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| 1 | 乳腺癌患者的心身症状与生活质量显示文摘目的:探讨乳腺癌患者抑郁、焦虑的心理症状与躯体症状之间的关系,心身症状与生活质量的关系以及心身症状和生活质量与患者所接受过的治疗和生存期的关系。方法:本研究采用横断面设计,对北京市315例符合入组标准的乳腺癌患者进行调查,所使用的调查工具包括病人健康问卷(PHQ-15)、病人健康问卷抑郁量表(PHQ-9)、广泛性焦虑量表(GAD-7)及癌症患者生命质量测定量表(QLQ-C30),并对255份有效数据进行了分析。结果:乳腺癌患者躯体症状的严重程度与抑郁、焦虑均呈正相关(r=0.44,0.56;均P<0.01);在重度躯体症状的患者中,抑郁的发生率为42.3%,焦虑的发生率为50%;抑郁、焦虑与乳腺癌患者总体健康状况相关(β=-0.22,-0.30;均P<0.01);接受化疗的患者其躯体症状和抑郁、焦虑得分高于未接受化疗的患者[(9.0±5.0)vs.(6.0±4.1),(8.3±6.0)vs.(4.0±3.5),(5.4±5.0)vs.(3.1±3.7);均P<0.01];生存期5年以上的乳腺癌患者只有焦虑分数低于5年以内的患者[(5.8±5.0)vs.(4.3±4.5),P<0.05],在躯体症状、抑郁和生活质量方面差异无统计学意义。结论:乳腺癌患者抑郁、焦虑的心理症状与其躯体症状和总体健康状况相关,接受化疗患者的心身症状和生活质量可能会更差一些,生存期5年以上的患者焦虑水平低于5年以内的患者,但躯体症状、抑郁以及生活质量与生存期的延长未见相关。 | 庞英 FISCHER Irmela KOCH Maike FRITZSCHE Kurt 唐丽丽 | 2013 | 中国心理卫生杂志2013，27，4： | 109 |
| 2 | 波前像差引导的LASIK手术的临床效果观察显示文摘目的 :观察波前像差引导的LASIK手术矫正近视性散光的效果。方法 :2 8例 35只眼 ,平均术前球镜屈光度为 (- 4.8± 2 .3)D ,柱镜屈光度为 (- 1.1± 0 .9)D。手术前和手术后均使用Tscherning像差计测量 ,分析波前像差。应用 1.0mm光斑、频率 2 0 0Hz的飞点扫描准分子激光进行屈光手术。结果 :术后 3个月 ,6 8.0 %的眼屈光度在± 0 .5D(正视眼 )内 ,93.5 %眼在± 1.0D内。 93.5 %的裸眼视力为 2 0 / 2 0或更好。裸眼超常视力(BSCVA在 2 0 / 10或更好 )占 16 .0 %。高阶像差 (球差 ,彗差 )矫正不足 ,而波前像差全部均方根增加值为 1.44± 0 .74,彗差的矫正好于球差。结论 :波前像差引导的LASIK手术是一种很可靠的技术 ,可有效地矫正屈光不正 ,改善视觉敏感度 ,提高视觉质量 ,尤其是提高夜间视力的视觉质量。 | Michael Mrochen Maik Kaemmerer Theo Seiler | 2001 | 眼视光学杂志2001，3，2： | 63 |
| 3 | 波前像差引导的LASIK术矫正眼球像差显示文摘目的 :观察波前像差引导的LASIK术矫正人眼像差后的效果 ,以确定人眼是否可获得超过一般的视敏度。方法 :波前像差引导的LASIK手术对 15只眼矫正近视和散光 ,同时矫正眼球的像差。结果 :手术后 1个月时 ,4只眼 (占 2 7% )获得了 2 0 /10以上的超常视力。波前像差的均方根值从 0 .6增加到 2 .3,与视觉敏感度的提高呈显著性相关 (P <0 .0 5 )。结论 :像差的矫正虽然还不能最令人满意 ,但这些结果表明 ,眼球的像差使人眼视敏度受限制 ,而通过手术矫正可获得超过一般的视敏度。 | Theo Seiler Michael Mrochen Maik Kaemmerer | 2001 | 眼视光学杂志2001，3，2： | 11 |
| 4 | Effects of biological soil crusts on water infiltration and evaporation Yanchi Ningxia, Maowusu Desert, China显示文摘Biological soil crusts serve as a vanguard for improving the ecological environment in arid,semi-arid desertification areas.It is a good indicator of the level of improvement which the local ecological environment is undertaking.In desert areas,water condition is a key factor of improving the ecological environment.As a first layer protection,biological crusts play an important role in local vegetation succession due to their abilities to conserve and maintain moisture.Using Maowusu desert in Yanchi of Ningxia province as an example,after three years of research,this paper chooses three kinds of biological crusts including lichen,moss and cyanobacterial which are under the cover of Artemisia ordosica as research objects.The results of this study indicate that,the closer biological crusts are to Artemisia ordosica vegetation,the thicker they become.In the same position of Artemisia ordosica vegetation,the thickness of moss crusts is the highest,followed by lichen crusts,and the thickness of cyanobacterial crusts is the lowest.Biological soil crusts coverage protects the natural water content of soil layers from0 to 5 cm.Also,it effects falling water to infiltrate deeper,and cannot prevent the surface water content from evaporating effectively.The effect of biological crusts blocking water infiltration decreases with the increase of rainfall.At the same rainfall level,moss crusts provide the strongest water infiltration blockage,followed by lichen crusts and cyanobacterial crusts.With the increase of