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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 9 |
| 3 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 4 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 4 |
| 5 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Special situations显示文摘 | Gert Van Assche Axel Dignass Walter Reinisch C. Janneke van der Woude Andreas Sturm Martine De Vos Mario Guslandi Bas Oldenburg Iris Dotan Philippe Marteau Alessandro Ardizzone Daniel C. Baumgart Geert D’Haens Paolo Gionchetti Francisco Portela Boris Vuce | 2009 | Journal of Crohn’s and Colitis2009，，1： | 3 |
| 6 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D’Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 7 | Novel Targets for Inflammatory Bowel Disease Therapeutics显示文摘 | Mark L?wenberg Geert D’Haens | 2013 | Current Gastroenterology Reports2013，，2： | 2 |
| 8 | Future directions in inflammatory bowel disease management显示文摘 | Geert R. D’Haens R. Balfour Sartor Mark S. Silverberg Joel Petersson Paul Rutgeerts | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 9 | Effects of Vedolizumab Induction Therapy for Patients With Crohn’s Disease in Whom Tumor Necrosis Factor Antagonist Treatment Had Failed显示文摘 | Bruce E. Sands Brian G. Feagan Paul Rutgeerts Jean-Frédéric Colombel William J. Sandborn Richmond Sy Geert D’Haens Shomron Ben-Horin Jing Xu Maria Rosario Irving Fox Asit Parikh Catherine Milch Stephen Hanauer | 2014 | Gastroenterology2014，，： | 2 |
| 10 | Ornidazole for prophylaxis of postoperative Crohn’s disease recurrence: A randomized, double-blind, placebo-controlled trial显示文摘 | Paul Rutgeerts Gert van Assche Séverine Vermeire Geert D’Haens Filip Baert Maja Noman Isolde Aerden Gert de Hertogh Karel Geboes Martin Hiele Andre D’Hoore Freddy Penninckx | 2005 | Gastroenterology2005，，4： | 2 |
| 11 | Effects of Adalimumab Therapy on Incidence of Hospitalization and Surgery in Crohn’s Disease: Results From the CHARM Study显示文摘 | Brian G. Feagan Remo Panaccione William J. Sandborn Geert R. D’Haens Stefan Schreiber Paul J. Rutgeerts Edward V. Loftus Kathleen G. Lomax Andrew P. Yu Eric Q. Wu Jingdong Chao Parvez Mulani | 2008 | Gastroenterology2008，，5： | 2 |
| 12 | Adalimumab for Crohn’s disease: Long-term sustained benefit in a population-based cohort of 438 patients显示文摘 | Charlotte P. Peters Emma J. Eshuis Florien M. Toxopeüs Merel E. Hellemons Jeroen M. Jansen Geert R.A.M. D’Haens Paul Fockens Pieter C.F. Stokkers Hans A.R.E. Tuynman Adriaan A. van Bodegraven Cyriel Y. Ponsioen | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 13 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D'Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 14 | Prevention of venous thromboembolism:American College of Chest Physicians evidence-based clinical practice guidelines,8th ed显示文摘 | Geerts WH Bergqvist D Pineo GF | 2008 | Chest2008，133，6： | 1 |
| 15 | Prevention of venous thromboemholism American college of chest physicians evi- dence-based clinical practice guidelines (8th Edition)显示文摘 | Geerts WH Bergqvist D Pineo GF | 2008 | Chest2008，133，6： | 1 |
| 16 | Traumatic aortic rupture,30 years of experience显示文摘 | Cindy M Sabrina H Kim D Geert M Inge F | | 0，，： | 1 |
| 17 | The paradox of the unfolded protein response in cancer显示文摘 | VANDEWYNCKEL Y P LAUKENS D GEERTS A | 2013 | Anticancer Res2013，33，11： | 1 |
| 18 | Prevention of venous thromboembolism:American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)显示文摘 | Geerts W H Bergqvist D Pineo G F | | 0，，6： | 1 |
| 19 | Prevention of ve- nous thromboembolism:American College of Chest Physi- cians Evidence Based Clinical Practice Guidelines (8th Edition) 显示文摘 | Geerts WH Bergqvist D Pineo GF | 2008 | Chest2008，133，1： | 1 |
| 20 | Percutaneous absorption of indomethaein from transparent oil/water gels in rabbit显示文摘 | VOS D F MUYNEK D C GEERTS M | 1991 | Pharm Pharmacol1991，43，4： | 1 |
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