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| 1 | Cytomegalovirus positive ulcerative colitis:A single center experience and literature review显示文摘AIM:To compare the clinical outcome of cytomegalovirus(CMV)-positive ulcerative colitis(UC) patients with and without antiviral therapy.METHODS:This was a retrospective case-controlled study.The database of UC patients in our institution was scanned for documented presence of CMV on colonic biopsies.Demographics,clinical data,endoscopy findings and pathology reports were extracted from the patients' charts and electronic records.When available,the data from colonoscopies preceding and following the diagnosis of colonic CMV infection were also ex-tracted.The primary outcomes of the study were colectomy/death during hospitalization and the secondary outcomes were colectomy/death through the course of the follow-up.RESULTS:Thirteen patients were included in the study,7(53.5%) of them were treated with gancyclovir and 6(46.5%) were not.Patients treated with antivirals presented with a more severe disease and 57% of them were treated with cyclosporine or infliximab before initiation of gancyclovir,while none of the patients without antivirals required rescue therapy.One patient died and another patient underwent urgent colectomy during hospitalization,both of them from the gancyclovir-treatment group.For the entire follow-up time(13 ± 13 mo),a total of 3 colectomies and one death occurred,all among the antiviral-treated patients(for colectomy:3/7 vs 0/6 patients,P = 0.19;for combined adverse outcome:4/7 vs 0/6 patients,P = 0.07).In 9/13 patients,immunohistochemistry for CMV was performed on biopsies obtained during a subsequent colonoscopy and was positive in one patient only.CONCLUSION:Gancyclovir-treated patients had a more severe disease and outcome,probably unrelated to antiviral therapy.Immunohistochemistry-CMV-positive patients with mild disease may recover without antiviral therapy. | Uri Kopylov Gila Sasson Bella Geyshis Michal Tepperberg Oikawa Iris Barshack Rami Eliakim Shomron Ben-Horin | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 10 |
| 2 | Antiviral therapy in cytomegalovirus-positive ulcerative colitis:A systematic review and meta-analysis显示文摘AIM:To evaluate the impact of antiviral treatment on cytomegalovirus(CMV)-positive ulcerative colitis patients.METHODS:We performed a systematic review and meta-analysis(MA)of comparative cohort and casecontrol studies published between January 1966 and March 2013.Studies focusing on colectomy series and studies including only less than 3 patients in the treated or non-treated arm were excluded.The primary outcome was colectomy within 30 d of diagnosis.Secondary outcomes included colectomy during the follow-up period Subgroup analyses by method of detection of CMV,study design,risk of bias and country of origin were performed.Quality of studies was evalu-ated according to modified New-Castle Ottawa Scale.RESULTS:After full-text review,nine studies with a total of 176 patients were included in our MA.All the included studies were of low to moderate quality.Patients who have received antiviral treatment had a higher risk of 30-d colectomy(OR=2.40;95%CI:1.05-5.50;I2=37.2%).A subgroup analysis including only patients in whom CMV diagnosis was based did not demonstrate a significant difference between the groups(OR=3.41;95%CI:0.39-29.83;I2=56.9%).Analysis of long-term colectomy rates was possible for 6 studies including110 patients.No statistically significant difference was found between the treated and untreated groups(OR=1.71;95%CI:0.71-4.13;6 studies,I2=0%).Analysis of mortality rate was not possible due to a very limited number of cases.Stratification of the outcomes by disease severity was not possible.CONCLUSION:No positive association between antiviral treatment and a favorable outcome was demonstrated.These findings should be interpreted cautiously due to primary studies’quality and potential biases. | Uri Kopylov Noa Eliakim-Raz Andrew Szilagy Ernest Seidman Shomron Ben-Horin Lior Katz | 2014 | World Journal of Gastroenterology2014，20，10： | 4 |