rainfall,the depth of water infiltration increases.At the same rainfall level,the relationship of water infiltration depth is as follows:cyanobacterial crusts > lichen crusts > moss crusts.With the increase of biological crusts thickness,they blocking water infiltration capacity is stronger,and the depth of water infiltration is smaller.Analysis on the characteristic of simulated rainfall process on biological crusts shows that sandy land can be fixed by applying appropriate artificial biological crusts to build a sustainable forest protection system and to create a stable ecosystem in desertification area. | Bai Li Jiarong Gao Xiuru Wang Lan Ma Qiang Cui Maik Vest | 2016 | International Journal of Sediment Research2016，31，4： | 10 |
| 5 | Auxin-Oxylipin Crosstalk:Relationship of Antagonists显示文摘Phytohormones regulate a wide array of developmental processes throughout the life cycle of plants.Herein,the various plant hormones may interact additively,synergistically,or antagonistically.By their cooperation they create a delicate regulatory network whose net output largely depends on the action of specific phytohormone combinations rather than on the independent activities of separate hormones.While most classical studies of plant hormonal control have focused mainly on the action of single hormones or on the synergistic interaction of hormones in regulating various developmental processes,recent work is beginning to shed light on the crosstalk of nominally antagonistic plant hormones,such as gibberellins and auxins with oxylipins or abscisic acid.In this review,we summarize our current understanding of how two of the first sight antagonistic plant hormones,i.e.auxins and oxylipins,interact in controlling plant responses and development. | Maik Hoffmann Mathias Hentrich Stephan Pollmann | 2011 | Journal of Integrative Plant Biology2011，53，6： | 7 |
| 6 | A break in the clouds显示文摘 | Luis M. Vaquero Luis Rodero-Merino Juan Caceres Maik Lindner | 2008 | ACM SIGCOMM Computer Communication Review2008，，1： | 5 |
| 7 | Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes显示文摘瞄准:调查阉羊 mono-ADP-ribosyltransferase 的相应蛋白质 3 (ART3 ) mRNA 在人的睾丸被表示并且那么,表示是否是房间类型特定。方法:ART3 mRNA 被反向的抄写聚合酶链反应(RT-PCR ) 在人的睾丸和精子决定。ART3 的 glycosyl-phosphatidylinositol 连接被与磷脂酶 C 对待 ART3-transfected HEK-293-T 房间显示出。荧光灯的激活的房间 sorter (FACS ) 分析被用来在成熟精子和免疫上检测 ART3 在睾丸检测蛋白质的组织学的研究。结果:ART3 蛋白质被显示在睾丸在场。它仅仅在 spermatocytes 上被发现。它不在精原细胞, spermatids 和精子。从精子的 ART3 的缺席被 FACS 分析证实。ART3 蛋白质既不在半走马疳以内也不在 Leydig 房间上被检测。结论:这里,我们第一次证明那 ART3 蛋白质特别地在 spermatocytes 上在睾丸被表示,显示 ART3 施加仅仅在精子发生的一个特别阶段要求的特定的功能。 | Maik Friedrich Andreas Grahnert Uwe Paasch Andrea Tannapfel Friedrich Koch-Nolte Sunna Hauschildt | 2006 | Asian Journal of Andrology2006，8，3： | 4 |
| 8 | Physiochemical Properties of Resistant Starch and Its Enhancement Approaches in Rice显示文摘With changes in food preferences and life styles,more and more attentions have been focused on healthier food.Nowadays,resistant starch(RS)which can resist digestion in the human intestine has been recognized and accepted.High RS diet shows great benefit for the human health,and breeding high RS rice variety is a great target for realizing dietary intervention.To provide guidance for RS improvement in rice,this review summarized the unique physiochemical properties of RS and the possible approaches,i.e.genetic regulation,for enhancing RS content in rice,and proposed the potential ways to obtain rice variety with high RS content. | Ding Yi Wang Maike Shen Yi Shu Xiaoli Wu Dianxing Song Wenjian | 2021 | Rice science2021，28，1： | 4 |
