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| 1 | 普通小麦多酚氧化酶活性的QTL分析显示文摘多酚氧化酶 (polyphenoloxidase ,PPO)是引起面团 (片 )颜色褐变的主要原因。利用 12 2对SSR引物、4对贮藏蛋白STS引物和 10对AFLP引物组合 ,分析了中优 95 0 7×CA96 32的 71个DH系的基因型 ,构建了由 173个位点组成的遗传连锁图 ,在小麦 2 1个连锁群上覆盖 2 881cM。将该群体种植于 3个环境 ,采用复合区间作图法 (CIM)进行了PPO活性的QTL分析。结果表明 ,控制籽粒PPO活性的主效QTL有 2个 ,分别位于染色体 2AL和 2DL上 ,贡献率分别为 37 9%~5 0 0 %和 2 5 0 %~ 2 9 1%。所有QTL都来自高PPO活性亲本中优 95 0 7。讨论了通过遗传途径降低PPO活性及利用分子标记辅助育种的可能性。 | 张立平 葛秀秀 何中虎 王德森 闫俊 夏先春 Mark W Sutherland | 2005 | 作物学报2005，31，1： | 62 |
| 2 | 普通小麦籽粒黄色素含量的QTL分析显示文摘小麦面粉黄色度b^*值是反映面粉颜色的重要指标,主要与籽粒黄色素含量有关。利用122对SSR引物、4对贮藏蛋白STS引物和10对AFLP引物组合,分析了中优9507×CA9632的71个DH系,构建了由173个位点组成的遗传连锁图,在小麦21个连锁群上覆盖2881cM。将该群体种植2年共计5个地点,测定籽粒黄色素和面粉黄色度b^*值含量。采用复合区间作图法(CIM)进行了籽粒黄色素含量和面粉黄色度QTL分析。结果表明,面粉黄色度b^*值的QTL位于染色体1DS、2DL、3A、4D、5D、6AL、6D和7AL上,其中7AL的QTL效应最大,贡献率为12.9%~37.6%;籽粒黄色素含量的QTL位于染色体2DL、3DL、4A、5A和7AL,其中7AL的QTL效应最大,贡献率为12.1%~33.9%。面粉黄色度b^*值与籽粒黄色素含量共同的QTL位于7AL,与Xgwm264b紧密连锁,遗传距离分别为0~3.9cM和0~0.9cM。 | 张立平 阎俊 夏先春 何中虎 Mark W Sutherland | 2006 | 作物学报2006，32，1： | 36 |
| 3 | Pine wilt disease: a short review of worldwide research显示文摘This article summarizes the results of the research papers presented at the International Symposium on pine wilt disease (IUFRO Working Party Meeting 4.04.03) held in July 2009, at Nanjing, China. The general topics covered were on pine wilt disease (PWD), its causal organism, the pinewood nematode (PWN) Bursaphelenchus xylophilus, plus other PWN-associated microorganisms that play a significant role in PWD such as bacteria (e.g. Pseudomonas fluorescens). Most of the papers that are reviewed are based on work on PWD-PWN in East Asia and Russia. Specific topics covered include: 1) the fundamental conceptions of PWD development, 2) pathogenicity, 3) host-parasite relationships including the histopathology of diseased conifers and the role of toxins from bacteria-nematode ecto-symbionts, 4) PWN life cycle and transmission, 5) B. xylophilus dissemination models, 6) associations (with other nematodes), 7) diagnostics, 8) quarantine and control of the PWN and 9) biocontrol of the PWN. | Alexander Yu. RYSS Oleg A. KULINICH Jack R. SUTHERLAND | 2011 | Forestry Studies in China2011，13，2： | 14 |
| 4 | 儿童多导人工耳蜗植入者康复效果影响因素分析显示文摘目的:探讨儿童人工耳蜗植入效果的影响因素及对康复效果的影响,为提高儿童人工耳蜗植入者的康复效果提供参考依据。方法:对76例使用人工耳蜗装置超过1年的儿童患者;使用《儿童人工耳蜗植入者调查问卷》,由经过培训的专业人员与患者及家属通过面对面或电话进行调查。结果:①术前使用过助听器并接受过康复训练时间超过3个月(康复训练组)和未使用过助听器也无康复训练(对照组)的两组患者,在开机后能对环境声音进行识别所需的时间不同,康复训练组患者所需的时间平均为0.9个月,对照组患者为1.9个月,两组差异有显著性(t=2.899,P<0.05)。②6岁以下接受手术(A组)和6岁以上手术(B组)的两组患者,经训练后可以进行基本交流、对话的人数不同,A组为81.4%(35/43),B组为59.3%(16/27),两组差异有显著性(χ2=4.110,P<0.05)。③术前患者及家属的期望值合理(C组)和不合理(D组)的两组患者,术后的满意度存在差异,C组满意率为73.6%(39/53),D组为42.1%(8/19),两组差异有显著性(χ2=6.115,P<0.05)。结论:术后康复效果与术前是否接受过助听器适应训练和康复训练有关;手术年龄越小,术后康复效果越好;术后患者家属的满意度与术前期望值是否合理有关,同时也可影响术后康复效果。 | 孔颖 陈雪清 Fiona Sutherland 王靓 宋妍 李海珍 孟黎晖 刘莎 刘博 莫玲燕 吴燕君 王硕 | 2004 | 中国临床康复2004，8，15： | 10 |
