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| 1 | 大数据时代的交通模型显示文摘通过新的大数据来源诸如手机通信记录、智能卡数据以及社交媒体地理编码记录,可以前所未有地观察和了解出行行为的细节。尽管有如此庞大的大数据来源,但在规划实践中使用的交通需求模型,其数据源仍大多来自交通调查和人口普查等传统方法。对近期利用大数据研究交通行为,以及使交通规划师可以进行假设情景分析的交通需求模型的最新进展进行梳理。从出行识别到出行活动推理,回顾和分析现有数据分析方法,这些传统方法使收集到的出行轨迹信息能响应交通需求模型。未来的研究应该侧重将概率模型和机器学习技术应用于数据科学。设计这些数据挖掘方法是为了处理由手机移动追踪数据衍生的零散和掺杂偏差的数据的不确定性。此外,这些方法还适用于将不同的相关数据组整合到一个数据融合方案中,以便用出行日志信息丰富大数据。总之,建模知识已经在交通运输领域发展成熟,因此强烈建议在交通规划方面应用数据驱动方法时应建立相应领域专业知识的基础。这些新的挑战呼吁交通模型师和数据科学家之间的多学科协作。 | Cuauhtemoc Anda Alexander Erath Pieter Jacobus Fourie(著) 宗晶(译) | 2019 | 城市交通2019，17，3： | 5 |
| 2 | Texture analysis on parametric maps derived from dynamic contrast-enhanced magnetic resonance imaging in head and neck cancer显示文摘AIM: To investigate the merits of texture analysis on parametric maps derived from pharmacokinetic modeling with dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) as imaging biomarkers for the prediction of treatment response in patients with head and neck squamous cell carcinoma(HNSCC). METHODS: In this retrospective study,19 HNSCC patients underwent pre- and intra-treatment DCEMRI scans at a 1.5T MRI scanner. All patients had chemo-radiation treatment. Pharmacokinetic modeling was performed on the acquired DCE-MRI images,generating maps of volume transfer rate(Ktrans) and volume fraction of the extravascular extracellular space(ve). Image texture analysis was then employed on maps of Ktrans and ve,generating two texture measures: Energy(E) and homogeneity.RESULTS: No significant changes were found for the mean and standard deviation for Ktrans and ve between pre- and intra-treatment(P > 0.09). Texture analysis revealed that the imaging biomarker E of ve was significantly higher in intra-treatment scans,relative to pretreatment scans(P < 0.04). CONCLUSION: Chemo-radiation treatment in HNSCC significantly reduces the heterogeneity of tumors. | Jacobus FA Jansen Yonggang Lu Gaorav Gupta Nancy Y Lee Hilda E Stambuk Yousef Mazaheri Joseph O Deasy Amita Shukla-Dave | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 3 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 4 | First isolation of glutinol and a bioactive fraction with good antiinflammatory activity from n-hexane fraction of Peltophorum africanum leaf显示文摘Objective: To investigate the anti-inflammatory activity of different fractions and glutinol(isolated compound),using nitric oxide synthase and cyclooxygenase(COX) inhibition as an indication of anti-inflammatory activity,Methods: Anti-inflammatory activity was evaluated using an in vitro assay determining the inhibition of the activity of pro-inflammatory enzyme model,Cyclooxygenases and inducible nitric oxide synthase are crucial enzymes involved in the pathogenesis of many chronic inflammatory conditions,Results: Sub-fraction F3.3 that was derived from n-hexane fraction of PA leaves significantly inhibited(P = 0.01) the catalytic activity of COX-2(IC50 = 0.67 μg/m L) better than isolated compound,glutinol(IC50 = 1.22 μg/m L),compound 2(CP2)(IC50 = 1.71 μg/m L) and sub-fraction F3.3.0(IC50 = 1.30 μg/m L),A similar trend was observed in investigation