| 9 | On the Impact of Precursor Unfolding during Protein Import into Chloroplasts显示文摘越过膜的蛋白质 translocation 是一个基本细胞的过程。象线粒体和叶绿体那样的细胞器的蛋白质的多数在 cytosol 被综合并且随后以一种 translational 以后方式进口了。先锋蛋白质不得不被展开至少因为 translocation,而是它也被假定他们在 cytosol 在运输期间被展开到细胞器。展开被女伴和 translocon 自己管理。同时,女伴为进口过程提供精力。叶绿体 translocon 的精力充沛的性质被熔化到叶绿体的运输肽的蛋白质 titin 指向了氧演变的肌肉的象 Ig 一样模块的进口学习 33 的复杂子单元 ? kDa (OE33 ) 。我们的结果建议 p (OE33 ) titin 在进口以前被合拢并且 translocation 被在在叶绿体表面跳了到 translocon 以后展开开始。使用 titin 的一套稳定并且使动摇的异种以前为 mitochondrial translocation 由原子力量显微镜学并且作为旅客分析了,我们学习了叶绿体 translocon 提供的展开的力量。把结果基于这些,为 translocation 的一个模型被讨论。 | Maike Ruprecht Tihana Bionda Takehiro Sato Maik S. Sommer Toshiya Endo Enrico Schleiff | 2010 | Molecular Plant2010，3，3： | 4 |
| 10 | Monitoring and modeling of urban sprawl through remote sensing and GIS in Kuala Lumpur, Malaysia显示文摘Introduction:Kuala Lumpur is currently experiencing a large-scale urban transformation.This study explores a multi-buffer ring method to investigate the spatial and temporal dynamics of urban growth in the Kuala Lumpur metropolitan area by using Geographical Information Systems(GIS)and remote sensing imageries from1989 to 2014.Methods:The first Landsat images from 1989,2001,and 2014 were classified with maximum likelihood classification to produce land cover maps and identify four types of land cover:urban/built-up,agriculture,forest,and water.Then,the area coverage for all the land use types at different points in time were measured and combined with distance from the city center.Later on,urbanization densities from the city center to the outside for every 1-km distance from 1 to 50 km are calculated.Results:City density on the distance of 5,8,15,20,and 30 km was very high in the years 1989 and 2014.Temporally,urban expansion shows fast and slow growth stages with high-speed growth shifting to the east side of the city.Conclusions:In general,the population,traffic conditions,industrialization,and policy are the major factors thatinfluenced the urban expansion. | Mukesh Singh Boori Maik Netzband Komal Choudhary Vít Voženílek | 2015 | Ecological Processes2015，4，1： | 2 |
| 11 | A break in the clouds显示文摘 | Luis M. Vaquero Luis Rodero-Merino Juan Caceres Maik Lindner | 2008 | ACM SIGCOMM Computer Communication Review2008，，1： | 2 |
| 12 | Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma显示文摘 | Janel L. Kopp Guido von Figura Erin Mayes Fen-Fen Liu Claire L. Dubois John P. Morris Fong Cheng Pan Haruhiko Akiyama Christopher V.E. Wright Kristin Jensen Matthias Hebrok Maike Sander | 2012 | Cancer Cell2012，，6： | 2 |
| 13 | In Vivo Function of Tic22, a Protein Import Component of the Intermembrane Space of Chloroplasts显示文摘进叶绿体的 Preprotein 进口在外部、内部的叶绿体信封膜(TOC 和 TIC ) 取决于 macromolecular 机械。两机械被 intermembrane 空间(IMS ) 的部件互连,这被建议。也就是说在其它之中, Tic22,二仔细联系了 isoforms 在 Arabidopsis thaliana 存在,也就是 atTic22-III 和 atTic22-IV。我们由分析相应基因的 T-DNA 插入线在 vivo 调查了 Tic22 的功能。当在单个基因的 T-DNA 插入引起了仅仅细微的缺点时,两 isoforms 的双异种在植物的光合的表演显示出延迟的生长,在热点条件下面的苍白的显型,减少的进口率,和减小。后者被变化在变异的植物的代谢物内容支持什么时候与相比野类型。因此,我们的结果支持 Tic22 直接涉及叶绿体 preprotein 进口并且可能在叶绿体生物的续生说指向到 Tic22 的特别重要性高进口率的时间的观点。 | Mareike Rudolf Anu B. Machettira Lucia E. Groβ Katrin L. Weber Kathrin Bolte Tihana Bionda Maik S. Sommer Uwe G. Maier Andreas RM. Weber Enrico Schleiff Joanna Tripp | 2013 | Molecular Plant2013，6，3： | 2 |