| 5 | Neural progenitor cells but not astrocytes respond distally to thoracic spinal cord injury in rat models显示文摘Traumatic spinal cord injury(SCI) is a detrimental condition that causes loss of sensory and motor function in an individual. Many complex secondary injury cascades occur after SCI and they offer great potential for therapeutic targeting. In this study, we investigated the response of endogenous neural progenitor cells,astrocytes, and microglia to a localized thoracic SCI throughout the neuroaxis. Twenty-five adult female Sprague-Dawley rats underwent mild-contusion thoracic SCI(n = 9), sham surgery(n = 8), or no surgery(n = 8). Spinal cord and brain tissues were fixed and cut at six regions of the neuroaxis. Immunohistochemistry showed increased reactivity of neural progenitor cell marker nestin in the central canal at all levels of the spinal cord. Increased reactivity of astrocyte-specific marker glial fibrillary acidic protein was found only at the lesion epicenter. The number of activated microglia was significantly increased at the lesion site,and activated microglia extended to the lumbar enlargement. Phagocytic microglia and macrophages were significantly increased only at the lesion site. There were no changes in nestin, glial fibrillary acidic protein,microglia and macrophage response in the third ventricle of rats subjected to mild-contusion thoracic SCI compared to the sham surgery or no surgery. These findings indicate that neural progenitor cells, astrocytes and microglia respond differently to a localized SCI, presumably due to differences in inflammatory signaling. These different cellular responses may have implications in the way that neural progenitor cells can be manipulated for neuroregeneration after SCI. This needs to be further investigated. | Tara Nguyen Yilin Mao Theresa Sutherland Catherine Anne Gorrie | 2017 | Neural Regeneration Research2017，12，11： | 8 |
| 6 | Identification and characterization of a new member of the TNF family that induces apoptosis显示文摘 | Steven R. Wiley Ken Schooley Pamela J. Smolak Wenie S. Din Chang-Pin Huang Jillian K. Nicholl Grant R. Sutherland Terri Davis Smith Charles Rauch Craig A. Smith Raymond G. Goodwin | 1995 | Immunity1995，，6： | 6 |
| 7 | β-内酰胺酶抑制剂与抗生素耐药性的逆转显示文摘细菌对β—内酰胺类抗生素(青霉素类、头孢菌素类及其相关抗生素如头霉素类、青霉烯类、碳青霉烯类和单酰胺菌素类)产生耐药性的最重要机理是产生β—内酰胺酶。该酶能水解药物分子中的β—内酰胺键而使其失活。对于青霉素类,反应产物是青霉噻唑酸。头孢菌素类等则分解为较小分子产物。许多细菌产生β—内酰胺酶,一些细菌编码酶的基因位于染色体上,其余的则由染色体外成份介导,或由质粒介导,或由转座子介导。 | Sutherland R 刘小康 | 1993 | 国外医药(抗生素分册)1993，14，4： | 6 |