of the inhibition of nitric oxide synthesis in RAW 264.7 cells by F3.3,glutinol,CP2 and F3.3.0,Inducible COX-2 and inducible nitric oxide synthase are among potent signalling enzymes that exacerbate inflammation,Conclusions: Bioactive sub-fractions(F3.3 and F3.3.0) derived from the n-hexane fraction of PA had good anti-inflammatory activity,and the isolated compound,and glutinol may be useful as a template for the development of new anti-inflammatory drugs. | Salmon A Adebayo Leshweni J Shai Jacobus N Eloff | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，1： | 2 |
| 5 | Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial显示文摘 | S Vincent Rajkumar Susanna Jacobus Natalie S Callander Rafael Fonseca David H Vesole Michael E Williams Rafat Abonour David S Siegel Michael Katz Philip R Greipp | 2010 | Lancet Oncology2010，，1： | 2 |
| 6 | Crop type mapping using LiDAR,Sentinel-2 and aerial imagery with machine learning algorithms显示文摘LiDAR data are becoming increasingly available,which has opened up many new applications.One such application is crop type mapping.Accurate crop type maps are critical for monitoring water use,estimating harvests and in precision agriculture.The traditional approach to obtaining maps of cultivated fields is by manually digitizing the fields from satellite or aerial imagery and then assigning crop type labels to each field-often informed by data collected during ground and aerial surveys.However,manual digitizing and labeling is time-consuming,expensive and subject to human error.Automated remote sensing methods is a cost-effective alternative,with machine learning gaining popularity for classifying crop types.This study evaluated the use of LiDAR data,Sentinel-2 imagery,aerial imagery and machine learning for differentiating five crop types in an intensively cultivated area.Different combinations of the three datasets were evaluated along with ten machine learning.The classification results were interpreted by comparing overall accuracies,kappa,standard deviation and f-score.It was found that LiDAR data successfully differentiated between different crop types,with XGBoost providing the highest overall accuracy of 87.8%.Furthermore,the crop type maps produced using the LiDAR data were in general agreement with those obtained by using Sentinel-2 data,with LiDAR obtaining a mean overall accuracy of 84.3%and Sentinel-2 a mean overall accuracy of 83.6%.However,the combination of all three datasets proved to be the most effective at differentiating between the crop types,with RF providing the highest overall accuracy of 94.4%.These findings provide a foundation for selecting the appropriate combination of remotely sensed data sources and machine learning algorithms for operational crop type mapping. | Adriaan Jacobus Prins Adriaan Van Niekerk | 2021 | Geo-Spatial Information Science2021，24，2： | 2 |
