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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Adalimumab for Crohn’s disease: Long-term sustained benefit in a population-based cohort of 438 patients显示文摘 | Charlotte P. Peters Emma J. Eshuis Florien M. Toxopeüs Merel E. Hellemons Jeroen M. Jansen Geert R.A.M. D’Haens Paul Fockens Pieter C.F. Stokkers Hans A.R.E. Tuynman Adriaan A. van Bodegraven Cyriel Y. Ponsioen | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 3 | Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins显示文摘 | GLOERICH M PONSIOEN B VLIEM M J | 2010 | Mol Cell Biol2010，30，22： | 1 |
| 4 | Epidemiology of primary sclerosing eholangitis and primary biliary cirrhosis: a systematic re- view 显示文摘 | Boonstra K Beuers U Ponsioen CY | 2012 | Hepatol2012，56，5： | 1 |
| 5 | Natural history of primary sclerosing cholangitis and prognostic value of cholangiography a Dutch population显示文摘 | Ponsioen CY Vrouenraets SM Prawirodirdjo W | 2002 | Gut2002，51，4： | 1 |
| 6 | 显示文摘 | Kuiper H Ten Kate FJ | 1999 | Eur J Gastroenterol Hepatol1999，11，7： | 1 |
| 7 | Formulation and process development of (recombinant human) deoxyribonuclease I as a powder for inhalation 显示文摘 | Zijlstra G S Ponsioen B J Hummel S A | 2009 | Pharm Dev Technol2009，14，4： | 1 |
| 8 | Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels 显示文摘 | Ponsioen B van Zeijl L Moolenaar WH | 2007 | Exp Cell Res2007，313，2： | 1 |
| 9 | GSK-3 is aetiviated by the tyrosine kinase Pyk2 during LPAl-mediated neurite restraction 显示文摘 | Sayas CL Ariaens A Ponsioen B | 2006 | Mol Biol Cell2006，17，4： | 1 |
| 10 | Direct measurement of cyclic AMP diffusion and signaling through connexin43 gap junctional channels 显示文摘 | Ponsioen B Van Zeijl L Moolenaar WH | 2007 | Exp Cell Res2007，313，： | 1 |
| 11 | Packages of vitreous collagen (type Ⅱ) in the human retina: an indication of postnatal turnover显示文摘 | Ponsioen T L van der Worp R J van Luyn M J | 2005 | Exper Eye Research2005，80，5： | 1 |
| 12 | Epidemiology of primary sclerosing cholangitis and primary biliary cirrhosis:a systematic review显示文摘 | Boonstra K Beuers U Ponsioen CY | 2012 | J Hepatol2012，56，5： | 1 |
| 13 | Vitamin D deficiency in Crohn′s disease and healthy controls: a prospective case-control study in the Netherlands显示文摘 | de Bruyn JR van Heeckeren R Ponsioen CY | 2014 | J Crohns Colitis2014，8，10： | 1 |
| 14 | The effect of appendectomy on the course of ulcerative coti- tis:a systematic review 显示文摘 | GARDENBROEK T J ESHUIS E J PONSIOEN C I | 2012 | Colorectal Dis2012，14，5： | 1 |
| 15 | In vitro phagocytosis of collagens by immortalised human retinal Muller cens显示文摘 | Ponsioen T L Van Luyn M J Van der Worp R J | 2007 | Graefes Arch Clin Exp Ophthalmol2007，245，1： | 1 |
| 16 | Mucosal morphology in Barrett’s esophagus: interobserver agreement and role of narrow band imaging显示文摘 | W. Curvers C. Bohmer R. Mallant-Hent A. Naber C. Ponsioen K. Ragunath R. Singh M. Wallace H. Wolfsen L.-M. Wong Kee Song R. Lindeboom P. Fockens J. Bergman | 2008 | Endoscopy2008，，： | 1 |
| 17 | Pilot study of probe-based confocal laser endomicroscopy during colonoscopic surveillance of patients with longstanding ulcerative colitis显示文摘 | F. van den Broek J. van Es S. van Eeden P. Stokkers C. Ponsioen J. Reitsma P. Fockens E. Dekker | 2011 | Endoscopy2011，，02： | 1 |
| 18 | Epidemiology of primary scleros- ing cholangitis and primary biliary cirrhosis: a systematic review 显示文摘 | Boonstra K Beuers U Ponsioen CY | 2012 | J Hepatol2012，56，5： | 1 |
| 19 | Epidemiology of pri-mary sclerosing cholangitis and primary biliary cirrhosis; a system-atic review显示文摘 | BOONSTRA K BEUERS U PONSIOEN CY | 2012 | J Hepatol2012，56，5： | 1 |
| 20 | Single-port versus multiport laparoscopic ileocecal resection for Crohn’s disease显示文摘 | Tjibbe J. Gardenbroek Tessa Verlaan Pieter J. Tanis Cyriel Y. Ponsioen Geert R.A.M. D’Haens Christianne J. Buskens Willem A. Bemelman | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
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