| 8 | 澳大利亚小麦品种Sunco抗条锈病性状的遗传分析显示文摘澳大利亚小麦品种Sunco成株期对中国条锈病小种条中32(CY32)表现高抗-免疫,而小麦品种川育12则表现为高感。利用Sunco/川育12的双单倍体(DH)群体对Sunco进行抗条锈病遗传研究,结果表明,品种Sunco可能具有持久抗性,抗性是由一对主效基因和两对微效基因联合作用的结果;主效基因的抗性反应为抗-中抗(R-MR),微效基因单独存在作用不明显,但与主效基因结合起来会加强抗条锈病能力。同时对微效多基因的持久抗性利用作了初步探讨。 | 杨恩年 邹裕春 杨武云 Mark Sutherland | 2006 | 中国农学通报2006，22，5： | 5 |
| 9 | Utility of endoscopic ultrasound, cytology and fluid carcinoembryonic antigen and CA 19-9 levels in pancreatic cystic lesions显示文摘AIM: To assess the diagnostic accuracy of endoscopic ultrasound (EUS), fluid tumor markers and cytology in distinguishing benign from (pre)malignant pancreatic cystic lesions. METHODS: 46 consecutive patients, referred to a gastroenterologist and surgeon for a symptomatic or incidental pancreatic cyst, were reviewed. EUS, cytology, and carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) levels were compared with the final diagnosis, based on surgical pathology and/or imaging follow-up of at least 12 mo. Cysts were classified as benign (pseudocyst, serous cystadenoma) or malignant/ pre-malignant (mucinous cystic neoplasm). Receiver- operator characteristics (ROC) curve analysis was performed. RESULTS: The mean age was 56 years; 29% were male and median cyst diameter was 3 cm. Final outcome was obtained in 41 (89%) patients. Twenty-three (56%) of these 41 had surgical pathology. Twenty-three (56%) had benign lesions and 18 (44%) had malignant/pre- malignant lesions. Sensitivity, specificity and positive and negative predictive value of EUS alone to distinguish benign from malignant/premalignant pancreatic cystic lesions were 50%, 56%, 36% and 54% and for cytology were 71%, 96%, 92% and 85%, respectively. The corresponding values for the ROC-derived ideal cutoffswere 75%, 90%, 75%, 90% for CA 19-9 (> 37 U/mL) and 70%, 85%, 79% and 78% for CEA (> 3.1 ng/mL). Subgroup analysis of those with surgical pathology yielded almost identical performance and cutoffs. CONCLUSION: Cytology and cyst fluid tumor marker analysis is a very useful tool in distinguishing benign from (pre)malignant pancreatic cystic lesions. | Abdulrahman M Aljebreen Joseph Romagnuolo Rafael Perini Francis Sutherland | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 10 | RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family显示文摘控制基因规定为维持繁殖潜力在配偶子开发期间是重要的。在哺乳动物的精子发生的复杂过程期间,尽管有重翻译要求,男细菌房间为继续的生长和区别经历不活跃的抄写的扩大时期。因此,精子发生高度依赖基因表示的 posttranscriptional 规定的机制,由 RNA 有约束力的蛋白质(RBP ) 便于,它仍然保持富有地在整个这进程表示了。一如此的组蛋白质是 Musashi 家庭,以前在果蝇识别了睾丸细菌房间开发和成熟分裂的同样批评的管理者,并且也出现对在老鼠的精子开发和繁殖潜力重要。这评论在男细菌房间开发的范围以内描述 RBP 的角色和函数,集中于我们在精子发生的 Musashi 蛋白质的最近的知识。RBP 在房间以内利用的功能的机制在与模式的关系深入地亚 cellular 本地化和阶段特定的表示的,和意义被构画出, posttranscriptional 规定的影响也被加亮。当原来在果蝇和 Xenopus 描绘了,我们在干细胞功能和房间命运决心强调 RBP 的 Musashi 家庭的历史的角色,并且与我们微分角色的当前的理解和哺乳动物的 Musashi 蛋白质, Musashi-1 和 Musashi-2 的功能得出结论,与我们在精子发生的调查结果的一个主要焦点。这评论两个都作为男配偶子开发的主人管理者加亮 RBP 的必要贡献到 posttranscriptional 规定和 Musashi 家庭的重要性。 | Jessie M Sutherland Nicole A Siddall Gary R Hime Eileen A McLaughlin | 2015 | Asian Journal of Andrology2015，17，4： | 4 |
