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| 1 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 2 | Direct growth of ZnO nanowires on civil engineering materials:smart materials for supported photodegradation显示文摘Photocatalysis is one of the most promising processes for treating air and water pollution.Innovative civil engineering materials for environmental depollution by photocatalysis have already been synthesized by incorporating TiO_(2) or ZnO nanoparticles in cement.This method suffers from two flaws:first,most of the NPs are incorporated into the cement and useless for photocatalysis;second,rain and wind could spread the potentially carcinogenic nanoparticles from the cement surface into nature.Thus,we propose the efficient synthesis of nontoxic and biocompatible ZnO nanostructures solely onto the surface of commercially available concrete and tiling pavements by a low-cost and lowtemperature hydrothermal method.Our samples exhibited enhanced photocatalytic activity for degrading organic dyes in aqueous media,and dye molecules are commonly used in the pharmaceutical,food,and textile industries.Durability studies showed no loss of efficiency after four photocatalysis experiments.Such supported structures,which are easy to implement onto the varying surfaces of commercially available materials,are promising for integration into civil engineering surfaces for environmental depollution in our daily life. | Marie Le Pivert Romain Poupart Martine Capochichi-Gnambodoe Nathan Martin Yamin Leprince-Wang | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 3 | Cystathionine β Synthase Deficiency Promotes Oxidative Stress, Fibrosis, and Steatosis in Mice Liver显示文摘 | Karine Robert Johnny Nehmé Emmanuel Bourdon Gérard Pivert Bertrand Friguet Claude Delcayre Jean–Maurice Delabar Nathalie Janel | 2005 | Gastroenterology2005，，5： | 2 |
| 4 | Ultrasound guided combined cryoablation and microencapsulated 5-Fluorouracil inhibits growth of human prostate tumors in xenogenic mouse model assessed by luminescence imaging显示文摘 | Le Pivert P Haddad RS Aller A | 2004 | Technol Cancer Res Treat2004，3，2： | 1 |
| 5 | CT-guided percutaneous chemoablation using an ethanol-ethiodol- doxorubicin emulsion for the treatment of metastatic lymph node carcinoma: a comparative study 显示文摘 | Liu S R Xiao Y Y Le Pivert P J | 2013 | Tech-nol Cancer Res Treat2013，12，2： | 1 |
| 6 | CT-guided percutaneous chemoablation using an ethanol- ethiodol- doxorubicin emulsion for the treatment of metastatic lymph node carcinoma: a comparative study 显示文摘 | Liu SH Xiao YY Le Pivert PJ | 2013 | Technol Cancer Res Treat2013，12，： | 1 |
| 7 | Cor- relation between the promoter basal core and precore mu rations and HBeAg quantification in French blood donors infected with hepatitis B virus显示文摘 | Pivert A Servant-Delmas A Lunel-Fabiani F | 2015 | J Med Virol2015，87，3： | 1 |
| 8 | SQLf: A Relational Database Language for Fuzzy Querying显示文摘 | Bosc E Pivert O | 1995 | IEEE Transactions on Fuzzy Systems1995，3，1： | 1 |
| 9 | On a fuzzy bipolar relational algebra显示文摘 | Patrick Bosc Olivier Pivert | 2013 | Information Sciences2013，，： | 1 |
| 10 | Assessment of new chemical disin- fectauts for HBV virucidal activity in a cell culture model显示文摘 | Payan C Pivert A KampfG | 2004 | J Hosp Infec2004，56，： | 1 |
| 11 | Empty versus overabundant answers to flexible relational queries 显示文摘 | Bosc P Hadjali A Pivert O | 2008 | Fuzzy Sets and Systems2008，159，12： | 1 |
| 12 | Artificial neural network based daily local forecasting for global solar radiation显示文摘 | Amrouche B Pivert X L | 2014 | Applied Energy2014，130，： | 1 |
| 13 | Empty versus overabundant answers to flexible relational queries显示文摘 | Bose P Hadjali A Pivert O | 2008 | Fuzzy Sets and Systems2008，，12： | 1 |
| 14 | Ultrasound guided combined cryoablation and microencapsulated 5-Fluorouracil inhibits growth of human prostate tumors in xenogenic mouse model assessed by luminescence imaging 显示文摘 | Le Pivert P Haddad RS Aller A | 2004 | Technol Cancer Res Treat2004，3，2： | 1 |
| 15 | Ultrasound guid-ed combined cryoablation and microencapsulated 5-Fluo-roura- cil inhibits groh of human prostate tumors inxenogenic mouse model assessed by 1 imaging 显示文摘 | Le Pivert P Haddad RS Aller A | 2004 | Techn- ol Cancer Res Treat2004，3，2： | 1 |
| 16 | Modeling and Querying Uncertain Relational Databases: a Survey of Approaches Based on the Possible Worlds Semantics 显示文摘 | Bosc P Pivert O | 2010 | International Journal of Uncertainty Fuzziness and Knowledge-Based Systems2010，18，5： | 1 |
| 17 | Ultrasound guided combined cryoablation and microencapsulated 5-Fluorouracil inhibits growth of human prostate tumors in xenogenic mouse model assessed by luminescence imaging 显示文摘 | Le Pivert P Haddad RS Aller A | 2004 | Technol Cancer Res Treat2004，3，2： | 1 |
| 18 | On database queries involving competitive conditional preferences显示文摘 | Bosc P Hadjali A Pivert O | 2011 | International Journal of Intelligent Systems2011，6，3： | 1 |
| 19 | Ultrasound guided combined cryoablationand microencapsulated 5-Fluorouracil inhibits growth of human prostate tumor s in xenogenic mouse model assessed by luminescence imaging显示文摘 | Le PIVERT P HADDAD R S ALLER A | 2004 | Technol Cancer Res Treat2004，3，： | 1 |
| 20 | SOLf:A relational database language for fuzzy querying显示文摘 | Patrick Bosc Oliver Pivert | 1995 | IEEE Transactions on Fuzzy Systems1995，23，1： | 1 |
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