic-kit-receptor (CD117) was carried out on conventional paraffin sections of the proximal and distal part. RESULTS: The neuronal and glial markers (PGP 9.5, NF, S-100) were expressed in hypertrophied ganglia and nerve fibres within the myenteric and submucosal plexuses. Furthermore, the submucous plexus contained typical giant ganglia. The innervation pattern of the proximal bowel resembled intestinal neuronal dysplasia. The density of myenteric ICCs was clearly reduced in the proximal bowel, whereas a moderate number of muscular ICCs were found. The anti-CD117 immunore- action revealed additional numerous mast cells. The distal bowel demonstrated normal morphology and density of the ENS, the ICCs and the mast cells.CONCLUSION: The proximal and distal bowel in small bowel atresia revealed clear changes in morphology and density of the ENS and ICCs. | Stefan Gfroerer Roman Metzger Henning Fiegel Priya Ramachandran Udo Rolle | 2010 | World Journal of Gastroenterology2010，16，45： | 9 |
| 7 | Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma显示文摘AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C HBV.METHODS: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing method.RESULTS: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV. | Danbi Lee Heather Lyu Young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu Young Joo Lee Soo Hyung Ryu | 2016 | World Journal of Gastroenterology2016，22，23： | 9 |
| 8 | Hepatic Hemangioendothelioma: An update显示文摘Primary epithelioid hemangioendotheliomas of the liver(EHL)are rare tumors with a low incidence.The molecular background of EHL is still under investigation,with WWTR1-CAMPTA1 mutation may function as a tumor marker.Commonly,this tumor is misdiagnosed with angiosarcoma,cholangiocarcinomas,metastatic carcinoma,and hepatocellular carcinoma(sclerosing variant).Characteristic features on imaging modalities such as ultrasound,computed tomography,magnetic resonance imaging and positron emission tomography/computed tomography guide in diagnosis and staging.The“halo sign”and the“lollipop sign”on computed tomography and magnetic resonance imaging are described in the literature.Currently,there are no standardized guidelines for treating EHL with treatment options are broad including:chemotherapy,ablation,surgery and liver transplantation with inconsistent results. | Mayur Virarkar Mohammed Saleh Radwan Diab Melissa Taggart Peeyush Bhargava Priya Bhosale | 2020 | World Journal of Gastrointestinal Oncology2020，12，3： | 8 |
| 9 | Spectrum of biliary complications following live donor liver transplantation显示文摘Liver transplantation is the optimal treatment for many patients with advanced liver disease, including decompensated cirrhosis, hepatocellular carcinoma and acute liver failure. Organ shortage is the maindeterminant of death on the waiting list and hence living donor liver transplantation(LDLT) assumes importance. Biliary complications are the most common post operative morbidity after LDLT and occur due to anatomical and technical reasons. They include biliary leaks, strictures and cast formation and occur in the recipient as well as the donor. The types of biliary complications after LDLT along with their etiology, presenting features, diagnosis and endoscopic and surgical management are discussed. | Priya Simoes Varun Kesar Jawad Ahmad | 2015 | World Journal of Hepatology2015，7，14： | 7 |
| 10 | Validation of reference genes for gene expression studies in the emerald ash borer (Agrilus planipennis)显示文摘翠玉灰 borer (EAB, Agrilus planipennis Fairmaire ) 一个异国情调的侵略昆虫害虫越过北美洲杀死了百万棵灰树(Fraxinus spp ) 并且更威胁十亿。我们验证了六 A。planipennis 参考基因(肌动朊,行动;贝它导管素,澡盆;glyceraldehyde-3-phosphate 脱氢酶, GAPDH;ribosomal 蛋白质, RPL7;翻译延伸因素 1, TEF-1;并且 ubiquitin, UBQ ) 在基因表示为目标送信人 RNA 层次的精确决心使用 geNorm, Normfinder 和 BestKeeper 学习。六参考基因的稳定性在不同幼虫的纸巾,发展阶段和 A 的二个处理被评估。用量的即时聚合酶链反应的 planipennis。尽管有,没有一致评价越过样品在参考基因之中观察了,全面分析作为最稳定的参考基因揭示了 TEF-1。GAPDH 和行为证明为所有样品的最少的稳定性学习了。我们断定 TEF-1 是为在 A 的基因表达式研究的最适当的引用基因。planipennis。获得的结果能为抄本在另外的侵略昆虫害虫介绍是适用的。进一步,这些验证参考基因能也在任何给定的昆虫系统用作候选人参考基因的选择的基础确认以后。 | Swapna Priya Rajarapu Praveen Mamidala Omprakash Mittapalli | 2012 | Insect Science2012，19，1： | 7 |
| 11 | Severe liver injury due to herbal and dietary supplements and the role of liver transplantation显示文摘Herbal and dietary supplements(HDS)are increasingly used worldwide for numerous,mainly unproven health benefits.The HDS industry is poorly regulated compared to prescription medicines and most products are easily obtainable.Drug induced liver injury(DILI)is a well-recognized entity associated with prescription and over the counter medications and many reports have emerged of potential HDS-related DILI.There is considerable geographic variability in the risk and severity of DILI associated with HDS but the presentation of severe liver injury is similar with a hepatocellular pattern accompanied by jaundice.This type of injury can lead to acute liver failure and the need for liver transplantation.Patients will often fail to mention their use of HDS,considering it natural and therefore harmless.Hence physicians should understand that these products can be associated with DILI and explicitly ask about HDS use in any patient with otherwise unexplained acute liver injury. | Priya Grewal Jawad Ahmad | 2019 | World Journal of Gastroenterology2019，25，46： | 6 |