| 11 | Oxidation controlled lift-off of 3D chiral plasmonic Au nano-hooks显示文摘Colloidal suspensions of plasmonic nanoparticles (NPs) are a well-established tool for biomedical applications and enhanced spectroscopy because of their strong optical response.The specific response is greatly dependent on the NP shape.The strong optical activity of chiral NPs has created special interest but fabrication of chiral NPs in solution remains challenging.Here,we present an approach whereby three-dimensional (3D) chiral Au nano-hooks,fabricated with the parallel hole-mask colloidal lithography (HMCL) method,can be lifted off from a glass substrate in a controllable manner by using a combined treatment with oxygen plasma oxidation and a reduction step in solution.This method has the advantage of being based on established techniques and not requiring strong acids or complex substrates as in etching based approaches.We furthermore demonstrate the integration of the hook NPs into reversibly cross-linked hydrogels inspired by mussel catechol chemistry but containing an oxidation resistant catechol analogue grafted onto poly(allylamine) crosslinked by coordination of Al^3+ and how this facilitates the remote analysis of hydrogel microenvironment,e.g.the water content.The suspended particles are promising candidates for optically active surface-enhanced Raman spectroscopy (SERS),asymmetric photo catalysis or aggregation sensing.The integration into hydrogels to produce functional hydrogels holds benefits for applications of metamaterials in optics,sensing or activation in environmental remediation or drug delivery. | Gunnar Klos Amanda Andersen Matteo Miola Henrik Birkedal Duncan S. Sutherland | 2019 | Nano Research2019，12，7： | 4 |
| 12 | Off-pump coronary artery bypass grafting versus optimal medical therapy alone:effectiveness of incomplete revascularization in high risk patients显示文摘有 multivessel 的 BackgroundGeriatric 病人冠的动脉疾病(CAD ) 是一个挑战性的组对待;这些盒子关于在这些病人上并且经常承担主要外科的实际利益在心队以内得到讨论导致放纵外科的选择。经皮的过程代表一种重要选择,但是冠的解剖可能是相反的。离开泵冠的动脉绕过(OPCAB ) 提供好质量没有暴露病人到的左前面的下降上的接枝(男孩) 心肺绕过,并且可能是在有多重 comorbidities 的病人的理想的选择,不是对合格经皮或在泵上过程。这研究的目的是没有经皮的选择在高风险的病人在中间的后续期间比较幸存,也与 OPCAB 对待或在回顾地从 2008 年 6 月评估到 2013 年 6 月的医药 therapy.MethodsWe 排出,有 multivessel CAD 的 83 个高风险的病人被包括:42 在男孩上用左内部乳房的动脉(LIMA ) 与不完全的离开泵 revascularization 被对待;41 在最佳的医药治疗(OMT ) 被解除,拒绝了外科。