| 14 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 15 | Molecular Mechanisms of Ischemia–Reperfusion Injury in Brain: Pivotal Role of the Mitochondrial Membrane Potential in Reactive Oxygen Species Generation显示文摘 | Thomas H. Sanderson Christian A. Reynolds Rita Kumar Karin Przyklenk Maik Hüttemann | 2013 | Molecular Neurobiology2013，，1： | 2 |
| 16 | Paramutation: A Heritable Change in Gene Expression by Allelic Interactions In Trans显示文摘Epigenetic 基因规定通过有丝分裂、有时平的 meiotic 包含基因活动状态的稳定的繁殖,没有在 DNA 的变化的房间部门定序。Paramutation 是在稳定地通过有丝分裂以及成熟分裂被播送的基因表示包含变化的 epigenetic 现象。这些可继承的变化被调停由在在不同染色体上的相应 DNA 序列之间的 trans 相互作用。在这些期间在 trans 相互作用, epigenetic 信息从基因的一等位基因被转移到一样的基因的另一等位基因,在基因表示导致一个变化。尽管 paramutation 开始在植物被发现,它最近也在哺乳动物被观察了,建议位于 paramutation 下面的机制可能 evolutionarily 被保存。最近的调查结果点到为在 paramutation 过程的小 RNA 的一个关键角色。在老鼠,,小 RNA 在玉米显得足够导致 paramutation,它似乎不是在这个过程的唯一的运动员。在这评论,潜在的机制在与各种各样的 paramutation 现象的关系被讨论。 | Maike Stam | 2009 | Molecular Plant2009，2，4： | 2 |
| 17 | Thinning effects on walnut stem and crown diameter growth and fruiting in the walnut-fruit forests of Kyrgyzstan显示文摘The walnut-fruit forests(Juglans regia L.) in southern Kyrgyzstan are considered to be biodiversity hotspots and of considerable economic and ecological importance to local populations. The fruiting ability and stability of these forests are, however, decreasing because of infrequent silvicultural interventions and non-existent natural regeneration. Continuous inventories and walnut harvest measurements were carried out on 18 trial and control plots over the course of 13 year. Results showed that i) thinning had a positive influence on diameter at breast height(dbh) increase, ii) dbh growth and crown area increases are strongly and positively correlated, iii) large crowns enhanced the production of fruits, and iv) temperature conditions had a major influence on the production of fruits. The above-mentioned points are particularly relevant for young plantations but are also valid for relatively old plantations(> 50 years). We conclude that regular thinning substantially improves diameter growth, fruit production and ability of trees to withstand wind and snow damage in both young stands and in older walnut-fruit forests. | Jean-Pierre SORG Zora Lea URECH Davlet MAMADZHAN0V Maik REHNUS | 2016 | Journal of Mountain Science2016，13，9： | 2 |
| 18 | Effects of photorefractive keratectomy and cataract surgery on ocular optical errors of higher order显示文摘 | P. Mierdel Maik Kaemmerer Hans-Eberhard Krinke Theo Seiler | 1999 | Graefe’s Archive for Clinical and Experimental Ophthalmology1999，，9： | 1 |
| 19 | Simultaneous determination of ammonia,dimethylamine,trimethylamine and trimethylamine-N -oxide in fish extracts by capillary electrophoresis with indirect UV-detection显示文摘 | Timm Maike Jorgensen Bo M | 2002 | Food Chem2002，76，： | 1 |
| 20 | Irradiation-induced stabilization of zircon (ZrSiO 4 ) at high pressure显示文摘 | Maik Lang Fuxiang Zhang Jie Lian Christina Trautmann Reinhard Neumann Rodney C. Ewing | 2008 | Earth and Planetary Science Letters2008，，1： | 1 |
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