| 12 | Salt Tolerance Mechanisms and Approaches:Future Scope of Halotolerant Genes and Rice Landraces显示文摘All rice plant developmental stages are severely affected by soil salinity. Salinity-induced ionic and osmotic stresses affect stomata closure and gaseous exchange, and reduce transpiration and the rate of carbon assimilation, and hence decrease plant yield. Understanding the response of rice plants toward salinity stress at the genetic level and developing salt-tolerant varieties are the vital mandates for its effective management. This review described the present status of salt-tolerance achieved in rice by various mechanisms including the ion homeostasis(Na^+/H^+, OsNHX antiporters), compatible organic solutes(glycine betaine and proline), antioxidative genes(OsECS, OsVTE1, OsAPX and OsMSRA4.1), salt responsive regulatory elements(transcription factors, cis-acting elements and miRNAs) and genes ecoding protein kinases(MAPKs, SAPKs and STRKs). Further, the future perspective of developing salt-tolerant varieties lies in exploring halotolerant gene homologs from rice varieties, especially the landraces. Genetic diversity among rice landraces can serve as a valuable resource for future studies toward variety improvement through breeding and genome editing. Further, identification, multiplication, preservation and utilization of biodiversity among landraces are the urgent buffers to be saved as a heritage for future generations to come. | Tarun Bhatt Aditi Sharma Sanjeev Puri Anu Priya Minhas | 2020 | Rice science2020，27，5： | 6 |
| 13 | Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis显示文摘AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.METHODS: The cyclic guanosine monophosphate(cG MP) stimulatory potency of plecanatide and dolcanatide was measured using a human colon carcinoma T84 cellbased assay. For animal studies all test agents were formulated in phosphate buffered saline. Sulfasalazine or 5-amino salicylic acid(5-ASA) served as positive controls. Effect of oral treatment with test agents on amelioration of acute colitis induced either by dextran sulfate sodium(DSS) in drinking water or by rectal instillation of trinitrobenzene sulfonic(TNBS) acid, was examined in BALB/c and/or BDF1 mice. Additionally, the effect of orally administered plecanatide on the spontaneous colitis in T-cell receptor alpha knockout(TCRα-/-) mice was also examined. Amelioration of colitis was assessed by monitoring severity of colitis, disease activity index and by histopathology. Frozen colon tissues were used to measure myeloperoxidase activity.RESULTS: Plecanatide and dolcanatide are structurally related analogs of uroguanylin, which is an endogenous ligand of guanylate cyclase-C(GC-C). As expected from the agonists of GC-C, both plecanatide and dolcanatide exhibited potent cG MP-stimulatory activity in T84 cells. Once-daily treatment by oral gavage with either of these analogs(0.05-0.5 mg/kg) ameliorated colitis in both DSS and TNBS-induced models of acute colitis, as assessed by body weight, reduction in colitis severity(P < 0.05) and disease activity index(P < 0.05). Amelioration of colitis by either of the drug candidates was comparable to that achieved by orally administered sulfasalazine or 5-ASA. Plecanatide also effectively ameliorated colitis in TCRα-/- mice, a model of spontaneous colitis. As dolcanatide exhibited higher resistance to proteolysis in simulated gastric and intestinal juices, it was selected for further studies. CONCLUSION: This is the first-ever study reporting the therapeutic utility of GC-C agonists as a new class of orally delivered and mucosally active drug candidates for the treatment of inflammatory bowel diseases. | Kunwar Shailubhai Vaseem Palejwala Krishna Priya Arjunan Sayali Saykhedkar Bradley Nefsky John A Foss Stephen Comiskey Gary S Jacob Scott E Plevy | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 5 |
| 14 | Exploration of the shared pathophysiological mechanisms of gestational diabetes and large for gestational age offspring显示文摘Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for the conditions and an increased prevalence of LGA offspring amongst pregnancies affected by GDM. Thus, it is important to elucidate potential shared underlying mechanisms of both LGA and GDM. One potential mechanistic link relates to macronutrient metabolism. Indeed, derangement of carbohydrate and lipid metabolism is present in GDM, and maternal biomarkers of glucose and lipid control are associated with LGA neonates in such pregnancies. The aim of this paper is therefore to reflect on the existing nutritional guidelines for GDM in light of our understanding of the pathophysiological mechanisms of GDM and LGA offspring. Lifestyle modification is first line treatment for GDM, and while there is some promise that nutritional interventions may favourably impact outcomes, there is a lack of definitive evidence that changing the macronutrient composition of the diet reduces the incidence of either GDM or LGA offspring. The quality of the available evidence is a major issue, and rigorous trials are needed to inform evidence-based treatment guidelines. | Sofia Nahavandi Sarah Price Priya Sumithran Elif Ilhan Ekinci | 2019 | World Journal of Diabetes2019，10，6： | 5 |