后续在 2015 年 3 月结束了,与一电话的会见。主要端点是从所有原因死亡的幸存;第二等的端点从非致命的主要不利心脏的事件(权标) 是从心脏相关的死亡和自由的幸存 .ResultsDuring 列在后面在上面,在 OPCAB 组的 11 死亡和在 OMT 组的 27 死亡发生了。死亡分别地由于在 6 和 15 个病人的心脏的因素。权标在 OMT 组在 OPCAB 组并且在 4 个病人在 6 个病人被观察。关于从所有原因死亡的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 <0.001 ) ,并且 OMT 组带倾向 3.862 的调整分数的危险比率(P <0.001 ) 。关于从心脏相关的事件的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 = 0.002 ) ,并且 OMT 组带倾向 3.663 的调整分数的危险比率(P = 0.010 ) 。有关从权标的自由没有统计上重要的差别(木头等级 = 0.273 ).ConclusionsFor 有 multivessel CAD 的高风险的病人,不是对在泵上合格完全的 revascularization 外科或经皮的过程,有 OPCAB LIMA-on-LAD 提议的不完全的 revascularization 在幸存受益什么时候与 OMT 相比独自一个。 | Filippo Prestipino Cristiano Spadaccio Antonio Nenna Fraser WH Sutherland Gwyn W Beattie Mario Lusini Francesco Nappi Massimo Chello | 2016 | Journal of Geriatric Cardiology2016，13，1： | 4 |
| 13 | Bed sediment-associated trace metals in an urban stream, Oahu, Hawaii显示文摘 | R. A. Sutherland | 2000 | Environmental Geology2000，，6： | 3 |
| 14 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D’Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 15 | A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance显示文摘 | Eva van Rooij Daniel Quiat Brett A. Johnson Lillian B. Sutherland Xiaoxia Qi James A. Richardson Robert J. Kelm Eric N. Olson | 2009 | Developmental Cell2009，，5： | 2 |
| 16 | Modular Timing Constraints for Delay-Insensitive Systems显示文摘这份报纸介绍 ARCtimer,为当模特儿,产生,验证,并且强制预定为单个自我预定的握手部件的限制的一个框架。限制保证门级的电路实现服从的部件部件握手协议说明。因为握手协议是 delayinsensitive,用证实 ARCtimer 的部件造的自我预定的系统也是延期感觉迟钝的。由小心地局部地考虑时间,我们能全球性忽略时间。ARCtimer 作为为以后的系统使用造验证部件的一个图书馆的部分在设计进程早来。图书馆也存储预定在任何自我预定的系统验证并且强制部件限制的代码造了使用图书馆的分析(STA ) 的静电干扰。对部件电路,协议,预定限制,和 STA 编码的一只握手的图书馆描述对以后技术印射或布局工具在设计进程使用的电路修正柔韧。除了介绍新工作并且讨论相关工作,这份报纸识别批评选择并且解释模块化的预定确认什么必要并且它怎么工作。 | Hoon Park Anping He Marly Roncken Xiaoyu Song Ivan Sutherland | 2016 | Journal of Computer Science & Technology2016，31，1： | 2 |
| 17 | Transanal Endoscopic Microsurgery: A Systematic Review显示文摘 | Philippa F. Middleton M.P.H. Leanne M. Sutherland Ph.D. Guy J. Maddern F.R.A.C.S. Ph.D | 2005 | Diseases of the Colon & Rectum2005，，2： | 2 |
| 18 | Atypical Bacterial Pneumonia and Asthma Risk显示文摘 | E. Rand Sutherland Jennifer M. Brandorff Richard J. Martin | 2004 | Journal of Asthma2004，，8： | 2 |
| 19 | Color Doppler velocity imaging of the myocardium 显示文摘 | McDicken WN Sutherland GR Moran CM | 1992 | Ultrasound Med Biol1992，18，： | 2 |
| 20 | Umbilical hernia repair in the presence of cirrhosis and ascites: results of a survey and review of the literature显示文摘 | A. McKay E. Dixon O. Bathe F. Sutherland | 2009 | Hernia2009，，5： | 2 |
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