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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn’s disease: an open randomised trial显示文摘 | Geert D’Haens Filip Baert Gert van Assche Philip Caenepeel Philippe Vergauwe Hans Tuynman Martine De Vos Sander van Deventer Larry Stitt Allan Donner Severine Vermeire Frank J Van De Mierop Jean-Charles R Coche Janneke van der Woude Thomas Ochsenkühn Ad A | 2008 | The Lancet2008，，9613： | 5 |
| 3 | Colonic work-up after incomplete colonoscopy: significant new findings during follow-up显示文摘 | M. Neerincx J. Terhaar sive Droste C. Mulder M. R?kers J. Bartelsman R. Loffeld H. Tuynman R. Brohet R. van der Hulst | 2010 | Endoscopy2010，，09： | 4 |
| 4 | Adalimumab for Crohn’s disease: Long-term sustained benefit in a population-based cohort of 438 patients显示文摘 | Charlotte P. Peters Emma J. Eshuis Florien M. Toxopeüs Merel E. Hellemons Jeroen M. Jansen Geert R.A.M. D’Haens Paul Fockens Pieter C.F. Stokkers Hans A.R.E. Tuynman Adriaan A. van Bodegraven Cyriel Y. Ponsioen | 2014 | Journal of Crohn’s and Colitis2014，，： | 2 |
| 5 | Nutritional management of patientswith acute pancreatitis: a Dutch observa- tional muhicentre study 显示文摘 | Spanier BW Mathus - Vliegen EM Tuynman HA | 2008 | Aliment Pharmacol Ther2008，28，9： | 1 |
| 6 | Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn 显示文摘 | LOWENBERG M TUYNMAN J BILDERBEEK J | 2005 | Blood2005，106，： | 1 |
| 7 | Cyclooxygenase-2 inhibition inhibits c-met kinase ctivity and Wnt activity in colon cancer显示文摘 | Tuynman JB Vermeulen L Boon EM | 2008 | Cancer Res2008，68，4： | 1 |
| 8 | Met ex- pression is an independent prognostic risk factor in pa- tients with oesophageal adenocarcinoma 显示文摘 | Tuynman JB Lagarde SM ten Kate FJW | 2008 | Br J Cancer2008，98，6： | 1 |
| 9 | Neoadjuvant selective COX-2 inhibition down-regulates important oncogenic pathways in patients with esophageal adenocarcinoma显示文摘 | Buskens CJ Kemper K | 2005 | Ann Surg2005，242，6： | 1 |
| 10 | Cyelooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer显示文摘 | Tuynman JB Vermeulen L Boon EM | 2008 | Cancer Res2008，68，4： | 1 |
| 11 | Cyclooxygenase- 2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer显示文摘 | Tuynman JB Vcrmeulen L Boon EM | 2008 | Cancer Res2008，68，4： | 1 |
| 12 | COX-2 inhibition as a tool to treat and prevent eoloreetal cancer显示文摘 | TUYNMAN J B PEPPELENBOSCH M P RICHEL D J | 2004 | Crit Rev Oncol Hematol2004，52，2： | 1 |
| 13 | Chemoprevention for colon cancer: New opportunities, fact or fiction?显示文摘 | J. S. Terhaar Sive Droste J. B. Tuynman H. M. Van Dullemen C. J. J. Mulder | 2006 | Scandinavian Journal of Gastroenterology . 2006 (S243)2006，，243： | 1 |
| 14 | Rapid immunosuppressive effects of glucoeorticoids mediated through Lck and Fyn 显示文摘 | Lowenberg M Tuynman J Bilderbeek J | 2005 | Blood2005，106，5： | 1 |
| 15 | Robotic transanal minimally invasive surgery for local excision of rectal neoplasms显示文摘 | R. Hompes S. M. Rauh F. Ris J. B. Tuynman N. J. Mortensen | 2014 | Br J Surg2014，，5： | 1 |
| 16 | Nutritional management of patients with acute pancreatitis: a Dutch observational muhicentre study显示文摘 | Spanier BW Mathus-Vliegen EM Tuynman HA | 2008 | Aliment Pharmacol Ther2008，28，9： | 1 |
| 17 | Rapid immunosuppressive effects of glucocorticoids mediated through Lck and Fyn显示文摘 | Lowenberg M Tuynman J | 2005 | Blood2005，17，5： | 1 |
| 18 | Met expression is an independent prognostic risk factor in patients with oesophageal adenocarcinoma显示文摘 | Tuynman JB Lagarde SM Ten Kate FJ | 2008 | Br J Cancer2008，98，6： | 1 |
| 19 | Population‐based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis显示文摘 | Kirsten Boonstra Rinse K. Weersma Karel J. Erpecum Erik A. Rauws B.W. Marcel Spanier Alexander C. Poen Karin M. Nieuwkerk Joost P. Drenth Ben J. Witteman Hans A. Tuynman Anton H. Naber Paul J. Kingma Henk R. Buuren Bart Hoek Frank P. Vleggaar Nan Geloven | 2013 | Hepatology2013，，6： | 1 |
| 20 | COX-2 inhibition as a tool to treat and prevent colorectal cancer显示文摘 | Tuynman JB Peppelenbosch MP Richel DJ | 2004 | Critical Reviews in Oncology/Hematology2004，52，： | 1 |
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