| 15 | Smart polymers for the controlled delivery of drugs–a concise overview显示文摘Smart polymers have enormous potential in various applications.In particular,smart polymeric drug delivery systems have been explored as“intelligent”delivery systems able to release,at the appropriate time and site of action,entrapped drugs in response to specific physiological triggers.These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties.The responses vary widely from swelling/contraction to disintegration.Synthesis of new polymers and crosslinkers with greater biocompatibility and better biodegradability would increase and enhance current applications.The most fascinating features of the smart polymers arise from their versatility and tunable sensitivity.The most significant weakness of all these external stimuli-sensitive polymers is slow response time.The versatility of polymer sources and their combinatorial synthesis make it possible to tune polymer sensitivity to a given stimulus within a narrow range.Development of smart polymer systems may lead to more accurate and programmable drug delivery.In this review,we discuss various mechanisms by which polymer systems are assembled in situ to form implanted devices for sustained release of therapeutic macromolecules,and we highlight various applications in the field of advanced drug delivery. | Honey Priya James Rijo John Anju Alex Anoop K.R. | 2014 | Acta Pharmaceutica Sinica B2014，4，2： | 5 |
| 16 | Fast and sensitive LC–MS/MS method for the simultaneous determination of lisinopril and hydrochlorothiazide in human plasma显示文摘A sensitive and rapid liquid chromatography-tandem mass spectrometry(LC–MS/MS) method has been developed for the simultaneous determination of lisinopril(LIS) and hydrochlorothiazide(HCTZ) in human plasma using their labeled internal standards(ISs). Sample pre-treatment involved solid phase extraction on Waters Oasis HLB cartridges using 100 μL of plasma, followed by liquid chromatography on Hypersil Gold C_(18)(50 mm×3.0 mm, 5 μm) column. The analytes were eluted within 2.0 min using acetonitrile-5.0 m M ammonium formate, p H 4.5(85:15, v/v) as the mobile phase. The analytes and ISs were analyzed in the negative ionization mode and quantified using multiple reaction monitoring. The method showed excellent linearity over the concentration range of 0.50–250.0 ng/m L for both the analytes. The intra-batch and inter-batch precision(% CV) was ≤5.26% and their extraction recoveries were in the range of 96.6%–103.1%. Matrix effect evaluated in terms of IS-normalized matrix factors ranged from 0.97 to 1.03 for both the analytes. The validated method was successfully applied to determine the plasma concentration of the drugs using 10 mg lisinopril and 12.5 mg hydrochlorothiazide fixed dose formulation in 18 healthy Indian volunteers. | Jaivik V.Shah Priyanka A.Shah Priya V.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 5 |
| 17 | Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models显示文摘AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability, integrity of tight junctions and on suppression of visceral hypersensitivity. METHODS Transport of fluorescein isothiocyanate(FITC)-dextran was measured to assess permeability across cell monolayers and rat colon tissues. Effects of plecanatide and dolcanatide on the integrity of tight junctions in Caco-2 and T84 monolayers and on the expression and localization of occludin and zonula occludens-1(ZO-1) were examined by immunofluorescence microscopy. Anti-nociceptive activity of these agonists was evaluated in trinitrobenzene sulfonic acid(TNBS)-induced inflammatory as well as in non-inflammatory partial restraint stress(PRS) rat models. Statistical significance between the treatment groups in the permeability studies were evaluated using unpaired t-tests.RESULTS Treatment of T84 and Caco-2 monolayers with lipopolysaccharide(LPS) rapidly increased permeability, which was effectively suppressed when monolayers were also treated with plecanatide or dolcanatide. Similarly, when T84 and Caco-2 monolayers were treated with LPS, cell surface localization of tight junction proteins occludin and ZO-1 was severely disrupted. When cell monolayers were treated with LPS in the presence of plecanatide or dolcanatide, occludin and ZO-1 were localized at the cell surface of adjoining cells, similar to that observed for vehicle treated cells. Treatment of cell monolayers with