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5篇 您的检索式：作者名="Howard Smart"

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		题名	作者	年代	出处	被引量
	1	Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data.	Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat	2013	World Journal of Gastroenterology2013，19，36：	7
	2	Crops that stay green显示文摘	THOMAS HOWARD SMART C M	1993	Annals of Applied Biology1993，123，1：	1
	3	Molecular Analysis to Detect Pancreatic Ductal Adenocarcinoma in High-Risk Groups显示文摘	Li Yan Christopher McFaul Nathan Howes Jane Leslie Gillian Lancaster Theresa Wong Jane Threadgold Jonathan Evans Ian Gilmore Howard Smart Martin Lombard John Neoptolemos William Greenhalf	2005	Gastroenterology2005，，7：	1
	4	Radiofrequency Ablation and Endoscopic Mucosal Resection for Dysplastic Barrett’s Esophagus and Early Esophageal Adenocarcinoma: Outcomes of the UK National Halo RFA Registry显示文摘	Rehan J. Haidry Jason M. Dunn Mohammed A. Butt Matthew G. Burnell Abhinav Gupta Sarah Green Haroon Miah Howard L. Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton John Morris Massimo Di Pietro Charles Gordon Ian Penman Hugh Barr Praf	2013	Gastroenterology2013，，1：	1
	5	Servitization of manufacture: Exploring the deployment and skills of people critical to the delivery of advanced services显示文摘	Tim Baines Howard Lightfoot Palie Smart Sarah Fletcher	2013	Journal of Manufacturing Technology Management2013，，4：	1

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