| 3 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 4 | Optimizing anti-TNF treatments in inflammatory bowel disease显示文摘 | Shomron Ben-Horin Uri Kopylov Yehuda Chowers | 2013 | Autoimmunity Reviews2013，，： | 2 |
| 5 | Effects of Vedolizumab Induction Therapy for Patients With Crohn’s Disease in Whom Tumor Necrosis Factor Antagonist Treatment Had Failed显示文摘 | Bruce E. Sands Brian G. Feagan Paul Rutgeerts Jean-Frédéric Colombel William J. Sandborn Richmond Sy Geert D’Haens Shomron Ben-Horin Jing Xu Maria Rosario Irving Fox Asit Parikh Catherine Milch Stephen Hanauer | 2014 | Gastroenterology2014，，： | 2 |
| 6 | Determinants of targe- ting by endogenous and exogenous microRNA and siRNAs显示文摘 | Nielsen CB Shomron N Sandberg R | 2007 | RNA2007，13，11： | 1 |
| 7 | MicroRNAs and pharmacogenomics 显示文摘 | Shomron N | 2010 | Pharmacog-enomics2010，，： | 1 |
| 8 | Clinical utility of antihuman lambda chain‐based enzyme‐linked immunosorbent assay (ELISA) versus double antigen ELISA for the detection of anti‐infliximab antibodies显示文摘 | Uri Kopylov Yoav Mazor Miri Yavzori Ella Fudim Lior Katz Daniel Coscas Orit Picard Yehuda Chowers Rami Eliakim Shomron Ben‐Horin | 2011 | Inflamm Bowel Dis2011，，9： | 1 |
| 9 | Identification of let-7-regulated oncofetal genes 显示文摘 | Boyerinas B Park SM Shomron N | 2008 | Cancer Res2008，68，8： | 1 |
| 10 | Recognition of unknown conserved alternatively spliced exons 显示文摘 | Ohler U Shomron N Burge CB | 2005 | pLoS ComputBi- ol2005，1，2： | 1 |
| 11 | Versatility of microRNA biogenesis显示文摘 | Volk N Shomron N | 2011 | PLoS One2011，6，19： | 1 |
| 12 | Identification of lel-7- regulated oncofetal genes 显示文摘 | Boyerinas B Park SM Shomron N | 2008 | Cancer Res2008，68，8： | 1 |
| 13 | Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor 显示文摘 | Cavel O Shomron O Shabtay A | 2012 | Cancer Res2012，72，22： | 1 |
| 14 | Endoneurial macrophagesinduce perineural invasion of pancreatic cancer cells by secretion ofGDNF and activation of RET tyrosine kinase receptor 显示文摘 | Cavel 0 Shomron 0 Shabtay A | 2012 | CancerRes2012，72，22： | 1 |
| 15 | Identification of let-7- regulated oncofetal genes 显示文摘 | Boyerinas B Park SM Shomron N | 2008 | Cancer Res2008，68，8： | 1 |
| 16 | Endoneurial macrophages induce perineural invasion of pancreatic cancer cells by secretion of GDNF and activation of RET tyrosine kinase receptor 显示文摘 | Cavel O Shomron O Shabtay A | 2012 | Cancer Res2012，72，22： | 1 |
| 17 | MicroRNA-biogenesis and Pre-mRNA splicing crosstalk显示文摘 | Shomron N Levy C | 2009 | Biomed Research International2009，2009，59： | 1 |
| 18 | Identification of let-7-regulated oncofetal genes显示文摘 | Boyerinas B Park SM Shomron N | 2008 | Cancer Res2008，68，： | 1 |
| 19 | Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing 显示文摘 | SHOMRON N ALBERSTEIN M REZNIK M | 2005 | Jnurnal of Cell Science2005，118，： | 1 |
| 20 | An evolu- tionary perspective of animal microRNAs and their tar- gets 显示文摘 | SHOMRON N GOLAN D HORNSTEIN E | 2009 | Biomed Research International2009，，1： | 1 |
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