| 7 | 基于一个大型随机试验预测稳定性心绞痛队列患者死亡、心肌梗死和卒中的危险评分显示文摘目的对需要抗心绞痛治疗并且左心室功能代偿症状稳定的心绞痛患者建立预测全因死亡、心肌梗死和导致致残性卒中的复合危险评分。设计大型多中心临床试验数据的多变量Cox回归分析。背景西欧、以色列、加拿大、澳大利亚和新西兰的心脏专科门诊患者。入选者7311例具有全部需要资料的患者被入选。主要结局的测量指标平均随访4.9年时间内所有原因的死亡、心肌梗死或者致残性卒中。结果1063例患者发生任何原因死亡或者持久性心肌梗死或者致残性卒中。这些复合终点的5年危险性在危险性最低的十分位患者为4%,而在危险性最高的十分位患者为35%。危险评分结合16项临床常规变量的降序排序是:年龄、左心室射血分数、吸烟、白细胞计数、糖尿病、随机血糖浓度、肌酐浓度、既往卒中病史、1周至少1次心绞痛发作、冠状动脉造影发现(如果能够获得)、降脂治疗、QT间期、收缩期血压≥150mmHg、抗心绞痛药物数量、陈旧性心肌梗死以及性别。把这个模型分别应用于任何原因所致的死亡、心肌梗死和卒中进行预测评估,所得的结果相似。危险评分似乎不能预测事件性质(39%的死亡、46%心肌梗死以及15%致残性卒中)或者冠状动脉造影或血管重建率(占29%的患者)。结论该危险评分对客观地决定稳定性心绞痛患者进一步治疗措施以减少重要预后事件发生是有帮助的。该危险评分同样可以用于将来的计划性试验。 | Tim C Clayton Stuart J Pocock Jacobus Lubsen Zoltán Vokó Bridget-Anne Kirwan Keith A A Fox Philip A Poole-Wilson | 2006 | 英国医学杂志中文版2006，9，1： | 2 |
| 8 | Burnout,engagement,coping and general health of service employees in the hospitality industry显示文摘 | JACOBUS PIENAAR SHARRON A WILLEMSE | 2008 | Tourism Management2008，29，6： | 1 |
| 9 | Predictive model for the full biaxial surface and subsurface residual stress profiles from turning显示文摘 | Devor R E Kapoor S G | 2001 | Journal of Manufacturing Science and Engineering2001，123，： | 1 |
| 10 | Evidence for a reversible oxygen radial-mediated component of reperfusion injury:reduction by recombinant human superoxide dismutase administered at the time of reflow显示文摘 | Ambrosio G Weisfeldt ML Jacobus WE | 1987 | J Circulation1987，75，： | 1 |
| 11 | The impact of common genetic variations in genes of the sex hormone metabolic pathways on steroid hormone levels and prostate cancer aggressiveness 显示文摘 | Sun T Oh W K Jacobus S | 2011 | Cancer Prev Res (Phila)2011，4，12： | 1 |
| 12 | Hydrolyzed Casein Decreases Postprandial Glucose Concentrations in T2DM Patients Irrespective of Leucine Content显示文摘 | Bart F. Geerts Marloes G.J. van Dongen Baukje Flameling Matthijs M. Moerland Marieke L. de Kam Adam F. Cohen Johannes A. Romijn Cindy C. Gerhardt Joris Kloek Jacobus Burggraaf | 2011 | Journal of Dietary Supplements2011，，3： | 1 |
| 13 | ^1H MR Spectroscopy of the brain: absolute quantification of metabolites显示文摘 | Jacobus J F Backes W H Nicolay K | 2006 | Radiology2006，240，2： | 1 |
| 14 | Small corona cage for wideband hvac radio noise studies: rati onale and critical design显示文摘 | Rodney G Urban Howard C Reader Jacobus P Holtzhausen | 2008 | IEEE Transactions on Power Delivery2008，23，11： | 1 |
| 15 | Respiratory control and the integration of heart high-energy phosphate metabolism by mitochondrial creatine kinase显示文摘 | JACOBUS WE | 1985 | Ann Rev Physiol1985，47，： | 1 |
| 16 | Vital Little Plans 显示文摘 | Jacobus J | 1991 | Urban Design International Journal1991，，1： | 1 |
| 17 | Effect of stress state on the stress-induced martensitic transformation in polycrystalline Ni-Ti alloy显示文摘 | Jacobus K Sehitoglu H Balzer M | 1996 | Metall Trans1996，27，10： | 1 |
| 18 | Phenolic metabolites from rooibos tea (Aspalathus limearis) 显示文摘 | Charlene R Jacobus AS Elizabeth J | 1994 | Phytochemistry1994，35，6： | 1 |
| 19 | 18F-2fluro-2-deoxy-Dglucose positron emission tomography in staging of locallgadvanced breast cancer显示文摘 | Jacobus JM Vander H Nanda CK | 2004 | J Clin Oncol2004，22，7： | 1 |
| 20 | In vitro activities of tigecycline against the Bacteroides fragilis group 显示文摘 | Jacobus N V MclDermott L A Ruthazer R | 2004 | Antimicrob Agents Chemother2004，48，3： | 1 |
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