plecanatide or dolcanatide without LPS did not alter permeability, integrity of tight junctions and cell surface localization of either of the tight junction proteins. In rat visceral hypersensitivity models, both agonists suppressed the TNBS-induced increase in abdominal contractions in response to colorectal distension without affecting the colonic wall elasticity, and both agonists also reduced colonic hypersensitivity in the PRS model. CONCLUSION Our results suggest that activation of GC-C signaling might be involved in maintenance of barrier function, possibly through regulating normal localization of tight junction proteins. Consistent with these findings, plecanatide and dolcanatide showed potent antinociceptive activity in rat visceral hypersensitivity models. These results imply that activation of GC-C signaling may be an attractive therapeutic approach to treat functional constipation disorders and inflammatory gastrointestinal conditions. | Illona-Marie Boulete Anusha Thadi Catherine Beaufrand Viren Patwa Apoorva Joshi John A Foss E Priya Eddy Helene Eutamene Vaseem A Palejwala Vassilia Theodorou Kunwar Shailubhai | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 18 | Contemporary approach to diagnosis and classification of renal cell carcinoma with mixed histologic features显示文摘Renal cell carcinoma (RCC) is an important contributor to cancer-specific mortality worldwide. Targeted agents that inhibit key subtype-specific signaling pathways have improved survival times and have recently become part of the standard of care for this disease. Accurately diagnosing and classifying RCC on the basis of tumor histology is thus critical. RCC has been traditionally divided into clear-cell and non-clearcell categories, with papillary RCC forming the most common subtype of non-clear-cell RCC. Renal neoplasms with overlapping histologies, such as tumors with mixed clear-cell and papillary features and hybrid renal oncocytic tumors, are increasingly seen in contemporary practice and present a diagnostic challenge with important therapeutic implications. In this review, we discuss the histologic, immunohistochemical, cytogenetic, and clinicopathologic aspects of these differential diagnoses and illustrate how the classification of RCC has evolved to integrate both the tumor's microscopic appearance and its molecular fingerprint. | Kanishka Sircar Priya Rao Eric Jonasch Federico A. Monzon Pheroze Tamboli | 2013 | Chinese Journal of Cancer2013，32，6： | 4 |
| 19 | IL-1 β genesis: the art of regulating the regulator显示文摘In a study published in Cellular and Molecular Immunology,Singh et al.demonstrated a new mechanism of monocyte IL-1βproduction.1 It was observed that TLR-4-and TLR-2-induced IRAK-ERK pathway cross-talk with p67phox-Nox-2 for reactive oxygen species(ROS)generation,thus regulating IL-1βtranscription and processing in monocytes.This study not only establishes a direct link between IRAK and ERK,but also demonstrates the regulation of p67phox-Nox-2 by ERK for ROS and IL-1βproduction(Fig.1).This study shows that the IRAK-ERK axis can regulate both IL-βtranscription and processing through ROS. | Priya Gupta Manoj K.Barthwal | 2018 | Cellular & Molecular Immunology2018，15，11： | 4 |
| 20 | Multiobjective genetic training and uncertainty quantification of reactive force fields显示文摘The ReaxFF reactive force-field approach has significantly extended the applicability of reactive molecular dynamics simulations to a wide range of material properties and processes.ReaxFF parameters are commonly trained to fit a predefined set of quantummechanical data,but it remains uncertain how accurately the quantities of interest are described when applied to complex chemical reactions.Here,we present a dynamic approach based on multiobjective genetic algorithm for the training of ReaxFF parameters and uncertainty quantification of simulated quantities of interest.ReaxFF parameters are trained by directly fitting reactive molecular dynamics trajectories against quantum molecular dynamics trajectories on the fly,where the Pareto optimal front for the multiple quantities of interest provides an ensemble of ReaxFF models for uncertainty quantification.Our in situ multiobjective genetic algorithm workflow achieves scalability by eliminating the file I/O bottleneck using interprocess communications.The in situ multiobjective genetic algorithm workflow has been applied to high-temperature sulfidation of MoO_(3) by H_(2)S precursor,which is an essential reaction step for chemical vapor deposition synthesis of MoS_(2) layers.Our work suggests a new reactive molecular dynamics simulation approach for far-from-equilibrium chemical processes,which quantitatively reproduces quantum molecular dynamics simulations while providing error bars. | Ankit Mishra Sungwook Hong Pankaj Rajak Chunyang Sheng Ken-ichi Nomura Rajiv K.Kalia Aiichiro Nakano Priya Vashishta | 2018 | npj Computational Materials2018，，1： | 3 |
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